Research graph
References from Delay of diabetic cataract progression by a chemical chaperone trimethylamine N-oxide through alleviating unfolded-protein-induced ER stress. Local targets link to admitted publications; unresolved targets remain external evidence.
Potential prophylactic effect of chemical chaperones for alleviation of endoplasmic reticulum stress in experimental diabetic cataract
10.1186/s42269-019-0089-7 · 2019 · External reference
Molecular mechanism for the preferential exclusion of TMAO from protein surfaces
10.1021/jp304298c · 2012 · External reference
Trimethylamine N-Oxide binds and activates PERK to promote metabolic dysfunction
10.1016/j.cmet.2019.08.021 · 2019 · External reference
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
10.1038/s41392-023-01570-w · 2023 · External reference
Attenuation of epithelial-mesenchymal transition via SGLT2 inhibition and diabetic cataract suppression by dapagliflozin nanoparticles treatment
10.1016/j.lfs.2023.122005 · 2023 · External reference
Can diet modulate trimethylamine N-oxide (TMAO) production? What do we know so far?
10.1007/s00394-021-02491-6 · 2021 · External reference
The association of trimethylamine N-oxide with diabetic retinopathy Pathology: insights from network toxicology and molecular docking analysis
10.1016/j.exer.2025.110399 · 2025 · External reference
Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
10.1016/j.jbiosc.2014.03.001 · 2014 · External reference
Trimethylamine N-oxide alleviates the severe aggregation and ER stress caused by G98R alphaA-crystallin
2009 · External reference
Diabetes and phacoemulsification cataract surgery: difficulties, risks and potential complications
10.3390/jcm8050716 · 2019 · External reference
Oxidative stress, epigenetic regulation and pathological processes of lens epithelial cells underlying diabetic cataract
10.1016/j.aopr.2023.10.001 · 2023 · External reference
Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats
10.1152/ajpheart.00536.2018 · 2018 · External reference
Role of the unfolded protein response (UPR) in cataract formation
10.1016/j.exer.2006.01.033 · 2006 · External reference
Aberrant basal fiber end migration underlies structural malformations in a streptozotocin-induced diabetic rat model
10.1016/j.exer.2009.03.022 · 2009 · External reference
A novel high resolution in vivo digital imaging system for the evaluation of experimental cataract in diabetic rats
10.1254/jphs.fp0071500 · 2008 · External reference
Temporal relationship between lens protein oxidation and cataract development in streptozotocin-induced diabetic rats
10.33549/physiolres.930613 · 2005 · External reference
Pharmacological prevention of diabetic cataract
10.1016/s1056-8727(03)00009-6 · 2004 · External reference
Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing
10.1016/j.cell.2007.10.057 · 2008 · External reference
Endoplasmic reticulum stress as a regulator of high glucose-induced epithelial-mesenchymal transition in human lens epithelial cells
10.1089/jop.2024.0210 · 2025 · External reference
SIRT1 inhibits high glucose-induced TXNIP/NLRP3 inflammasome activation and cataract formation
10.1167/iovs.64.3.16 · 2023 · External reference
Preventative effects of Ginkgo biloba extract (EGb761) on high glucose-cultured opacity of rat lens
10.1002/ptr.5060 · 2014 · External reference
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
10.1074/jbc.m200903200 · 2002 · External reference
Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota
10.1038/s41392-022-01027-6 · 2022 · External reference
Counteracting effects of trimethylamine N-Oxide against urea in aqueous solutions: insights from theoretical two-dimensional infrared spectroscopy
10.1021/acs.jpcb.3c03864 · 2023 · External reference
The unfolded protein response in lens epithelial cells from galactosemic rat lenses
10.1167/iovs.06-0193 · 2006 · External reference
Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats
2007 · External reference
5-Nitro-2-(3-phenylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway
10.3892/ijmm.2021.4892 · 2021 · External reference
The role of endoplasmic reticulum stress in human pathology
10.1146/annurev-pathol-012513-104649 · 2015 · External reference
Diabetic cataracts: mechanisms and management
10.1002/dmrr.1075 · 2010 · External reference
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
10.1126/science.1128294 · 2006 · External reference
Diabetic cataract-pathogenesis, epidemiology and treatment
10.1155/2010/608751 · 2010 · External reference
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/Glycolysis pathways
10.1172/jci.insight.158183 · 2023 · External reference
Systemically administered mini α-crystallin peptide delays cataract progression in streptozotocin-induced diabetic rats
10.1016/j.bbagen.2025.130814 · 2025 · External reference
The TMAO-producing enzyme flavin-containing monooxygenase 3 regulates obesity and the beiging of white adipose tissue
10.1016/j.celrep.2017.06.053 · 2017 · External reference
TFEB-mediated lysosomal restoration alleviates high glucose-induced cataracts via attenuating oxidative stress
10.1167/iovs.63.6.26 · 2022 · External reference
Prospective associations of systemic and urinary choline metabolites with incident type 2 diabetes
10.1373/clinchem.2015.250761 · 2016 · External reference
Unfolded protein response activation in cataracts
10.1016/j.jcrs.2014.02.038 · 2014 · External reference
The unfolded protein response: from stress pathway to homeostatic regulation
10.1126/science.1209038 · 2011 · External reference
The role of trimethylamine-N-oxide level in the diagnosis of diabetic retinopathy and the differential diagnosis of diabetic and nondiabetic retinopathy
10.5935/0004-2749.2021-0527 · 2022 · External reference
Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses
10.1242/jeb.01730 · 2005 · External reference
Endoplasmic reticulum stress regulates epithelial-mesenchymal transition in human lens epithelial cells
2020 · External reference
Diabetic cataracts: mechanisms and management
10.1002/dmrr.1075 · ExternalCitation · doi-reference
Preventative effects of Ginkgo biloba extract (EGb761) on high glucose-cultured opacity of rat lens
10.1002/ptr.5060 · ExternalCitation · doi-reference
Can diet modulate trimethylamine N-oxide (TMAO) production? What do we know so far?
10.1007/s00394-021-02491-6 · ExternalCitation · doi-reference
Oxidative stress, epigenetic regulation and pathological processes of lens epithelial cells underlying diabetic cataract
10.1016/j.aopr.2023.10.001 · ExternalCitation · doi-reference
Systemically administered mini α-crystallin peptide delays cataract progression in streptozotocin-induced diabetic rats
10.1016/j.bbagen.2025.130814 · ExternalCitation · doi-reference
Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing
10.1016/j.cell.2007.10.057 · ExternalCitation · doi-reference
The TMAO-producing enzyme flavin-containing monooxygenase 3 regulates obesity and the beiging of white adipose tissue
10.1016/j.celrep.2017.06.053 · ExternalCitation · doi-reference
Trimethylamine N-Oxide binds and activates PERK to promote metabolic dysfunction
10.1016/j.cmet.2019.08.021 · ExternalCitation · doi-reference
Role of the unfolded protein response (UPR) in cataract formation
10.1016/j.exer.2006.01.033 · ExternalCitation · doi-reference
Aberrant basal fiber end migration underlies structural malformations in a streptozotocin-induced diabetic rat model
10.1016/j.exer.2009.03.022 · ExternalCitation · doi-reference
The association of trimethylamine N-oxide with diabetic retinopathy Pathology: insights from network toxicology and molecular docking analysis
10.1016/j.exer.2025.110399 · ExternalCitation · doi-reference
Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
10.1016/j.jbiosc.2014.03.001 · ExternalCitation · doi-reference
Unfolded protein response activation in cataracts
10.1016/j.jcrs.2014.02.038 · ExternalCitation · doi-reference
Attenuation of epithelial-mesenchymal transition via SGLT2 inhibition and diabetic cataract suppression by dapagliflozin nanoparticles treatment
10.1016/j.lfs.2023.122005 · ExternalCitation · doi-reference
Pharmacological prevention of diabetic cataract
10.1016/s1056-8727(03)00009-6 · ExternalCitation · doi-reference
Counteracting effects of trimethylamine N-Oxide against urea in aqueous solutions: insights from theoretical two-dimensional infrared spectroscopy
10.1021/acs.jpcb.3c03864 · ExternalCitation · doi-reference
Molecular mechanism for the preferential exclusion of TMAO from protein surfaces
10.1021/jp304298c · ExternalCitation · doi-reference
Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota
10.1038/s41392-022-01027-6 · ExternalCitation · doi-reference
Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
10.1038/s41392-023-01570-w · ExternalCitation · doi-reference
Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress
10.1074/jbc.m200903200 · ExternalCitation · doi-reference
Endoplasmic reticulum stress as a regulator of high glucose-induced epithelial-mesenchymal transition in human lens epithelial cells
10.1089/jop.2024.0210 · ExternalCitation · doi-reference
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
10.1126/science.1128294 · ExternalCitation · doi-reference
The unfolded protein response: from stress pathway to homeostatic regulation
10.1126/science.1209038 · ExternalCitation · doi-reference
The role of endoplasmic reticulum stress in human pathology
10.1146/annurev-pathol-012513-104649 · ExternalCitation · doi-reference
Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats
10.1152/ajpheart.00536.2018 · ExternalCitation · doi-reference
Diabetic cataract-pathogenesis, epidemiology and treatment
10.1155/2010/608751 · ExternalCitation · doi-reference
The unfolded protein response in lens epithelial cells from galactosemic rat lenses
10.1167/iovs.06-0193 · ExternalCitation · doi-reference
TFEB-mediated lysosomal restoration alleviates high glucose-induced cataracts via attenuating oxidative stress
10.1167/iovs.63.6.26 · ExternalCitation · doi-reference
SIRT1 inhibits high glucose-induced TXNIP/NLRP3 inflammasome activation and cataract formation
10.1167/iovs.64.3.16 · ExternalCitation · doi-reference
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/Glycolysis pathways
10.1172/jci.insight.158183 · ExternalCitation · doi-reference
Potential prophylactic effect of chemical chaperones for alleviation of endoplasmic reticulum stress in experimental diabetic cataract
10.1186/s42269-019-0089-7 · ExternalCitation · doi-reference
Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses
10.1242/jeb.01730 · ExternalCitation · doi-reference
A novel high resolution in vivo digital imaging system for the evaluation of experimental cataract in diabetic rats
10.1254/jphs.fp0071500 · ExternalCitation · doi-reference
Prospective associations of systemic and urinary choline metabolites with incident type 2 diabetes
10.1373/clinchem.2015.250761 · ExternalCitation · doi-reference
Temporal relationship between lens protein oxidation and cataract development in streptozotocin-induced diabetic rats
10.33549/physiolres.930613 · ExternalCitation · doi-reference
Diabetes and phacoemulsification cataract surgery: difficulties, risks and potential complications
10.3390/jcm8050716 · ExternalCitation · doi-reference
5-Nitro-2-(3-phenylpropylamino) benzoic acid induces apoptosis of human lens epithelial cells via reactive oxygen species and endoplasmic reticulum stress through the mitochondrial apoptosis pathway
10.3892/ijmm.2021.4892 · ExternalCitation · doi-reference
The role of trimethylamine-N-oxide level in the diagnosis of diabetic retinopathy and the differential diagnosis of diabetic and nondiabetic retinopathy
10.5935/0004-2749.2021-0527 · ExternalCitation · doi-reference
