Research graph
References from Metabolic threat to vision: Hyperuricemia-associated retinal ganglion cell damage through inflammatory and apoptotic pathways. Local targets link to admitted publications; unresolved targets remain external evidence.
Role of uric acid in neurodegenerative diseases, focusing on Alzheimer and Parkinson disease: a new perspective
10.1002/npr2.12445 · 2024 · External reference
Review of the ophthalmic manifestations of gout and uric acid crystal deposition
10.1111/ceo.12749 · 2017 · External reference
Could be serum uric acid a risk factor for thrombosis and/or uveitis in Behcet's disease?
10.1177/1708538117742831 · 2018 · External reference
Radiculopathy in a patient with chronic tophaceus gout: vertebral imaging
2017 · External reference
Central retinal artery occlusion in a patient with metabolic syndrome x
2010 · External reference
Surgical versus pharmacologic treatment of intraspinal gout
10.1097/01.blo.0000151456.52270.39 · 2005 · External reference
Serum uric acid and intermediate age-related macular degeneration: a nationally representative Study in the United States
10.1167/tvst.14.8.6 · 2025 · External reference
Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adults
10.1186/s12886-017-0470-y · 2017 · External reference
Hyperuricemia and epiretinal pathologies: a review of pathophysiological links and clinical implications
10.37349/emed.2024.00253 · 2024 · External reference
10.1016/s0140-6736(21)00569-9
10.1016/s0140-6736(21)00569-9 · 2021 · External reference
Tophaceous gout causing thoracic spinal cord compression: case report and review of the literature
10.1016/j.neuchi.2017.11.002 · 2018 · External reference
Optogenetic stimulation of the superior colliculus confers retinal neuroprotection in a mouse glaucoma model
10.1523/jneurosci.0872-18.2018 · 2019 · External reference
Urbanisation and health in China
10.1016/s0140-6736(11)61878-3 · 2012 · External reference
Potential contribution of the neurodegenerative disorders risk loci to cognitive performance in an elderly male gout population
2017 · External reference
Higher serum uric Acid levels are associated with an increased risk of vision-threatening diabetic retinopathy in type 2 diabetes patients
10.1167/iovs.62.4.23 · 2021 · External reference
Formononetin attenuates hydrogen peroxide (H2O2)-induced apoptosis and NF-kappaB activation in RGC-5 cells
2014 · External reference
Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration
10.7150/thno.29422 · 2019 · External reference
Retinal complications of gout: a case report and review of the literature
10.1186/s12886-018-0669-6 · 2018 · External reference
Relation between prognostic impact of hyperuricemia and sympathetic overactivation in patients with heart failure
10.1016/j.jjcc.2018.08.008 · 2019 · External reference
Uric acid puzzle: dual role as anti-oxidantand pro-oxidant
10.5049/ebp.2014.12.1.1 · 2014 · External reference
Neurite outgrowth in retinal ganglion cell culture
2007 · External reference
Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants
10.1080/10715760310001604189 · 2003 · External reference
Global epidemiology of gout: prevalence, incidence and risk factors
10.1038/nrrheum.2015.91 · 2015 · External reference
Effects of urate-lowering agents on arrhythmia vulnerability in post-infarcted rat hearts
10.1016/j.jphs.2016.03.009 · 2016 · External reference
The toxic effect of ALLN on primary rat retinal neurons
10.1007/s12640-016-9624-6 · 2016 · External reference
COX-2/mPGES-1/PGE2 cascade activation mediates uric acid-induced mesangial cell proliferation
10.18632/oncotarget.14363 · 2017 · External reference
Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies
2017 · External reference
A review of the evidence for a protective role of uric acid in Parkinson's disease
10.1038/s41531-025-01169-8 · 2025 · External reference
Association between primary angle closure glaucoma and uric acid levels in serum and aqueous humor
10.1016/j.heliyon.2024.e30721 · 2024 · External reference
[Chronic orchialgia. A diagnostic and therapeutic hypothesis]
1997 · External reference
Peripheral neuropathy in patients with gout, beyond focal nerve compression: a cross-sectional study
10.1007/s10067-024-07044-w · 2024 · External reference
Gasdermin D promotes hyperuricemia-induced renal tubular injury through RIG-I/caspase-1 pathway
10.1016/j.isci.2023.108463 · 2023 · External reference
Involvement of calpain/p35-p25/Cdk5/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons
10.1371/journal.pone.0042318 · 2012 · External reference
Signaling via the NFkappaB system
10.1002/wsbm.1331 · 2016 · External reference
Uric acid and glaucoma: a systematic review and meta-analysis
10.3389/fmed.2023.1159316 · 2023 · External reference
Uric acid and neurological disease: a narrative review
10.3389/fneur.2023.1164756 · 2023 · External reference
Short-Term hyperuricemia leads to structural retinal changes that can be reversed by Serum uric acid lowering agents in mice
10.1167/iovs.63.10.8 · 2022 · External reference
Current updates for hyperuricemia and gout in age-related macular degeneration
10.1096/fj.202400421r · 2024 · External reference
Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina
10.1016/j.expneurol.2022.114233 · 2023 · External reference
NFkB-signaling promotes glial reactivity and suppresses Muller glia-mediated neuron regeneration in the mammalian retina
10.1002/glia.24181 · 2022 · External reference
Global estimates of visual impairment: 2010
10.1136/bjophthalmol-2011-300539 · 2012 · External reference
Elevated level of uric acid in aqueous humour is associated with posterior subcapsular cataract in human lens
10.1111/ceo.13835 · 2020 · External reference
Elevated level of uric acid, but not glucose, in aqueous humor as a risk factor for diabetic macular edema in patients with type 2 diabetes
10.1097/iae.0000000000003424 · 2022 · External reference
Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes
10.2337/diabetes.51.7.2241 · 2002 · External reference
Uric acid: the oxidant-antioxidant paradox
10.1080/15257770802138558 · 2008 · External reference
Beyond joints: a review of ocular abnormalities in gout and hyperuricemia
10.1007/s11926-016-0586-8 · 2016 · External reference
Relationship between serum uric acid and cerebral white matter lesions in the elderly
10.1016/j.numecd.2010.06.005 · 2012 · External reference
Monosodium urate contributes to retinal inflammation and progression of diabetic retinopathy
10.2337/db18-0912 · 2019 · External reference
Increased susceptibility of atrial fibrillation induced by hyperuricemia in rats: mechanisms and implications
10.1007/s12012-020-09611-4 · 2021 · External reference
High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes
10.1186/s13098-025-01656-1 · 2025 · External reference
Gout tophus on an intradural fascicle: a case description
10.1007/s00586-015-4309-z · 2016 · External reference
Targeting uric acid: a promising intervention against oxidative stress and neuroinflammation in neurodegenerative diseases
10.1186/s12964-024-01965-4 · 2025 · External reference
Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010
10.1016/s0140-6736(13)61097-1 · 2013 · External reference
Hyperuricemia accompanied with changes in the retinal microcirculation in a Chinese high-risk population for diabetes
2011 · External reference
Germacrone protects against NF-kappaB-Mediated inflammatory signaling, apoptosis, and retinal ganglion cell survival in a rat glaucoma model
10.1620/tjem.2024.j028 · 2024 · External reference
The role of uric acid in the pathogenesis of diabetic retinopathy based on Notch pathway
10.1016/j.bbrc.2018.06.097 · 2018 · External reference