Research graph
References from Knocking down FSTL1 reduces TGF-β2–induced trabecular meshwork fibrosis and ocular hypertension via inhibition of the Smad3 signaling pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Advances in targeting the extracellular matrix for glaucoma therapy: current updates
10.1080/14728222.2023.2293748 · 2023 · External reference
Effects of FSTL1 on cell proliferation in breast cancer cell line MDA-MB-231 and its brain metastatic variant MDA-MB-231-BR
10.3892/or.2017.6004 · 2017 · External reference
[Primary open-angle glaucoma]
10.1016/j.revmed.2018.12.001 · 2019 · External reference
The trabecular meshwork: structure, function and clinical implications. A review of the literature
10.1016/j.jfo.2020.05.002 · 2020 · External reference
Effect of transforming growth factor-beta(2) on extracellular matrix synthesis in bovine trabecular meshwork cells
2002 · External reference
Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice
10.1084/jem.20121878 · 2015 · External reference
Transforming growth factor beta-2 drives trabecular meshwork progenitor cell differentiation through SMAD2/3 signaling
10.1093/stmcls/sxag033 · 2026 · External reference
TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure
10.1167/iovs.05-1060 · 2006 · External reference
Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis
10.1038/s41467-023-41832-3 · 2023 · External reference
Efficacy and drug interactions of glaucoma medications: a systematic review and component network meta-analysis
10.1016/j.ophtha.2025.07.009 · 2025 · External reference
Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes
10.1007/s004170000241 · 2001 · External reference
Consensus recommendations for trabecular meshwork cell isolation, characterization and culture
10.1016/j.exer.2018.03.001 · 2018 · External reference
Comparative effects of TGF-beta2/Smad2 and TGF-beta2/Smad3 signaling pathways on proliferation, migration, and extracellular matrix production in a human lens cell line
10.1016/j.exer.2011.01.009 · 2011 · External reference
FSTL1 secreted by activated fibroblasts promotes hepatocellular carcinoma metastasis and stemness
10.1158/0008-5472.can-20-4226 · 2021 · External reference
TGFbeta2 alters segmental outflow and ECM ultrastructure in the trabecular meshwork
10.1016/j.exer.2025.110377 · 2025 · External reference
Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice
10.1016/j.exer.2013.10.017 · 2013 · External reference
TGF-beta/Smad signaling in renal fibrosis
10.3389/fphys.2015.00082 · 2015 · External reference
Follistatin-like protein 1 functions as a potential target of gene therapy in proliferative diabetic retinopathy
10.18632/aging.202678 · 2021 · External reference
Higher concentration of transforming growth factor-beta in aqueous humor of glaucomatous eyes and diabetic eyes
10.1016/s0021-5155(01)00523-8 · 2002 · External reference
The aqueous levels of TGF-beta2 in patients with glaucoma
10.1023/b:inte.0000018524.48581.79 · 2004 · External reference
The number of people with glaucoma worldwide in 2010 and 2020
10.1136/bjo.2005.081224 · 2006 · External reference
Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins
10.1167/iovs.11-7587 · 2011 · External reference
Adenoviral gene transfer of active human transforming growth factor-beta2 elevates intraocular pressure and reduces outflow facility in rodent eyes
10.1167/iovs.09-4567 · 2010 · External reference
Cloning from a mouse osteoblastic cell line of a set of transforming-growth-factor-beta 1-regulated genes, one of which seems to encode a follistatin-related polypeptide
10.1111/j.1432-1033.1993.tb18212.x · 1993 · External reference
TXNDC5 in POAG: promoting extracellular matrix protein accumulation and raising intraocular pressure
10.1167/iovs.67.4.46 · 2026 · External reference
'See-saw' expression of microRNA-198 and FSTL1 from a single transcript in wound healing
10.1038/nature11890 · 2013 · External reference
Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis
10.1016/j.ophtha.2014.05.013 · 2014 · External reference
Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2
10.1006/exer.1994.1158 · 1994 · External reference
Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma
10.1016/j.exer.2014.07.014 · 2015 · External reference
Updates on the diagnosis and management of glaucoma
10.1016/j.mayocpiqo.2022.09.007 · 2022 · External reference
Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
10.1038/nature15372 · 2015 · External reference
The role of TGF-beta2 and bone morphogenetic proteins in the trabecular meshwork and glaucoma
10.1089/jop.2013.0220 · 2014 · External reference
FSTL1 accelerates nucleus pulposus-derived mesenchymal stem cell apoptosis in intervertebral disc degeneration by activating TGF-beta-mediated Smad2/3 phosphorylation
10.1186/s12967-025-06231-w · 2025 · External reference
MicroRNA-210-3p mediates trabecular meshwork extracellular matrix accumulation and ocular hypertension - implication for novel glaucoma therapy
10.1016/j.exer.2022.109350 · 2023 · External reference
TGF-beta1 induces Fstl1 via the Smad3-c-Jun pathway in lung fibroblasts
10.1152/ajplung.00523.2016 · 2017 · External reference
Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages
10.1038/s41392-025-02162-6 · 2025 · External reference
Transforming growth factor-beta2 increases extracellular matrix proteins in optic nerve head cells via activation of the Smad signaling pathway
2011 · External reference
