Research graph
References from Rodent Models of Glaucoma: Pathogenic Mechanisms, Phenotyping Strategies, and Translational Relevance. Local targets link to admitted publications; unresolved targets remain external evidence.
Genetic rodent models of glaucoma in representing disease phenotype and insights into the pathogenesis
10.1016/j.mam.2023.101228 · 2023 · External reference
Rodent models of glaucoma: How mice and rats can help human vision move out of the woods and into the light
10.3390/cells14211648 · 2025 · External reference
Glaucoma: Now and beyond
10.1016/s0140-6736(23)01289-8 · 2023 · External reference
Advances in understanding glaucoma pathogenesis: A multifaceted molecular approach for clinician scientists
10.1016/j.mam.2023.101223 · 2023 · External reference
Two decades of angle-closure glaucoma research
2025 · External reference
Diurnal cycle of translaminar pressure in nonhuman primates quantified with continuous wireless telemetry
10.1167/iovs.61.2.37 · 2020 · External reference
Intra-subject variability and diurnal cycle of ocular perfusion pressure as characterized by continuous telemetry in nonhuman primates
10.1167/iovs.61.6.7 · 2020 · External reference
Posture-dependent 24-hour intraocular pressure fluctuation patterns in an intraocular hypertension monkey model
10.1167/tvst.8.3.63 · 2019 · External reference
A novel tree shrew (tupaia belangeri) model of glaucoma
10.1167/iovs.18-24261 · 2018 · External reference
Anterior segment anatomy and conventional outflow physiology of the tree shrew (tupaia belangeri)
10.1167/iovs.63.1.21 · 2022 · External reference
Study of tree shrew biology and models: A booming and prosperous field for biomedical research
10.24272/j.issn.2095-8137.2024.199 · 2024 · External reference
Review of rodent hypertensive glaucoma models
10.1111/aos.13983 · 2019 · External reference
Pathophysiology of human glaucomatous optic nerve damage: Insights from rodent models of glaucoma
10.1016/j.exer.2010.08.005 · 2011 · External reference
Comparative anatomy of the trabecular meshwork, the optic nerve head and the inner retina in rodent and primate models used for glaucoma research
10.3390/vision1010004 · 2017 · External reference
Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments
10.1016/j.preteyeres.2024.101261 · 2024 · External reference
In vitro comparison of human and murine trabecular meshwork cells: Implications for glaucoma research
10.1038/s41598-024-73057-9 · 2024 · External reference
Pericytes in the optic nerve head
10.1016/j.preteyeres.2025.101375 · 2025 · External reference
IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors
10.1016/j.preteyeres.2023.101232 · 2024 · External reference
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
10.1083/jcb.200706181 · 2007 · External reference
Ocular pressure-volume relationship and ganglion cell death in glaucoma
10.21926/obm.neurobiol.2102098 · 2021 · External reference
Mice with an induced mutation in collagen 8a2 exhibit axial elongation and are resistant to retinal ganglion cell damage in an experimental glaucoma model
2012 · External reference
Glaucoma in adults-screening, diagnosis, and management: A review
10.1001/jama.2020.21899 · 2021 · External reference
Comparative in vivo imaging of retinal structures in tree shrews, humans, and mice
10.1523/eneuro.0373-23.2024 · 2024 · External reference
Retinal ganglion cell subtypes and their vulnerability in glaucoma
10.1007/978-1-0716-4140-8_16 · 2025 · External reference
Chronic human glaucoma causing selectively greater loss of large optic nerve fibers
10.1016/s0161-6420(88)33176-3 · 1988 · External reference
Subtype-specific response of retinal ganglion cells to optic nerve crush
10.1038/s41420-018-0069-y · 2018 · External reference
Selective vulnerability of specific retinal ganglion cell types and synapses after transient ocular hypertension
10.1523/jneurosci.0940-16.2016 · 2016 · External reference
Optimizing retinal ganglion cell nuclear staining for automated cell counting
10.1016/j.exer.2024.109881 · 2024 · External reference
How many aqueous humor outflow pathways are there?
10.1016/j.survophthal.2019.10.002 · 2020 · External reference
A model of the mechanisms underpinning unconventional aqueous humor outflow
10.1167/iovs.66.4.75 · 2025 · External reference
Novel discovery of a lymphatic bridge connecting schlemm's canal to limbal and conjunctival lymphatic pathway
10.1016/j.jtos.2023.05.009 · 2023 · External reference
Aqueous humor as eye lymph: A crossroad between venous and lymphatic system
10.1016/j.exer.2024.109904 · 2024 · External reference
The microbead occlusion model of ocular hypertension in mice
10.1007/978-1-4939-7407-8_3 · 2018 · External reference
A magnetic microbead occlusion model to induce ocular hypertension-dependent glaucoma in mice
2016 · External reference
A comprehensive protocol for microbead-induced ocular hypertension in mice
10.1007/978-1-0716-4140-8_20 · 2025 · External reference
A fair assessment of evaluation tools for the murine microbead occlusion model of glaucoma
10.3390/ijms22115633 · 2021 · External reference
Strain specific responses in a microbead rat model of experimental glaucoma
10.1080/02713683.2020.1805472 · 2021 · External reference
Microbead-induced ocular hypertension in a rodent model of glaucoma
10.1007/978-1-0716-3409-7_8 · 2023 · External reference
Downregulation of SARM1 protects retinal ganglion cell axonal and somal degeneration via JNK activation in a glaucomatous model of ocular hypertension
10.1167/iovs.65.13.7 · 2024 · External reference
Restored retinal physiology after administration of niacin with citicoline in a mouse model of hypertensive glaucoma
10.3389/fmed.2023.1230941 · 2023 · External reference
The anti-inflammatory and antioxidant properties of acebuche oil exert a retinoprotective effect in a murine model of high-tension glaucoma
10.3390/nu16030409 · 2024 · External reference
Induction of significant intraocular pressure diurnal fluctuation in rats using a modified technique of microbead occlusion
2018 · External reference
Influence of sex on neuroretinal degeneration: Six-month follow-up in rats with chronic glaucoma
10.1167/iovs.62.13.9 · 2021 · External reference
Mimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres
10.1080/10717544.2022.2096712 · 2022 · External reference
Differential susceptibility to experimental glaucoma among 3 mouse strains using bead and viscoelastic injection
10.1016/j.exer.2010.06.018 · 2010 · External reference
The microbead occlusion model: A paradigm for induced ocular hypertension in rats and mice
10.1167/iovs.09-3947 · 2010 · External reference
Using retinal function to define ischemic exclusion criteria for animal models of glaucoma
10.1016/j.exer.2020.108354 · 2021 · External reference
Photocrosslinkable sericin hydrogel injected into the anterior chamber of mice with chronic ocular hypertension efficacy, medication sensitivity, and material safety
10.3390/bioengineering11060607 · 2024 · External reference
A dietary combination of forskolin with homotaurine, spearmint and b vitamins protects injured retinal ganglion cells in a rodent model of hypertensive glaucoma
10.3390/nu12041189 · 2020 · External reference
Molecular and histological characterization of a novel hydrogel-based strategy for inducing experimental glaucoma in mice
10.3390/ijms26209860 · 2025 · External reference
A murine glaucoma model induced by rapid in vivo photopolymerization of hyaluronic acid glycidyl methacrylate
10.1371/journal.pone.0196529 · 2018 · External reference
Mouse model of ocular hypertension with retinal ganglion cell degeneration
10.1371/journal.pone.0208713 · 2019 · External reference
A laser-induced mouse model with long-term intraocular pressure elevation
10.1371/journal.pone.0107446 · 2014 · External reference
Rodent models of glaucoma and their applicability for drug discovery
10.1080/17460441.2017.1281244 · 2017 · External reference
Effect of pigmentation intensity of trabecular meshwork cells on mechanisms of micropulse laser trabeculoplasty
10.1038/s41598-022-14637-5 · 2022 · External reference
Inducible rodent models of glaucoma
10.1016/j.preteyeres.2019.100799 · 2020 · External reference
Changes in the inner and outer retinal layers after acute increase of the intraocular pressure in adult albino Swiss mice
10.1016/j.exer.2010.05.020 · 2010 · External reference
Laser-induced ocular hypertension in a mouse model of glaucoma
10.1007/978-1-0716-3409-7_6 · 2023 · External reference
The pathological association between the anterior eye segment and the retina in a murine model of neovascular glaucoma
10.1096/fj.202101917r · 2022 · External reference
A pharmacological approach in newly established retinal vein occlusion model
10.1038/srep43509 · 2017 · External reference
Neovascular glaucoma regulation by arylsulfonyl indoline-benzamide (ASIB) through targeting NF-kB signalling pathway
10.1007/s13205-019-1730-8 · 2019 · External reference
Tunable degrees of neurodegeneration in rats based on microsphere-induced models of chronic glaucoma
10.1038/s41598-022-24954-4 · 2022 · External reference
Hypertonic saline injection model of experimental glaucoma in rats
10.1007/978-1-4939-7407-8_2 · 2018 · External reference
Proteomics-based identification of retinal protein networks impacted by elevated intraocular pressure in the hypertonic saline injection model of experimental glaucoma
10.3390/ijms241612592 · 2023 · External reference
Modeling glaucoma in rats by sclerosing aqueous outflow pathways to elevate intraocular pressure
10.1016/j.exer.2015.05.012 · 2015 · External reference
Regional differences of the sclera in the ocular hypertensive rat model induced by circumlimbal suture
10.1186/s40662-022-00319-w · 2023 · External reference
A minimally invasive experimental model of acute ocular hypertension with acute angle closure characteristics
10.1167/tvst.9.7.24 · 2020 · External reference
Circumlimbal suture and laser burns: Comparison between two different chronic glaucoma models
2024 · External reference
Effect of strain on rodent glaucoma models: Magnetic bead injection versus hydrogel injection versus circumlimbal suture
10.1167/tvst.11.9.31 · 2022 · External reference
An inducible rodent glaucoma model that exhibits gradual sustained increase in intraocular pressure with distinct inner retina and optic nerve inflammation
10.1038/s41598-021-02057-w · 2021 · External reference
Longitudinal outcomes of circumlimbal suture model-induced chronic ocular hypertension in Sprague-Dawley albino rats
10.1007/s00417-020-04820-7 · 2020 · External reference
Comparative analysis of retinal ganglion cell damage in three glaucomatous rat models
10.1016/j.exer.2018.03.019 · 2018 · External reference
Characterization of the most resistant and vulnerable retinal ganglion cell subtypes in a chronic model of glaucoma in rat
10.1167/iovs.66.13.5 · 2025 · External reference
Mechanical property changes of glial LC and RGC axons in response to high intraocular pressure
10.3389/fbioe.2025.1574231 · 2025 · External reference
Full-circle cauterization of limbal vascular plexus for surgically induced glaucoma in rodents
2022 · External reference
Longitudinal evaluation of morphological, functional and vascular alterations in a rat model of experimental glaucoma
10.1016/j.visres.2024.108458 · 2024 · External reference
Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine
10.1016/j.preteyeres.2016.09.003 · 2017 · External reference
Steroid-induced glaucoma: Epidemiology, pathophysiology, and clinical management
10.1016/j.survophthal.2020.01.002 · 2020 · External reference
Dexamethasone stiffens trabecular meshwork, trabecular meshwork cells, and matrix
10.1167/iovs.15-16739 · 2015 · External reference
Mitochondria and autophagy dysfunction in glucocorticoid-induced ocular hypertension/glaucoma mice model
10.1080/02713683.2019.1657462 · 2020 · External reference
Ultrastructural changes associated with dexamethasone-induced ocular hypertension in mice
10.1167/iovs.14-14429 · 2014 · External reference
CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma
10.1186/s13024-020-00400-9 · 2020 · External reference
Dexamethasone-induced ocular hypertension in mice: Effects of myocilin and route of administration
10.1016/j.ajpath.2016.12.003 · 2017 · External reference
Time-course characterization of intraocular pressure in murine steroid-induced ocular hypertension: Effects of route, schedule, and concentration
10.1002/ame2.70177 · 2026 · External reference
Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma
10.1172/jci69774 · 2014 · External reference
Topical ocular dexamethasone decreases intraocular pressure and body weight in rats
10.1186/s12952-016-0048-x · 2016 · External reference
Long-term corticosteroid-induced chronic glaucoma model produced by intracameral injection of dexamethasone-loaded PLGA microspheres
10.1080/10717544.2021.1998245 · 2021 · External reference
Understanding the ocular hypertension model in mice induced by Dexamethasone-21-acetate - implications for glaucoma research
10.1080/02713683.2024.2380445 · 2024 · External reference
A chronic ocular-hypertensive rat model induced by injection of the sclerosant agent polidocanol in the aqueous humor outflow pathway
10.3390/ijms20133209 · 2019 · External reference
Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse
10.7554/elife.45881 · 2019 · External reference
Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension
10.1038/s41598-021-88690-x · 2021 · External reference
Comparing silicone oil-induced ocular hypertension with other inducible glaucoma models in mice
10.4103/1673-5374.276330 · 2020 · External reference
Experimental glaucoma model with controllable intraocular pressure history
10.1038/s41598-019-57022-5 · 2020 · External reference
A new model of axon degeneration in the mouse optic nerve using repeat intraocular pressure challenge
10.1016/j.exer.2023.109722 · 2024 · External reference
Nerve fibre layer degeneration and retinal ganglion cell loss long term after optic nerve crush or transection in adult mice
10.1016/j.exer.2018.02.010 · 2018 · External reference
Carnosine decreases retinal ganglion cell death in a mouse model of optic nerve crushing
10.1016/j.neulet.2019.134431 · 2019 · External reference
The mechanisms of neuroprotection by topical Rho kinase inhibition in experimental mouse glaucoma and optic neuropathy
10.1167/iovs.65.13.43 · 2024 · External reference
Differential retinal ganglion cell resilience to optic nerve injury across vertebrate species
10.3389/fnins.2025.1596464 · 2025 · External reference
Optic nerve crush does not induce retinal ganglion cell loss in the contralateral eye
10.1167/iovs.66.3.49 · 2025 · External reference
7,8-Dihydroxiflavone maintains retinal functionality and protects various types of RGCs in adult rats with optic nerve transection
10.3390/ijms222111815 · 2021 · External reference
Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy
10.3389/fimmu.2022.860070 · 2022 · External reference
Application of proteomics analysis and animal models in optic nerve injury diseases
2023 · External reference
Quantitative iTRAQ analysis of retinal ganglion cell degeneration after optic nerve crush
10.1021/pr2004055 · 2011 · External reference
Mtorc2 activation protects retinal ganglion cells via akt signaling after autophagy induction in traumatic optic nerve injury
10.1038/s12276-019-0298-z · 2019 · External reference
Optic nerve crush in mice to study retinal ganglion cell survival and regeneration
10.21769/bioprotoc.3559 · 2020 · External reference
The extent of extra-axonal tissue damage determines the levels of CSPG upregulation and the success of experimental axon regeneration in the CNS
10.1038/s41598-018-28209-z · 2018 · External reference
Molecular mechanisms of NMDA excitotoxicity in the retina
10.1038/s41598-023-45855-0 · 2023 · External reference
Survival of alpha and intrinsically photosensitive retinal ganglion cells in NMDA-induced neurotoxicity and a mouse model of normal tension glaucoma
10.1167/iovs.19-27145 · 2019 · External reference
Retinal glutamate neurotransmission: From physiology to pathophysiological mechanisms of retinal ganglion cell degeneration
2022 · External reference
Positive AMPA and kainate receptor modulators and their therapeutic potential in CNS diseases: A comprehensive review
10.3390/ijms26136450 · 2025 · External reference
Ripa-56 protects retinal ganglion cells in glutamate-induced retinal excitotoxic model of glaucoma
10.1038/s41598-024-54075-z · 2024 · External reference
Concentration-dependent inner retina layer damage and optic nerve degeneration in a NMDA model
10.1007/s12031-017-0978-x · 2017 · External reference
N-methyl-D-aspartate-induced neurotoxicity in the adult rat retina
10.1017/s0952523800005666 · 1992 · External reference
Dose-dependent effects of NMDA on retinal and optic nerve morphology in rats
2019 · External reference
Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse
10.1007/s12031-010-9434-x · 2011 · External reference
Assessment of intrinsic and extrinsic signaling pathway in excitotoxic retinal ganglion cell death
10.1038/s41598-018-22848-y · 2018 · External reference
Longitudinal and simultaneous imaging of retinal ganglion cells and inner retinal layers in a mouse model of glaucoma induced by n-methyl-d-aspartate
10.1167/iovs.10-6654 · 2011 · External reference
Oral memantine for the treatment of glaucoma: Design and results of 2 randomized, placebo-controlled, phase 3 studies
10.1016/j.ophtha.2018.06.017 · 2018 · External reference
Prospects for neuroprotective therapies in glaucoma: Drug targets and emerging clinical strategies
2026 · External reference
Cataract as an endpoint-dependent confounder in trials of neuroprotective therapies for glaucoma [letter]
10.2147/dddt.s635506 · 2026 · External reference
Recent clinical findings with memantine should not mean that the idea of neuroprotection in glaucoma is abandoned
10.1111/j.1755-3768.2008.01459.x · 2009 · External reference
Citicoline in pre-clinical animal models of stroke: A meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial
10.1111/j.1471-4159.2012.07891.x · 2012 · External reference
LCN2 deficiency mitigates the neuroinflammatory damage following acute glaucoma
10.7150/thno.104752 · 2025 · External reference
A pyruvate dehydrogenase kinase inhibitor prevents retinal cell death and improves energy metabolism in rat retinas after ischemia/reperfusion injury
10.1016/j.exer.2020.107997 · 2020 · External reference
Metformin protects retinal ganglion cells in a preclinical model of retinal ischemia/reperfusion injury and stabilizes visual field in diabetic patients with glaucoma
10.1038/s41420-025-02824-y · 2025 · External reference
Effect of bromfenac on reducing neuroinflammation in an ischemia-reperfusion glaucoma model
10.3390/cells13121046 · 2024 · External reference
Peptains block retinal ganglion cell death in animal models of ocular hypertension: Implications for neuroprotection in glaucoma
10.1038/s41419-022-05407-2 · 2022 · External reference
N,n-dimethyl-3β-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia/reperfusion injury by inhibiting ninjurin 1
10.1186/s12974-023-02754-5 · 2023 · External reference
Enhanced retinal ganglion cell survival via autophagy activation in a novel retinal ischemia/reperfusion rat model
10.3390/ijms27021031 · 2026 · External reference
Structural, functional and blood perfusion changes in the rat retina associated with elevated intraocular pressure, measured simultaneously with a combined oct+erg system
10.1371/journal.pone.0193592 · 2018 · External reference
Elevated plasma aldosterone levels are associated with a reduction in retinal ganglion cell survival
10.1177/1470320318795001 · 2018 · External reference
Compromised blood flow in the optic nerve head after systemic administration of aldosterone in rats: A possible rat model of retinal ganglion cell loss
10.1080/02713683.2022.2029907 · 2022 · External reference
The relationship between aldosterone-induced retinal ganglion cell loss, blood pressure, and intraocular pressure
10.1007/s10384-025-01201-7 · 2025 · External reference
Glaucoma: A degenerative optic neuropathy related to neuroinflammation?
2020 · External reference
10.3390/ijms26073129
10.3390/ijms26073129 · External reference
Differential protein expression and metabolite profiling in glaucoma: Insights from a multi-omics analysis
10.1002/biof.2079 · 2024 · External reference
Increased ratios of complement factors C3a to C3 in aqueous humor and serum mark glaucoma progression
10.1016/j.exer.2021.108460 · 2021 · External reference
Expression of IL-4 and IL-12 in the aqueous humor of patients with chronic primary angle-closure glaucoma
2024 · External reference
IL-38: A new player in inflammatory autoimmune disorders
10.3390/biom9080345 · 2019 · External reference
Role of heat shock proteins in glaucoma
10.3390/ijms20205160 · 2019 · External reference
Synapse and receptor alterations in two different s100b-induced glaucoma-like models
10.3390/ijms21196998 · 2020 · External reference
Heat shock protein upregulation supplemental to complex mrna alterations in autoimmune glaucoma
10.3390/biom12101538 · 2022 · External reference
In a novel autoimmune and high-pressure glaucoma model a complex immune response is induced
10.3389/fimmu.2024.1296178 · 2024 · External reference
Does HSP27 injection induce glaucoma damage in mice?
10.4103/nrr.nrr-d-23-01912 · 2024 · External reference
Intermittent fasting reduces glaucomatous damage in an HSP27 autoimmune mouse model
2025 · External reference
Transfer of the experimental autoimmune glaucoma model from rats to mice-new options to study glaucoma disease
10.3390/ijms20102563 · 2019 · External reference
The S1P1 receptor-selective agonist CYM-5442 protects retinal ganglion cells in endothelin-1 induced retinal ganglion cell loss
10.1016/j.exer.2017.08.005 · 2017 · External reference
Involvement of c-Jun N-terminal kinase 2 (JNK2) in endothelin-1 (ET-1) mediated neurodegeneration of retinal ganglion cells
10.1167/iovs.62.6.13 · 2021 · External reference
Long-term effects on retinal structure and function in a mouse endothelin-1 model of retinal ganglion cell degeneration
10.1167/iovs.64.11.15 · 2023 · External reference
SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration
10.1083/jcb.201912047 · 2020 · External reference
Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma
10.1186/s12974-021-02236-6 · 2021 · External reference
Loss of the extracellular matrix molecule tenascin-c leads to absence of reactive gliosis and promotes anti-inflammatory cytokine expression in an autoimmune glaucoma mouse model
10.3389/fimmu.2020.566279 · 2020 · External reference
Mechanism for altered dark-adapted electroretinogram responses in DBA/2J mice includes pupil dilation deficits
10.1080/02713683.2022.2044055 · 2022 · External reference
Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma (DBA/2J) mice
10.4103/1673-5374.375341 · 2024 · External reference
Natural history of glaucoma progression in the DBA/2J model: Early contribution of müller cell gliosis
10.3390/cells12091272 · 2023 · External reference
Age-related changes in eye, brain and visuomotor behavior in the DBA/2J mouse model of chronic glaucoma
10.1038/s41598-018-22850-4 · 2018 · External reference
DBA/2J mouse model for experimental glaucoma: Pitfalls and problems
10.1111/ceo.12992 · 2017 · External reference
Vitamin b3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice
10.1126/science.aal0092 · 2017 · External reference
Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma
10.1167/iovs.05-0925 · 2006 · External reference
Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning
10.1136/bjophthalmol-2018-312724 · 2019 · External reference
The contribution of anterior segment abnormalities to changes in intraocular pressure in the DBA/2J mouse model of glaucoma: DBA/2J-gpnmb+/sjj mice as critical controls
10.3389/fnins.2021.801184 · 2022 · External reference
A transcriptomic atlas of immune cell populations in glaucomatous mouse retina and optic nerve
2025 · External reference
Temporal single-cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury
10.1038/s41590-023-01437-w · 2023 · External reference
Effect of ocular hypertension on the pattern of retinal ganglion cell subtype loss in a mouse model of early-onset glaucoma
10.1016/j.exer.2019.107703 · 2019 · External reference
Quantification and image-derived phenotyping of retinal ganglion cell nuclei in the nee mouse model of congenital glaucoma
10.1016/j.exer.2021.108774 · 2021 · External reference
Anterior segment dysgenesis and early-onset glaucoma in nee mice with mutation of sh3pxd2b
10.1167/iovs.10-5993 · 2011 · External reference
The sh3pxd2bnee−/− mouse reveals developmental features of frank-ter haar syndrome
10.1242/dev.204631 · 2026 · External reference
Molecular genetics of primary open-angle glaucoma
10.4103/ijo.ijo_2570_22 · 2023 · External reference
Detection of mutations in MYOC, OPTN, NTF4, WDR36 and CYP1B1 in Chinese juvenile onset open-angle glaucoma using exome sequencing
10.1038/s41598-018-22337-2 · 2018 · External reference
Physiological function of myocilin and its role in the pathogenesis of glaucoma in the trabecular meshwork
2019 · External reference
Systemic genotype-phenotype analysis of MYOC variants based on exome sequencing and literature review
10.1097/apo.0000000000000382 · 2021 · External reference
Human Pro370Leu mutant myocilin induces the phenotype of open-angle glaucoma in transgenic mice
10.1007/s10571-022-01280-x · 2023 · External reference
Absence of glaucoma in Tg-MYOCY437H mice of diverse genetic backgrounds
10.1167/iovs.66.12.40 · 2025 · External reference
Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma
10.1128/mcb.01127-06 · 2006 · External reference
Mutant human myocilin induces strain specific differences in ocular hypertension and optic nerve damage in mice
10.1016/j.exer.2012.04.016 · 2012 · External reference
Glaucoma-causing myocilin mutants require the peroxisomal targeting signal-1 receptor (pts1r) to elevate intraocular pressure
10.1093/hmg/ddm001 · 2007 · External reference
The vital role for nitric oxide in intraocular pressure homeostasis
10.1016/j.preteyeres.2020.100922 · 2021 · External reference
Aqueous humor outflow physiology in NOS3 knockout mice
10.1167/iovs.15-16564 · 2015 · External reference
Endothelial cell-specific postnatal deletion of Nos3 preserves intraocular pressure homeostasis via macrophage recruitment and NOS2 upregulation
10.1172/jci183440 · 2025 · External reference
A light-activatable nitric oxide donor for targeted glaucoma therapy with real-time monitoring capabilities
10.1002/adhm.202404221 · 2025 · External reference
Enos activity in CAV1 knockout mouse eyes
10.1167/iovs.15-18841 · 2016 · External reference
Genetic deletion of the NOS3 gene in CAV1−/− mice restores aqueous humor outflow function
10.1167/iovs.16-21072 · 2017 · External reference
Caveolin-1 ablation imparts partial protection against inner retinal injury in experimental glaucoma and reduces apoptotic activation
10.1007/s12035-020-01948-9 · 2020 · External reference
Caveolin-1 regulates human trabecular meshwork cell adhesion, endocytosis, and autophagy
10.1002/jcb.28613 · 2019 · External reference
A role of caveolae in trabecular meshwork mechanosensing and contractile tone
10.3389/fcell.2022.855097 · 2022 · External reference
Loss of Caveolin-1 impairs light flicker-induced neurovascular coupling at the optic nerve head
10.3389/fnins.2021.764898 · 2021 · External reference
Physiologic consequences of Caveolin-1 ablation in conventional outflow endothelia
10.1167/iovs.61.11.32 · 2020 · External reference
Longitudinal age effects of optineurin E50K mutation and deficiency on visual function
2021 · External reference
Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma
10.1093/hmg/ddab099 · 2021 · External reference
Retinal ganglion cells with a glaucoma OPTN(E50K) mutation exhibit neurodegenerative phenotypes when derived from three-dimensional retinal organoids
10.1016/j.stemcr.2020.05.009 · 2020 · External reference
Chitosan–rapamycin carbon dots rejuvenate autologous Sca-1+ stem cells paracrine function for neuroprotection in normal tension glaucoma
10.1186/s13287-026-04944-3 · 2026 · External reference
Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: Possible relationship with glaucoma pathology
10.1371/journal.pone.0101206 · 2014 · External reference
E50K-OPTN-induced retinal cell death involves the rab gtpase-activating protein, TBC1D17 mediated block in autophagy
10.1371/journal.pone.0095758 · 2014 · External reference
The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro
10.1038/s41420-021-00432-0 · 2021 · External reference
Protein misfolding and mitochondrial dysfunction in glaucoma
10.3389/fcell.2025.1595121 · 2025 · External reference
Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells
10.1016/j.stemcr.2022.05.006 · 2022 · External reference
EAAT1 variants associated with glaucoma
10.1016/j.bbrc.2020.06.099 · 2020 · External reference
Ferroptosis contributes to retinal ganglion cell loss in GLAST knockout mouse model of normal tension glaucoma
10.1167/iovs.66.5.26 · 2025 · External reference
Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model
10.1038/s41598-020-78731-2 · 2020 · External reference
Edaravone suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma
10.1038/cddis.2017.341 · 2017 · External reference
Topical ripasudil suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma
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Absence of cytochrome P450-1b1 increases susceptibility of pressure-induced axonopathy in the murine retinal projection
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Targeted deletion of Cyp1b1 in pericytes results in attenuation of retinal neovascularization and trabecular meshwork dysgenesis
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Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice
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Potential involvements of cilia-centrosomal genes in primary congenital glaucoma
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DNA polymorphism of the LOXL1 promoter region in exfoliation syndrome in Uygur individuals in xinjiang, China
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Genetic background determines severity of loxl1-mediated systemic and ocular elastosis in mice
10.1242/dmm.050392 · 2023 · External reference
Progressive ocular axial elongation and retinal ganglion cell degeneration in mice with elastic fiber disorder
10.3390/ijms26189221 · 2025 · External reference
Lack of evidence for GWAS signals of exfoliation glaucoma working via monogenic loss-of-function mutation in the nearest gene
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Exfoliation syndrome genetics in the era of post-GWAS
10.1016/j.visres.2024.108518 · 2025 · External reference
Uveitic glaucoma-like features in Yap conditional knockout mice
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YAP/TAZ maintain the proliferative capacity and structural organization of radial glial cells during brain development
10.1016/j.ydbio.2021.08.010 · 2021 · External reference
YAP inhibition by verteporfin causes downregulation of desmosomal genes and proteins leading to the disintegration of intercellular junctions
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The role of the Hippo/YAP pathway in the physiological activities and lesions of lens epithelial cells
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YAP in development and disease: Navigating the regulatory landscape from retina to brain
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Astrocytic YAP prevents the glutamate neurotoxicity by upregulation of EAAT2 expression and promotes the gain of stemness in astrocytes in ischemic stroke mice
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Investigation of intraocular pressure fluctuation as a risk factor of glaucoma progression
10.2147/opth.s186526 · 2019 · External reference
Comparing 24-hour IOP fluctuation slope curve between newly diagnosed ocular hypertension and primary open-angle glaucoma
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Intraocular pressure fluctuation: Is it important?
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Joint modeling of longitudinal visual field changes and time to detect progression in glaucoma patients: A secondary data analysis
2025 · External reference
Retinal molecular changes are associated with neuroinflammation and loss of RGCs in an experimental model of glaucoma
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Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model
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Comparison of Brn3a and RBPMS labeling to assess retinal ganglion cell loss during aging and in a model of optic neuropathy
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Morphometric analysis of retinal ganglion cell axons in normal and glaucomatous brown norway rats optic nerves
10.1167/tvst.12.3.8 · 2023 · External reference
Automated axon counting in rodent optic nerve sections with axonj
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Efficient determination of axon number in the optic nerve: A stereological approach
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Global and regional damages in retinal ganglion cell axon bundles monitored non-invasively by visible-light optical coherence tomography fibergraphy
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The rd8 mutation of the crb1 gene is present in vendor lines of c57bl/6n mice and embryonic stem cells, and confounds ocular induced mutant phenotypes
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Differential visual system organization and susceptibility to experimental models of optic neuropathies in three commonly used mouse strains
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Missing optomotor head-turning reflex in the DBA/2J mouse
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Age- and sex-related differences in contrast sensitivity in c57bl/6 mice
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Influence of sex on neuroretinal degeneration: Six-month follow-up in rats with chronic glaucoma
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Exploring the current use of animal models in glaucoma drug discovery: Where are we in 2023?
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The relationship between scleral strain change and differential cumulative intraocular pressure exposure in the nonhuman primate chronic ocular hypertension model
10.1167/iovs.19-27060 · 2019 · External reference
Pluripotent stem cell-derived retinal organoids for disease modeling and development of therapies
10.1002/stem.3239 · 2020 · External reference
Organoids for the study of retinal development and developmental abnormalities
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Generation of xenobiotic free retinofugal assembloids
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