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References from Naringin alleviates ocular surface inflammation in dry eye disease by enhancing autophagic flux and mitigating oxidative stress through downregulation of the PI3K/AKT/mTOR pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Citrus flavonoids as potential therapeutic agents: a review
10.1002/ptr.7261 · 2022 · External reference
Effects of natural antioxidants in neurodegenerative disease
10.1179/1476830511y.0000000028 · 2012 · External reference
TFOS lifestyle report: impact of environmental conditions on the ocular surface
10.1016/j.jtos.2023.04.007 · 2023 · External reference
The roles of autophagy and mitophagy in corneal pathology: current knowledge and future perspectives
10.3389/fmed.2023.1064938 · 2023 · External reference
TFOS DEWS II pathophysiology report
10.1016/j.jtos.2017.05.011 · 2017 · External reference
Potential new target for dry eye disease-oxidative stress
10.3390/antiox13040422 · 2024 · External reference
Inhibition of histone methyltransferase G9a activates autophagy and provides protection in dry eye disease
10.1167/iovs.66.14.52 · 2025 · External reference
TFOS DEWS II definition and classification report
10.1016/j.jtos.2017.05.008 · 2017 · External reference
Quercetin inhibits hypertonicity-induced inflammatory injury in human corneal epithelial cells via the PTEN/PI3K/AKT pathway
10.1016/j.tice.2024.102465 · 2024 · External reference
Prevalence of dry eye during the COVID-19 pandemic: a systematic review and meta-analysis
10.1371/journal.pone.0288523 · 2023 · External reference
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
10.1038/ncb2152 · 2011 · External reference
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
10.4161/auto.4451 · 2007 · External reference
Biological functions of autophagy genes: a disease perspective
10.1016/j.cell.2018.09.048 · 2019 · External reference
Evodiamine promotes autophagy and alleviates oxidative stress in dry eye disease through the p53/mTOR pathway
10.1167/iovs.66.3.44 · 2025 · External reference
Salidroside alleviates oxidative stress in dry eye disease by activating autophagy through AMPK-Sirt1 pathway
10.1016/j.intimp.2023.110397 · 2023 · External reference
ZRANB1-mediated EZH2 stabilization drives S100B/S100A4 transcriptional activation and corneal neovascularization in alkali burns
2026 · External reference
Autophagy in human diseases
10.1056/nejmra2022774 · 2020 · External reference
Oxidative and antioxidative stress markers in dry eye disease: a systematic review and meta-analysis
10.1111/aos.14892 · 2022 · External reference
The pathophysiology of dry eye disease: what we know and future directions for research
10.1016/j.ophtha.2017.07.010 · 2017 · External reference
mTOR signaling in growth, metabolism, and disease
10.1016/j.cell.2017.03.035 · 2017 · External reference
TFOS DEWS II epidemiology report
10.1016/j.jtos.2017.05.003 · 2017 · External reference
Induction of DDIT4 impairs autophagy through oxidative stress in dry eye
10.1167/iovs.19-27072 · 2019 · External reference
MiR-93-5p loaded lipid nanoparticles break the dry eye vicious cycle via targeting MAP3K8
10.1021/acsami.5c25210 · 2026 · External reference
Autophagy pathway: cellular and molecular mechanisms
10.1080/15548627.2017.1378838 · 2018 · External reference
Proteomics analysis of the mechanism of the treatment of corneal injury in dry-eye mice
2025 · External reference
Naringin attenuates alcoholic liver injury by reducing lipid accumulation and oxidative stress
10.1016/j.lfs.2018.07.031 · 2019 · External reference
