Research graph
References from Centenarians and oldest olds in Liguria – COOL: A multidisciplinary cohort study to investigate the genetic determinants of cognitive well-being in Genoa, Italy. Rationale, study protocol and baseline cohort profile. Local targets link to admitted publications; unresolved targets remain external evidence.
Centenarians as models of resistance and resilience to Alzheimer's disease and related dementias
2020 · External reference
Resistance vs resilience to Alzheimer disease: clarifying terminology for preclinical studies
10.1212/wnl.0000000000005303 · 2018 · External reference
Neuropsychological test performance of cognitively healthy centenarians: normative data from the Dutch 100-plus study
10.1111/jgs.15729 · 2019 · External reference
Association of cognitive function trajectories in centenarians with postmortem neuropathology, physical health, and other risk factors for cognitive decline
10.1001/jamanetworkopen.2020.31654 · 2021 · External reference
Centenarians: an excellent example of resilience for successful ageing
10.1016/j.mad.2019.111199 · 2020 · External reference
ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups
10.1186/s12883-016-0569-4 · 2016 · External reference
Development and validation of a short form of the Geriatric Anxiety Inventory—the GAI-SF
10.1017/s1041610210001237 · 2011 · External reference
Development of a short-form version of the Reading the Mind in the Eyes Test for assessing theory of mind in older adults
10.1002/gps.5369 · 2020 · External reference
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
10.1126/science.8346443 · 1993 · External reference
Evidence of sex–linked effects on the inheritance of human longevity: a population–based study in the Valserine valley (French Jura), 18–20th centuries
10.1098/rspb.2000.1105 · 2000 · External reference
The Clinical Dementia Rating scale: community-based validation of ‘profound’ and ‘terminal’ stages
10.1212/wnl.46.6.1746 · 1996 · External reference
Financial protection in health among the elderly – a global stocktake
10.1080/23288604.2021.1911067 · 2021 · External reference
Searching for justice: the discovery of IQ gains over time
10.1037/0003-066x.54.1.5 · 1999 · External reference
“Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician
10.1016/0022-3956(75)90026-6 · 1975 · External reference
Treatment for Alzheimer's disease
10.1016/s0140-6736(25)01329-7 · 2025 · External reference
Application of the Trail Making Test in differentiating neuropsychological impairment of elderly persons
10.2466/pms.1985.61.3f.1283 · 1985 · External reference
Neuropsychological assessment in cognitively healthy nonagenarians and centenarians: an updated systematic review and meta-analysis
10.1016/j.exger.2025.112796 · 2025 · External reference
A validation study of The Geriatric Depression Scale short form
10.1002/(sici)1099-1166(199605)11:5<457::aid-gps325>3.0.co;2-2 · 1996 · External reference
The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870–1900
10.1007/bf02185763 · 1996 · External reference
The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description
10.1007/s10654-018-0451-3 · 2018 · External reference
Cumulative Illness Rating Scale was a reliable and valid index in a family practice context
10.1016/j.jclinepi.2004.10.017 · 2005 · External reference
A new clinical scale for the staging of dementia
10.1192/bjp.140.6.566 · 1982 · External reference
Unresolved reference
2021 · External reference
Unresolved reference
2025 · External reference
The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms
10.1017/s0033291700005742 · 1989 · External reference
The spectrum of genetic risk in Alzheimer disease
10.1212/nxg.0000000000200224 · 2025 · External reference
What have we learned from cognition in the oldest-old
10.1097/wco.0000000000000910 · 2021 · External reference
Public health premise for national research priorities: mortality versus disability
10.1016/j.jalz.2005.06.016 · 2005 · External reference
Global aging: the challenge of success
2005 · External reference
Assessment of older people: self-maintaining and instrumental activities of daily living
10.1093/geront/9.3_part_1.179 · 1969 · External reference
Cognitive functioning of individuals aged 90 years and older without dementia: a systematic review
10.1016/j.arr.2017.02.006 · 2017 · External reference
The association of vascular disorders with incident dementia in different age groups
10.1186/s13195-019-0496-x · 2019 · External reference
Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
10.1016/s0140-6736(24)01296-0 · 2024 · External reference
Preserved cognitive–functional phenotype in centenarians and its association with modifiable risk factors for dementia: results from the Colombian centenarians project
10.1002/alz.71034 · 2025 · External reference
Functional evaluation: the Barthel index
1965 · External reference
Protective genetic variants against Alzheimer's disease
10.1016/s1474-4422(25)00116-4 · 2025 · External reference
The mini-mental state examination: normative study of an Italian random sample
10.1080/87565649109540545 · 1993 · External reference
Neuropsychological test norms in cognitively intact oldest-old
10.1017/s1355617719000122 · 2019 · External reference
Concepts and definitions of healthy ageing: a systematic review and synthesis of theoretical models
10.1016/j.eclinm.2022.101821 · 2023 · External reference
Heritability of life span in the Old Order Amish
10.1002/ajmg.1483 · 2001 · External reference
Demographic, genetic and phenotypic characteristics of centenarians in Italy: focus on gender differences
10.1016/j.mad.2017.04.008 · 2017 · External reference
Clinical Dementia Rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type
10.1017/s1041610297004870 · 1997 · External reference
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease
10.1212/wnl.39.9.1159 · 1989 · External reference
The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals
2012 · External reference
Cognitive Reserve Index questionnaire (CRIq): a new instrument for measuring cognitive reserve
10.1007/bf03654795 · 2012 · External reference
Validation of the Cumulative Illness Rating Scale in a geriatric residential population
10.1111/j.1532-5415.1995.tb06377.x · 1995 · External reference
Social support may buffer the effect of APOE ε4 allele on cognition in older adults
10.1177/13872877241293811 · 2024 · External reference
Centenarians who avoid dementia
10.1016/j.tins.2004.07.012 · 2004 · External reference
The Ligurian migration phenomenon: the “internal” case of Genoa, from the Unification of Italy to the early Twentieth Century
2021 · External reference
Aging without dementia is achievable: current evidence from epidemiological research
10.3233/jad-171037 · 2018 · External reference
Worldwide demography of centenarians
10.1016/j.mad.2017.03.004 · 2017 · External reference
The genetics of extreme longevity: lessons from the New England Centenarian Study
10.3389/fgene.2012.00277 · 2012 · External reference
p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial
10.1038/s41591-024-02977-w · 2024 · External reference
Centenarians in Europe
10.1016/j.maturitas.2017.08.005 · 2017 · External reference
Unresolved reference
2026 · External reference
Cohort profile: ‘Centenari a Trieste’ (CaT), a study of the health status of centenarians in a small defined area of Italy
10.1136/bmjopen-2017-019250 · 2018 · External reference
Lecanemab and APOE genotyping in clinical practice—navigating uncharted terrain
10.1001/jamaneurol.2023.0207 · 2023 · External reference
Unresolved reference
2024 · External reference
Leisure activities and the risk of dementia in the elderly
10.1056/nejmoa022252 · 2003 · External reference
Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
2007 · External reference
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part V. A normative study of the neuropsychological battery
10.1212/wnl.44.4.609 · 1994 · External reference
Neuropsychological data in nondemented oldest old: the 90+ study
10.1080/13803390600678038 · 2007 · External reference
Unresolved reference
2020 · External reference
Resilience and resistance to the accumulation of amyloid plaques and neurofibrillary tangles in centenarians: an age-continuous perspective
10.1002/alz.12899 · 2023 · External reference
Robust genomic control for association studies
10.1086/500054 · 2006 · External reference
