Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from The nuclear oncoprotein SET is necessary for MLL/KMT2A mediated transcriptional activation. Local targets link to admitted publications; unresolved targets remain external evidence.
A comprehensive and perspective view of oncoprotein SET in cancer
10.1002/cam4.1526 · 2018 · External reference
Thirty years of SET/TAF1beta/I2PP2A: from the identification of the biological functions to its implications in cancer and Alzheimer's disease
10.1042/bsr20221280 · 2022 · External reference
The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A
10.1074/jbc.271.19.11059 · 1996 · External reference
Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3′ half to different genes: characterization of the set gene
1992 · External reference
Disparate leukemia mutations converge on nuclear phase-separated condensates
10.1016/j.cell.2025.10.010 · 2025 · External reference
HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A
10.1074/jbc.272.45.28407 · 1997 · External reference
10.1016/j.celrep.2016.03.018
10.1016/j.celrep.2016.03.018 · External reference
HoxA9 transforms murine myeloid cells by a feedback loop driving expression of key oncogenes and cell cycle control genes
10.1182/bloodadvances.2018025866 · 2018 · External reference
The impact of SETBP1 mutations in neurological diseases and cancer
10.1111/gtc.13057 · 2023 · External reference
SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub
10.1038/s41467-018-04462-8 · 2018 · External reference
Mutated SETBP1 activates transcription of Myc programs to accelerate CSF3R-driven myeloproliferative neoplasms
10.1182/blood.2021014777 · 2022 · External reference
Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10
10.1182/blood-2011-10-388710 · 2012 · External reference
Exploiting PP2A dependent and independent effects of forskolin for therapeutic targeting of KMT2A (MLL)-rearranged acute leukaemia
10.1111/bph.70158 · 2025 · External reference
SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML
10.1038/s41388-023-02840-1 · 2023 · External reference
Unopposed cathepsin G, neutrophil elastase, and proteinase 3 cause severe lung damage and emphysema
10.1016/j.ajpath.2014.04.015 · 2014 · External reference
Meis1 supports leukemogenesis through stimulation of ribosomal biogenesis and Myc
10.3324/haematol.2022.280831 · 2022 · External reference
Exploitable metabolic dependencies in MLL-ENL-induced leukemia
10.1182/bloodadvances.2020001710 · 2020 · External reference
MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program
10.1038/celldisc.2016.8 · 2016 · External reference
KMT2 Family of H3K4 Methyltransferases: Enzymatic Activity-dependent and -independent Functions
10.1016/j.jmb.2024.168453 · 2024 · External reference
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer
10.1016/j.cell.2021.04.022 · 2021 · External reference
Identification of E74-like factor 1 (ELF1) as a transcriptional regulator of the Hox cofactor MEIS1
10.1016/j.exphem.2010.06.006 · 2010 · External reference
Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes
10.1186/s13072-016-0103-3 · 2016 · External reference
Mitogen- and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states
10.1139/bcb-2022-0371 · 2023 · External reference
MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein
10.1128/mcb.21.7.2249-2258.2001 · 2001 · External reference
Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells
10.1038/onc.2010.254 · 2010 · External reference
Role of the MOZ/MLL-mediated transcriptional activation system for self-renewal in normal hematopoiesis and leukemogenesis
10.1111/febs.16180 · 2022 · External reference
The YEATS domain epigenetic reader proteins ENL and AF9 and their therapeutic value in leukemia
10.1016/j.exphem.2023.06.001 · 2023 · External reference
Modulation of cellular processes by histone and non-histone protein acetylation
10.1038/s41580-021-00441-y · 2022 · External reference
Misguided transcriptional elongation causes mixed lineage leukemia
10.1371/journal.pbio.1000249 · 2009 · External reference
Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells
10.7554/elife.46667 · 2019 · External reference
Enhanced MAPK signaling induced by CSF3R mutants confers dependence to DUSP1 for leukemic transformation
10.1182/bloodadvances.2023010830 · 2024 · External reference
The Impact of PI3-kinase/RAS Pathway Cooperating Mutations in the Evolution of KMT2A-rearranged Leukemia
10.1097/hs9.0000000000000195 · 2019 · External reference
Overcoming menin inhibitor resistance in AML cells with combinations including BET proteins and a dual BRG1/BRM inhibitor
10.1182/blood.2025031486 · 2026 · External reference
Combining menin and MEK inhibition to target poor prognosis KMT2A-rearranged RAS pathway-mutant acute myeloid leukemia
10.1182/bloodadvances.2025016208 · 2026 · External reference
