Research graph
References from Dynamic contributions of astrocytes in Alzheimer’s disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis
10.7554/elife.85751 · 2023 · External reference
Sonic hedgehog signaling is negatively regulated in reactive astrocytes after forebrain stab injury
10.1038/s41598-018-37555-x · 2019 · External reference
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
10.1126/science.1206936 · 2011 · External reference
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
10.1038/nature24016 · 2017 · External reference
The molecular basis of water transport in the brain
10.1038/nrn1252 · 2003 · External reference
Aging-related down-regulation of neprilysin, a putative β-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of β-amyloid plaques
10.1016/s0304-3940(03)00030-2 · 2003 · External reference
Tripartite synapses: glia, the unacknowledged partner
10.1016/s0166-2236(98)01349-6 · 1999 · External reference
GLUT4 mobilization supports energetic demands of active synapses
10.1016/j.neuron.2016.12.020 · 2017 · External reference
Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology
10.1007/s00401-021-02275-6 · 2021 · External reference
Astrocyte calcium signaling: the third wave
10.1038/nn.4201 · 2016 · External reference
Increasing hexokinase 1 expression improves mitochondrial and glycolytic functional deficits seen in sporadic Alzheimer’s disease astrocytes
10.1038/s41380-024-02746-8 · 2025 · External reference
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease
10.1038/s41591-023-02380-x · 2023 · External reference
The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer’s and Huntington’s diseases
10.1523/jneurosci.3516-14.2015 · 2015 · External reference
Astrocytes functionally integrate multiple synapses via specialized leaflet domains
10.1016/j.cell.2025.08.036 · 2025 · External reference
Aducanumab therapy to treat Alzheimer’s disease: a narrative review
10.1155/2022/9343514 · 2022 · External reference
CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity
10.1038/89490 · 2001 · External reference
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
10.1186/s13024-024-00788-8 · 2025 · External reference
Early involvement of D-serine in β-amyloid-dependent pathophysiology
10.1007/s00018-025-05691-z · 2025 · External reference
NF-κB and TNF affect the astrocytic differentiation from neural stem cells
10.3390/cells10040840 · 2021 · External reference
Aβ oligomers induce glutamate release from hippocampal neurons
10.2174/156720511796391917 · 2011 · External reference
Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load
10.1038/s41380-021-01193-z · 2021 · External reference
Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG
10.2967/jnumed.110.087031 · 2012 · External reference
Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease
10.1186/s40478-018-0606-1 · 2018 · External reference
BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease
10.1186/1750-1326-7-52 · 2012 · External reference
Apolipoprotein E: structural insights and links to Alzheimer disease pathogenesis
10.1016/j.neuron.2020.10.008 · 2021 · External reference
Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau
10.1016/j.neuron.2025.04.027 · 2025 · External reference
Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy
10.1126/science.ads3972 · 2026 · External reference
High-density lipoprotein mimetic peptide 4F mitigates amyloid-β-induced inhibition of apolipoprotein E secretion and lipidation in primary astrocytes and microglia
10.1111/jnc.14554 · 2018 · External reference
Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes
10.1186/ar4162 · 2013 · External reference
FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
10.1073/pnas.1014154108 · 2011 · External reference
Inhibition of STAT3 phosphorylation attenuates impairments in learning and memory in 5XFAD mice, an animal model of Alzheimer’s disease
10.1016/j.jphs.2020.05.009 · 2020 · External reference
Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model
10.1186/s13041-021-00823-5 · 2021 · External reference
Astrocytic Sox9 overexpression in Alzheimer’s disease mouse models promotes Aβ plaque phagocytosis and preserves cognitive function
2025 · External reference
Motor learning and dopamine-dependent striatal synaptic plasticity are controlled by astrocytic MEGF10
10.1038/s41467-026-69129-1 · 2026 · External reference
Molecular mechanism of ligand gating and opening of NMDA receptor
10.1038/s41586-024-07742-0 · 2024 · External reference
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production
10.1038/s41593-020-00735-y · 2020 · External reference
Astrocyte regulation of synapse formation, maturation, and elimination
10.1101/cshperspect.a041352 · 2024 · External reference
Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment
10.1186/s13195-021-00804-9 · 2021 · External reference
Siponimod (BAF312) activates Nrf2 while hampering NFκB in human astrocytes, and protects from astrocyte-induced neurodegeneration
10.3389/fimmu.2020.00635 · 2020 · External reference
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation
10.1126/sciadv.aaq1702 · 2018 · External reference
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
10.1038/s41573-020-0072-x · 2020 · External reference
Propagation of tau pathology in a model of early Alzheimer’s disease
10.1016/j.neuron.2011.11.033 · 2012 · External reference
Specialized astrocytes mediate glutamatergic gliotransmission in the CNS
10.1038/s41586-023-06502-w · 2023 · External reference
Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models
10.1038/s43587-022-00281-1 · 2022 · External reference
Synapse loss in frontal cortex biopsies in Alzheimer’s disease: correlation with cognitive severity
10.1002/ana.410270502 · 1990 · External reference
Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model
10.1038/ncomms6422 · 2014 · External reference
Astrocyte endfeet in brain function and pathology: open questions
10.1146/annurev-neuro-091922-031205 · 2023 · External reference
Cell-specific expression of key mitochondrial enzymes limits OXPHOS in astrocytes of the adult human neocortex and hippocampal formation
10.1038/s42003-024-06751-z · 2024 · External reference
Altered metabolic function induced by Aβ-oligomers and PSEN1 mutations in iPSC-derived astrocytes
10.1111/jnc.16267 · 2025 · External reference
Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
10.1186/s40478-024-01745-8 · 2024 · External reference
An acidic protein isolated from fibrous astrocytes
10.1016/0006-8993(71)90668-8 · 1971 · External reference
Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer’s disease patients
10.1002/alz.14125 · 2024 · External reference
Reactive astrocyte nomenclature, definitions, and future directions
10.1038/s41593-020-00783-4 · 2021 · External reference
S100B induces tau protein hyperphosphorylation via Dickopff-1 up-regulation and disrupts the Wnt pathway in human neural stem cells
10.1111/j.1582-4934.2008.00159.x · 2008 · External reference
Microglia-astrocyte crosstalk regulates synapse remodeling via Wnt signaling
10.1016/j.cell.2025.08.023 · 2025 · External reference
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease
10.1038/s41593-025-02103-0 · 2026 · External reference
Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer’s disease
10.1523/jneurosci.2323-12.2012 · 2012 · External reference
Blockade of astrocytic calcineurin/NFAT signaling helps to normalize hippocampal synaptic function and plasticity in a rat model of traumatic brain injury
10.1523/jneurosci.1930-15.2016 · 2016 · External reference
Characterization of STAT3-expressing cells in the postnatal rat brain
10.1016/j.brainres.2006.04.115 · 2006 · External reference
The role of astrocytes in CNS inflammation
10.1016/j.it.2020.07.007 · 2020 · External reference
Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models
10.1016/j.stemcr.2024.07.002 · 2024 · External reference
Alzheimer’s Aβ42 and Aβ40 peptides form interlaced amyloid fibrils
10.1111/jnc.12202 · 2013 · External reference
Complex roles for reactive astrocytes in the triple transgenic mouse model of Alzheimer disease
10.1016/j.neurobiolaging.2020.02.010 · 2020 · External reference
Disease-associated astrocytes in Alzheimer’s disease and aging
10.1038/s41593-020-0624-8 · 2020 · External reference
Cell-mediated neuroprotection in a mouse model of human tauopathy
10.1523/jneurosci.0834-10.2010 · 2010 · External reference
Alzheimer’s disease: the amyloid cascade hypothesis
10.1126/science.1566067 · 1992 · External reference
A novel histone deacetylase inhibitor-based approach to eliminate microglia and retain astrocyte properties in glial cell culture
10.1111/jnc.15581 · 2022 · External reference
Differential effects of calcineurin inhibitors, tacrolimus and cyclosporin a, on interferon-induced antiviral protein in human hepatocyte cells: differential effects of calcineurin inhibitors
10.1002/lt.21358 · 2008 · External reference
BACE1 regulates hippocampal astrogenesis via the Jagged1-Notch pathway
10.1016/j.celrep.2013.06.005 · 2013 · External reference
Astrocyte EV-induced lincRNA-Cox2 regulates microglial phagocytosis: implications for morphine-mediated neurodegeneration
10.1016/j.omtn.2018.09.019 · 2018 · External reference
Plasma p-tau217 as a biomarker of Alzheimer’s disease pathology in individuals with Down syndrome
10.1038/s41467-025-65882-x · 2025 · External reference
Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity
10.1016/j.cell.2019.04.001 · 2019 · External reference
Astrocyte-secreted neurocan controls inhibitory synapse formation and function
10.1016/j.neuron.2024.03.007 · 2024 · External reference
Region-specific reduction of Aβ-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging
10.1002/jnr.10390 · 2002 · External reference
APOE4 derived from astrocytes leads to blood–brain barrier impairment
10.1093/brain/awab478 · 2022 · External reference
Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks
10.1242/jcs.03423 · 2007 · External reference
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology
10.1038/s41467-021-27702-w · 2022 · External reference
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer’s disease
10.1038/nm.3639 · 2014 · External reference
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
10.1038/s41591-020-0815-6 · 2020 · External reference
Exploring fatty acid metabolism in Alzheimer’s disease: the key role of CPT1A
10.1038/s41598-024-82999-z · 2024 · External reference
Astrocyte activation is suppressed in both normal and injured brain by FGF signaling
10.1073/pnas.1320401111 · 2014 · External reference
The complex morphology of reactive astrocytes controlled by fibroblast growth factor signaling: reactive astrocyte morphology involves FGF
10.1002/glia.22684 · 2014 · External reference
Blood phosphorylated tau 181 as a biomarker for Alzheimer’s disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts
10.1016/s1474-4422(20)30071-5 · 2020 · External reference
Neuronally derived soluble abeta evokes cell-wide astrocytic calcium dysregulation in absence of amyloid plaques in vivo
10.1523/jneurosci.1988-22.2023 · 2023 · External reference
Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin
10.1038/s41467-022-34412-4 · 2022 · External reference
Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
10.1016/j.neuron.2023.08.012 · 2023 · External reference
Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain
10.1038/s41598-018-19442-7 · 2018 · External reference
Fate-mapping of GM-CSF expression identifies a discrete subset of inflammation-driving T helper cells regulated by cytokines IL-23 and IL-1β
10.1016/j.immuni.2019.04.006 · 2019 · External reference
Calcineurin inhibitors improve memory loss and neuropathological changes in mouse model of dementia
10.1016/j.pbb.2016.12.018 · 2017 · External reference
Astrocytic Ca2+ prevents synaptic depotentiation by limiting repetitive activity in dendrites during motor learning
10.1038/s41593-025-02072-4 · 2025 · External reference
Astrocytic EphB3 receptors regulate d-serine-gated synaptic plasticity and memory
10.1016/j.pneurobio.2025.102747 · 2025 · External reference
Plasma p-tau181 accurately predicts Alzheimer’s disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline
10.1007/s00401-020-02195-x · 2020 · External reference
Upregulation of adenosine A2A receptor in astrocytes is sufficient to trigger hippocampal multicellular dysfunctions and memory deficits
10.1038/s41380-025-03115-9 · 2025 · External reference
10.1056/nejmc2301380
10.1056/nejmc2301380 · 2023 · External reference
APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation
10.1016/j.stemcr.2021.07.017 · 2021 · External reference
Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis
10.1038/s41586-020-03060-3 · 2021 · External reference
ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes
10.1016/j.celrep.2023.113183 · 2023 · External reference
Astrocyte priming enhances microglial Aβ clearance and is compromised by APOE4
10.1038/s41467-025-62995-1 · 2025 · External reference
α7 nicotinic acetylcholine receptors in the hippocampal circuit: taming complexity
10.1016/j.tins.2021.11.006 · 2022 · External reference
Inhibition of NF-κB in astrocytes is sufficient to delay neurodegeneration induced by proteotoxicity in neurons
10.1186/s12974-018-1278-2 · 2018 · External reference
Neurons require glucose uptake and glycolysis in vivo
2023 · External reference
Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease
10.1038/s41467-023-37240-2 · 2023 · External reference
NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer’s disease
10.1016/j.neuron.2014.11.018 · 2015 · External reference
Neurotoxic reactive astrocytes are induced by activated microglia
10.1038/nature21029 · 2017 · External reference
Functional morphology of the blood–brain barrier in health and disease
10.1007/s00401-018-1815-1 · 2018 · External reference
APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes in human iPSC-derived brain cell types
10.1016/j.neuron.2018.06.011 · 2018 · External reference
Complement C3aR inactivation attenuates tau pathology and reverses an immune network deregulated in tauopathy models and Alzheimer’s disease
10.1016/j.neuron.2018.10.031 · 2018 · External reference
Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals
10.1038/s41380-021-01429-y · 2022 · External reference
Lactate in the brain: from metabolic end-product to signalling molecule
10.1038/nrn.2018.19 · 2018 · External reference
Astrocytic α2-Na/K ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model
10.1126/scitranslmed.abm4107 · 2022 · External reference
Cross-talk between calcineurin/NFAT and Jak/STAT signalling induces cardioprotective αB-crystallin gene expression in response to hypertrophic stimuli
10.1111/j.1582-4934.2009.00804.x · 2009 · External reference
Amyloid-β regulates gap junction protein connexin 43 trafficking in cultured primary astrocytes
10.1074/jbc.ra120.013705 · 2020 · External reference
Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation
10.1038/nm.3681 · 2014 · External reference
Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes
10.1073/pnas.2220551120 · 2023 · External reference
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration
10.1038/s42255-023-00756-4 · 2023 · External reference
Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s disease
2022 · External reference
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
10.1126/science.abm6131 · 2024 · External reference
APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline
10.1038/s41586-020-2247-3 · 2020 · External reference
Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition
10.1038/s42255-023-00835-6 · 2023 · External reference
Alpha-smooth muscle actin (α-SMA) and nestin expression in reactive astrocytes in multiple sclerosis lesions: potential regulatory role of transforming growth factor-beta 1 (TGF-β1)
10.1111/j.1365-2990.2007.00910.x · 2008 · External reference
Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer’s disease
2009 · External reference
Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
10.1186/s40478-023-01589-8 · 2023 · External reference
Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway
10.1073/pnas.2303809120 · 2023 · External reference
Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway
10.1038/s41593-024-01669-5 · 2024 · External reference
Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction
10.1038/s41591-018-0297-y · 2019 · External reference
Aging-associated cognitive decline is reversed by D-serine supplementation
10.1523/eneuro.0176-22.2022 · 2022 · External reference
The NMDA receptor activation by d-serine and glycine is controlled by an astrocytic Phgdh-dependent serine shuttle
10.1073/pnas.1909458116 · 2019 · External reference
Increased serum beta-secretase 1 activity is an early marker of Alzheimer’s disease
10.3233/jad-215542 · 2022 · External reference
Glial protein S100B modulates long-term neuronal synaptic plasticity
10.1073/pnas.052020999 · 2002 · External reference
Astroglial responses to amyloid-beta progression in a mouse model of Alzheimer’s disease
10.1007/s11307-017-1153-z · 2018 · External reference
ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
10.1111/j.1471-4159.2011.07210.x · 2011 · External reference
Amyloid β-induced death in neurons involves glial and neuronal hemichannels
10.1523/jneurosci.6417-10.2011 · 2011 · External reference
Plasma phospho-tau217 as a predictive biomarker for Alzheimer’s disease in a large south American cohort
10.1186/s13195-024-01655-w · 2025 · External reference
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
10.1038/nrn3504 · 2013 · External reference
Therapeutic targeting of α7 nicotinic acetylcholine receptors
10.1124/pharmrev.120.000097 · 2021 · External reference
Septal cholinergic neuromodulation tunes the astrocyte-dependent gating of hippocampal NMDA receptors to wakefulness
10.1016/j.neuron.2017.04.021 · 2017 · External reference
Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease
10.1126/sciadv.aav0316 · 2019 · External reference
Astrocyte biomarkers GFAP and YKL-40 mediate early Alzheimer’s disease progression
10.1002/alz.13450 · 2024 · External reference
Astrocyte transforming growth factor beta 1 protects synapses against Aβ oligomers in Alzheimer’s disease model
10.1523/jneurosci.3351-16.2017 · 2017 · External reference
PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer’s disease
10.1186/s40478-024-01876-y · 2024 · External reference
Cellular mechanisms of brain lipid metabolism in health and disease
10.1038/s41556-026-01880-5 · 2026 · External reference
Astrocytes respond to a neurotoxic Aβ fragment with state-dependent Ca2+ alteration and multiphasic transmitter release
10.1186/s40478-021-01146-1 · 2021 · External reference
Loss of direct vascular contact to astrocytes in the hippocampus as an initial event in Alzheimer’s disease. evidence from patients, in vivo and in vitro experimental models
10.1007/s12035-023-03897-5 · 2024 · External reference
Glutamate mediates acute glucose transport inhibition in hippocampal neurons
10.1523/jneurosci.1882-04.2004 · 2004 · External reference
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
10.1038/s44321-024-00162-7 · 2024 · External reference
Greasing the synaptic vesicle cycle by membrane lipids
10.1016/j.tcb.2013.05.002 · 2013 · External reference
ApoE4 impairs neuron-astrocyte coupling of fatty acid metabolism
10.1016/j.celrep.2020.108572 · 2021 · External reference
Astrocyte-microglia crosstalk through Hevin and Toll-like receptor signaling controls developmental thalamocortical synapse refinement
10.1016/j.neuron.2025.12.028 · 2026 · External reference
Transcription factors of the NFAT family: regulation and function
10.1146/annurev.immunol.15.1.707 · 1997 · External reference
Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses
10.1016/j.neuron.2007.11.023 · 2008 · External reference
Expression of non-adrenergic imidazoline sites in rat cerebral cortical astrocytes
10.1002/jnr.490340611 · 1993 · External reference
Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer’s disease model
10.15252/emmm.201809665 · 2019 · External reference
Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease
10.1038/s41593-020-00728-x · 2020 · External reference
Astroglial CB1 receptors determine synaptic D-serine availability to enable recognition memory
10.1016/j.neuron.2018.04.034 · 2018 · External reference
Astrocyte S100β expression and selective differentiation to GFAP and GS in the entorhinal cortex during ageing in the 3xTg-Alzheimer’s disease mouse model
10.1016/j.acthis.2023.152131 · 2024 · External reference
Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease
10.1093/brain/awv404 · 2016 · External reference
PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation
10.1186/1742-2094-7-78 · 2010 · External reference
Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of Alzheimer’s disease
10.1111/jnc.16014 · 2024 · External reference
Aqp4 stop codon readthrough facilitates amyloid-β clearance from the brain
10.1093/brain/awac199 · 2022 · External reference
Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation
10.1073/pnas.2108870119 · 2022 · External reference
Clinical trials and late-stage drug development for Alzheimer’s disease: an appraisal from 1984 to 2014
10.1111/joim.12191 · 2014 · External reference
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
10.1038/s41593-024-01791-4 · 2024 · External reference
Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease
10.1016/j.celrep.2022.111280 · 2022 · External reference
An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology
10.1016/j.neuron.2023.05.006 · 2023 · External reference
A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging
10.1038/s41593-025-02067-1 · 2025 · External reference
Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions
10.1186/s40478-017-0478-9 · 2017 · External reference
Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice
10.1186/s13195-022-00999-5 · 2022 · External reference
Differences between blood and cerebrospinal fluid glial fibrillary acidic protein levels: the effect of sample stability
10.1002/alz.12806 · 2022 · External reference
Astrocytes: biology and pathology
10.1007/s00401-009-0619-8 · 2010 · External reference
Unresolved reference
2024 · External reference
Calcineurin/NFAT signaling in activated astrocytes drives network hyperexcitability in Aβ-bearing mice
10.1523/jneurosci.0877-17.2017 · 2017 · External reference
Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease
10.1080/15548627.2016.1159375 · 2016 · External reference
Astrocytes enhance plasticity response during reversal learning
10.1038/s42003-024-06540-8 · 2024 · External reference
Unresolved reference
2026 · External reference
S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α
10.18632/aging.101760 · 2019 · External reference
Astrocyte-neuron lactate transport is required for long-term memory formation
10.1016/j.cell.2011.02.018 · 2011 · External reference
Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease
10.1084/jem.20140413 · 2015 · External reference
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
10.1073/pnas.1306832110 · 2013 · External reference
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia
10.1016/j.cell.2022.05.017 · 2022 · External reference
Knowing the enemy: strategic targeting of complement to treat Alzheimer disease
10.1038/s41582-025-01073-y · 2025 · External reference
Adenosine signalling to astrocytes coordinates brain metabolism and function
10.1038/s41586-024-07611-w · 2024 · External reference
Astrocytic GLUT1 deletion in adult mice enhances glucose metabolism and resilience to stroke
10.1038/s41467-025-59400-2 · 2025 · External reference
Bridging regional neurovascular unit heterogeneity and cognitive function: a review
10.1186/s12987-025-00697-y · 2025 · External reference
Fibroblast growth factor signalling: from development to cancer
10.1038/nrc2780 · 2010 · External reference
Evaluation of 11C-BU99008, a positron emission tomography ligand for the Imidazoline2 binding site in human brain
10.2967/jnumed.118.208009 · 2018 · External reference
Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection
10.1111/jnc.14064 · 2017 · External reference
Astrocytes and microglia: in sickness and in health
10.1016/j.tins.2020.01.003 · 2020 · External reference
The role of sphingosine 1-phosphate metabolism in brain health and disease
10.1016/j.pharmthera.2023.108381 · 2023 · External reference
Calcium-dependent signaling in astrocytes: downstream mechanisms and implications for cognition
10.1111/jnc.70019 · 2025 · External reference
The accumulation of tau-immunoreactive hippocampal granules and corpora amylacea implicates reactive glia in tau pathogenesis during aging
10.1016/j.isci.2020.101255 · 2020 · External reference
Filamentous recombinant human Tau activates primary astrocytes via an integrin receptor complex
10.1038/s41467-020-20322-w · 2021 · External reference
β-Amyloid1–42 binds to α7 nicotinic acetylcholine receptor with high affinity
10.1074/jbc.275.8.5626 · 2000 · External reference
Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer’s brain: Aβ-degrading enzymes profiling in Alzheimer’s brain
10.1111/j.1471-4159.2010.06899.x · 2010 · External reference
Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia
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