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References from Microglial state dynamics in intracerebral hemorrhage: A systems-level integration from molecular networks to precision therapeutics. Local targets link to admitted publications; unresolved targets remain external evidence.
Neu1 is released from activated microglia, stimulating microglial phagocytosis and sensitizing neurons to glutamate
10.3389/fncel.2022.917884 · 2022 · External reference
Aging microglia
10.1007/s00018-023-04775-y · 2023 · External reference
Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage
10.1126/sciimmunol.abd6279 · 2021 · External reference
Microglia and macrophage phenotypes in intracerebral haemorrhage injury: therapeutic opportunities
10.1093/brain/awz393 · 2020 · External reference
Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy
10.1080/15548627.2023.2165313 · 2023 · External reference
Immunometabolism in the brain: how metabolism shapes microglial function
10.1016/j.tins.2020.08.008 · 2020 · External reference
Neuronal loss after stroke due to microglial phagocytosis of stressed neurons
10.3390/ijms222413442 · 2021 · External reference
Microglial phagocytosis of neurons in neurodegeneration, and its regulation
10.1111/jnc.15327 · 2021 · External reference
Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage
10.1172/jci95612 · 2018 · External reference
HO-1 represses NF-κB signaling pathway to mediate microglia polarization and phagocytosis in intracerebral hemorrhage
10.1016/j.neuroscience.2024.12.020 · 2025 · External reference
Perihematomal edema after intracerebral hemorrhage: An update on pathogenesis, risk factors, and therapeutic advances
2021 · External reference
Progress of CD47 immune checkpoint blockade agents in anticancer therapy: a hematotoxic perspective
10.1007/s00432-021-03815-z · 2022 · External reference
Targeting the Nrf2-Heme Oxygenase-1 Axis after intracerebral hemorrhage
10.2174/1381612822666161027150616 · 2017 · External reference
Brain border-associated macrophages: common denominators in infection, aging, and Alzheimer’s disease?
10.1016/j.it.2024.03.007 · 2024 · External reference
Intermittent fasting reduces neuroinflammation in intracerebral hemorrhage through the Sirt3/Nrf2/HO-1 pathway
10.1186/s12974-022-02474-2 · 2022 · External reference
The chemical basis of intracerebral hemorrhage and cell toxicity with contributions from Eryptosis and Ferroptosis
10.3389/fncel.2020.603043 · 2020 · External reference
Pathophysiology of RAGE in inflammatory diseases
10.3389/fimmu.2022.931473 · 2022 · External reference
Astrocytes in intracerebral hemorrhage: impact and therapeutic objectives
10.3389/fnmol.2024.1327472 · 2024 · External reference
Comprehensive insight on immune landscape in intracerebral hemorrhage patients with single-cell RNA sequencing: from blood to hematoma
10.1186/s12974-025-03518-z · 2025 · External reference
Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury
10.1186/s12974-020-01973-4 · 2020 · External reference
Neutrophil-like pH-responsive pro-efferocytic nanoparticles improve neurological recovery by promoting erythrophagocytosis after intracerebral hemorrhage
10.7150/thno.90370 · 2024 · External reference
Autophagy regulates inflammation in intracerebral hemorrhage: enemy or friend?
2022 · External reference
White matter injury after intracerebral hemorrhage
10.3389/fneur.2021.562090 · 2021 · External reference
Alterations in chromatin structure and function in the microglia
2020 · External reference
Microglial mechanisms and therapeutic potential in brain injury post-intracerebral hemorrhage
10.2147/jir.s498809 · 2025 · External reference
Research developments in the neurovascular unit and the blood-brain barrier (review)
10.3892/br.2025.1966 · 2025 · External reference
Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milie
10.1172/jci.insight.145857 · 2021 · External reference
2022 guideline for the management of patients with spontaneous intracerebral hemorrhage: a guideline from the American Heart Association/American Stroke Association
10.1161/str.0000000000000407 · 2022 · External reference
Unraveling dynamic immunological landscapes in intracerebral hemorrhage: insights from single-cell and spatial transcriptomic profiling
2024 · External reference
The role of MMPs in intracerebral hemorrhage
10.3389/fcell.2025.1667228 · 2025 · External reference
Improving outcomes in intracerebral hemorrhage through microglia/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes
10.1016/j.biomaterials.2023.122277 · 2023 · External reference
Multipotent mesenchymal stromal cell-derived exosomes improve functional recovery after experimental intracerebral hemorrhage in the rat
2019 · External reference
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
10.1038/nn1805 · 2006 · External reference
Fatty acid-binding protein 4 drives microglia-mediated neuroinflammation through promoting S100A9 expression and lipid droplet accumulation after intracerebral hemorrhage
10.1186/s12974-025-03573-6 · 2025 · External reference
A new perspective on the regulation of neuroinflammation in intracerebral hemorrhage: mechanisms of NLRP3 inflammasome activation and therapeutic strategies
2025 · External reference
Towards a definition of microglia heterogeneity
10.1038/s42003-022-04081-6 · 2022 · External reference
The role of complement in brain injury following intracerebral hemorrhage: a review
10.1016/j.expneurol.2021.113654 · 2021 · External reference
The novel Nrf2 activator omaveloxolone regulates microglia phenotype and ameliorates secondary brain injury after intracerebral hemorrhage in mice
10.1155/2022/4564471 · 2022 · External reference
Upregulation of AQP4 improves blood-brain barrier integrity and Perihematomal edema following intracerebral hemorrhage
10.1007/s13311-021-01126-2 · 2021 · External reference
Immune-mediated disruption of the blood-brain barrier after intracerebral hemorrhage: insights and potential therapeutic targets
10.1111/cns.14853 · 2024 · External reference
PPARγ/RAD21 alleviates peripheral secondary brain injury in rat cerebral hemorrhage model through promoting M2 polarization of microglial cells
10.1016/j.intimp.2022.109572 · 2023 · External reference
Neuroinflammation and blood-brain barrier breakdown in acute, clinical intracerebral hemorrhage
10.1177/0271678x241274685 · 2025 · External reference
Neuroinflammation and iron metabolism after intracerebral hemorrhage: a glial cell perspective
2024 · External reference
HMGB1/TLR4 axis promotes pyroptosis after ICH by activating the NLRP3 inflammasome
10.1016/j.jneuroim.2024.578401 · 2024 · External reference
Colony stimulating factor 1 receptor inhibition eliminates microglia and attenuates brain injury after intracerebral hemorrhage
10.1177/0271678x16666551 · 2017 · External reference
Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36
10.1016/j.bbi.2021.02.001 · 2021 · External reference
CNS-peripheral immune interactions in hemorrhagic stroke
10.1177/0271678x221145089 · 2023 · External reference
Impaired microglial glycolysis promotes inflammatory responses after intracerebral haemorrhage via HK2-dependent mitochondrial dysfunction
10.1016/j.jare.2024.08.016 · 2025 · External reference
Therapeutic strategies for intracerebral hemorrhage
10.3389/fneur.2022.1032343 · 2022 · External reference
Translational intracerebral hemorrhage research: has current neuroprotection research ARRIVEd at a standard for experimental design and reporting?
10.1007/s12975-020-00824-x · 2020 · External reference
Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage
10.1186/1742-2094-9-46 · 2012 · External reference
Microglia: a double-edged sword in intracerebral hemorrhage from basic mechanisms to clinical research
2021 · External reference
Erythrophagocytosis by microglia/macrophage in intracerebral hemorrhage: from mechanisms to translation
2022 · External reference
Neutrophil extracellular traps in intracerebral hemorrhage: implications for pathogenesis and therapeutic targets
10.1007/s11011-023-01268-6 · 2023 · External reference
Targeted macrophage phagocytosis by Irg1/itaconate axis improves the prognosis of intracerebral hemorrhagic stroke and peritonitis
10.1016/j.ebiom.2024.104993 · 2024 · External reference
A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke
10.1186/s12974-023-02779-w · 2023 · External reference
Cerebral hemorrhage: pathophysiology, treatment, and future directions
10.1161/circresaha.121.319949 · 2022 · External reference
Microglia heterogeneity in the single-cell era
10.1016/j.celrep.2020.01.010 · 2020 · External reference
Cells of the blood-brain barrier: an overview of the neurovascular unit in health and disease
10.1007/978-1-0716-2289-6_1 · 2022 · External reference
Role of erythrocyte CD47 in intracerebral hematoma clearance
10.1161/strokeaha.115.010920 · 2016 · External reference
Metabolic regulation of immune memory and function of microglia
2025 · External reference
Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions
10.1186/s13024-025-00867-4 · 2025 · External reference
Role of inflammatory processes in hemorrhagic stroke
10.1161/strokeaha.122.037155 · 2023 · External reference
Microglia states and nomenclature: a field at its crossroads
10.1016/j.neuron.2022.10.020 · 2022 · External reference
Neuroinflammatory in vitro cell culture models and the potential applications for neurological disorders
10.3389/fphar.2021.671734 · 2021 · External reference
Cognitive impairment after intracerebral hemorrhage: a systematic review of current evidence and knowledge gaps
10.3389/fneur.2021.716632 · 2021 · External reference
Microglia and central nervous system-associated macrophages-from origin to disease modulation
10.1146/annurev-immunol-093019-110159 · 2021 · External reference
The implications of microglial regulation in neuroplasticity-dependent stroke recovery
10.3390/biom13030571 · 2023 · External reference
Epigenetic regulations of microglia/macrophage polarization in ischemic stroke
10.3389/fnmol.2021.697416 · 2021 · External reference
A new understanding of TMEM119 as a marker of microglia
10.3389/fncel.2022.902372 · 2022 · External reference
Potential blood biomarkers that can be used as prognosticators of spontaneous intracerebral hemorrhage: a systematic review and meta-analysis
10.1371/journal.pone.0315333 · 2025 · External reference
Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: role of Cxcr2 activation and glycosaminoglycan interactions
10.1002/jlb.3a0820-207r · 2021 · External reference
Intracerebral haemorrhage - mechanisms, diagnosis and prospects for treatment and prevention
10.1038/s41582-024-01035-w · 2024 · External reference
Deferoxamine mesylate in patients with intracerebral haemorrhage (i-DEF): a multicentre, randomised, placebo-controlled, double-blind phase 2 trial
10.1016/s1474-4422(19)30069-9 · 2019 · External reference
Role of regulatory T cells in intracerebral hemorrhage
10.1007/s12035-024-04281-7 · 2025 · External reference
Secondary brain injury by oxidative stress after cerebral hemorrhage: recent advances
10.3389/fncel.2022.853589 · 2022 · External reference
CD4(+) T cells aggravate hemorrhagic brain injury
10.1126/sciadv.abq0712 · 2023 · External reference
Role of thrombin in central nervous system injury and disease
10.3390/biom11040562 · 2021 · External reference
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function
10.1007/s00401-021-02384-2 · 2022 · External reference
Role of damage-associated molecular patterns in the pathogenesis and therapeutics of traumatic brain injury
10.1093/burnst/tkaf043 · 2025 · External reference
Ferroptosis and Iron metabolism after intracerebral hemorrhage
10.3390/cells12010090 · 2022 · External reference
Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor
10.1002/eji.201848013 · 2020 · External reference
Neutrophil extracellular traps induce brain edema around intracerebral hematoma via ERK-mediated regulation of MMP9 and AQP4
10.1007/s12975-024-01318-w · 2025 · External reference
CD47 blocking antibody accelerates hematoma clearance after intracerebral hemorrhage in aged rats
10.1007/s12975-019-00745-4 · 2020 · External reference
Pathological mechanisms and future therapeutic directions of thrombin in intracerebral hemorrhage: a systematic review
10.3389/fphar.2024.1293428 · 2024 · External reference
Immune cells in intracerebral hemorrhage
10.1016/j.hest.2025.02.001 · 2025 · External reference
TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage
10.1172/jci88647 · 2017 · External reference
Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets
10.5853/jos.2019.02236 · 2020 · External reference
Augmenting hematoma-scavenging capacity of innate immune cells by CDNF reduces brain injury and promotes functional recovery after intracerebral hemorrhage
10.1038/s41419-022-05520-2 · 2023 · External reference
Iron toxicity, lipid peroxidation and ferroptosis after intracerebral haemorrhage
10.1136/svn-2018-000205 · 2019 · External reference
Brain edema formation and therapy after intracerebral hemorrhage
10.1016/j.nbd.2022.105948 · 2023 · External reference
The roles of chemokines following intracerebral hemorrhage in animal models and humans
2022 · External reference
Role of complement component 3 in early erythrolysis in the hematoma after experimental intracerebral hemorrhage
10.1161/strokeaha.121.034372 · 2021 · External reference
Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice
10.1186/s12974-017-1039-7 · 2018 · External reference
Intracerebral hemorrhage: the effects of aging on brain injury
10.3389/fnagi.2022.859067 · 2022 · External reference
Free heme induces neuroinflammation and cognitive impairment by microglial activation via the TLR4/MyD88/NF-κB signaling pathway
10.1186/s12964-023-01387-8 · 2024 · External reference
A multi-model pipeline for translational intracerebral Haemorrhage research
10.1007/s12975-020-00830-z · 2020 · External reference
Risk factors associated with mortality and neurologic disability after intracerebral hemorrhage in a racially and ethnically diverse cohort
10.1001/jamanetworkopen.2022.1103 · 2022 · External reference
LncRNA TCONS_00145741 knockdown prevents thrombin-induced M1 differentiation of microglia in intracerebral hemorrhage by enhancing the interaction between DUSP6 and JNK
2021 · External reference
MST4 attenuates NLRP3 inflammasome-mediated neuroinflammation and affects the prognosis after intracerebral hemorrhage in mice
10.1016/j.brainresbull.2021.09.006 · 2021 · External reference
snRNA-seq reveals key transcription factors in the inflammatory response of microglia after intracerebral hemorrhage
2025 · External reference
The fate of erythrocytes after cerebral hemorrhage
10.1007/s12975-021-00980-8 · 2022 · External reference
Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolution
10.1016/j.neuron.2025.04.026 · 2025 · External reference
Neuroinflammation mediated by NLRP3 inflammasome after intracerebral hemorrhage and potential therapeutic targets
10.1007/s12035-020-02082-2 · 2020 · External reference
T cell receptor activation contributes to brain damage after intracerebral hemorrhage in mice
10.1186/s12974-025-03402-w · 2025 · External reference
IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice
10.1073/pnas.2018497117 · 2020 · External reference
Opportunities and challenges for anti-CD47 antibodies in hematological malignancies
2024 · External reference
Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation
10.1016/s1474-4422(20)30364-1 · 2020 · External reference
Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats
10.1016/j.trsl.2020.09.002 · 2021 · External reference
Neuroinflammation of microglia polarization in intracerebral hemorrhage and its potential targets for intervention
10.3389/fnmol.2022.1013706 · 2022 · External reference
The CCL2-CCR2 system affects the progression and clearance of intracerebral hemorrhage
10.1002/glia.22323 · 2012 · External reference
The role of thrombin in brain injury after hemorrhagic and ischemic stroke
10.1007/s12975-020-00855-4 · 2021 · External reference
Characteristics of activation of monocyte-derived macrophages versus microglia after mouse experimental intracerebral hemorrhage
10.1177/0271678x231173187 · 2023 · External reference
Neuron derived fractalkine promotes microglia to absorb hematoma via CD163/HO-1 after intracerebral hemorrhage
10.1007/s00018-022-04212-6 · 2022 · External reference
Long non-coding RNAs in intracerebral hemorrhage
10.3389/fnmol.2023.1119275 · 2023 · External reference
Single-cell RNA sequencing reveals the evolution of the immune landscape during perihematomal edema progression after intracerebral hemorrhage
10.1186/s12974-024-03113-8 · 2024 · External reference
Revisiting minocycline in intracerebral hemorrhage: mechanisms and clinical translation
2022 · External reference
Unveiling the inflammatory messengers after intracerebral hemorrhage: the crosstalk between peripheral NETs and microglia
2025 · External reference
The hallmark and crosstalk of immune cells after intracerebral hemorrhage: immunotherapy perspectives
2022 · External reference
Epigenetic regulation of innate immune memory in microglia
10.1186/s12974-022-02463-5 · 2022 · External reference
Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination
10.1186/s12974-021-02101-6 · 2021 · External reference
Temporal dynamics of microglia-astrocyte interaction in neuroprotective glial scar formation after intracerebral hemorrhage
10.1016/j.jpha.2023.02.007 · 2023 · External reference
Role of complement C1q/C3-CR3 signaling in brain injury after experimental intracerebral hemorrhage and the effect of minocycline treatment
2022 · External reference
The critical role of erythrolysis and microglia/macrophages in clot resolution after intracerebral hemorrhage: a review of the mechanisms and potential therapeutic targets
10.1007/s10571-021-01175-3 · 2023 · External reference
Soluble Trem2 is a negative regulator of erythrophagocytosis after intracerebral hemorrhage in a CD36 receptor recycling manner
10.1016/j.jare.2022.03.011 · 2023 · External reference
Wogonin accelerates hematoma clearance and improves neurological outcome via the PPAR-γ pathway after intracerebral hemorrhage
10.1007/s12975-020-00842-9 · 2021 · External reference
Early inflammatory cytokine expression in cerebrospinal fluid of patients with spontaneous intraventricular hemorrhage
10.3390/biom11081123 · 2021 · External reference
Novel targets, treatments, and advanced models for intracerebral haemorrhage
10.1016/j.ebiom.2022.103880 · 2022 · External reference
