Research graph
References from Stage-specific antileishmanial activity and selectivity of cynarin, apigenin, and luteolin against Leishmania tropica in vitro models. Local targets link to admitted publications; unresolved targets remain external evidence.
In vitro activity and mode of action of phenolic compounds on Leishmania donovani
10.1371/journal.pntd.0007206 · 2019 · External reference
A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity
10.1016/j.pharmthera.2012.01.001 · 2012 · External reference
Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasis
10.1371/journal.pntd.0007843 · 2020 · External reference
Current treatment approaches to leishmaniasis
10.1097/00001432-200310000-00005 · 2003 · External reference
Research in the field of drug design and development
10.3390/ph16091283 · 2023 · External reference
Characterization of targeted phenolic compounds in globe artichoke heads and waste from vegetatively and “Seed”-Propagated genotypes
10.3390/plants12132579 · 2023 · External reference
Cytotoxic and antileishmanial effects of the monoterpene β-Ocimene
10.3390/ph16020183 · 2023 · External reference
Apigenin is a promising molecule for treatment of visceral leishmaniasis
10.3389/fcimb.2023.1066407 · 2023 · External reference
Effect of apigenin on Leishmania amazonensis is associated with reactive oxygen species production followed by mitochondrial dysfunction
10.1021/acs.jnatprod.5b00011 · 2015 · External reference
Use of natural products in leishmaniasis chemotherapy: an overview
10.3389/fchem.2020.579891 · 2020 · External reference
Unresponsiveness to glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites
10.1371/journal.pmed.0030162 · 2006 · External reference
Antileishmanial activities of medicinal herbs and phytochemicals in vitro and in vivo: an update for the years 2015 to 2021
10.3390/molecules27217579 · 2022 · External reference
Luteolin as a potent anti-leishmanial agent against intracellular Leishmania tropica parasite
10.4314/tjpr.v16i2.11 · 2017 · External reference
A parasite rescue and transformation assay for antileishmanial screening against intracellular Leishmania donovani amastigotes in THP1 human acute monocytic leukemia cell line
10.3791/4054 · 2012 · External reference
Antimony resistance in leishmania, focusing on experimental research
10.1155/2011/695382 · 2011 · External reference
Hit and lead criteria in drug discovery for infectious diseases of the developing world
10.1038/nrd4683 · 2015 · External reference
In vitro anti-leishmanial activities of methanol extract of Brucea antidysenterica J.F. mill seeds and its solvent fractions
10.2147/jep.s397352 · 2023 · External reference
Leishmaniasis: recent epidemiological studies in the Middle East
10.3389/fmicb.2022.1052478 · 2023 · External reference
In vitro antileishmanial activity of thioridazine on amphotericin B unresponsive/sensitive Leishmania donovani promastigotes and intracellular amastigotes
10.1016/j.exppara.2023.108688 · 2024 · External reference
Amphotericin B: a drug of choice for visceral leishmaniasis
10.1016/j.actatropica.2022.106661 · 2022 · External reference
Flavonoids in the treatment of Leishmania amazonensis: a review of efficacy and mechanisms
10.3389/fphar.2025.1642005 · 2025 · External reference
In vitro and ultrastructural evaluation of the cytotoxic and antileishmanial activities of thiosemicarbazone compounds against promastigotes and axenic amastigotes of Leishmania infantum
10.3390/tropicalmed10110325 · 2025 · External reference
Review of the clinical presentation, pathology, diagnosis, and treatment of leishmaniasis
10.1093/labmed/lmac134 · 2023 · External reference
Isopropyl gallate, a gallic acid derivative: in silico and in vitro investigation of its effects on Leishmania major
10.3390/pharmaceutics14122701 · 2022 · External reference
Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis
10.1007/bf03401792 · 2000 · External reference
Recent updates on source, biosynthesis, and therapeutic potential of natural flavonoid luteolin: a review
10.3390/metabo12111145 · 2022 · External reference
Natural products as sources of new drugs over the period 1981-2002
10.1021/np030096l · 2003 · External reference
Advancing drug innovation for neglected diseases - criteria for lead progression
10.1371/journal.pntd.0000440 · 2009 · External reference
The current epidemiology of leishmaniasis in Turkey, Azerbaijan and Georgia and implications for disease emergence in European countries
10.1111/zph.12977 · 2022 · External reference
Opportunities and challenges in antiparasitic drug discovery
10.1038/nrd1824 · 2005 · External reference
Plants as source of drugs
10.1016/s0041-0101(00)00154-9 · 2001 · External reference
A review of natural products with antileishmanial activity
10.1016/j.phymed.2003.10.006 · 2005 · External reference
Safety surveillance during drug development: comparative evaluation of existing regulations
10.1007/s12325-023-02492-3 · 2023 · External reference
Antileishmanial activity of flavones-rich fraction from Arrabidaea chica verlot (Bignoniaceae)
10.3389/fphar.2021.703985 · 2021 · External reference
Bioactivity of natural polyphenols as antiparasitic agents and their biochemical targets
10.2174/1389557522666220404090429 · 2022 · External reference
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies
10.1128/aac.50.4.1352-1364.2006 · 2006 · External reference
Extraction of cynarine and chlorogenic acid from Artichoke leaves (Cynara scolymus L.) and evaluation of antioxidant activity, antibacterial activity of extract
10.1002/vjch.202100117 · 2022 · External reference
Flavonoid dimers as novel, potent antileishmanial agents
10.1021/jm301172v · 2012 · External reference
Medicinal plants with promising antileishmanial activity in Ethiopia: a systematic review and meta-analysis
2024 · External reference
Assessment of In-vitro antileishmanial activities of Cynara scolymus extracts against Leishmania tropica
2021 · External reference
Semen Cannabis and Oleum Hyperici: antileishmanial activity against Leishmania tropica promastigotes and intracellular amastigotes
10.1016/j.parint.2024.102950 · 2024 · External reference
Comparative evaluation of isolation and purification strategies for intracellular Leishmania tropica amastigotes in THP-1 macrophages
10.1016/j.actatropica.2026.108085 · 2026 · External reference
Extraction of cynarine and chlorogenic acid from Artichoke leaves (Cynara scolymus L.) and evaluation of antioxidant activity, antibacterial activity of extract
10.1002/vjch.202100117 · ExternalCitation · doi-reference
Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis
10.1007/bf03401792 · ExternalCitation · doi-reference
Safety surveillance during drug development: comparative evaluation of existing regulations
10.1007/s12325-023-02492-3 · ExternalCitation · doi-reference
Amphotericin B: a drug of choice for visceral leishmaniasis
10.1016/j.actatropica.2022.106661 · ExternalCitation · doi-reference
Comparative evaluation of isolation and purification strategies for intracellular Leishmania tropica amastigotes in THP-1 macrophages
10.1016/j.actatropica.2026.108085 · ExternalCitation · doi-reference
In vitro antileishmanial activity of thioridazine on amphotericin B unresponsive/sensitive Leishmania donovani promastigotes and intracellular amastigotes
10.1016/j.exppara.2023.108688 · ExternalCitation · doi-reference
Semen Cannabis and Oleum Hyperici: antileishmanial activity against Leishmania tropica promastigotes and intracellular amastigotes
10.1016/j.parint.2024.102950 · ExternalCitation · doi-reference
A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity
10.1016/j.pharmthera.2012.01.001 · ExternalCitation · doi-reference
A review of natural products with antileishmanial activity
10.1016/j.phymed.2003.10.006 · ExternalCitation · doi-reference
Plants as source of drugs
10.1016/s0041-0101(00)00154-9 · ExternalCitation · doi-reference
Effect of apigenin on Leishmania amazonensis is associated with reactive oxygen species production followed by mitochondrial dysfunction
10.1021/acs.jnatprod.5b00011 · ExternalCitation · doi-reference
Flavonoid dimers as novel, potent antileishmanial agents
10.1021/jm301172v · ExternalCitation · doi-reference
Natural products as sources of new drugs over the period 1981-2002
10.1021/np030096l · ExternalCitation · doi-reference
Opportunities and challenges in antiparasitic drug discovery
10.1038/nrd1824 · ExternalCitation · doi-reference
Hit and lead criteria in drug discovery for infectious diseases of the developing world
10.1038/nrd4683 · ExternalCitation · doi-reference
Review of the clinical presentation, pathology, diagnosis, and treatment of leishmaniasis
10.1093/labmed/lmac134 · ExternalCitation · doi-reference
Current treatment approaches to leishmaniasis
10.1097/00001432-200310000-00005 · ExternalCitation · doi-reference
The current epidemiology of leishmaniasis in Turkey, Azerbaijan and Georgia and implications for disease emergence in European countries
10.1111/zph.12977 · ExternalCitation · doi-reference
Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies
10.1128/aac.50.4.1352-1364.2006 · ExternalCitation · doi-reference
Antimony resistance in leishmania, focusing on experimental research
10.1155/2011/695382 · ExternalCitation · doi-reference
Unresponsiveness to glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites
10.1371/journal.pmed.0030162 · ExternalCitation · doi-reference
Advancing drug innovation for neglected diseases - criteria for lead progression
10.1371/journal.pntd.0000440 · ExternalCitation · doi-reference
In vitro activity and mode of action of phenolic compounds on Leishmania donovani
10.1371/journal.pntd.0007206 · ExternalCitation · doi-reference
Antileishmanial activity of Urtica dioica extract against zoonotic cutaneous leishmaniasis
10.1371/journal.pntd.0007843 · ExternalCitation · doi-reference
In vitro anti-leishmanial activities of methanol extract of Brucea antidysenterica J.F. mill seeds and its solvent fractions
10.2147/jep.s397352 · ExternalCitation · doi-reference
Bioactivity of natural polyphenols as antiparasitic agents and their biochemical targets
10.2174/1389557522666220404090429 · ExternalCitation · doi-reference
Use of natural products in leishmaniasis chemotherapy: an overview
10.3389/fchem.2020.579891 · ExternalCitation · doi-reference
Apigenin is a promising molecule for treatment of visceral leishmaniasis
10.3389/fcimb.2023.1066407 · ExternalCitation · doi-reference
Leishmaniasis: recent epidemiological studies in the Middle East
10.3389/fmicb.2022.1052478 · ExternalCitation · doi-reference
Antileishmanial activity of flavones-rich fraction from Arrabidaea chica verlot (Bignoniaceae)
10.3389/fphar.2021.703985 · ExternalCitation · doi-reference
Flavonoids in the treatment of Leishmania amazonensis: a review of efficacy and mechanisms
10.3389/fphar.2025.1642005 · ExternalCitation · doi-reference
Recent updates on source, biosynthesis, and therapeutic potential of natural flavonoid luteolin: a review
10.3390/metabo12111145 · ExternalCitation · doi-reference
Antileishmanial activities of medicinal herbs and phytochemicals in vitro and in vivo: an update for the years 2015 to 2021
10.3390/molecules27217579 · ExternalCitation · doi-reference
Cytotoxic and antileishmanial effects of the monoterpene β-Ocimene
10.3390/ph16020183 · ExternalCitation · doi-reference
Research in the field of drug design and development
10.3390/ph16091283 · ExternalCitation · doi-reference
Isopropyl gallate, a gallic acid derivative: in silico and in vitro investigation of its effects on Leishmania major
10.3390/pharmaceutics14122701 · ExternalCitation · doi-reference
Characterization of targeted phenolic compounds in globe artichoke heads and waste from vegetatively and “Seed”-Propagated genotypes
10.3390/plants12132579 · ExternalCitation · doi-reference
In vitro and ultrastructural evaluation of the cytotoxic and antileishmanial activities of thiosemicarbazone compounds against promastigotes and axenic amastigotes of Leishmania infantum
10.3390/tropicalmed10110325 · ExternalCitation · doi-reference
A parasite rescue and transformation assay for antileishmanial screening against intracellular Leishmania donovani amastigotes in THP1 human acute monocytic leukemia cell line
10.3791/4054 · ExternalCitation · doi-reference
Luteolin as a potent anti-leishmanial agent against intracellular Leishmania tropica parasite
10.4314/tjpr.v16i2.11 · ExternalCitation · doi-reference
