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References from Gut microbiota modulation mediates the protective effects of Lycium ruthenicum polysaccharide against periodontitis and its hepato-renal complications. Local targets link to admitted publications; unresolved targets remain external evidence.
Periodontitis, chronic liver diseases, and the emerging oral‐gut‐liver axis
10.1111/prd.12427 · 2000 · External reference
Food restriction reduces hepatic alterations associated with experimental periodontitis
10.1002/jper.20-0772 · 2022 · External reference
Temperature-switchable deep eutectic solvent extraction of polysaccharides from wolfberry fruits: Process optimization, structure characterization, and antioxidant activity
10.1016/j.molliq.2024.124352 · 2024 · External reference
Exosomes derived from periodontitis induce hepatic steatosis through the SCD-1/AMPK signaling pathway
10.1016/j.bbadis.2024.167343 · 2024 · External reference
The role of Sirt3‐induced autophagy in renal structural damage caused by periodontitis in rats
10.1111/jre.13071 · 2023 · External reference
Resective surgery for the treatment of furcation involvement: A systematic review
10.1111/jcpe.13241 · 2020 · External reference
Anthocyanins from Lycium ruthenicum murray mitigate cadmium-induced oxidative stress and testicular toxicity by activating the Keap1/Nrf2 signaling pathway
10.3390/ph17030322 · 2024 · External reference
The role of short chain fatty acids in inflammation and body health
10.3390/ijms25137379 · 2024 · External reference
Ameliorative effects of crocin on the inflammation and oxidative stress-induced kidney damages by experimental periodontitis in rat
2021 · External reference
Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis
10.1016/j.phrs.2022.106616 · 2023 · External reference
Oral pathogens meet the gut microbiome: New mechanistic insights on systemic disease
10.3389/fcimb.2025.1673512 · 2026 · External reference
Immune basis of therapeutic effects of Solanum tuberosum L. polysaccharide on chronic peptic ulcer healing
10.3390/ph18040502 · 2025 · External reference
PAP polypeptide promotes osteogenesis in Jaw bone defect repair by inhibiting inflammatory reactions
10.3389/fbioe.2022.916330 · 2022 · External reference
Sequential extraction, preliminary characterization and functional properties of sesame (Sesamum indicum L.) hull polysaccharides
2022 · External reference
Preparation of NIR responsive resveratrol@au nanocages using for regulating oxidative stress microenvironment of periodontitis
10.1016/j.cej.2024.158774 · 2025 · External reference
Efficient extraction of polysaccharides from Lycium barbarum L. by aqueous two-phase system combined with tissue-smashing extraction
10.1016/j.indcrop.2022.115036 · 2022 · External reference
Isochlorogenic acid A attenuated periodontitis by inhibiting inflammation via ACE/PGK1/STAT1 signaling
10.1021/acs.jafc.4c13299 · 2025 · External reference
Ulcerative colitis-driven gut dysbiosis exacerbates periodontal bone loss through the gut–oral axis/Th17/Treg imbalance
10.1038/s41522-026-01015-6 · 2026 · External reference
Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis
10.1038/s41467-024-45473-y · 2024 · External reference
Oral pathogenic bacteria and the oral–gut–liver axis: A new understanding of chronic liver diseases
10.3390/diagnostics13213324 · 2023 · External reference
Mizhuo Guanchangye enema delays the decline of renal function in rats with chronic kidney disease by intervening in the TLR4/MyD88/NF-κB pathway
2024 · External reference
Salidroside improves periodontitis by mitigating inflammatory reactions and enhancing osteogenic differentiation of human periodontal Ligament stem cells
10.2147/dddt.s530311 · 2025 · External reference
Resveratrol protects renal damages induced by periodontitis via preventing mitochondrial dysfunction in rats
10.1111/odi.14148 · 2023 · External reference
Advances in the preparation, structure and bioactivity of polysaccharides from Lycium ruthenicum Murr.: A review
10.3390/foods13131995 · 2024 · External reference
Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus
10.1016/j.bioactmat.2023.10.022 · 2024 · External reference
Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation
10.1016/j.bioactmat.2024.02.011 · 2024 · External reference
Lycium ruthenicum murr. Polysaccharide attenuated inflammatory response and intestinal Flora dysbiosis in LPS-induced acute lung injury in mice
10.3390/nu17182944 · 2025 · External reference
Periodontal inflammation and the risk of cardiovascular disease
10.1007/s11883-020-00848-6 · 2020 · External reference
Treatment of stage I–III periodontitis—The EFP S3 level clinical practice guideline
10.1111/jcpe.13290 · 2020 · External reference
Plant-based dietary fibers and polysaccharides as modulators of gut microbiota in intestinal and lung inflammation: Current state and challenges
10.3390/nu15153321 · 2023 · External reference
Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy
10.1186/s12951-021-01175-x · 2021 · External reference
Akkermansia muciniphila inhibited the periodontitis caused by Fusobacterium nucleatum
10.1038/s41522-023-00417-0 · 2023 · External reference
Bioactive polysaccharides targeting gut microbiota to modulate host health: A gear effect theory
10.1002/fft2.70048 · 2025 · External reference
Role of prebiotic dietary fiber in periodontal disease: A systematic review of animal studies
10.3389/fnut.2023.1130153 · 2023 · External reference
Evaluation of an antibiotic cocktail for fecal microbiota transplantation in mouse
10.3389/fnut.2022.918098 · 2022 · External reference
Neutral polysaccharide from Dendrobium officinale alleviates acute alcohol-induced liver injury via the gut microbiota−short chain fatty acids−liver axis
10.1016/j.ijbiomac.2025.144719 · 2025 · External reference
Role of nonalcoholic fatty liver disease in periodontitis: A bidirectional relationship
10.7759/cureus.63775 · 2024 · External reference
Effect of calcium ions on rheological properties and structure of Lycium barbarum L. polysaccharide and its gelation mechanism
10.1016/j.foodhyd.2021.107079 · 2022 · External reference
Structural features of an acidic polysaccharide with the potential of promoting osteoblast differentiation from Lycium ruthenicum murr
10.1080/14786419.2018.1452014 · 2020 · External reference
Expression of angiogenesis-related proteins in bone marrow mesenchymal stem cells induced by osteoprotegerin during osteogenic differentiation in rats
10.1016/j.intimp.2021.107821 · 2021 · External reference
Plant and fungal polysaccharides in periodontitis treatment: Diverse mechanisms and therapeutic roles
10.1155/ijod/7284794 · 2025 · External reference
Periodontal bacteria influence systemic diseases through the gut microbiota
10.3389/fcimb.2024.1478362 · 2024 · External reference
The effect of antibiotics on the gut microbiome: A metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice
10.1186/s12864-020-6665-2 · 2020 · External reference
Maintaining a protective state for human periodontal tissue
10.1111/prd.12367 · 2000 · External reference
The role of short-chain fatty acids in immunity, inflammation and metabolism
10.1080/10408398.2020.1854675 · 2022 · External reference
MicroRNA let‐7c‐5p promotes osteogenic differentiation of dental pulp stem cells by inhibiting lipopolysaccharide‐induced inflammation via HMGA2/PI3K/Akt signal blockade
10.1111/1440-1681.13059 · 2019 · External reference
The role of TLR4/MyD88/NF‐κB pathway in periodontitis‐induced liver inflammation of rats
10.1111/odi.13616 · 2021 · External reference
CGRP‐Loaded ROS‐Responsive hydrogel restores neuro‐angiogenic signaling to promote bone regeneration in diabetes‐associated periodontitis
10.1002/advs.202506438 · 2025 · External reference
An update on periodontal inflammation and bone loss
2024 · External reference
Akkermansia muciniphila regulates the gut microenvironment and alleviate periodontal inflammmation in mice with periodontitis
2025 · External reference
The microbial metabolite isovaleric acid aggravates gelatinase‐mediated periodontal tissue destruction via the NF‐κB signaling pathway
2025 · External reference
Advances in hydrogels for the treatment of periodontitis
10.1039/d3tb00835e · 2023 · External reference
CGRP‐Loaded ROS‐Responsive hydrogel restores neuro‐angiogenic signaling to promote bone regeneration in diabetes‐associated periodontitis
10.1002/advs.202506438 · ExternalCitation · doi-reference
Bioactive polysaccharides targeting gut microbiota to modulate host health: A gear effect theory
10.1002/fft2.70048 · ExternalCitation · doi-reference
Food restriction reduces hepatic alterations associated with experimental periodontitis
10.1002/jper.20-0772 · ExternalCitation · doi-reference
Periodontal inflammation and the risk of cardiovascular disease
10.1007/s11883-020-00848-6 · ExternalCitation · doi-reference
Exosomes derived from periodontitis induce hepatic steatosis through the SCD-1/AMPK signaling pathway
10.1016/j.bbadis.2024.167343 · ExternalCitation · doi-reference
Exosomes derived from impaired liver aggravate alveolar bone loss via shuttle of Fasn in type 2 diabetes mellitus
10.1016/j.bioactmat.2023.10.022 · ExternalCitation · doi-reference
Piezoelectric hydrogel for treatment of periodontitis through bioenergetic activation
10.1016/j.bioactmat.2024.02.011 · ExternalCitation · doi-reference
Preparation of NIR responsive resveratrol@au nanocages using for regulating oxidative stress microenvironment of periodontitis
10.1016/j.cej.2024.158774 · ExternalCitation · doi-reference
Effect of calcium ions on rheological properties and structure of Lycium barbarum L. polysaccharide and its gelation mechanism
10.1016/j.foodhyd.2021.107079 · ExternalCitation · doi-reference
Neutral polysaccharide from Dendrobium officinale alleviates acute alcohol-induced liver injury via the gut microbiota−short chain fatty acids−liver axis
10.1016/j.ijbiomac.2025.144719 · ExternalCitation · doi-reference
Efficient extraction of polysaccharides from Lycium barbarum L. by aqueous two-phase system combined with tissue-smashing extraction
10.1016/j.indcrop.2022.115036 · ExternalCitation · doi-reference
Expression of angiogenesis-related proteins in bone marrow mesenchymal stem cells induced by osteoprotegerin during osteogenic differentiation in rats
10.1016/j.intimp.2021.107821 · ExternalCitation · doi-reference
Temperature-switchable deep eutectic solvent extraction of polysaccharides from wolfberry fruits: Process optimization, structure characterization, and antioxidant activity
10.1016/j.molliq.2024.124352 · ExternalCitation · doi-reference
Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis
10.1016/j.phrs.2022.106616 · ExternalCitation · doi-reference
Isochlorogenic acid A attenuated periodontitis by inhibiting inflammation via ACE/PGK1/STAT1 signaling
10.1021/acs.jafc.4c13299 · ExternalCitation · doi-reference
Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis
10.1038/s41467-024-45473-y · ExternalCitation · doi-reference
Akkermansia muciniphila inhibited the periodontitis caused by Fusobacterium nucleatum
10.1038/s41522-023-00417-0 · ExternalCitation · doi-reference
Ulcerative colitis-driven gut dysbiosis exacerbates periodontal bone loss through the gut–oral axis/Th17/Treg imbalance
10.1038/s41522-026-01015-6 · ExternalCitation · doi-reference
Advances in hydrogels for the treatment of periodontitis
10.1039/d3tb00835e · ExternalCitation · doi-reference
The role of short-chain fatty acids in immunity, inflammation and metabolism
10.1080/10408398.2020.1854675 · ExternalCitation · doi-reference
Structural features of an acidic polysaccharide with the potential of promoting osteoblast differentiation from Lycium ruthenicum murr
10.1080/14786419.2018.1452014 · ExternalCitation · doi-reference
MicroRNA let‐7c‐5p promotes osteogenic differentiation of dental pulp stem cells by inhibiting lipopolysaccharide‐induced inflammation via HMGA2/PI3K/Akt signal blockade
10.1111/1440-1681.13059 · ExternalCitation · doi-reference
Resective surgery for the treatment of furcation involvement: A systematic review
10.1111/jcpe.13241 · ExternalCitation · doi-reference
Treatment of stage I–III periodontitis—The EFP S3 level clinical practice guideline
10.1111/jcpe.13290 · ExternalCitation · doi-reference
The role of Sirt3‐induced autophagy in renal structural damage caused by periodontitis in rats
10.1111/jre.13071 · ExternalCitation · doi-reference
The role of TLR4/MyD88/NF‐κB pathway in periodontitis‐induced liver inflammation of rats
10.1111/odi.13616 · ExternalCitation · doi-reference
Resveratrol protects renal damages induced by periodontitis via preventing mitochondrial dysfunction in rats
10.1111/odi.14148 · ExternalCitation · doi-reference
Maintaining a protective state for human periodontal tissue
10.1111/prd.12367 · ExternalCitation · doi-reference
Periodontitis, chronic liver diseases, and the emerging oral‐gut‐liver axis
10.1111/prd.12427 · ExternalCitation · doi-reference
Plant and fungal polysaccharides in periodontitis treatment: Diverse mechanisms and therapeutic roles
10.1155/ijod/7284794 · ExternalCitation · doi-reference
The effect of antibiotics on the gut microbiome: A metagenomics analysis of microbial shift and gut antibiotic resistance in antibiotic treated mice
10.1186/s12864-020-6665-2 · ExternalCitation · doi-reference
Remodeling immune microenvironment in periodontitis using resveratrol liposomes as an antibiotic-free therapeutic strategy
10.1186/s12951-021-01175-x · ExternalCitation · doi-reference
Salidroside improves periodontitis by mitigating inflammatory reactions and enhancing osteogenic differentiation of human periodontal Ligament stem cells
10.2147/dddt.s530311 · ExternalCitation · doi-reference
PAP polypeptide promotes osteogenesis in Jaw bone defect repair by inhibiting inflammatory reactions
10.3389/fbioe.2022.916330 · ExternalCitation · doi-reference
Periodontal bacteria influence systemic diseases through the gut microbiota
10.3389/fcimb.2024.1478362 · ExternalCitation · doi-reference
Oral pathogens meet the gut microbiome: New mechanistic insights on systemic disease
10.3389/fcimb.2025.1673512 · ExternalCitation · doi-reference
Evaluation of an antibiotic cocktail for fecal microbiota transplantation in mouse
10.3389/fnut.2022.918098 · ExternalCitation · doi-reference
Role of prebiotic dietary fiber in periodontal disease: A systematic review of animal studies
10.3389/fnut.2023.1130153 · ExternalCitation · doi-reference
Oral pathogenic bacteria and the oral–gut–liver axis: A new understanding of chronic liver diseases
10.3390/diagnostics13213324 · ExternalCitation · doi-reference
Advances in the preparation, structure and bioactivity of polysaccharides from Lycium ruthenicum Murr.: A review
10.3390/foods13131995 · ExternalCitation · doi-reference
The role of short chain fatty acids in inflammation and body health
10.3390/ijms25137379 · ExternalCitation · doi-reference
Plant-based dietary fibers and polysaccharides as modulators of gut microbiota in intestinal and lung inflammation: Current state and challenges
10.3390/nu15153321 · ExternalCitation · doi-reference
Lycium ruthenicum murr. Polysaccharide attenuated inflammatory response and intestinal Flora dysbiosis in LPS-induced acute lung injury in mice
10.3390/nu17182944 · ExternalCitation · doi-reference
Anthocyanins from Lycium ruthenicum murray mitigate cadmium-induced oxidative stress and testicular toxicity by activating the Keap1/Nrf2 signaling pathway
10.3390/ph17030322 · ExternalCitation · doi-reference
Immune basis of therapeutic effects of Solanum tuberosum L. polysaccharide on chronic peptic ulcer healing
10.3390/ph18040502 · ExternalCitation · doi-reference
Role of nonalcoholic fatty liver disease in periodontitis: A bidirectional relationship
10.7759/cureus.63775 · ExternalCitation · doi-reference
