Research graph
References from Paired CYP1A2/3A4-HepG2 phenotyping supports machine-learning classification of literature-curated hepatotoxicity categories. Local targets link to admitted publications; unresolved targets remain external evidence.
Optuna: a next-generation hyperparameter optimization framework
2019 · External reference
Drug-metabolizing gene expression identity: comparison across liver tissues and model cell lines
10.3390/biomedicines13112722 · 2025 · External reference
Can in vitro metabolism-dependent covalent binding data distinguish hepatotoxic from nonhepatotoxic drugs? An analysis using human hepatocytes and liver S-9 fraction
10.1021/tx800407w · 2009 · External reference
A large-scale human toxicogenomics resource for drug-induced liver injury prediction
10.1038/s41467-025-65690-3 · 2025 · External reference
An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons
10.1016/s0041-008x(03)00128-5 · 2003 · External reference
Random forests
10.1023/a:1010933404324 · 2001 · External reference
Hepatocyte cell lines: their use, scope and limitations in drug metabolism studies
10.1517/17425255.2.2.183 · 2006 · External reference
ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
10.1038/ajg.2014.131 · 2014 · External reference
Optimizing the cell painting assay for image-based profiling
10.1038/s41596-023-00840-9 · 2023 · External reference
A systematic study of key elements underlying molecular property prediction
10.1038/s41467-023-41948-6 · 2023 · External reference
High-content screening for the detection of drug-induced oxidative stress in liver cells
10.3390/antiox10010106 · 2021 · External reference
EASL clinical practice guidelines: drug-induced liver injury
10.1016/j.jhep.2019.02.014 · 2019 · External reference
Drug-induced liver injury network (DILIN) prospective study: rationale, design and conduct
10.2165/00002018-200932010-00005 · 2009 · External reference
Metabolic activation of pesticide isoprocarb mediated by CYP3A4 and the possible correlation with its cytotoxicity
10.1021/acs.jafc.2c07206 · 2023 · External reference
Cytochrome P450 and chemical toxicology
10.1021/tx700079z · 2008 · External reference
Preclinical evaluation of chemically reactive metabolites and mitigation of bioactivation in drug discovery
10.1016/j.drudis.2023.103621 · 2023 · External reference
Prediction of cytochrome P450-mediated bioactivation using machine learning models and in vitro validation
10.1007/s00204-024-03701-w · 2024 · External reference
Bioluminescence measurement of time-dependent dynamic changes of CYP-mediated cytotoxicity in CYP-expressing luminescent HepG2 cells
10.3390/ijms22062843 · 2021 · External reference
Mitochondrial damage and biogenesis in acetaminophen-induced liver injury
10.1016/j.livres.2019.10.002 · 2019 · External reference
Human cytochrome P450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1′-hydroxymethyleugenol
10.1021/tx050267h · 2006 · External reference
Predicting toxicities of reactive metabolite-positive drug candidates
10.1146/annurev-pharmtox-010814-124720 · 2015 · External reference
Utilizing multiple behavioral endpoints to identify negative control chemicals in a larval zebrafish behavior assay
10.3390/toxics13090727 · 2025 · External reference
Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio
10.2131/jts.44.347 · 2019 · External reference
Lysosomal stress response (LSR): physiological importance and pathological relevance
10.1007/s11481-021-09990-7 · 2021 · External reference
Reactive metabolite trapping screens and potential pitfalls: bioactivation of a homomorpholine and formation of an unstable thiazolidine adduct
10.1021/tx5000409 · 2014 · External reference
Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat hepatocytes
10.1016/j.toxlet.2009.02.012 · 2009 · External reference
Inducibility of cytochrome P450-mediated 7-methoxycoumarin-O-demethylase activity in zebrafish (Danio rerio) embryos
10.1016/j.aquatox.2020.105540 · 2020 · External reference
A unified approach to interpreting model predictions
2017 · External reference
UMAP: uniform manifold approximation and projection for dimension reduction
10.21105/joss.00861 · 2018 · External reference
Cytochrome P450 expression and chemical metabolic activity before full liver development in zebrafish
10.3390/ph13120456 · 2020 · External reference
Generation of HepG2 cells with high expression of multiple drug-metabolizing enzymes for drug discovery research using a PITCh system
10.3390/cells11101677 · 2022 · External reference
Post-marketing withdrawal of 462 medicinal products because of adverse drug reactions: a systematic review of the world literature
10.1186/s12916-016-0553-2 · 2016 · External reference
Hepa-ToxMOA: a pathway-screening method for evaluating cellular stress and hepatic metabolic-dependent toxicity of natural products
10.1038/s41598-024-54634-4 · 2024 · External reference
Artificial intelligence in drug discovery and development
10.1016/j.drudis.2020.10.010 · 2021 · External reference
Scikit-learn: machine learning in Python
2011 · External reference
Nutrient environment improves drug metabolic activity in human iPSC-derived hepatocytes and HepG2
10.1007/s00204-025-04139-4 · 2025 · External reference
Utility of spherical human liver microtissues for prediction of clinical drug-induced liver injury
10.1007/s00204-017-2002-1 · 2017 · External reference
Innate immune regulation in inflammation resolution and liver regeneration in drug-induced liver injury
10.1007/s00204-024-03886-0 · 2025 · External reference
Acetaminophen hepatotoxicity
10.1055/s-0039-1679919 · 2019 · External reference
Xenobiotic metabolism in the zebrafish: a review of the spatiotemporal distribution, modulation and activity of cytochrome P450 families 1 to 3
10.2131/jts.41.1 · 2016 · External reference
Methotrexate-induced liver injury is associated with oxidative stress, impaired mitochondrial respiration, and endoplasmic reticulum stress in vitro
10.3390/ijms232315116 · 2022 · External reference
Cell painting: a decade of discovery and innovation in cellular imaging
10.1038/s41592-024-02528-8 · 2025 · External reference
Reactive metabolites: current and emerging risk and hazard assessments
10.1021/acs.chemrestox.5b00410 · 2016 · External reference
High-content screening technology for studying drug-induced hepatotoxicity in cell models
10.1007/s00204-015-1503-z · 2015 · External reference
HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved
10.1007/s00204-013-1012-x · 2013 · External reference
Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury
10.1007/s00204-017-2036-4 · 2018 · External reference
Bioactivation of drugs: risk and drug design
10.1146/annurev-pharmtox-010510-100514 · 2011 · External reference
Fraxinellone induces hepatotoxicity in zebrafish through oxidative stress and the transporters pathway
10.3390/molecules27092647 · 2022 · External reference
Role of metabolic activation in elemicin-induced cellular toxicity
10.1021/acs.jafc.9b02137 · 2019 · External reference
Drug safety sciences and the bottleneck in drug development
10.1038/clpt.2011.63 · 2011 · External reference
Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
10.1016/j.cbi.2015.10.009 · 2016 · External reference
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities and impact of genetic variation
10.1016/j.pharmthera.2012.12.007 · 2013 · External reference
A simple statistical parameter for use in evaluation and validation of high-throughput screening assays
10.1177/108705719900400206 · 1999 · External reference
