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References from Integrating epidemiology and mechanistic studies links PFAS exposure to ocular diseases and implicates PFOS-associated glaucoma risk through the PI3K/Akt-MMP3 axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Association of matrix metalloproteinases polymorphisms with glaucoma risk, glaucoma phenotype, and response to treatment with selective laser trabeculoplasty or latanoprost
10.3390/ijms252413464 · 2024 · External reference
Individual and mixture associations of perfluoroalkyl substances on liver function biomarkers in the Canadian health measures survey
10.1186/s12940-022-00892-6 · 2022 · External reference
Estimating outcome-exposure associations when exposure biomarker detection limits vary across batches
10.1097/ede.0000000000001052 · 2019 · External reference
Per- and polyfluoroalkyl substances (PFAS) exposure in the U.S. population: NHANES 1999-March 2020
10.1016/j.envres.2025.120916 · 2025 · External reference
Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis
10.1016/s2214-109x(17)30293-0 · 2017 · External reference
Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins
10.1002/ieam.258 · 2011 · External reference
Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant
2017 · External reference
Association between adjustable dietary factors and periodontitis: NHANES 2009-2014 and Mendelian randomization
10.1186/s12967-024-05972-4 · 2025 · External reference
Serum lipids mediate the association of per- and polyfluoroalkyl substances exposure and age-related macular degeneration
2025 · External reference
LGALS3 regulates endothelial-to-mesenchymal transition via PI3K/AKT signaling pathway in silica-induced pulmonary fibrosis
10.1016/j.tox.2024.153962 · 2024 · External reference
Long-term effects of vitamins C and E, β-carotene, and zinc on age-related macular degeneration: AREDS report no. 35
10.1016/j.ophtha.2013.01.021 · 2013 · External reference
Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the right to sight: an analysis for the Global Burden of disease study
10.1016/s2214-109x(20)30489-7 · 2021 · External reference
Copyright 2022 by the national academy of sciences
2022 · External reference
Visual function, social position, and health and life chances: the UK biobank study
2016 · External reference
The association of ideal cardiovascular health and ocular diseases among US adults
10.1016/j.amjmed.2020.06.004 · 2021 · External reference
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary
10.1093/humupd/dmaa018 · 2020 · External reference
The effect of mixture of heavy metals on obesity in individuals ≥50 years of age
10.1007/s12011-021-02972-z · 2022 · External reference
Per- and polyfluoroalkyl substances in the environment
10.1126/science.abg9065 · 2022 · External reference
Per- and polyfluoroalkyl substance toxicity and human health review: current state of knowledge and strategies for informing future research
10.1002/etc.4890 · 2021 · External reference
Historical and current usage of per- and polyfluoroalkyl substances (PFAS): a literature review
10.1002/ajim.23362 · 2023 · External reference
An overview of the uses of per- and polyfluoroalkyl substances (PFAS)
10.1039/d0em00291g · 2020 · External reference
Association of emotional and behavioral problems with single and multiple suicide attempts among Chinese adolescents: modulated by academic performance
10.1016/j.jad.2019.07.085 · 2019 · External reference
Exploring the link between Di-2-ethylhexyl phthalate (DEHP) exposure and muscle mass: a systematic investigation utilizing NHANES data analysis, network toxicology and molecular docking approaches
10.1016/j.ecoenv.2025.118132 · 2025 · External reference
Novel insights into the adverse health effects of per- and polyfluoroalkyl substances on the kidney via human urine metabolomics
10.1021/acs.est.3c06480 · 2023 · External reference
Identification of hub genes and pathways associated with cellular senescence in diabetic foot ulcers via comprehensive transcriptome analysis
2024 · External reference
Serum concentrations of selected perfluoroalkyl substances for US females compared to males as they age
10.1016/j.scitotenv.2022.156891 · 2022 · External reference
Unresolved reference
2024 · External reference
MMP3 at the crossroads: linking molecular pathways to disease diagnosis and therapy
10.1016/j.phrs.2025.107750 · 2025 · External reference
Information bias in epidemiological studies with a special focus on obstetrics and gynecology
10.1111/aogs.13330 · 2018 · External reference
Associations of exposure to metal and metal mixtures with thyroid hormones: results from the NHANES 2007-2012
10.1016/j.envres.2022.113413 · 2022 · External reference
PubChem 2023 update
10.1093/nar/gkac956 · 2023 · External reference
Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model
10.1007/s00204-018-2365-y · 2019 · External reference
In vitro comparison of human and murine trabecular meshwork cells: implications for glaucoma research
10.1038/s41598-024-73057-9 · 2024 · External reference
Perfluorooctane sulfonate promotes the migration of colorectal cancer cells by inducing epithelial-mesenchymal transition
10.1016/j.jes.2023.09.031 · 2024 · External reference
Association of exposure to perfluoroalkyl substances and risk of the acute coronary syndrome: a case-control study in shijiazhuang Hebei Province
10.1016/j.chemosphere.2022.137464 · 2023 · External reference
Mind the gap: characterizing bias due to population mismatch in two-sample Mendelian randomization
10.1016/j.ajhg.2026.02.002 · 2026 · External reference
Phthalate metabolite mixtures and dose-response associations with depressive symptoms in U.S. adults
2025 · External reference
Per- and polyfluoroalkyl substances in food contact materials: Migration, health risks and sustainable alternatives
10.1016/j.tifs.2026.105667 · 2026 · External reference
Association between systemic immune inflammation index and cataract incidence from 2005 to 2008
10.1038/s41598-024-84204-7 · 2025 · External reference
Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water
10.1136/oemed-2017-104651 · 2018 · External reference
Immunotoxicity mechanisms of perfluorinated compounds PFOA and PFOS
10.1016/j.chemosphere.2021.132892 · 2022 · External reference
Role of chronic inflammation in myopia progression: clinical evidence and experimental validation
10.1016/j.ebiom.2016.07.021 · 2016 · External reference
Perfluorooctanesulfonic acid contributes to primary open-angle glaucoma in a FABP4-Dependent manner: a novel mechanism for environmental risk of glaucoma
10.3389/fgene.2026.1807152 · 2026 · External reference
Protective effect of fucoidan against MPP(+)-induced SH-SY5Y cells apoptosis by affecting the PI3K/Akt pathway
10.3390/md18060333 · 2020 · External reference
PFOS promotes lung adenocarcinoma cell proliferation through PI3K/AKT/NF-κB mediated EMT
10.1016/j.fct.2025.115714 · 2025 · External reference
Association of Per- and polyfluoroalkyl substance exposure with cataract prevalence among U.S. adults: a NHANES analysis (2005-2008)
10.1167/tvst.14.4.1 · 2025 · External reference
A state-of-the-science review of interactions of Per- and polyfluoroalkyl substances (PFAS) with renal transporters in health and disease: implications for population variability in PFAS toxicokinetics
10.1289/ehp11885 · 2023 · External reference
Matrix metalloproteinase-3 (MMP-3)-mediated gene therapy for glaucoma
2023 · External reference
Estrogen receptor in the human eye: influence of gender and age on gene expression
1999 · External reference
Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
10.1289/ehp.10009 · 2007 · External reference
Bias in occupational epidemiology studies
10.1136/oem.2006.026690 · 2007 · External reference
Perfluorooctane sulfonate (PFOS) disrupts testosterone biosynthesis via CREB/CRTC2/StAR signaling pathway in leydig cells
10.1016/j.tox.2020.152663 · 2021 · External reference
Perfluorooctane sulfonate interferes with non-genomic estrogen receptor signaling pathway, inhibits ERK1/2 activation and induces apoptosis in mouse spermatocyte-derived cells
10.1016/j.tox.2021.152871 · 2021 · External reference
Mendelian randomization: concepts and scope
10.1101/cshperspect.a040501 · 2022 · External reference
Diet as an exposure source and mediator of Per- and polyfluoroalkyl substance (PFAS) toxicity
10.3389/ftox.2020.601149 · 2020 · External reference
Exposure to a mixture of legacy, alternative, and replacement per- and polyfluoroalkyl substances (PFAS) results in sex-dependent modulation of cholesterol metabolism and liver injury
10.1016/j.envint.2021.106843 · 2021 · External reference
Multivariable mendelian randomization and mediation
10.1101/cshperspect.a038984 · 2021 · External reference
The global extent of undetected glaucoma in adults: a systematic review and meta-analysis
10.1016/j.ophtha.2021.04.009 · 2021 · External reference
PFAS and cancer, a scoping review of the epidemiologic evidence
10.1016/j.envres.2020.110690 · 2021 · External reference
Correlation analysis between per-fluoroalkyl and poly-fluoroalkyl substances exposure and depressive symptoms in adults: NHANES 2005-2018
10.1016/j.scitotenv.2023.167639 · 2024 · External reference
Chronic conditions more than age drive health system use in Canadian seniors
10.12927/hcq.2011.22485 · 2011 · External reference
Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis
10.1016/j.ophtha.2014.05.013 · 2014 · External reference
Src mediates TGF-β-induced intraocular pressure elevation in glaucoma
10.1002/jcp.27044 · 2019 · External reference
Unresolved reference
2026 · External reference
Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the right to sight: an analysis for the global burden of disease study
10.1016/s2214-109x(20)30489-7 · 2021 · External reference
Association of systemic inflammatory biomarkers with ocular disease: a large population-based cross-sectional study
10.1186/s40001-025-02473-y · 2025 · External reference
The role of matrix metalloproteinase 9 in fibrosis diseases and its molecular mechanisms
10.1016/j.biopha.2023.116116 · 2024 · External reference
Perfluorooctane sulfonate induces autophagy-associated apoptosis through oxidative stress and the activation of extracellular signal-regulated kinases in renal tubular cells
10.1371/journal.pone.0245442 · 2021 · External reference
Using self-reported health as a social determinants of health outcome: a scoping review of reviews
10.1093/heapro/daad165 · 2023 · External reference
Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma
10.1007/s11427-022-2344-5 · 2023 · External reference
Perfluorooctane sulfonate (PFOS) induces Caspase-8-mediated pyroptosis via GSDMD and GSDME to drive retinal disease: evidence from epidemiological and experimental studies
10.1016/j.envpol.2026.127896 · 2026 · External reference
Chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs) are associated with eye diseases in humans and eye toxicity in zebrafish
10.1021/envhealth.3c00148 · 2024 · External reference
Caspase-8 promotes NLRP3 inflammasome activation mediates eye development defects in zebrafish larvae exposed to perfulorooctane sulfonate (PFOS)
10.1016/j.envpol.2024.124252 · 2024 · External reference
Exposure to per- and polyfluoroalkyl substance and metabolic syndrome: a nationally representative cross-sectional study from NHANES, 2003-2018
10.1016/j.envpol.2024.123615 · 2024 · External reference
Association between exposure to per- and polyfluoroalkyl substances (PFAS) and chronic cough in American adults: results from NHANES 2003-2012
10.1016/j.ecoenv.2025.117901 · 2025 · External reference
Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG
10.1172/jci.insight.174836 · 2024 · External reference
Serum half-lives for Short- and long-chain perfluoroalkyl acids after ceasing exposure from drinking water contaminated by firefighting foam
10.1289/ehp6785 · 2020 · External reference
Longitudinal changes in global cataract surgery rate inequality and associations with socioeconomic indices
10.1111/ceo.13430 · 2019 · External reference
TMCO1 promotes ferroptosis and ECM deposition in glaucomatous trabecular meshwork via ERK1/2 signaling
2025 · External reference
Folate concentrations and serum perfluoroalkyl and polyfluoroalkyl substance concentrations in adolescents and adults in the USA (national health and Nutrition Examination Study 2003-16): an observational study
10.1016/s2542-5196(23)00088-8 · 2023 · External reference
Associations of prenatal PFAS exposure and early childhood neurodevelopment: evidence from the Shanghai Maternal-Child pairs cohort
10.1016/j.envint.2023.107850 · 2023 · External reference
Elucidating acceptance and clinical indications to support the rational design of drug-eluting contact lenses
10.1016/j.ijpharm.2024.124702 · 2024 · External reference
The association of mixed multi-metal exposure with sleep duration and self-reported sleep disorder: a subgroup analysis from the national health and nutrition examination survey (NHANES)
10.1016/j.envpol.2024.124798 · 2024 · External reference
Estimation of species- and sex-specific PFAS pharmacokinetics in mice, rats, and non-human primates using a Bayesian hierarchical methodology
10.1016/j.taap.2025.117336 · 2025 · External reference
