Research graph
References from Development of bimolecular biosensors to detect chemicals with agonist activity toward rat PXR. Local targets link to admitted publications; unresolved targets remain external evidence.
Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment
10.1002/etc.34 · 2010 · External reference
Nuclear receptors and their selective pharmacologic modulators
10.1124/pr.112.006833 · 2013 · External reference
NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells
10.1021/acschembio.5b00753 · 2016 · External reference
Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities
10.2131/jts.41.677 · 2016 · External reference
Engineered luciferase reporter from a deep sea shrimp utilizing a novel imidazopyrazinone substrate
10.1021/cb3002478 · 2012 · External reference
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
10.1038/47069 · 1999 · External reference
Nuclear receptor PXR, transcriptional circuits and metabolic relevance
10.1016/j.bbadis.2011.01.014 · 2011 · External reference
Adverse outcome pathway for pregnane X receptor-induced hypercholesterolemia
10.1007/s00204-023-03575-4 · 2023 · External reference
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution
10.1210/mend.14.1.0409 · 2000 · External reference
The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism
10.1210/er.2001-0038 · 2002 · External reference
Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats
10.2131/jts.46.569 · 2021 · External reference
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
10.1172/jci3703 · 1998 · External reference
Construction of a linker library with widely controllable flexibility for fusion protein design
10.1007/s00253-015-6985-3 · 2016 · External reference
Characterization of human pregnane X receptor activators identified from a screening of the Tox21 compound library
10.1016/j.bcp.2020.114368 · 2021 · External reference
The Roles of Xenobiotic Receptors: Beyond Chemical Disposition
10.1124/dmd.118.081042 · 2018 · External reference
Development of nanoluciferase-based sensing system that can specifically detect 1α,25-dihydroxyvitamin D in living cells
10.1016/j.jsbmb.2022.106233 · 2023 · External reference
Mechanism of the nuclear receptor molecular switch
10.1016/j.tibs.2004.04.006 · 2004 · External reference
Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver
10.1074/jbc.m610072200 · 2007 · External reference
Molecular determinants of nuclear receptor-corepressor interaction
10.1101/gad.13.24.3198 · 1999 · External reference
Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning
10.3390/cells10113137 · 2021 · External reference
The flip side: Identifying small molecule regulators of nuclear receptors
2004 · External reference
Helix 12 stabilization contributes to basal transcriptional activity of PXR
10.1016/j.jbc.2021.100978 · 2021 · External reference
Bisphenol A and its analogues activate human pregnane X receptor
10.1289/ehp.1104426 · 2012 · External reference
Unveiling a new essential cis element for the transactivation of the CYP3A4 gene by xenobiotics
10.1124/mol.108.050575 · 2009 · External reference
Adverse outcome pathway (AOP) development I: strategies and principles
10.1093/toxsci/kfu199 · 2014 · External reference
Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor
10.1016/s0022-2836(03)00795-2 · 2003 · External reference
Decoding luciferase signal dynamics: A roadmap to reliable luminescent assays
10.1021/jacsau.5c01622 · 2026 · External reference
Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR
10.1016/j.bcp.2010.12.003 · 2011 · External reference
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
10.1073/pnas.0438010100 · 2003 · External reference
Humanized xenobiotic response in mice expressing nuclear receptor SXR
10.1038/35019116 · 2000 · External reference
