Research graph
References from RIFM 60th anniversary special issue: Toxicological impact of RIFM science throughout the years. Local targets link to admitted publications; unresolved targets remain external evidence.
RIFM natural complex substance (NCS) fragrance ingredient safety assessment, ho bark oil, CAS registry number 8022-91-1, RIFM ID 217-C2.12
2025 · External reference
RIFM natural complex substance (NCS) fragrance ingredient safety assessment, ho wood oil, CAS Registry Number 8022-91-1, RIFM ID 217-D2.12
2025 · External reference
RIFM natural complex substance (NCS) fragrance ingredient safety assessment, savory winter oil, CAS registry number 90106-57-3, RIFM ID 1181-E2.12
2025 · External reference
RIFM natural complex substance (NCS) fragrance ingredient safety assessment, lovage leaf oil, CAS registry number 8016-31-7, RIFM ID 813-E2.12
2026 · External reference
RIFM Natural Complex Substance (NCS) fragrance ingredient safety assessment, clove bud absolute, CAS Registry number 8000-34-8, RIFM ID 583-F2.1
2025 · External reference
Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials
10.1016/j.yrtph.2020.104805 · 2020 · External reference
Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients
10.1016/j.yrtph.2007.10.008 · 2008 · External reference
The RIFM approach to evaluating Natural Complex Substances (NCS)
2022 · External reference
RIFM natural complex substance (NCS) fragrance ingredient safety assessment, petitgrain mandarin oil, CAS registry number 8014-17-3, RIFM ID: 250-E2.12
2023 · External reference
RIFM Natural Complex Substance (NCS) fragrance ingredient safety assessment, orange essence oil, CAS Registry Number 68514-75-0, RIFM ID 192-G2.10
2024 · External reference
Criteria for the Research Institute for Fragrance Materials, inc. (RIFM) safety evaluation process for fragrance ingredients
2015 · External reference
Skin sensitization quantitative risk assessment: a review of underlying assumptions
10.1016/j.yrtph.2015.11.013 · 2016 · External reference
The safety assessment of fragrance materials
10.1016/s0273-2300(03)00003-5 · 2003 · External reference
Use of NAMs in a weight of evidence approach to evaluate the safety via the inhalation route of acetylated vetiver oil, in spray products
10.1016/j.yrtph.2025.105905 · 2025 · External reference
Updating the Dermal Sensitisation Thresholds using an expanded dataset and an in silico expert system
10.1016/j.yrtph.2022.105200 · 2022 · External reference
Novel database for exposure to fragrance ingredients in cosmetics and personal care products
10.1016/j.yrtph.2015.05.012 · 2015 · External reference
Integrating habits and practices data for soaps, cosmetics and air care products into an existing aggregate exposure model
10.1016/j.yrtph.2017.05.017 · 2017 · External reference
Clustering a chemical inventory for safety assessment of fragrance ingredients: identifying read-across analogs to address data gaps
10.1021/acs.chemrestox.9b00518 · 2020 · External reference
In vitro assessment of skin sensitization, photosensitization and phototoxicity potential of commercial glyphosate-containing formulations
10.1016/j.tiv.2017.04.001 · 2017 · External reference
The 'BlueScreen HC' assay as a decision making test in the genotoxicity assessment of flavour and fragrance materials
10.1016/j.tiv.2015.05.005 · 2015 · External reference
A review of the scientific basis for uncertainty factors for use in quantitative risk assessment for the induction of allergic contact dermatitis
10.1034/j.1600-0536.2002.470502.x · 2002 · External reference
Application of the risk assessment paradigm to the induction of allergic contact dermatitis
10.1016/s0273-2300(02)00021-1 · 2003 · External reference
Criteria for development of a database for safety evaluation of fragrance ingredients
10.1006/rtph.1999.1362 · 2000 · External reference
Understanding fragrance allergy using an exposure-based risk assessment approach
10.1034/j.1600-0536.2001.450603.x · 2001 · External reference
Proposal for a risk assessment methodology for skin sensitization based on sensitization potency data
10.1016/j.yrtph.2003.07.001 · 2003 · External reference
Ecotoxicological thresholds-practical application to an industrial inventory
10.1002/etc.2875 · 2015 · External reference
Incorporating Singaporean habits and practices for cosmetics and personal care products into a global consumer aggregate exposure model
10.1016/j.yrtph.2024.105752 · 2025 · External reference
Mode of Action (MOA) assignment classifications for ecotoxicology: an evaluation of approaches
10.1021/acs.est.7b02337 · 2017 · External reference
A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data
10.1006/rtph.1996.1076 · 1997 · External reference
Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet
10.1016/j.fct.2003.08.006 · 2004 · External reference
Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients
10.1016/j.fct.2007.06.021 · 2007 · External reference
Critical evaluation of low-molecular weight respiratory sensitizers and their protein reactivity potential toward lysine residues
10.1093/toxsci/kfab055 · 2021 · External reference
Aquatic risk of fragrance materials: advancing prioritization in aquatic systems
10.1093/etojnl/vgaf214 · 2025 · External reference
Updates to the research institute for fragrance materials, inc. Confirmation of no induction in human test standard protocol
10.1089/derm.2025.0125 · 2025 · External reference
Derivation of the no expected sensitization induction level for dermal quantitative risk assessment of fragrance ingredients using a weight of evidence approach
10.1016/j.fct.2021.112705 · 2022 · External reference
Quantitative next generation risk assessment for skin sensitization - application of regression models based on in vitro data to estimate point of departure
10.1016/j.yrtph.2025.105964 · 2026 · External reference
Predicting points of departure and potency categories for fragrance ingredients by integrating OECD in vitro models
10.1016/j.fct.2024.114998 · 2024 · External reference
Assessment of the skin sensitization potential of fragrance ingredients using the U-SENS™ assay
10.1016/j.tiv.2021.105298 · 2022 · External reference
Detailed aggregate exposure analysis shows that exposure to fragrance ingredients in consumer products is low: many orders of magnitude below thresholds of concern
10.1016/j.yrtph.2024.105569 · 2024 · External reference
Integrating new habits and practices data and homecare products into the Creme RIFM aggregate exposure model
10.1016/j.yrtph.2026.106097 · 2026 · External reference
An end point-specific framework for read-across analog selection for human health effects
10.1021/acs.chemrestox.2c00286 · 2022 · External reference
Advancing chemical grouping: development and application of signature-based structure-activity groups for non-animal safety assessments
10.1016/j.comtox.2025.100391 · 2025 · External reference
Benchmarking performance of SENS-IS assay against weight of evidence skin sensitization potency categories
10.1016/j.yrtph.2022.105128 · 2022 · External reference
Weight of evidence approach for skin sensitization potency categorization of fragrance ingredients
10.1097/der.0000000000000854 · 2022 · External reference
Fragrance skin sensitization evaluation and human testing: 30-year experience
10.1097/der.0000000000000684 · 2021 · External reference
Derivation of a point of departure using NAMs for application in quantitative risk assessment of fragrance materials
10.1016/j.yrtph.2026.106052 · 2026 · External reference
Application of the dermal sensitization threshold concept to chemicals classified as high potency category for skin sensitization assessment of ingredients for consumer products
10.1016/j.yrtph.2020.104732 · 2020 · External reference
Test no. 432: in vitro 3T3 NRU phototoxicity test
2019 · External reference
Test no. 471: bacterial reverse mutation test
2020 · External reference
Test no. 487: in vitro mammalian cell micronucleus test
2023 · External reference
Test no. 498: in vitro phototoxicity - reconstructed human epidermis phototoxicity test method
2023 · External reference
A standard method for measuring benzene and formaldehyde emissions from candles in emission test chambers for human health risk assessment purposes
10.1039/c3em00011g · 2013 · External reference
Human health risk evaluation of selected VOC, SVOC and particulate emissions from scented candles
10.1016/j.yrtph.2014.02.010 · 2014 · External reference
The research institute for fragrance materials' human repeated insult patch test protocol
10.1016/j.yrtph.2007.11.004 · 2008 · External reference
"In Litero" screening: retrospective evaluation of clinical evidence to establish a reference list of human chemical respiratory sensitizers
10.3389/ftox.2022.916370 · 2022 · External reference
Unresolved reference
2025 · External reference
Unresolved reference
2026 · External reference
Unresolved reference
2026 · External reference
Unresolved reference
2026 · External reference
Unresolved reference
2026 · External reference
Use of alternative test methods in a tiered testing approach to address photoirritation potential of fragrance materials
10.1016/j.yrtph.2021.105098 · 2022 · External reference
The importance of exposure estimation in the assessment of skin sensitization risk
10.1034/j.1600-0536.2000.042005251.x · 2000 · External reference
Identifying a reference list of respiratory sensitizers for the evaluation of novel approaches to study respiratory sensitization
10.1080/10408444.2021.2024142 · 2021 · External reference
Application of the expanded creme RIFM consumer exposure model to fragrance ingredients in cosmetic, personal care and air care products
10.1016/j.yrtph.2017.02.021 · 2017 · External reference
The dermal sensitisation Threshold- a TTC approach for allergic contact dermatitis
10.1016/j.yrtph.2008.02.010 · 2008 · External reference
Extension of the dermal sensitisation threshold (DST) approach to incorporate chemicals classified as reactive
10.1016/j.yrtph.2015.04.020 · 2015 · External reference
Macrocyclic fragrance materials--a screening-level environmental assessment using chemical categorization
10.1016/j.ecoenv.2011.05.002 · 2011 · External reference
A framework for prioritizing fragrance materials for aquatic risk assessment
10.1002/etc.5620210627 · 2002 · External reference
Use and limitations of clinical data in the identification and classification of low molecular weight chemicals (LMWCs) as respiratory sensitizers: recommendations for improvement
10.1080/10408444.2024.2433222 · 2025 · External reference
Addendum
10.1080/10408444.2026.2686569 · 2026 · External reference
Opinion on dermal sensitisation quantitative risk assessment (QRA) for fragrance ingredients
2008 · External reference
Opinion on fragrance allergens in cosmetic products
2012 · External reference
Unresolved reference
2017 · External reference
Opinion on skin sensitisation quantitative risk assessment for fragrance ingredients (QRA2)
2018 · External reference
An in silico skin absorption model for fragrance materials
10.1016/j.fct.2014.09.015 · 2014 · External reference
Environmental risk assessment of musk ketone and musk xylene in the Netherlands in accordance with the EU-TGD
10.1016/s0045-6535(97)00261-0 · 1997 · External reference
The BlueScreen HC assay to predict the genotoxic potential of fragrance materials
10.1093/mutage/geac004 · 2022 · External reference
Assessment of genotoxic potential of fragrance materials in the chicken egg assays
10.1002/em.22627 · 2024 · External reference
The chicken egg genotoxicity assay (CEGA): assessing target tissue exposure and metabolism in the embryo-fetal chicken livers
10.1002/em.70015 · 2025 · External reference
Use of the EpiDermTM 3D reconstructed skin micronucleus assay for fragrance materials
10.1093/mutage/geab040 · 2022 · External reference
A framework for using structural, reactivity, metabolic and physicochemical similarity to evaluate the suitability of analogs for SAR-based toxicological assessments
10.1016/j.yrtph.2009.09.006 · 2010 · External reference
