Research graph
References from Low- and no-calorie sweeteners lack shared target organs or modes of action required for cumulative risk assessment. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2018 · External reference
Methodology for health risk assessment of combined exposures to multiple chemicals
10.1016/j.fct.2020.111520 · 2020 · External reference
Do mixtures of several sweeteners pose risks for human health? BfR Opinion no. 005/2023
2023 · External reference
IARC use of oxidative stress as key mode of action characteristic for facilitating cancer classification: glyphosate case example illustrating a lack of robustness in interpretative implementation
10.1016/j.yrtph.2017.03.004 · 2017 · External reference
Risk assessment of combined exposure to multiple chemicals at the European Food Safety Authority: principles, guidance documents, applications and future challenges
10.3390/toxins15010040 · 2023 · External reference
Lack of potential carcinogenicity for sucralose - systematic evaluation and integration of mechanistic data into the totality of the evidence
10.1016/j.fct.2019.110898 · 2020 · External reference
Lack of potential carcinogenicity for acesulfame potassium - systematic evaluation and integration of mechanistic data into the totality of the evidence
10.1016/j.fct.2020.111375 · 2020 · External reference
Cumulative risk assessment for quantitative response data
10.1002/env.587 · 2003 · External reference
Scientific report on the establishment of cumulative assessment groups of pesticides for their effects on the nervous system
2019 · External reference
Scientific Opinion on the identification of pesticides to be included in cumulative assessment groups on the basis of their toxicological profile
2013 · External reference
Scientific opinion on the re-evaluation of aspartame (E 951)
2013 · External reference
Guidance Document on Scientific criteria for grouping chemicals into assessment groups for human risk assessment of combined exposure to multiple chemicals
2021 · External reference
Re-evaluation of saccharin (E 954)
2024 · External reference
Specific effects on kidneys relevant for performing a dietary cumulative risk assessment of pesticide residues
2025 · External reference
Specific effects on liver relevant for performing a dietary cumulative risk assessment of pesticide residues
2025 · External reference
Unresolved reference
2000 · External reference
Unresolved reference
2002 · External reference
Pesticide cumulative risk assessment: framework for screening analysis purpose
2016 · External reference
Unresolved reference
2025 · External reference
Risk assessment of chemical mixtures in foods: a comprehensive methodological and regulatory review
2026 · External reference
The effect of radiofrequency electromagnetic fields (RF-EMF) on biomarkers of oxidative stress in vivo and in vitro: a protocol for a systematic review
10.1016/j.envint.2021.106932 · 2022 · External reference
Artificial sweeteners: a double-edged sword for Gut Microbiome
2025 · External reference
Cumulative intake of artificially sweetened and sugar-sweetened beverages and risk of incident type 2 diabetes in young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study
10.1093/ajcn/nqz154 · 2019 · External reference
Toxicity of aspartame and its diketopiperazine for Wistar rats by dietary administration for 104 weeks
10.1016/0300-483x(81)90119-0 · 1981 · External reference
Unresolved reference
2023 · External reference
Scientific and regulatory Policy Committee: recommended (“Best”) practices for determining, communicating, and using adverse effect data from nonclinical studies
10.1177/0192623315623265 · 2016 · External reference
Data collection, hazard characterisation and establishment of cumulative assessment groups in view of the cumulative risk assessment of pesticide residues for kidneys
10.2903/sp.efsa.2026.en-9965 · 2026 · External reference
A combined chronic toxicity/carcinogenicity study of sucralose in sprague-dawley rats
10.1016/s0278-6915(00)00029-6 · 2000 · External reference
Effect of dose of sodium saccharin on the induction of rat urinary bladder proliferation
1981 · External reference
The influence of sucralose on body weight, food intake and organ weights of rats
1988 · External reference
Aspartame ingestion increases urinary calcium, but not oxalate excretion, in healthy subjects
10.1210/jcem.83.1.4511 · 1998 · External reference
Unresolved reference
1999 · External reference
Unresolved reference
2025 · External reference
Towards systematic read-across using Generalised Read-Across (GenRA)
10.1016/j.comtox.2022.100258 · 2023 · External reference
Wrangling whole mixtures risk assessment: recent advances in determining sufficient similarity
2023 · External reference
Evaluation of the toxic effects of food additives, alone or in mixture, in four human cell models
2025 · External reference
Mixture math: deciding what to add in a cumulative risk assessment
2022 · External reference
Evaluation of the dose response and in utero exposure to saccharin in the rat
10.1016/0278-6915(85)90142-5 · 1985 · External reference
Monitoring population exposure to Low- and No-Calorie sweeteners via pooled urine analysis
10.1002/fsn3.71795 · 2026 · External reference
Spontaneous age-related lesions of the kidney fornices in Sprague-Dawley rats
10.1177/0192623315621193 · 2016 · External reference
Health and economic benefits of reducing sugar intake in the USA
10.1136/bmjopen-2016-013543 · 2017 · External reference
