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References from Integrative multi-omics analysis reveals FAAH and LIPE as candidate targets in OBS-induced spermatogenic and fertility impairment. Local targets link to admitted publications; unresolved targets remain external evidence.
An overview of hormone-sensitive lipase (hsl)
10.1155/2022/1964684 · 2022 · External reference
Infertility and testicular defects in hormone-sensitive lipase-deficient mice
10.1210/endo.142.10.8424 · 2001 · External reference
Exposure to environmentally relevant concentration of sodium p-perfluorous nonenoxybenzene sulfonate is associated with aberrant barbering behavior in diabetic mice
10.1016/j.ecoenv.2026.119906 · 2026 · External reference
The fatty acid amide hydrolase (faah)
10.1054/plef.2001.0358 · 2002 · External reference
Pfoa and pfos impair human sperm capacitation by inducing mitochondrial-mediated apoptosis and ferroptosis
10.1016/j.ecoenv.2026.119743 · 2026 · External reference
The emerging role of insulin-like growth factors in testis development and function
10.1186/2051-4190-24-12 · 2014 · External reference
Insulin receptor substrate 2 is required for testicular development
10.1371/journal.pone.0062103 · 2013 · External reference
The endocannabinoid system and spermatogenesis
10.3389/fendo.2013.00192 · 2013 · External reference
Molecular mechanisms regulating spermatogenesis in vertebrates: environmental, metabolic, and epigenetic factor effects
10.1016/j.anireprosci.2021.106896 · 2022 · External reference
Alterations in the testis of hormone sensitive lipase-deficient mice is associated with decreased sperm counts, sperm motility, and fertility
10.1002/mrd.20800 · 2008 · External reference
Emissions, isomer-specific environmental behavior, and transformation of obs from one major fluorochemical manufacturing facility in China
10.1021/acs.est.2c01287 · 2022 · External reference
Health risks associated with infertility and non-obstructive azoospermia
10.4103/aja20256 · 2025 · External reference
Omega-3 polyunsaturated fatty acids ameliorate high-fat-diet-induced structural and functional impairments of testicular tissue via er stress inhibition
10.1007/s11248-025-00448-7 · 2025 · External reference
Transplacental transfer of per- and polyfluoroalkyl substances identified in paired maternal and cord sera using suspect and nontarget screening
10.1021/acs.est.9b06505 · 2020 · External reference
Hypoxia exposure impairs male fertility via inhibiting septin2-mediated spermatogonial proliferation
10.1093/hropen/hoaf027 · 2025 · External reference
Immunotoxicity mechanisms of perfluorinated compounds pfoa and pfos
10.1016/j.chemosphere.2021.132892 · 2022 · External reference
Using network toxicology and molecular docking to identify core targets and pathways underlying tacrolimus-induced tremor in organ transplant recipients
2025 · External reference
A biosynthetic pathway for anandamide
10.1073/pnas.0601832103 · 2006 · External reference
Pathophysiological effects of hypoxia on testis function and spermatogenesis
10.1038/s41585-024-00969-6 · 2025 · External reference
Exposure to sodium p-perfluorous nonenoxybenzenesulfonate induces renal fibrosis in mice by disrupting lysine metabolism
10.1021/acs.est.4c10724 · 2025 · External reference
Unraveling the reproductive toxicity mechanisms of emerging environmental contaminants 6:2 and 8:2 dipaps in male mice: an integrated transcriptome-metabolome investigation
10.1016/j.envpol.2025.127357 · 2026 · External reference
European association of urology guidelines on male sexual and reproductive health: 2021 update on male infertility
10.1016/j.eururo.2021.08.014 · 2021 · External reference
Procreation, potency, and the price of paternity: the social and psychological impact of a diagnosis of male factor infertility
10.1016/j.urology.2026.01.013 · 2026 · External reference
Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia
10.1038/s41585-023-00837-9 · 2024 · External reference
Chronic dietary exposure to environmental levels of glyphosate increases the risk of reproductive dysfunction in male mice
10.1021/acs.est.5c03589 · 2025 · External reference
Tissue distribution and bioaccumulation of a novel polyfluoroalkyl benzenesulfonate in crucian carp
10.1016/j.envint.2019.105418 · 2020 · External reference
Mechanistic insights into targeting apln/apj for ameliorating testosterone deficiency and reproductive disorders in diabetic mice
10.1186/s12964-025-02474-8 · 2025 · External reference
Long term exposure to road traffic noise and air pollution and risk of infertility in men and women: nationwide danish cohort study
10.1136/bmj-2024-080664 · 2024 · External reference
Genetic loss of faah compromises male fertility in mice
10.1095/biolreprod.108.072736 · 2009 · External reference
Maternal sodium p-perfluorous nonenoxybenzene sulfonate exposure disturbed lipid metabolism and induced an imbalance in tyrosine metabolism in the f1 generation of mice
10.1021/acs.chemrestox.1c00424 · 2022 · External reference
Maternal exposure of mice to sodium p-perfluorous nonenoxybenzene sulfonate causes endocrine disruption in both dams and offspring
10.1507/endocrj.ej20-0781 · 2021 · External reference
Pfoa exposure decreases acrosome reaction and increases dna oxidative damage by impairing the sperm head shaping in mice
2026 · External reference
Prenatal exposure to perfluoroalkyl substances and cognitive and neurobehavioral development in children at 6 years of age
10.1021/acs.est.2c06535 · 2023 · External reference
A mini-review on the health risks associated with sodium p-perfluorous nonenoxybenzene sulfonate exposure
10.1515/reveh-2025-0055 · 2025 · External reference
Sodium p-perfluorous nonenoxybenzene sulfonate induces ros-mediated necroptosis by directly targeting catalase in hepg2 cells
10.1016/j.scitotenv.2023.168446 · 2024 · External reference
The effect of various environmental pollutants on the reproductive health in children: a brief review of the literature
10.1007/s13668-024-00557-5 · 2024 · External reference
Per- and polyfluoroalkyl substances (pfass) and their potential effects on female reproductive diseases
10.3390/toxics12080539 · 2024 · External reference
Hepatotoxicity assessment investigations on pfass targeting l-fabp using binding affinity data and machine learning-based qsar model
10.1016/j.ecoenv.2023.115310 · 2023 · External reference
Tissue distribution of sodium p-perfluorous nonenoxybenzene sulfonate (obs) in mice via oral exposure
10.1016/j.envint.2022.107289 · 2022 · External reference