Research graph
References from Modified Hu-lu-ba-wan and its active component trigonelline ameliorate diabetic renal tubular injury via enhancing PACS2-regulated mitochondria-endoplasmic reticulum contacts and mitophagy. Local targets link to admitted publications; unresolved targets remain external evidence.
IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045
10.1016/j.diabres.2021.109119 · 2022 · External reference
Global, regional, and national burden of chronic kidney disease in adults, 1990-2023, and its attributable risk factors: a systematic analysis for the global burden of disease study 2023
10.1016/s0140-6736(25)01853-7 · 2025 · External reference
Molecular mechanisms and therapeutic targets for diabetic kidney disease
10.1016/j.kint.2022.05.012 · 2022 · External reference
Novel insights into diabetic kidney disease
10.3390/ijms251810222 · 2024 · External reference
Mitochondrial dysfunction: the silent catalyst of kidney disease progression
10.3390/cells14110794 · 2025 · External reference
Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes
10.1042/cs20150838 · 2016 · External reference
Mitochondrial dysfunction in diabetic kidney disease
10.1038/nrneph.2018.9 · 2018 · External reference
Mitophagy in human health, ageing and disease
10.1038/s42255-023-00930-8 · 2023 · External reference
TRPC6-Calpain-1 axis promotes tubulointerstitial inflammation by inhibiting mitophagy in diabetic kidney disease
10.1016/j.ekir.2024.08.019 · 2024 · External reference
The role of PINK1-Parkin in mitochondrial quality control
10.1038/s41556-024-01513-9 · 2024 · External reference
Mitochondria associated membranes (MAMs): architecture and physiopathological role
10.1016/j.ceca.2020.102343 · 2021 · External reference
ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells
10.1126/science.aaf5549 · 2016 · External reference
Crosstalk between mitochondria-ER contact sites and the apoptotic machinery as a novel health meter
10.1016/j.tcb.2024.08.007 · 2025 · External reference
Mitochondria-associated endoplasmic reticulum membranes in health and diseases
10.1002/mco2.70379 · 2025 · External reference
Plastic mitochondria-endoplasmic reticulum (ER) contacts use chaperones and tethers to mould their structure and signaling
10.1016/j.ceb.2018.04.014 · 2018 · External reference
PACS-2: a key regulator of mitochondria-associated membranes (MAMs)
10.1016/j.phrs.2020.105080 · 2020 · External reference
PACS-2 ameliorates tubular injury by facilitating endoplasmic reticulum-mitochondria contact and mitophagy in diabetic nephropathy
10.2337/db21-0983 · 2022 · External reference
Blood-glucose-lowering effect of Coptidis Rhizoma extracts from different origins via gut microbiota modulation in db/db mice
10.3389/fphar.2021.684358 · 2021 · External reference
Galactomannan-based mucilage from Trigonella foenum-graecum L.: structural insights, extraction strategies, and applications in food and sustainable biomaterials
10.1021/acs.jafc.5c07510 · 2025 · External reference
Achyranthes bidentata Blume (Amaranthaceae): a review of its botany, traditional uses, phytochemistry, pharmacology, and toxicology
10.1093/jpp/rgae012 · 2024 · External reference
Syringaresinol from Cinnamomum cassia (L.) J.Presl ameliorates cognitive deficits and AD pathology via AMPK in a DM-AD mouse model
10.1016/j.jep.2025.120374 · 2025 · External reference
Clinical study of the amelioration of modified-Hulubawan on diabetic kidney disease with deficiency of kidney Yang through anti-oxidative stress
2021 · External reference
Platelets induce epithelial to mesenchymal transition in renal proximal tubular epithelial cells through TGF-β signaling pathway
10.1186/s10020-025-01355-7 · 2025 · External reference
A comprehensive review of new potential biomarkers in the detection of chronic kidney disease
2025 · External reference
Insulin resistance in type 2 diabetes mellitus
10.1038/s41574-025-01114-y · 2025 · External reference
CKD in China: evolving Spectrum and public health implications
10.1053/j.ajkd.2019.05.032 · 2020 · External reference
Diabetes Management in Chronic Kidney Disease: a consensus report by the American Diabetes Association (ADA) and kidney disease: improving global outcomes (KDIGO)
10.2337/dci22-0027 · 2022 · External reference
The legacy effect in type 2 diabetes: impact of early glycemic control on future complications (the Diabetes & Aging Study)
10.2337/dc17-1144 · 2019 · External reference
An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory
10.1186/s10020-024-00824-9 · 2024 · External reference
Angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers for advanced chronic kidney disease : a systematic review and retrospective individual participant-level meta-analysis of clinical trials
10.7326/m23-3236 · 2024 · External reference
A series of diabetic ketoacidosis associated with the use of sodium-glucose co-transporter-2 inhibitors in secondary care
10.1016/j.dsx.2022.102658 · 2022 · External reference
Advances in traditional Chinese medicine research in diabetic kidney disease treatment
10.1080/13880209.2024.2314705 · 2024 · External reference
Modified Hu-lu-Ba-wan protects diabetic glomerular podocytes via promoting PKM2-mediated mitochondrial dynamic homeostasis
2024 · External reference
Update on diabetic kidney disease (DKD): focus on non-albuminuric DKD and cardiovascular risk
10.3390/biom13050752 · 2023 · External reference
Tubular injury in diabetic kidney disease: molecular mechanisms and potential therapeutic perspectives
2023 · External reference
Mitochondrial dysfunction in diabetic tubulopathy
10.1016/j.metabol.2022.155195 · 2022 · External reference
Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation
10.7150/thno.79876 · 2023 · External reference
Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases
10.1016/j.bcp.2022.115011 · 2022 · External reference
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses
10.1080/15548627.2020.1749490 · 2021 · External reference
PACS-2 mitigates NPSC apoptosis and intervertebral disc degeneration by preserving MAM integrity via the SP1/LRRK2/Mfn2 axis
2025 · External reference
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy
10.1038/s41419-023-06175-3 · 2023 · External reference
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease
10.1186/s10020-022-00545-x · 2022 · External reference
Pharmacological activities, therapeutic effects, and mechanistic actions of Trigonelline
10.3390/ijms25063385 · 2024 · External reference
Mitochondria-associated endoplasmic reticulum membranes in health and diseases
10.1002/mco2.70379 · ExternalCitation · doi-reference
Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases
10.1016/j.bcp.2022.115011 · ExternalCitation · doi-reference
Plastic mitochondria-endoplasmic reticulum (ER) contacts use chaperones and tethers to mould their structure and signaling
10.1016/j.ceb.2018.04.014 · ExternalCitation · doi-reference
Mitochondria associated membranes (MAMs): architecture and physiopathological role
10.1016/j.ceca.2020.102343 · ExternalCitation · doi-reference
IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045
10.1016/j.diabres.2021.109119 · ExternalCitation · doi-reference
A series of diabetic ketoacidosis associated with the use of sodium-glucose co-transporter-2 inhibitors in secondary care
10.1016/j.dsx.2022.102658 · ExternalCitation · doi-reference
TRPC6-Calpain-1 axis promotes tubulointerstitial inflammation by inhibiting mitophagy in diabetic kidney disease
10.1016/j.ekir.2024.08.019 · ExternalCitation · doi-reference
Syringaresinol from Cinnamomum cassia (L.) J.Presl ameliorates cognitive deficits and AD pathology via AMPK in a DM-AD mouse model
10.1016/j.jep.2025.120374 · ExternalCitation · doi-reference
Molecular mechanisms and therapeutic targets for diabetic kidney disease
10.1016/j.kint.2022.05.012 · ExternalCitation · doi-reference
Mitochondrial dysfunction in diabetic tubulopathy
10.1016/j.metabol.2022.155195 · ExternalCitation · doi-reference
PACS-2: a key regulator of mitochondria-associated membranes (MAMs)
10.1016/j.phrs.2020.105080 · ExternalCitation · doi-reference
Crosstalk between mitochondria-ER contact sites and the apoptotic machinery as a novel health meter
10.1016/j.tcb.2024.08.007 · ExternalCitation · doi-reference
Global, regional, and national burden of chronic kidney disease in adults, 1990-2023, and its attributable risk factors: a systematic analysis for the global burden of disease study 2023
10.1016/s0140-6736(25)01853-7 · ExternalCitation · doi-reference
Galactomannan-based mucilage from Trigonella foenum-graecum L.: structural insights, extraction strategies, and applications in food and sustainable biomaterials
10.1021/acs.jafc.5c07510 · ExternalCitation · doi-reference
Mitochondrial dysfunction in diabetic kidney disease
10.1038/nrneph.2018.9 · ExternalCitation · doi-reference
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy
10.1038/s41419-023-06175-3 · ExternalCitation · doi-reference
The role of PINK1-Parkin in mitochondrial quality control
10.1038/s41556-024-01513-9 · ExternalCitation · doi-reference
Insulin resistance in type 2 diabetes mellitus
10.1038/s41574-025-01114-y · ExternalCitation · doi-reference
Mitophagy in human health, ageing and disease
10.1038/s42255-023-00930-8 · ExternalCitation · doi-reference
Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes
10.1042/cs20150838 · ExternalCitation · doi-reference
CKD in China: evolving Spectrum and public health implications
10.1053/j.ajkd.2019.05.032 · ExternalCitation · doi-reference
Advances in traditional Chinese medicine research in diabetic kidney disease treatment
10.1080/13880209.2024.2314705 · ExternalCitation · doi-reference
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses
10.1080/15548627.2020.1749490 · ExternalCitation · doi-reference
Achyranthes bidentata Blume (Amaranthaceae): a review of its botany, traditional uses, phytochemistry, pharmacology, and toxicology
10.1093/jpp/rgae012 · ExternalCitation · doi-reference
ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells
10.1126/science.aaf5549 · ExternalCitation · doi-reference
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease
10.1186/s10020-022-00545-x · ExternalCitation · doi-reference
An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory
10.1186/s10020-024-00824-9 · ExternalCitation · doi-reference
Platelets induce epithelial to mesenchymal transition in renal proximal tubular epithelial cells through TGF-β signaling pathway
10.1186/s10020-025-01355-7 · ExternalCitation · doi-reference
PACS-2 ameliorates tubular injury by facilitating endoplasmic reticulum-mitochondria contact and mitophagy in diabetic nephropathy
10.2337/db21-0983 · ExternalCitation · doi-reference
The legacy effect in type 2 diabetes: impact of early glycemic control on future complications (the Diabetes & Aging Study)
10.2337/dc17-1144 · ExternalCitation · doi-reference
Diabetes Management in Chronic Kidney Disease: a consensus report by the American Diabetes Association (ADA) and kidney disease: improving global outcomes (KDIGO)
10.2337/dci22-0027 · ExternalCitation · doi-reference
Blood-glucose-lowering effect of Coptidis Rhizoma extracts from different origins via gut microbiota modulation in db/db mice
10.3389/fphar.2021.684358 · ExternalCitation · doi-reference
Update on diabetic kidney disease (DKD): focus on non-albuminuric DKD and cardiovascular risk
10.3390/biom13050752 · ExternalCitation · doi-reference
Mitochondrial dysfunction: the silent catalyst of kidney disease progression
10.3390/cells14110794 · ExternalCitation · doi-reference
Pharmacological activities, therapeutic effects, and mechanistic actions of Trigonelline
10.3390/ijms25063385 · ExternalCitation · doi-reference
Novel insights into diabetic kidney disease
10.3390/ijms251810222 · ExternalCitation · doi-reference
Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation
10.7150/thno.79876 · ExternalCitation · doi-reference
Angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers for advanced chronic kidney disease : a systematic review and retrospective individual participant-level meta-analysis of clinical trials
10.7326/m23-3236 · ExternalCitation · doi-reference
