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References from Gomisin A: a bioactive lignan from Schisandra chinensis with diverse pharmacological activities and therapeutic potential. Local targets link to admitted publications; unresolved targets remain external evidence.
Ayurveda research: emerging trends and mapping to sustainable development goals
10.1016/j.jaim.2023.100809 · 2023 · External reference
The impact of climate change on medicinal plants and natural products: a scoping review
10.3389/fphar.2025.1697581 · 2025 · External reference
Dibenzocyclooctadiene lignans from the stems of Schisandra sphaerandra
10.1080/14786419.2020.1779268 · 2022 · External reference
Gomisin N in the herbal drug gomishi (Schisandra chinensis) suppresses inducible nitric oxide synthase gene via C/EBPβ and NF-κB in rat hepatocytes
10.1016/j.niox.2012.10.003 · 2013 · External reference
Chemical characterization and potential mechanism of the anti-asthmatic activity of a subfraction from Schisandra chinensis fruit extract
10.1021/acs.jafc.2c01034 · 2022 · External reference
Acetylcholinesterase inhibitory effect of lignans isolated from Schizandra chinensis
10.1007/bf02977628 · 2007 · External reference
Unresolved reference
2022 · External reference
Comprehensive review on Schisandra chinesis
2024 · External reference
Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology
10.1186/s13020-024-00879-0 · 2024 · External reference
A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment
10.1186/s13020-025-01096-z · 2025 · External reference
Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A1
10.1055/s-2007-969504 · 1985 · External reference
Preventive effect of gomisin A, a lignan component of shizandra fruits, on acetaminophen-induced hepatotoxicity in rats
10.1016/0006-2952(93)90674-l · 1993 · External reference
Effects of gomisin A, a lignan component of Schizandra fruits, on experimental liver injuries and liver microsomal drug-metabolizing enzymes
10.1254/fpj.87.169 · 1986 · External reference
Rapid induction of hepatocyte growth factor mRNA after administration of gomisin A, a lignan component of shizandra fruits
1996 · External reference
Transcriptome analysis of the effects of gomisin A on the recovery of carbon tetrachloride-induced damage in rat liver
10.5625/lar.2011.27.2.161 · 2011 · External reference
The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury
10.1248/bpb.35.171 · 2012 · External reference
Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury
10.3892/ijmm.2013.1263 · 2013 · External reference
Effects of gomisin A on liver functions in hepatotoxic chemicals-treated rats
10.1254/jjp.38.347 · 1985 · External reference
Effect of gomisin A (TJN-101), a lignan compound isolated from Schisandra fruits, on liver function in rats
10.1254/fpj.91.237 · 1988 · External reference
10.1254/fpj.88.321
10.1254/fpj.88.321 · 1986 · External reference
Polyamines
10.1146/annurev.bi.53.070184.003533 · 1984 · External reference
Effect of Gomisin A (TJN-101) on liver regeneration
10.1055/s-2006-961532 · 1992 · External reference
Effects of TJN-101, a lignan compound isolated from Schisandra fruits, on liver fibrosis and on liver regeneration after partial hepatectomy in rats with chronic liver injury induced by CCl4
10.1254/fpj.90.51 · 1987 · External reference
Inhibitory effect of TJN-101 ((+)-(6S,7S,R-biar)-5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy -6,7-dimethyl-10,11- methylenedioxy-6-dibenzo[a,c]cyclooctenol) on immunologically induced liver injuries
10.1254/jjp.44.179 · 1987 · External reference
The effect of gomisin A on immunologic liver injury in mice
10.1055/s-2006-961766 · 1989 · External reference
Effect of gomisin A in an immunologically-induced acute hepatic failure model
10.1055/s-2006-960006 · 1991 · External reference
Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice
10.1254/jphs.fp0071738 · 2008 · External reference
Effect of gomisin A (TJN-101) on the arachidonic acid cascade in macrophages
10.1016/s0021-5198(19)40068-1 · 1990 · External reference
Effects of gomisin A on hepatocarcinogenesis by 3′-methyl-4-dimethylaminoazobenzene in rats
10.1254/jjp.57.71 · 1991 · External reference
Gomisin A, a lignan component of Schizandora fruits, inhibits development of preneoplastic lesions in rat liver by 3′-methyl-4-dimethylamino-azobenzene
10.1016/0304-3835(94)90128-7 · 1994 · External reference
Inhibition by gomisin A, a lignan compound, of hepatocarcinogenesis by 3′-methyl-4-dimethylaminoazobenzene in rats
10.1248/bpb.17.808 · 1994 · External reference
Effects of gomisin A on the promotor action and serum bile acid concentration in hepatocarcinogenesis induced by 3′-methyl-4-dimethylamino-azobenzene
10.1248/bpb.18.1443 · 1995 · External reference
Deoxycholic acid as an endogenous risk factor for hepatocarcinogenesis and effects of gomisin A, a lignan component of Schizandra fruits
1996 · External reference
Gomisin A from Schisandra chinensis induces endothelium-dependent and direct relaxation in rat thoracic aorta
10.1055/s-2007-993757 · 2007 · External reference
Gomisin A induces Ca2+−dependent activation of eNOS in human coronary artery endothelial cells
10.1016/j.jep.2009.06.028 · 2009 · External reference
Effects of gomisin A on vascular contraction in rat aortic rings
10.1007/s00210-010-0571-0 · 2011 · External reference
Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability
10.1038/hr.2012.50 · 2012 · External reference
Gomisin A inhibits hypoxia/reoxygenation induced myocardial cell injury by modulating TLR4 NF κB pathway
10.4314/tjpr.v22i3.3 · 2023 · External reference
Effects of Schisandra chinensis fruit extract and gomisin A on the contractility of penile corpus cavernosum smooth muscle: a potential mechanism through the nitric oxide - cyclic guanosine monophosphate pathway
10.4162/nrp.2018.12.4.291 · 2018 · External reference
Gomisin A improves scopolamine-induced memory impairment in mice
10.1016/j.ejphar.2006.06.015 · 2006 · External reference
Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway
10.1016/j.fct.2013.10.048 · 2014 · External reference
Inhibitory effectiveness of Gomisin A, a dibenzocyclooctadiene lignan isolated from Schizandra chinensis, on the amplitude and gating of voltage-gated Na+ current
10.3390/ijms21228816 · 2020 · External reference
A molecular basis for the inhibition of transient receptor potential vanilloid type 1 by gomisin A
10.1155/2017/6451905 · 2017 · External reference
Gomisin A exerts neuroprotective effects on spinal cord injury through the EGFR/JAK2/STAT3 signaling pathway to inhibit ferroptosis
10.1016/j.jep.2026.121601 · 2026 · External reference
Gomisin A attenuates cerebral ischemia/reperfusion injury through activation of the VEGF/PI3K/AKT/NOS3 signaling pathway
10.1007/s12013-026-02141-w · 2026 · External reference
Gomisin A decreases the LPS-induced expression of iNOS and COX-2 and activation of RIP2/NF-κB in mouse peritoneal macrophages
10.3109/08923973.2014.909848 · 2014 · External reference
Gomisin A modulates aging progress via mitochondrial biogenesis in human diploid fibroblast cells
10.1111/1440-1681.12914 · 2018 · External reference
Mitochondrial biogenesis: cell-cycle-dependent investment in making mitochondria
10.1016/j.cub.2014.12.006 · 2015 · External reference
Effect of gomisin A on osteoblast differentiation in high glucose-mediated oxidative stress
10.1016/j.phymed.2019.153107 · 2020 · External reference
Efficacy and mechanism of Schisandra chinensis active component Gomisin A on diabetic skin wound healing: network pharmacology and in vivo experimental validation
10.1016/j.jep.2024.118828 · 2025 · External reference
Gomisin A inhibits tumor promotion by 12-O-tetra-decanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin
1992 · External reference
Action of the natural compound gomisin A on Ca2+ movement in human prostate cancer cells
10.4103/cjp.cjp_6_22 · 2022 · External reference
Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells
10.1016/j.bcp.2006.06.036 · 2006 · External reference
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer
10.3892/or.2022.8417 · 2022 · External reference
Gomisin a suppresses colorectal lung metastasis by inducing AMPK/p38-mediated apoptosis and decreasing metastatic abilities of colorectal cancer cells
10.3389/fphar.2018.00986 · 2018 · External reference
Gomisin a ameliorates metastatic melanoma by inhibiting AMPK and ERK/JNK-mediated cell survival and metastatic phenotypes
10.1016/j.phymed.2019.153147 · 2020 · External reference
Schisandra chinensis lignans improve insulin resistance by targeting TLR4 and activating IRS-1/PI3K/AKT and NF-κB signaling pathways
10.1016/j.intimp.2024.113069 · 2024 · External reference
Gomisin A alleviates obesity by regulating the phenotypic switch between white and brown adipocytes
10.1142/s0192415x21500919 · 2021 · External reference
Gomisin A and metformin co-treatment attenuates diabetic nephropathy and cardiovascular dysfunction by modulating the AGE/RAGE pathway in a diabetic rat model
10.1007/s11010-026-05497-y · 2026 · External reference
Inhibition of cytochrome P450 3A4 activity by schisandrol A and gomisin A isolated from fructus Schisandrae chinensis
10.1016/j.phymed.2009.12.005 · 2010 · External reference
Gomisin A is a novel isoform-specific probe for the selective sensing of human cytochrome P450 3A4 in liver microsomes and living cells
10.1208/s12248-015-9827-4 · 2016 · External reference
Time- and NADPH-dependent inhibition on CYP3A by gomisin A and the pharmacokinetic interactions between gomisin A and cyclophosphamide in rats
10.3390/molecules22081298 · 2017 · External reference
