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References from Pseudolaric acid B: Natural sources, preparation, structural modification, bioactivities, and translational challenges. Local targets link to admitted publications; unresolved targets remain external evidence.
Chemistry and biological properties of ascaridole: a systematic review
10.1016/j.fitote.2025.106982 · 2026 · External reference
Progress of anti-tumor research on natural products combined with doxorubicin
10.1016/j.fitote.2025.107076 · 2026 · External reference
New species, varieties and combinations from the herbarium and the collections of the Arnold Arboretum
1919 · External reference
Fengshui forests as a conservation paradigm of the golden larch in China
10.1016/j.foreco.2022.120358 · 2022 · External reference
Pseudolaric acids: isolation, bioactivity and synthetic studies
10.1039/b906520m · 2010 · External reference
Some progress on the chemistry of natural bioactive terpenoids form chinese medicinal plants
10.1590/s0074-02761991000600049 · 1991 · External reference
The cytotoxic principles of pseudolarix kaempferi: pseudolaric acid-a and -B and related Derivatives1
10.1055/s-2006-960989 · 1990 · External reference
Diterpenoid constituents in Pseudolarix amabilis and their antitumor activities in vitro
2023 · External reference
Pseudoamaolides a-O, anti-inflammatory triterpene spiroketal lactones from seeds of Pseudolarix amabilis
10.1016/j.bioorg.2022.106180 · 2022 · External reference
Covalent targeting of PP2A scaffold subunit PPP2R1A by pseudolarolide B enhances holoenzyme assembly to exert anti-inflammatory activity
10.1016/j.bioorg.2026.109684 · 2026 · External reference
New triterpenoids and PTP1B inhibitory constituents of pseudolarix amabilis
10.1016/j.fitote.2019.104414 · 2019 · External reference
3,4-secocycloartane triterpenoids from the cones of pseudolarix amabilis
10.1007/s13659-020-00285-7 · 2021 · External reference
Trisecocycloartane triterpene dilactones from the cones of pseudolarix amabilis
10.1016/j.phytol.2021.08.001 · 2021 · External reference
New eudesmane-type sesquiterpenoids from the root bark of pseudolarix kaempferi
10.1080/10286020.2015.1117455 · 2015 · External reference
Inhibition of HL-60 cell growth via cell cycle arrest and apoptosis induction by a cycloartane–labdane heterodimer from Pseudolarix amabilis
10.1039/c5ob02661j · 2016 · External reference
Pseudolaric acid B ameliorates fungal keratitis progression by suppressing inflammation and reducing fungal load
10.1021/acsinfecdis.2c00536 · 2023 · External reference
A systematic review of the immune-regulating and anticancer activities of pseudolaric acid B
10.3389/fphar.2017.00394 · 2017 · External reference
Antifungal evaluation of pseudolaric acid B, a major constituent of pseudolarix kaempferi
10.1021/np50115a007 · 1995 · External reference
Metabolic pathway and metabolites of pseudolaric acid B
2012 · External reference
Pseudolaric acid B alleviates non-alcoholic fatty liver disease by targeting PPARα to regulate lipid metabolism and promote mitochondrial biogenesis
10.1007/s11655-025-3832-y · 2025 · External reference
Gut microbiota-based metabolism contributes to the protection of pseudolaric acid B against MAFLD
10.1016/j.phymed.2025.157235 · 2025 · External reference
Pseudolaric acid B combats drug-resistant Candida albicans infection via dual-action mechanisms of direct antifungals and vaginal microbiota restoration
2026 · External reference
Five new diterpenoids from pseudolarix kaempferi
10.1021/np0200010 · 2002 · External reference
Pseudoamaolide P, a 1,2:3,4:9,10:9,19-tetraseco-cycloartane triterpene spiroketal lactone from seeds of pseudolarix amabilis
10.1080/10286020.2023.2286994 · 2024 · External reference
HPLC analysis of bioactive diterpenoids from the root bark of Pseudolarix kaempferi
2020 · External reference
Biosynthesis of the microtubule-destabilizing diterpene pseudolaric acid B from golden larch involves an unusual diterpene synthase
10.1073/pnas.1612901114 · 2017 · External reference
Late miocene Pseudolarix amabilis bract-scale complex from Zhejiang, East China
10.1371/journal.pone.0180979 · 2017 · External reference
Assessing the impact of climate change on habitat shifts of typical endemic relict trees in China
2025 · External reference
A simple method to optimize the HSCCC two-phase solvent system by predicting the partition coefficient for target compound
10.1002/jssc.200700582 · 2008 · External reference
Application of step-wise gradient high-performance counter-current chromatography for rapid preparative separation and purification of diterpene components from Pseudolarix kaempferi Gordon
10.1016/j.chroma.2012.01.040 · 2012 · External reference
Total synthesis of pseudolaric acid a
10.1002/anie.200602056 · 2006 · External reference
Total synthesis of (−)-pseudolaric acid B
10.1021/ja076165q · 2007 · External reference
Formal synthesis of pseudolaric acid B
10.1055/s-0039-1690829 · 2020 · External reference
Synthetic studies on pseudolaric acid B: enantioselective synthesis of C4,C10-di-epi-trans-fused [5–7]-bicyclic skeleton
10.1016/j.cclet.2020.09.023 · 2021 · External reference
Exo-selective intramolecular (4+3) cycloadditions to trans-fused perhydroazulenes: an asymmetric formal synthesis of (−)-pseudolaric acid B
10.1002/anie.202509650 · 2025 · External reference
Interaction of pseudolaric acid B with the colchicine site of tubulin
10.1016/j.bcp.2012.05.014 · 2012 · External reference
Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicine and a structure–activity relationship study
10.1021/jm070906g · 2008 · External reference
Antifungal diterpenoids of pseudolarix kaempferi, and their structure–activity relationship study
10.1016/s0968-0896(03)00531-5 · 2003 · External reference
Cytotoxic diterpenoids from the bark of Pseudolarix kaempferi and their structure-activity relationships
10.1021/np060439q · 2007 · External reference
Design, synthesis, and biological evaluation of pseudolaric acid B derivatives as ferroptosis inducers in colon cancer cells
10.1016/j.bioorg.2025.108852 · 2025 · External reference
Discovery of hydrazineyl amide derivative of pseudolaric acid B for reprogramming tumor-associated macrophages against tumor growth
10.3390/molecules30102088 · 2025 · External reference
Design, synthesis, and evaluation of antitumor activity in pseudolaric acid B azole derivatives: novel and potent angiogenesis inhibitor via regulation of the PI3K/AKT and MAPK mediated HIF-1/VEGF signaling pathway
10.1016/j.ejmech.2024.116813 · 2024 · External reference
Design, synthesis, and in vivo and in vitro biological screening of pseudolaric acid B derivatives as potential anti-tumor agents
10.1016/j.bioorg.2024.107670 · 2024 · External reference
Synthesis and biological evaluation of pseudolaric acid B derivatives as potential immunosuppressive agents
10.1080/10286020.2015.1030400 · 2015 · External reference
New antifungal strategies and drug development against WHO critical priority fungal pathogens
2025 · External reference
Aspiring antifungals: review of current antifungal pipeline developments
10.3390/jof6010028 · 2020 · External reference
Antifungal drugs for the treatment of invasive fungal infections—a limited therapeutic toolbox facing growing resistances
10.3390/ph18081220 · 2025 · External reference
Natural substances as valuable alternative for improving conventional antifungal chemotherapy: lights and shadows
2024 · External reference
Effect of pseudolaric acid B on biochemical and physiologic characteristics in colletotrichum gloeosporioides
10.1016/j.pestbp.2017.09.006 · 2018 · External reference
In vitro synergy of pseudolaric acid B and fluconazole against clinical isolates of Candida albicans
10.1111/j.1439-0507.2010.01935.x · 2011 · External reference
Potent antifungal activity of pure compounds from traditional Chinese medicine extracts against six oral Candida species and the synergy with fluconazole against azole-resistant Candida albicans
10.1155/2012/106583 · 2012 · External reference
Synergistic effect of pseudolaric acid B with fluconazole against resistant isolates and biofilm of Candida tropicalis
10.2147/idr.s261299 · 2020 · External reference
Pseudolaric acid B exerts an antifungal effect and targets SIRT1 to ameliorate inflammation by regulating Nrf2/NF-κB pathways in fungal keratitis
10.1007/s10787-023-01408-5 · 2024 · External reference
A novel pseudolaric acid B derivative, hexahydropseudolaric acid B, exterts an immunomodulatory effect in vitro/in vivo evaluation
10.1016/j.ejphar.2014.10.009 · 2014 · External reference
Structural damage and organelle destruction: mechanisms of pseudolaric acid B against S. parasitica
10.1016/j.fsi.2024.109894 · 2024 · External reference
Anti-hyphal properties of potential bioactive compounds for oral rinse in suppression of candida growth
10.1080/13102818.2017.1348255 · 2017 · External reference
Targeting survivin with tanshinone IIA inhibits tumor growth and overcomes chemoresistance in colorectal cancer
10.1038/s41420-023-01622-8 · 2023 · External reference
Calceolarioside B targets MMP12 in the tumor microenvironment to inhibit M2 macrophage polarization and suppress hepatocellular carcinoma progression
10.1016/j.phymed.2025.156805 · 2025 · External reference
Tailoring traditional Chinese medicine in cancer therapy
10.1186/s12943-024-02213-6 · 2025 · External reference
Harnessing the power of traditional Chinese medicine monomers and compound prescriptions to boost cancer immunotherapy
10.3389/fimmu.2023.1277243 · 2023 · External reference
The pharmacological mechanism of Chinese herbs effective in treating advanced ovarian cancer: integrated meta-analysis and network pharmacology analysis
2022 · External reference
Molecular targets and mechanisms of traditional Chinese medicine combined with chemotherapy for gastric cancer: a meta-analysis and multi-omics approach
10.1080/07853890.2025.2494671 · 2025 · External reference
Harnessing HDAC-targeted oleanolic acid derivatives for combined anti-cancer and hepatoprotective effects
10.1016/j.ijbiomac.2025.139761 · 2025 · External reference
Modulation of gut microbiota and immune response by soy peptides mitigates irinotecan induced intestinal toxicity
10.3389/fphys.2025.1538733 · 2025 · External reference
Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial–mesenchymal transition via directly targeting TGFβR1
10.1016/j.apsb.2023.05.006 · 2023 · External reference
Berberine versus placebo for the prevention of recurrence of colorectal adenoma: a multicentre, double-blinded, randomised controlled study
10.1016/s2468-1253(19)30409-1 · 2020 · External reference
Plant-derived natural products and combination therapy in liver cancer
2023 · External reference
Therapeutic potential of certain terpenoids as anticancer agents: a scoping review
10.3390/cancers14051100 · 2022 · External reference
Nanoformulated terpenoids in cancer: a review of therapeutic applications, mechanisms, and challenges
10.3390/cancers17183013 · 2025 · External reference
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
SH3BP5L triggers the RAB11A-regulated integrin recycling network implicated in breast cancer metastasis
10.1172/jci192705 · 2026 · External reference
Ultrastable cerasomes nanoplatform co-delivering sonosensitizer and Nrf2 inhibitor for enhanced sonodynamic therapy of triple-negative breast cancer
10.1016/j.matdes.2026.115841 · 2026 · External reference
Triple-negative breast cancer
10.1056/nejmra1001389 · 2010 · External reference
Pseudolaric acid B induces apoptosis, senescence, and mitotic arrest in human breast cancer MCF-7
10.1111/j.1745-7254.2007.00706.x · 2007 · External reference
Protein tyrosine kinase, JNK, and ERK involvement in pseudolaric acid B-induced apoptosis of human breast cancer MCF-7 cells1
10.1111/j.1745-7254.2008.00835.x · 2008 · External reference
Pseudolaric acid B induces apoptosis associated with the mitochondrial and PI3K/AKT/mTOR pathways in triple-negative breast cancer
10.3892/or.2023.8630 · 2023 · External reference
Co-loaded lapatinib/PAB by ferritin nanoparticles eliminated ECM-detached cluster cells via modulating EGFR in triple-negative breast cancer
10.1038/s41419-022-05007-0 · 2022 · External reference
Pseudolaric acid B exhibits anti-cancer activity on human hepatocellular carcinoma through inhibition of multiple carcinogenic signaling pathways
10.1016/j.phymed.2018.11.019 · 2019 · External reference
Pseudolaric acid B triggers cell apoptosis by activating AMPK/JNK/DRP1/mitochondrial fission pathway in hepatocellular carcinoma
10.1016/j.tox.2023.153556 · 2023 · External reference
Antitumor effect of pseudolaric acid B involving regulation of Notch1/akt signaling response in human hepatoma cell in vitro
2022 · External reference
Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-κB pathway in HT-29 cells
10.1007/s00432-011-1120-z · 2012 · External reference
Pseudolaric acid B inhibits the secretion of hepatitis B virus
10.3892/or.2016.5254 · 2017 · External reference
Role of pseudolaric acid B in A549 lung cancer cell proliferation and apoptosis
10.3892/mmr.2013.1800 · 2014 · External reference
Blocking the utilization of glucose induces the switch from senescence to apoptosis in pseudolaric acid B-treated human lung cancer cells in vitro
10.1038/aps.2017.39 · 2017 · External reference
Activation of p53 contributes to pseudolaric acid B-induced senescence in human lung cancer cells in vitro
10.1038/aps.2016.8 · 2016 · External reference
Pseudolaric acid B promotes lung cancer cells ferroptosis depending on JNK/ERK-mediated upregulation of survivin
2026 · External reference
Pseudolaric acid B suppresses NSCLC progression through the ROS/AMPK/mTOR/autophagy signalling pathway
10.1016/j.biopha.2024.116614 · 2024 · External reference
Pseudolaric acid B inhibits FLT4-induced proliferation and migration in non-small cell lung cancer
10.2174/0118715206313028240819103933 · 2024 · External reference
Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT
10.1016/j.canlet.2018.04.021 · 2018 · External reference
Pseudolaric acid B inhibits neuroglioma cell proliferation through DNA damage response
10.3892/or.2017.5861 · 2017 · External reference
Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene
10.1016/j.ejphar.2006.12.004 · 2007 · External reference
Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells
10.1016/j.canlet.2016.09.007 · 2016 · External reference
Pseudolaric acid B induces caspase-dependent cell death in human ovarian cancer cells
10.3892/or.2013.2869 · 2014 · External reference
Radiosensitivity of human ovarian cancer cells is enhanced by pseudolaric acid B due to the inhibition of the ras/raf/ERK signaling pathway
2018 · External reference
Pseudolaric acid B inhibits gastric cancer cell metastasis in vitro and in haematogenous dissemination model through PI3K/AKT, ERK1/2 and mitochondria-mediated apoptosis pathways
10.1016/j.yexcr.2017.01.012 · 2017 · External reference
Pseudolaric acid B-induced apoptosis through p53-dependent pathway in human gastric carcinoma cells
10.1080/10286020802573420 · 2009 · External reference
Pseudolaric acid B induces apoptosis in human rhabdomyosarcoma RD cells
10.3892/ol.2020.12222 · 2020 · External reference
Identification of pseudolaric acid B as a novel hedgehog pathway inhibitor in medulloblastoma
10.1016/j.bcp.2021.114593 · 2021 · External reference
Pseudolaric acid B induces G2/M arrest and inhibits invasion and migration in HepG2 hepatoma cells
2018 · External reference
ATM-p53 pathway causes G2/M arrest, but represses apoptosis in pseudolaric acid B-treated HeLa cells
10.1016/j.abb.2014.05.029 · 2014 · External reference
Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B
10.1007/s00432-010-0784-0 · 2010 · External reference
Pseudolaric acid B induces mitotic arrest and apoptosis in both imatinib-sensitive and -resistant chronic myeloid leukaemia cells
10.1016/j.ejphar.2020.173064 · 2020 · External reference
Pseudolaric acid B induces apoptosis in U937 human leukemia cells via caspase-9-mediated activation of the mitochondrial death pathway
10.3892/mmr.2013.1571 · 2013 · External reference
Bcl-2 family proteins were involved in pseudolaric acid B–induced autophagy in murine fibrosarcoma L929 cells
10.1254/jphs.08091fp · 2008 · External reference
Pseudolaric acid B induced cell cycle arrest, autophagy and senescence in murine fibrosarcoma l929 cell
10.7150/ijms.5726 · 2013 · External reference
Pseudolaric acid B induces mitotic catastrophe followed by apoptotic cell death in murine fibrosarcoma L929 cells
10.1016/j.ejphar.2012.02.035 · 2012 · External reference
Pseudolaric acid B–induced autophagy contributes to senescence via enhancement of ROS generation and mitochondrial dysfunction in murine fibrosarcoma L929 cells
10.1254/jphs.12269fp · 2013 · External reference
mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 cells
10.1016/j.ejphar.2013.05.051 · 2013 · External reference
In vitro antimetastatic potential of pseudolaric acid B in HSC-3 human tongue squamous carcinoma cell line
10.1016/j.archoralbio.2024.105940 · 2024 · External reference
Pseudolaric acid B induces G2/M phase arrest in canine mammary tumor cells by targeting CDK1
10.3389/fvets.2025.1644200 · 2025 · External reference
Pseudolaric acid B inhibits proliferation, invasion, and angiogenesis in esophageal squamous cell carcinoma through regulating CD147
10.2147/dddt.s269915 · 2020 · External reference
Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factor-mediated anti-apoptotic effect
10.1016/j.ejphar.2004.07.063 · 2004 · External reference
Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1α by promoting proteasome-mediated degradation
10.1158/1078-0432.ccr-04-0951 · 2004 · External reference
Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPARγ to inhibit NF-κB signalling pathway
10.1111/jcmm.16670 · 2021 · External reference
Trojan-horse diameter-reducible nanotheranostics for macroscopic/microscopic imaging-monitored chemo-antiangiogenic therapy
10.1021/acsami.1c22350 · 2022 · External reference
Pseudolaric acid B attenuates atopic dermatitis-like skin lesions by inhibiting interleukin-17-induced inflammation
2017 · External reference
Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents
10.1016/j.lfs.2014.01.075 · 2014 · External reference
Therapeutic applications of terpenes on inflammatory diseases
10.3389/fphar.2021.704197 · 2021 · External reference
Pseudolaric acid B attenuates high salt intake-induced hypertensive left ventricular remodeling by modulating monocyte/macrophage phenotypes
10.12659/msm.932404 · 2021 · External reference
Inhibitory effects of pseudolaric acid B on inflammatory response and M1 phenotype polarization in RAW264.7 macrophages induced by lipopolysaccharide
2016 · External reference
Pseudolaric acid B inhibits T-cell mediated immune response in vivo via p38MAPK signal cascades and PPARγ activation
10.1016/j.lfs.2014.11.020 · 2015 · External reference
Topical application of pseudolaric acid B improve DNFB-induced contact hypersensitivity via regulating the balance of Th1/Th17/treg cell subsets
10.1016/j.ejps.2012.01.005 · 2012 · External reference
Pseudolaric acid B suppresses T lymphocyte activation through inhibition of NF-κB signaling pathway and p38 phosphorylation
10.1002/jcb.22230 · 2009 · External reference
Inhibition of NF-κB and ERK signaling pathways in osteoclasts and M1 macrophage polarization: mechanistic insights into the anti-osteoporotic effects of pseudolaric acid B
10.1016/j.lfs.2024.122592 · 2024 · External reference
Development and validation of LC–MS/MS method for quantification of pseudolaric acid B from the root bark of Pseudolarix kaempferi in rat plasma: application to a pharmacokinetic study
10.1016/j.jpba.2015.01.050 · 2015 · External reference
Synthetic studies toward pseudolaric acids: radical cyclization to form bridged scaffold
10.1002/cjoc.202400085 · 2024 · External reference
Domino enyne metathesis en route to skeletally diverse, privileged scaffolds: synthesis of the tricyclic core of pseudolaric acid F
10.1039/c9qo00477g · 2019 · External reference
Synthetic studies on pseudolaric acid B: construction of the trans-fused [5–7] ring system via dieckmann condensation
10.1016/j.tetlet.2018.05.069 · 2018 · External reference
A review on thermal analyses of cyclodextrins and cyclodextrin complexes
10.1007/s10311-018-0806-8 · 2019 · External reference
Dramatic improvement of the solubility of pseudolaric acid B by cyclodextrin complexation: preparation, characterization and validation
10.1016/j.ijpharm.2015.01.005 · 2015 · External reference
A comparison report of three advanced methods for drug-cyclodextrin interaction measurements
10.1016/j.jpba.2016.11.037 · 2017 · External reference
Modified release and improved stability of unstable BCS II drug by using cyclodextrin complex as carrier to remotely load drug into niosomes
10.1021/acs.molpharmaceut.5b00566 · 2016 · External reference
Microemulsion based gel for topical dermal delivery of pseudolaric acid B: in vitro and in vivo evaluation
10.1016/j.ijpharm.2015.07.058 · 2015 · External reference
Supramolecular hybrid hydrogel based on host–guest interaction and its application in drug delivery
10.1021/am505649q · 2014 · External reference
Tannic acid-modified silver nanoparticles for antibacterial and anticancer applications
10.1021/acsanm.3c01291 · 2023 · External reference
Liposomes in cancer therapy: how did we start and where are we now
10.3390/ijms24076615 · 2023 · External reference
Liposomal bupivacaine: effective, cost-effective, or (just) costly?
10.1097/aln.0000000000003658 · 2021 · External reference
CRGD-modified, pH-sensitive liposomes for co-delivery of docetaxel and ABCG2 siRNA enhance therapeutic efficacy in triple-negative breast cancer
10.1016/j.colsurfb.2026.115616 · 2026 · External reference
Suppressive effect of pseudolaric acid B on Echinococcus multilocularis involving regulation of TGF-β1 signaling in vitro and in vivo
10.3389/fmicb.2022.1008274 · 2022 · External reference
Angiogenesis inhibition and cell cycle arrest induced by treatment with pseudolarix acid B alone or combined with 5-fluorouracil
10.1093/abbs/gms029 · 2012 · External reference
Pseudolaric acid B inhibits proliferation, invasion and epithelial-to-mesenchymal transition in human pancreatic cancer cell
10.3349/ymj.2018.59.1.20 · 2018 · External reference
Efficacy and safety of pseudolaric acid B against echinococcus multilocularis in vitro and in a murine infection model
10.3389/fmed.2025.1503472 · 2025 · External reference
Anticancer effect of terpenes: focus on malignant melanoma
10.1007/s43440-023-00512-1 · 2023 · External reference