Research graph
References from Integrated metabolomics and network pharmacology to decipher habitat-driven metabolic diversity and α-glucosidase inhibitory mechanisms in guava leaves. Local targets link to admitted publications; unresolved targets remain external evidence.
Multiple functional roles of flavonoids in photoprotection
10.1111/j.1469-8137.2010.03269.x · 2010 · External reference
Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin–Ciocalteu reagent
10.1038/nprot.2007.102 · 2007 · External reference
The gene ontology knowledgebase in 2023
2023 · External reference
OMIM.org: Leveraging knowledge across phenotype-gene relationships
10.1093/nar/gky1151 · 2019 · External reference
In vitro potential of Ascophyllum nodosum phenolic antioxidant-mediated α-glucosidase and α-amylase inhibition
10.1111/j.1750-3841.2010.01544.x · 2010 · External reference
The Protein Data Bank
10.1093/nar/28.1.235 · 2000 · External reference
Understanding RAGE, the receptor for advanced glycation end products
10.1007/s00109-005-0688-7 · 2005 · External reference
Flavonoids as antioxidants and developmental regulators: Relative significance in plants and humans
10.3390/ijms14023540 · 2013 · External reference
Guava (Psidium guajava): A brief overview of its therapeutic and health potential
2025 · External reference
Norwogonin attenuates LPS-induced acute lung injury through inhibiting Src/AKT1/NF-kappaB signaling pathway
10.1016/j.phymed.2025.156432 · 2025 · External reference
Estimation of Total flavonoid content in Propolis by two complementary colorimetric methods
2002 · External reference
A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: Application in the study of Rice metabolomics
10.1093/mp/sst080 · 2013 · External reference
Mechanistic study of Jaceosidin in regulating secondary inflammation after spinal cord injury in mouse by inhibiting PKM2 activity
10.1007/s12017-025-08877-7 · 2025 · External reference
DAVID: Database for annotation, visualization, and integrated discovery
10.1186/gb-2003-4-5-p3 · 2003 · External reference
Determination of guava (Psidium guajava L.) leaf phenolic compounds using HPLC-DAD-QTOF-MS
10.1016/j.jff.2016.01.040 · 2016 · External reference
Health effects of Psidium guajava L. leaves: An overview of the last decade
10.3390/ijms18040897 · 2017 · External reference
Natural products and plant disease resistance
10.1038/35081178 · 2001 · External reference
Stress-induced Phenylpropanoid metabolism
10.2307/3870059 · 1995 · External reference
Anthocyanin profile, antioxidant activity and total phenolic content of a strawberry (Fragaria × ananassa Duch) genetic resource collection
10.1016/j.fbio.2020.100620 · 2020 · External reference
Harvest time and soil-plant relationship effects on phytochemical constituency and biological activities of psidium guajava L. leaves
10.1038/s41598-025-11323-0 · 2025 · External reference
Polyphenols: Chemistry, bioavailability, bioactivity, nutritional aspects and human health benefits: A review
10.1016/j.ijbiomac.2024.134223 · 2024 · External reference
Plant-derived and dietary phenolic cinnamic acid derivatives: Anti-inflammatory properties
10.1016/j.foodchem.2024.140080 · 2024 · External reference
The human disease network
10.1073/pnas.0701361104 · 2007 · External reference
Psidium guajava: A review of its traditional uses, phytochemistry and pharmacology
10.1016/j.jep.2008.01.025 · 2008 · External reference
10.1002/(sici)1096-987x(199604)17:5/6<490::aid-jcc1>3.0.co;2-p
10.1002/(sici)1096-987x(199604)17:5/6<490::aid-jcc1>3.0.co;2-p · External reference
1 - the plant and its biochemical adaptation to the environment
1993 · External reference
Network pharmacology: The next paradigm in drug discovery
10.1038/nchembio.118 · 2008 · External reference
Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology
10.1371/journal.pone.0083922 · 2014 · External reference
KEGG: Kyoto encyclopedia of genes and genomes
10.1093/nar/28.1.27 · 2000 · External reference
PubChem 2023 update
10.1093/nar/gkac956 · 2023 · External reference
LigPlot+: Multiple ligand–protein interaction diagrams for drug discovery
10.1021/ci200227u · 2011 · External reference
Metabolomics applications for plant-based foods origin tracing, cultivars identification and processing: Feasibility and future aspects
10.1016/j.foodchem.2024.139227 · 2024 · External reference
Effect of altitude and solvent on Psidium guajava Linn. leaves extracts: Phytochemical analysis, antioxidant, cytotoxicity and antimicrobial activity against food spoilage microbes
10.1186/s13065-023-00948-9 · 2023 · External reference
Structural requirements of flavonoids for nitric oxide production inhibitory activity and mechanism of action
10.1016/s0968-0896(03)00067-1 · 2003 · External reference
Flavonoids as important molecules of plant interactions with the environment
10.3390/molecules191016240 · 2014 · External reference
Β-Glucosidases as detonators of plant chemical defense
10.1016/j.phytochem.2008.03.006 · 2008 · External reference
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
10.1002/jcc.21256 · 2009 · External reference
Natural flavone jaceosidin is a neuroinflammation inhibitor
10.1002/ptr.4737 · 2013 · External reference
The phytochemistry and medicinal value of Psidium guajava (guava)
10.1186/s40816-018-0093-8 · 2018 · External reference
MetaboAnalyst 6.0: Towards a unified platform for metabolomics data processing, analysis and interpretation
10.1093/nar/gkae253 · 2024 · External reference
Ethnobotany of mountain regions: Andes – Bolivia, Chile, Peru
2020 · External reference
10.1007/s44372-024-00063-6 · 2024 · Admitted local publication
Evaluation of Aluminium complexation reaction for flavonoid content assay
10.1007/s12161-014-9814-x · 2014 · External reference
Flavonoids as Antioxidants
10.1021/np9904509 · 2000 · External reference
Environmental factors regulate plant secondary metabolites
2023 · External reference
A comprehensive and critical review of the unstandardized Folin-Ciocalteu assay to determine the total content of polyphenols: The conundrum of the experimental factors and method validation
10.1016/j.talanta.2024.125771 · 2024 · External reference
Antioxidant activity applying an improved ABTS radical cation decolorization assay
10.1016/s0891-5849(98)00315-3 · 1999 · External reference
Flavonoid UDP-glycosyltransferase in plants: Functional identification, substrate recognition mechanism, and biotechnology application
10.1007/s11101-024-10042-0 · 2024 · External reference
Structure-antioxidant activity relationships of flavonoids and phenolic acids
10.1016/0891-5849(95)02227-9 · 1996 · External reference
Characterization of phenolic and other polar compounds in peel and flesh of pink guava (Psidium guajava L. cv. ‘Criolla’) by ultra-high performance liquid chromatography with diode array and mass spectrometric detection
10.1016/j.foodres.2016.12.004 · 2017 · External reference
The GeneCards suite
2021 · External reference
AGE-RAGE axis blockade in diabetic nephropathy: Current status and future directions
10.1016/j.ejphar.2018.06.001 · 2018 · External reference
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
10.1172/jci200114002 · 2001 · External reference
Unresolved reference
External reference
Cytoscape: A software environment for integrated models of biomolecular interaction networks
10.1101/gr.1239303 · 2003 · External reference
Response of Phenylpropanoid pathway and the role of polyphenols in plants under abiotic stress
10.3390/molecules24132452 · 2019 · External reference
Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity
10.1016/j.foodchem.2022.132531 · 2022 · External reference
In silico predictive model to determine vector-mediated transport properties for the blood-brain barrier choline transporter
10.2147/aabc.s63749 · 2014 · External reference
Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic acid reagents
10.5344/ajev.1965.16.3.144 · 1965 · External reference
Proposed minimum reporting standards for chemical analysis
10.1007/s11306-007-0082-2 · 2007 · External reference
The STRING database in 2025: Protein networks with directionality of regulation
10.1093/nar/gkae1113 · 2025 · External reference
Differential accumulation of flavonoids and hydroxycinnamates in leaves of Ligustrum vulgare under excess light and drought stress
10.1111/j.1469-8137.2004.01126.x · 2004 · External reference
Flavonoid aglycones from the leaf surfaces of some Labiatae species
10.1007/bf00940856 · 1990 · External reference
10.3389/fpls.2022.878616
10.3389/fpls.2022.878616 · External reference
Glycosyltransferases in plant natural product synthesis: Characterization of a supergene family
10.1016/s1360-1385(00)01720-9 · 2000 · External reference
Norwogonin attenuates inflammatory Osteolysis and collagen-induced arthritis via modulating redox Signalling and calcium oscillations
10.1111/jcmm.70492 · 2025 · External reference
Fermentation and complex enzyme hydrolysis for improving the total soluble phenolic contents, flavonoid aglycones contents and bio-activities of guava leaves tea
10.1016/j.foodchem.2018.05.035 · 2018 · External reference
Unresolved reference
2010 · External reference
Flavones and Flavonols
1982 · External reference
Inhibitory effects of guava (Psidium guajava L.) leaf extracts and its active compounds on the glycation process of protein
10.1016/j.foodchem.2008.07.025 · 2009 · External reference
Dietary flavonoid aglycones and their glycosides: Which show better biological significance?
2017 · External reference
Inhibitory activity of luteolin on α-glucosidase and pancreatic lipase in vitro and in vivo
10.1111/ijfs.17115 · 2024 · External reference
Role of advanced glycation endproduct (AGE)-receptor for advanced glycation endproduct (RAGE) axis in cardiovascular disease and its therapeutic intervention
10.1253/circj.cj-19-0618 · 2019 · External reference
Guava leaf extract attenuates insulin resistance via the PI3K/Akt signaling pathway in a type 2 diabetic mouse model
10.2147/dmso.s231979 · 2020 · External reference
Exploring geographic variations in quinoa grains: Unveiling anti-Alzheimer activity via GC–MS, LC-QTOF-MS/MS, molecular networking, and chemometric analysis
10.1016/j.foodchem.2024.141918 · 2025 · External reference
In-depth profiling of Phenolics in strawberries and their potential modulatory effects on the oxidative stress-disease Axis: Insights from UHPLC-QTOF-MS-based untargeted metabolomics, network pharmacology, and molecular docking
10.1016/j.foodchem.2025.145044 · 2025 · External reference
Glycosylation of plant secondary metabolites: Regulating from chaos to harmony
10.1016/j.envexpbot.2021.104703 · 2022 · External reference
The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals
10.1016/s0308-8146(98)00102-2 · 1999 · External reference
