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References from Molecular mechanism of SIRT1 activation by polymethoxyflavonoids derived from citrus peels. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.softx.2015.06.001 · 2015 · Admitted local publication
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
PGC-1α in aging and anti-aging interventions
10.1016/j.bbagen.2009.04.005 · 2009 · External reference
Mechanism of human SIRT1 activation by resveratrol
10.1074/jbc.m501250200 · 2005 · External reference
Mitochondrial dysfunction in neurodegenerative disorders: Potential therapeutic application of mitochondrial transfer to central nervous system-residing cells
10.1186/s12967-023-04493-w · 2023 · External reference
Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
10.1101/gad.265462.115 · 2015 · External reference
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
10.1038/ncomms8645 · 2015 · External reference
Peptide folding: When simulation meets experiment
10.1002/(sici)1521-3773(19990115)38:1/2<236::aid-anie236>3.0.co;2-m · 1999 · External reference
Structural and functional analysis of human SIRT1
10.1016/j.jmb.2013.10.009 · 2014 · External reference
Isolation and characterization of neuroprotective components from Citrus peel and their application as functional food
10.1248/cpb.c20-00265 · 2021 · External reference
Ex-527 inhibits sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism
10.1073/pnas.1303628110 · 2013 · External reference
GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation
10.1021/ct700301q · 2008 · External reference
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
10.1038/nature01960 · 2003 · External reference
Role of mitochondrial dysfunction in cancer progression
10.1177/1535370216641787 · 2016 · External reference
Evidence for a common mechanism of SIRT1 regulation by allosteric activators
10.1126/science.1231097 · 2013 · External reference
Small molecule SIRT1 activators for the treatment of aging and age-related diseases
10.1016/j.tips.2013.12.004 · 2014 · External reference
The differing effects of a dual acting regulator on SIRT1
10.3389/fmolb.2023.1260489 · 2023 · External reference
Inhibition of nitric oxide production and inducible nitric oxide synthase expression by a Polymethoxyflavone from young fruits of Citrus unshiu in rat primary astrocytes
10.1271/bbb.120215 · 2012 · External reference
Unresolved reference
External reference
Cancer chemopreventive activity of 3,5,6,7,8,3′,4′-heptamethoxyflavone from the peel of citrus plants
10.1016/s0304-3835(00)00691-1 · 2001 · External reference
The role of lipid metabolism in aging, lifespan regulation, and age-related disease
10.1111/acel.13048 · 2019 · External reference
Comparison of simple potential functions for simulating liquid water
10.1063/1.445869 · 1983 · External reference
Identification and evaluation of citrus peel-derived polymethoxyflavonoids as natural SIRT1 activators
10.1016/j.foodchem.2026.149800 · 2026 · External reference
Disease chemopreventive effects and molecular mechanisms of hydroxylated polymethoxyflavones
10.1002/biof.1236 · 2015 · External reference
Sirt1 activation by resveratrol is substrate sequence-selective
10.18632/aging.100542 · 2013 · External reference
Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells
10.1007/s11010-010-0618-z · 2010 · External reference
Hydroxylated Polymethoxyflavones and methylated flavonoids in sweet Orange (Citrus sinensis) Peel
10.1021/jf060234n · 2006 · External reference
Mechanism and design of allosteric activators of SIRT1
2023 · External reference
ff14SB: Improving the accuracy of protein side chain and backbone parameters from ff99SB
10.1021/acs.jctc.5b00255 · 2015 · External reference
Anti-inflammatory activity of an orange peel polymethoxylated flavone, 3′,4′,3,5,6,7,8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays
10.1021/jf801222h · 2008 · External reference
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
10.1038/nature06261 · 2007 · External reference
Lipid droplet-derived monounsaturated fatty acids traffic via PLIN5 to allosterically activate SIRT1
10.1016/j.molcel.2019.12.003 · 2020 · External reference
Senescence and aging: The critical roles of p53
10.1038/onc.2012.640 · 2013 · External reference
Nobiletin potentially reduce lipid accumulation by up-regulating the SIRT1-AMPK signaling pathway in HepG2 hepatocarcinoma cells
10.1007/s11033-025-10587-z · 2025 · External reference
Economic implications of health care burden for elderly population
2022 · External reference
An update on citrus polymethoxyflavones: Chemistry, metabolic fate, and relevant bioactivities
10.1007/s00217-024-04529-5 · 2024 · External reference
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
10.1002/jcc.21334 · 2010 · External reference
Development and testing of a general amber force field
10.1002/jcc.20035 · 2004 · External reference
Citrus nobiletin suppresses inducible nitric oxide synthase gene expression in interleukin-1β-treated hepatocytes
10.1016/j.bbrc.2013.08.029 · 2013 · External reference
Nobiletin promotes antioxidant and anti-inflammatory responses and elicits protection against ischemic stroke in vivo
10.1016/j.brainres.2016.02.013 · 2016 · External reference
Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1
2021 · External reference
