Research graph
References from Ergothioneine promotes functional recovery after spinal cord injury by stabilizing VPS35 to suppress mitochondrial damage-driven neuroinflammation and oxidative stress. Local targets link to admitted publications; unresolved targets remain external evidence.
Acute spinal cord injury: pathophysiology and pharmacological intervention
10.3892/mmr.2021.12056 · 2021 · External reference
Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms
10.3390/ijms21207533 · 2020 · External reference
Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway
10.1186/s12967-024-05089-8 · 2024 · External reference
SIK2 mediated mitochondrial homeostasis in spinal cord injury: modulating oxidative stress and the AIM2 inflammasome via CRTC1/CREB signaling
10.1186/s12974-025-03606-0 · 2025 · External reference
Injectable ROS homeostasis protective hydrogel inhibiting microglial ferroptosis through the Nrf2/Slc7a11/Gpx4 to alleviate neuropathic pain and promote spinal cord injury repair
10.1016/j.redox.2025.103816 · 2025 · External reference
Dual roles of microglia in the pathological injury and repair of hemorrhagic cerebrovascular diseases
2024 · External reference
Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration
10.1186/s12974-021-02337-2 · 2021 · External reference
Role of microglia in spinal cord injury
10.1016/j.neulet.2019.134370 · 2019 · External reference
Interaction of microglia with the microenvironment in spinal cord injury
10.1016/j.neuroscience.2024.11.074 · 2025 · External reference
Neuroinflammation: targeting microglia for neuroprotection and repair after spinal cord injury
10.3389/fimmu.2025.1670650 · 2025 · External reference
A critical role for microglia in regulating metabolic homeostasis and neural repair after spinal cord injury
10.1016/j.freeradbiomed.2024.10.288 · 2024 · External reference
Ergothioneine and its congeners: anti-ageing mechanisms and pharmacophore biosynthesis
10.1093/procel/pwad048 · 2024 · External reference
Ergothioneine, recent developments
10.1016/j.redox.2021.101868 · 2021 · External reference
Safe and effective antioxidant: the biological mechanism and potential pathways of ergothioneine in the skin
10.3390/molecules28041648 · 2023 · External reference
Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits
10.1038/s41588-024-01973-7 · 2024 · External reference
Improved synthesis of an ergothioneine PET radioligand for imaging oxidative stress in Alzheimer's disease
10.1002/1873-3468.14303 · 2022 · External reference
Ergothioneine exerts neuroprotective effects in Parkinson's disease: targeting α-synuclein aggregation and oxidative stress
10.1016/j.foodres.2024.115590 · 2025 · External reference
Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST
10.1016/j.cmet.2025.01.024 · 2025 · External reference
Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model
10.1039/d4fo02321h · 2024 · External reference
Ergothioneine treatment ameliorates the pathological phenotypes of Parkinson's disease models
10.1111/jnc.70168 · 2025 · External reference
Protective effect of ergothioneine against stroke in rodent models
10.1007/s12017-022-08727-w · 2023 · External reference
Sub-parts-per-trillion level sensitivity in trace gas detection by cantilever-enhanced photo-acoustic spectroscopy
10.1038/s41598-018-20087-9 · 2018 · External reference
Basso Mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
10.1089/neu.2006.23.635 · 2006 · External reference
Monoammonium glycyrrhizinate ameliorates mitochondrial dysfunction-mediated oxidative stress and neuroinflammation via the NRF2/NQO1 axis after spinal cord injury
10.1080/13510002.2025.2585221 · 2025 · External reference
Challenges and opportunities for repairing the injured spinal cord: inflammation, regeneration, and functional reconstruction
2025 · External reference
Role of non-neuronal cells in neurorepair: a focus on proteinopathy and neurodegeneration
2024 · External reference
The secondary injury cascade after spinal cord injury: an analysis of local cytokine/chemokine regulation
10.4103/1673-5374.385849 · 2024 · External reference
Iridium metal complex targeting oxidation resistance 1 protein attenuates spinal cord injury by inhibiting oxidative stress-associated reactive oxygen species
10.1016/j.redox.2023.102913 · 2023 · External reference
Zinc ions regulate mitochondrial quality control in neurons under oxidative stress and reduce PANoptosis in spinal cord injury models via the Lgals3-Bax pathway
10.1016/j.freeradbiomed.2024.05.037 · 2024 · External reference
Mitochondrial function in spinal cord injury and regeneration
10.1007/s00018-022-04261-x · 2022 · External reference
Mechanism and prospects of mitochondrial transplantation for spinal cord injury treatment
10.1186/s13287-024-04077-5 · 2024 · External reference
Ergothioneine alleviates osteoporosis via the ROS-MAPK signaling Axis
10.1016/j.bone.2025.117496 · 2025 · External reference
Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing
10.1016/j.biotechadv.2012.09.005 · 2013 · External reference
Ergothioneine alleviates senescence of fibroblasts induced by UVB damage of keratinocytes via activation of the Nrf2/HO-1 pathway and HSP70 in keratinocytes
10.1016/j.yexcr.2021.112516 · 2021 · External reference
Mitochondrial complex I: the key to sustained microglia activation and neuroinflammation maintenance
10.1186/s40779-024-00554-3 · 2024 · External reference
cGAS-STING drives ageing-related inflammation and neurodegeneration
10.1038/s41586-023-06373-1 · 2023 · External reference
Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration
10.1038/s42255-023-00756-4 · 2023 · External reference
VPS35 deficiency or mutation causes dopaminergic neuronal loss by impairing mitochondrial fusion and function
10.1016/j.celrep.2015.08.001 · 2015 · External reference
VPS35 and the mitochondria: connecting the dots in Parkinson's disease pathophysiology
10.1016/j.nbd.2020.105056 · 2020 · External reference
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA
10.1038/s41467-022-34205-9 · 2022 · External reference
Soluble Trem2 is a negative regulator of erythrophagocytosis after intracerebral hemorrhage in a CD36 receptor recycling manner
10.1016/j.jare.2022.03.011 · 2023 · External reference
Increased microglial activity, impaired adult hippocampal neurogenesis, and depressive-like behavior in microglial VPS35-Depleted mice
10.1523/jneurosci.3621-17.2018 · 2018 · External reference
Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology
10.1186/s12974-022-02422-0 · 2022 · External reference
Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease
10.1186/s13195-024-01489-6 · 2024 · External reference
