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References from Brown adipocyte Acss1 restoration ameliorates redox-metabolic dysfunction and systemic metabolic decline during aging. Local targets link to admitted publications; unresolved targets remain external evidence.
The hallmarks of aging
10.1016/j.cell.2013.05.039 · 2013 · External reference
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction
10.1186/s12979-025-00545-5 · 2025 · External reference
Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: oxidative eustress
10.1016/j.redox.2016.12.035 · 2017 · External reference
Oxidative stress
10.1146/annurev-biochem-061516-045037 · 2017 · External reference
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
10.1038/s41574-021-00626-7 · 2022 · External reference
Mitochondrial TCA cycle metabolites control physiology and disease
10.1038/s41467-019-13668-3 · 2020 · External reference
Mitochondria as signaling organelles
10.1186/1741-7007-12-34 · 2014 · External reference
Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans
10.2337/db14-0746 · 2014 · External reference
Cold-activated brown adipose tissue in healthy men
10.1056/nejmoa0808718 · 2009 · External reference
Identification and importance of brown adipose tissue in adult humans
10.1056/nejmoa0810780 · 2009 · External reference
Functional brown adipose tissue in healthy adults
10.1056/nejmoa0808949 · 2009 · External reference
Brown adipose tissue activity controls triglyceride clearance
10.1038/nm.2297 · 2011 · External reference
The past, present, and future of adipose tissue browning and aging: a review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades
10.1016/j.arr.2025.102959 · 2026 · External reference
Brown and beige adipose tissue and aging
10.3389/fendo.2019.00368 · 2019 · External reference
Caloric restriction retards the age-related decline in mitochondrial function of brown adipose tissue
10.1089/rej.2007.0626 · 2008 · External reference
Aging attenuates diurnal lipid uptake by brown adipose tissue
10.18632/aging.204318 · 2022 · External reference
Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging
10.1038/s41467-023-38842-6 · 2023 · External reference
Pathophysiologically relevant bisphenol S exposure accelerates aging by disrupting brown adipose tissue-regulated energy metabolism
10.1073/pnas.2420437122 · 2025 · External reference
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
10.1172/jci62308 · 2013 · External reference
Transplantation of cold-stimulated subcutaneous adipose tissue improves fat retention and recipient metabolism
10.1093/asj/sjae070 · 2024 · External reference
Brown adipose tissue as a secretory organ
10.1038/nrendo.2016.136 · 2017 · External reference
The lives and times of brown adipokines
10.1016/j.tem.2017.10.005 · 2017 · External reference
Brown adipose tissue-derived metabolites and their role in regulating metabolism
10.1016/j.metabol.2023.155709 · 2024 · External reference
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44
10.1038/s41586-019-1503-x · 2019 · External reference
BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis
10.1016/j.cell.2024.03.030 · 2024 · External reference
The metabolic fate of acetate in cancer
10.1038/nrc.2016.87 · 2016 · External reference
ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis
10.1016/j.celrep.2024.114988 · 2024 · External reference
Acetyl-CoA derived from hepatic peroxisomal β-Oxidation inhibits autophagy and promotes steatosis via mTORC1 activation
10.1016/j.molcel.2020.05.007 · 2020 · External reference
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
10.1038/nature22405 · 2017 · External reference
Mitochondrial fatty acid oxidation drives senescence
10.1126/sciadv.ado5887 · 2024 · External reference
Cardioprotection and lifespan extension by the natural polyamine spermidine
10.1038/nm.4222 · 2016 · External reference
Higher spermidine intake is linked to lower mortality: a prospective population-based study
10.1093/ajcn/nqy102 · 2018 · External reference
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
10.18632/aging.101354 · 2018 · External reference
The effect of spermidine on memory performance in older adults at risk for dementia: a randomized controlled trial
10.1016/j.cortex.2018.09.014 · 2018 · External reference
Aging is associated with a systemic length-associated transcriptome imbalance
10.1038/s43587-022-00317-6 · 2022 · External reference
Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway
10.1038/s41467-024-46944-y · 2024 · External reference
Human germinal centres engage memory and naive B cells after influenza vaccination
10.1038/s41586-020-2711-0 · 2020 · External reference
Short-term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue
10.1111/febs.15604 · 2021 · External reference
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function
10.1038/s42255-024-01033-8 · 2024 · External reference
ATF4 protects the heart from failure by antagonizing oxidative stress
10.1161/circresaha.122.321050 · 2022 · External reference
Deep autoencoder for interpretable tissue-adaptive deconvolution and cell-type-specific gene analysis
10.1038/s41467-022-34550-9 · 2022 · External reference
Postprandial oxidative metabolism of human brown fat indicates thermogenesis
10.1016/j.cmet.2018.05.020 · 2018 · External reference
Ageing hallmarks exhibit organ-specific temporal signatures
10.1038/s41586-020-2499-y · 2020 · External reference
Thermoneutrality decreases thermogenic program and promotes adiposity in high-fat diet-fed mice
2016 · External reference
Benchmarking of RNA-sequencing analysis workflows using whole-transcriptome RT-qPCR expression data
10.1038/s41598-017-01617-3 · 2017 · External reference
12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII
10.1038/s41467-025-62474-7 · 2025 · External reference
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
10.1172/jci131126 · 2020 · External reference
The crystal structure of spermidine/spermine N1-acetyltransferase in complex with spermine provides insights into substrate binding and catalysis
10.1021/bi8009357 · 2008 · External reference
12-Lipoxygenase regulates cold adaptation and glucose metabolism by producing the Omega-3 lipid 12-HEPE from brown fat
10.1016/j.cmet.2019.07.001 · 2019 · External reference
Secretin-Activated brown fat mediates prandial thermogenesis to induce satiation
10.1016/j.cell.2018.10.016 · 2018 · External reference
Brown adipose tissue is associated with cardiometabolic health
10.1038/s41591-020-1126-7 · 2021 · External reference
The past, present, and future of adipose tissue browning and aging: a review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades
10.1016/j.arr.2025.102959 · ExternalCitation · doi-reference
The hallmarks of aging
10.1016/j.cell.2013.05.039 · ExternalCitation · doi-reference
Secretin-Activated brown fat mediates prandial thermogenesis to induce satiation
10.1016/j.cell.2018.10.016 · ExternalCitation · doi-reference
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · ExternalCitation · doi-reference
BCAA-nitrogen flux in brown fat controls metabolic health independent of thermogenesis
10.1016/j.cell.2024.03.030 · ExternalCitation · doi-reference
ACSS1-dependent acetate utilization rewires mitochondrial metabolism to support AML and melanoma tumor growth and metastasis
10.1016/j.celrep.2024.114988 · ExternalCitation · doi-reference
Postprandial oxidative metabolism of human brown fat indicates thermogenesis
10.1016/j.cmet.2018.05.020 · ExternalCitation · doi-reference
12-Lipoxygenase regulates cold adaptation and glucose metabolism by producing the Omega-3 lipid 12-HEPE from brown fat
10.1016/j.cmet.2019.07.001 · ExternalCitation · doi-reference
The effect of spermidine on memory performance in older adults at risk for dementia: a randomized controlled trial
10.1016/j.cortex.2018.09.014 · ExternalCitation · doi-reference
Brown adipose tissue-derived metabolites and their role in regulating metabolism
10.1016/j.metabol.2023.155709 · ExternalCitation · doi-reference
Acetyl-CoA derived from hepatic peroxisomal β-Oxidation inhibits autophagy and promotes steatosis via mTORC1 activation
10.1016/j.molcel.2020.05.007 · ExternalCitation · doi-reference
Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: oxidative eustress
10.1016/j.redox.2016.12.035 · ExternalCitation · doi-reference
The lives and times of brown adipokines
10.1016/j.tem.2017.10.005 · ExternalCitation · doi-reference
The crystal structure of spermidine/spermine N1-acetyltransferase in complex with spermine provides insights into substrate binding and catalysis
10.1021/bi8009357 · ExternalCitation · doi-reference
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory
10.1038/nature22405 · ExternalCitation · doi-reference
Brown adipose tissue activity controls triglyceride clearance
10.1038/nm.2297 · ExternalCitation · doi-reference
Cardioprotection and lifespan extension by the natural polyamine spermidine
10.1038/nm.4222 · ExternalCitation · doi-reference
The metabolic fate of acetate in cancer
10.1038/nrc.2016.87 · ExternalCitation · doi-reference
Brown adipose tissue as a secretory organ
10.1038/nrendo.2016.136 · ExternalCitation · doi-reference
Mitochondrial TCA cycle metabolites control physiology and disease
10.1038/s41467-019-13668-3 · ExternalCitation · doi-reference
Deep autoencoder for interpretable tissue-adaptive deconvolution and cell-type-specific gene analysis
10.1038/s41467-022-34550-9 · ExternalCitation · doi-reference
Senescent immune cells accumulation promotes brown adipose tissue dysfunction during aging
10.1038/s41467-023-38842-6 · ExternalCitation · doi-reference
Involution of brown adipose tissue through a Syntaxin 4 dependent pyroptosis pathway
10.1038/s41467-024-46944-y · ExternalCitation · doi-reference
12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII
10.1038/s41467-025-62474-7 · ExternalCitation · doi-reference
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
10.1038/s41574-021-00626-7 · ExternalCitation · doi-reference
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44
10.1038/s41586-019-1503-x · ExternalCitation · doi-reference
Ageing hallmarks exhibit organ-specific temporal signatures
10.1038/s41586-020-2499-y · ExternalCitation · doi-reference
Human germinal centres engage memory and naive B cells after influenza vaccination
10.1038/s41586-020-2711-0 · ExternalCitation · doi-reference
Brown adipose tissue is associated with cardiometabolic health
10.1038/s41591-020-1126-7 · ExternalCitation · doi-reference
Benchmarking of RNA-sequencing analysis workflows using whole-transcriptome RT-qPCR expression data
10.1038/s41598-017-01617-3 · ExternalCitation · doi-reference
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function
10.1038/s42255-024-01033-8 · ExternalCitation · doi-reference
Aging is associated with a systemic length-associated transcriptome imbalance
10.1038/s43587-022-00317-6 · ExternalCitation · doi-reference
Cold-activated brown adipose tissue in healthy men
10.1056/nejmoa0808718 · ExternalCitation · doi-reference
Functional brown adipose tissue in healthy adults
10.1056/nejmoa0808949 · ExternalCitation · doi-reference
Identification and importance of brown adipose tissue in adult humans
10.1056/nejmoa0810780 · ExternalCitation · doi-reference
Pathophysiologically relevant bisphenol S exposure accelerates aging by disrupting brown adipose tissue-regulated energy metabolism
10.1073/pnas.2420437122 · ExternalCitation · doi-reference
Caloric restriction retards the age-related decline in mitochondrial function of brown adipose tissue
10.1089/rej.2007.0626 · ExternalCitation · doi-reference
Higher spermidine intake is linked to lower mortality: a prospective population-based study
10.1093/ajcn/nqy102 · ExternalCitation · doi-reference
Transplantation of cold-stimulated subcutaneous adipose tissue improves fat retention and recipient metabolism
10.1093/asj/sjae070 · ExternalCitation · doi-reference
Short-term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue
10.1111/febs.15604 · ExternalCitation · doi-reference
Mitochondrial fatty acid oxidation drives senescence
10.1126/sciadv.ado5887 · ExternalCitation · doi-reference
Oxidative stress
10.1146/annurev-biochem-061516-045037 · ExternalCitation · doi-reference
ATF4 protects the heart from failure by antagonizing oxidative stress
10.1161/circresaha.122.321050 · ExternalCitation · doi-reference
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
10.1172/jci131126 · ExternalCitation · doi-reference
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
10.1172/jci62308 · ExternalCitation · doi-reference
Mitochondria as signaling organelles
10.1186/1741-7007-12-34 · ExternalCitation · doi-reference
Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction
10.1186/s12979-025-00545-5 · ExternalCitation · doi-reference
Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
10.18632/aging.101354 · ExternalCitation · doi-reference
Aging attenuates diurnal lipid uptake by brown adipose tissue
10.18632/aging.204318 · ExternalCitation · doi-reference
Brown adipose tissue improves whole-body glucose homeostasis and insulin sensitivity in humans
10.2337/db14-0746 · ExternalCitation · doi-reference
Brown and beige adipose tissue and aging
10.3389/fendo.2019.00368 · ExternalCitation · doi-reference
