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References from Superoxide dismutase 2 haplodeficiency alters spermatogenesis and early development in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Free radicals, metals and antioxidants in oxidative stress-induced cancer
10.1016/j.cbi.2005.12.009 · 2006 · External reference
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
10.1038/s41580-020-0230-3 · 2020 · External reference
Radical decisions in cancer: redox control of cell growth and death
10.3390/cancers4020442 · 2012 · External reference
Requirement for generation of H2O2 for platelet-derived growth factor signal transduction
10.1126/science.270.5234.296 · 1995 · External reference
Epidermal growth factor (EGF)-induced generation of hydrogen peroxide: role in egf receptor-mediated tyrosine phosphorylation
10.1074/jbc.272.1.217 · 1997 · External reference
From sulfenylation to sulfhydration: what a thiolate needs to tolerate
10.1126/scisignal.2002943 · 2012 · External reference
Oxidant signals and oxidative stress
10.1016/s0955-0674(03)00002-4 · 2003 · External reference
Free radicals and antioxidants in normal physiological functions and human disease
10.1016/j.biocel.2006.07.001 · 2007 · External reference
Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype
10.1073/pnas.102660199 · 2002 · External reference
Role of mitochondrial reactive oxygen species in osteoclast differentiation
10.1111/j.1749-6632.2009.05377.x · 2010 · External reference
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure
10.1016/j.cell.2012.07.029 · 2012 · External reference
ROS, thiols and thiol-regulating systems in male gametogenesis
10.1016/j.bbagen.2014.10.020 · 2015 · External reference
Spermatogonial stem cell regulation and spermatogenesis
10.1098/rstb.2010.0026 · 2010 · External reference
Sertoli cells- immunological sentinels of spermatogenesis
10.1016/j.semcdb.2014.02.011 · 2014 · External reference
The regulation of spermatogenesis by androgens
10.1016/j.semcdb.2014.02.012 · 2014 · External reference
Roles of reactive oxygen species in the spermatogenesis regulation
10.3389/fendo.2014.00056 · 2014 · External reference
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
10.1038/ng1295-376 · 1995 · External reference
Transgenic models for the study of lung antioxidant defense: enhanced manganese-containing superoxide dismutase activity gives partial protection to B6C3 hybrid mice exposed to hyperoxia
10.1165/ajrcmb.18.4.2959 · 1998 · External reference
Fixation of testes and eyes using a modified davidson's fluid: Comparison with bouin's fluid and conventional davidson's fluid
10.1080/01926230290105721 · 2002 · External reference
Assessment of spermatogenesis through staging of seminiferous tubules
2013 · External reference
A chemical method for fast and sensitive detection of DNA synthesis in vivo
10.1073/pnas.0712168105 · 2008 · External reference
Computerized spermatogenesis staging (CSS) of mouse testis sections via quantitative histomorphological analysis
10.1016/j.media.2020.101835 · 2021 · External reference
STAGETOOL, a novel automated approach for mouse testis histological analysis
2023 · External reference
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
10.1083/jcb.119.3.493 · 1992 · External reference
Mouse redox histology using genetically encoded probes
10.1126/scisignal.aad3895 · 2016 · External reference
Mechanisms and applications of redox-sensitive green fluorescent protein-based hydrogen peroxide probes
10.1089/ars.2017.7449 · 2018 · External reference
Proximity-based protein thiol oxidation by H2O2-scavenging peroxidases
10.1074/jbc.m109.059246 · 2009 · External reference
OpenCASA: a new open-source and scalable tool for sperm quality analysis
10.1371/journal.pcbi.1006691 · 2019 · External reference
Classification of mouse sperm motility patterns using an automated multiclass support vector machines Model1
10.1095/biolreprod.110.088989 · 2011 · External reference
PerlPrimer: cross-platform, graphical primer design for standard, bisulphite and real-time PCR
10.1093/bioinformatics/bth254 · 2004 · External reference
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
10.1016/0003-2697(76)90527-3 · 1976 · External reference
Transient NADPH oxidase 2-dependent H2O2 production drives early palmitate-induced lipotoxicity in pancreatic islets
10.1016/j.freeradbiomed.2020.11.023 · 2021 · External reference
Male infertility
10.1016/s0140-6736(20)32667-2 · 2021 · External reference
The role of genetics and oxidative stress in the etiology of Male infertility—A unifying hypothesis?
10.3389/fendo.2020.581838 · 2020 · External reference
Role of oxidative stress in male infertility
2023 · External reference
Antioxidant enzymes and Male fertility: lessons from knockout models
10.1089/ars.2019.7985 · 2020 · External reference
Effects of aging and oxidative stress on spermatozoa of superoxide-dismutase 1- and catalase-null Mice1
2016 · External reference
Are superoxide dismutase 2 and nitric oxide synthase polymorphisms associated with idiopathic infertility?
10.1089/ars.2014.5831 · 2014 · External reference
Seminal superoxide dismutase activity and its relationship with semen quality and SOD gene polymorphism
10.1007/s10815-014-0215-2 · 2014 · External reference
Genetic variants in antioxidant genes are associated with sperm DNA damage and risk of male infertility in a Chinese population
10.1016/j.freeradbiomed.2011.11.032 · 2012 · External reference
Influence of Val16Ala-SOD2 polymorphism on sperm quality parameters
10.1080/14647273.2017.1339916 · 2018 · External reference
Genetic variations of antioxidant genes and their association with male infertility in Vietnamese men
10.1002/jcla.24829 · 2023 · External reference
Genetic association in the maintenance of the mitochondrial microenvironment and sperm capacity
10.1155/2021/5561395 · 2021 · External reference
Impact of oxidative stress SNPs on sperm DNA damage and male infertility in a south-east Iranian population
10.1071/rd21305 · 2022 · External reference
Influences of the polymorphisms of the Sod2 gene (rs4880) on the motility and vigor of X- and Y-bearing sperm at different pH values
10.1016/j.biopha.2021.111993 · 2021 · External reference
Variation of the genes encoding antioxidant enzymes SOD2 (rs4880), GPX1 (rs1050450), and CAT (rs1001179) and susceptibility to male infertility: a genetic association study and in silico analysis
10.1007/s11356-023-28474-0 · 2023 · External reference
Association of polymorphisms in genes coding for antioxidant enzymes and human male infertility
10.1111/ahg.12286 · 2019 · External reference
SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer
10.1073/pnas.1902308116 · 2019 · External reference
Mitochondrial deacetylase Sirt3 reduces vascular dysfunction and hypertension while Sirt3 depletion in essential hypertension is linked to vascular inflammation and oxidative stress
10.1161/circresaha.119.315767 · 2020 · External reference
Nicotinamide mononucleotide enhances porcine sperm quality by activating the SIRT3-SOD2/ROS pathway and promoting oxidative phosphorylation
10.1016/j.anireprosci.2025.107797 · 2025 · External reference
Mitochondrial ROS-associated integrated stress response is involved in arsenic-induced blood-testis barrier disruption and protective effect of melatonin
10.1016/j.envint.2025.109346 · 2025 · External reference
Supplementing boar diet with nicotinamide mononucleotide improves sperm quality probably through the activation of the SIRT3 signaling pathway
10.3390/antiox13050507 · 2024 · External reference
Expression of stress response genes in germ cells during Spermatogenesis1
10.1095/biolreprod65.1.119 · 2001 · External reference
Glutathione peroxidases
2004 · External reference
Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx)
10.1515/bc.2003.070 · 2005 · External reference
Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice
10.1038/s41598-020-74667-9 · 2020 · External reference
Reactive oxygen species in male reproduction: a boon or a bane?
10.1111/and.13577 · 2021 · External reference
Developmental expression of glutathione peroxidase, catalase, and manganese superoxide dismutase mRNAs during spermatogenesis in the mouse
10.1002/j.1939-4640.1996.tb01781.x · 1996 · External reference
ROS inhibit the expression of testicular steroidogenic enzyme genes via the suppression of Nur77 transactivation
10.1016/j.freeradbiomed.2009.09.004 · 2009 · External reference
p38 MAPK regulates steroidogenesis through transcriptional repression of StAR gene
10.1530/jme-13-0287 · 2014 · External reference
The cell cycle is a redox cycle: linking phase-specific targets to cell fate
10.1016/j.freeradbiomed.2009.05.026 · 2009 · External reference
A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase
10.1016/j.devcel.2022.06.008 · 2022 · External reference
Redox control of cell proliferation
10.1016/j.tcb.2012.08.002 · 2012 · External reference
Manganese superoxide dismutase regulates a metabolic switch during the mammalian cell cycle
10.1158/0008-5472.can-11-1063 · 2012 · External reference
Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth
10.1111/j.1474-9726.2008.00384.x · 2008 · External reference
Manganese superoxide dismutase regulates a redox cycle within the cell cycle
10.1089/ars.2013.5303 · 2014 · External reference
The role of retinoic acid in the commitment to meiosis
10.4103/aja202156 · 2021 · External reference
Retinoic acid and germ cell development in the ovary and testis
10.3390/biom9120775 · 2019 · External reference
Retinoic acid signaling pathways
10.1242/dev.167502 · 2019 · External reference
Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis
10.1073/pnas.1710837114 · 2017 · External reference
c-Jun N-terminal kinase activation by oxidative stress suppresses retinoid signaling through proteasomal degradation of retinoic acid receptor α protein in hepatic cells
10.1111/j.1349-7006.2011.01889.x · 2011 · External reference
Redox regulation of transcriptional activity of retinoic acid receptor by thioredoxin glutathione reductase (TGR)
10.1016/j.bbrc.2009.09.097 · 2009 · External reference
The relationship between vitamin A status and oxidative stress in animal production
10.1080/09712119.2023.2239319 · 2023 · External reference
All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NFκB
10.1016/j.freeradbiomed.2008.01.015 · 2008 · External reference
Age-related elevation of O-GlcNAc causes meiotic arrest in male mice
10.1038/s41420-023-01433-x · 2023 · External reference
PHB regulates meiotic recombination via JAK2-mediated histone modifications in spermatogenesis
10.1093/nar/gkaa203 · 2020 · External reference
The ATM signaling Cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes
10.1371/journal.pgen.1005017 · 2015 · External reference
BDE-209 induce spermatocytes arrest at early-pachytene stage during meiotic prophase I in mice
10.1016/j.tox.2021.153061 · 2022 · External reference
Aging results in differential regulation of DNA repair pathways in pachytene spermatocytes in the brown Norway Rat1
10.1095/biolreprod.111.094219 · 2011 · External reference
Defects in meiotic recombination delay progression through pachytene in Tex19.1−/− mouse spermatocytes
10.1007/s00412-018-0674-9 · 2018 · External reference
Differential sperm motility mediates the sex ratio drive shaping mouse sex chromosome evolution
10.1016/j.cub.2019.09.031 · 2019 · External reference
MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice
10.1371/journal.pgen.1007300 · 2018 · External reference
Oxidative stress-induced apoptosis and autophagy: balancing the contrary forces in spermatogenesis
2023 · External reference
Unraveling the harmful effect of oxidative stress on male fertility: a mechanistic insight
10.3389/fendo.2023.1070692 · 2023 · External reference
Role of sperm apoptosis and oxidative stress in male infertility: a narrative review
2021 · External reference
Apoptosis, spermatogenesis and male infertility
10.2741/e415 · 2012 · External reference
Functions and effects of reactive oxygen species in male fertility
10.1016/j.anireprosci.2020.106456 · 2020 · External reference
Differences in ATP generation via glycolysis and oxidative phosphorylation and relationships with sperm motility in mouse species
10.1074/jbc.m115.664813 · 2015 · External reference
Capacitation promotes a shift in energy metabolism in murine sperm
10.3389/fcell.2022.950979 · 2022 · External reference
Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development
10.1186/s13072-018-0224-y · 2018 · External reference
Impacts of oxidative stress on bovine sperm function and subsequent in vitro embryo development
10.21451/1984-3143-ar2018-0041 · 2018 · External reference
Early and late paternal effects of reactive oxygen species in semen on embryo development after intracytoplasmic sperm injection
10.1080/19396368.2020.1720865 · 2020 · External reference
Reactive oxygen species impact on sperm DNA and its role in male infertility
10.1111/and.13012 · 2018 · External reference
Sperm redox biology challenges the role of antioxidants as a treatment for male factor infertility
2022 · External reference
Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs
10.1038/s41586-024-07472-3 · 2024 · External reference
Double-edged sword: effects of human sperm reactive oxygen species on embryo development in IVF cycles
10.1186/s12958-022-01053-7 · 2023 · External reference
