Research graph
References from Coordinated retinal metabolic remodeling reveals mitochondrial stress and redox vulnerability in experimental myopia. Local targets link to admitted publications; unresolved targets remain external evidence.
Global prevalence, trend and projection of myopia in children and adolescents from 1990 to 2050: a comprehensive systematic review and meta-analysis
10.1136/bjo-2024-325427 · 2025 · External reference
IMI risk factors for myopia
10.1167/iovs.62.5.3 · 2021 · External reference
Interventions recommended for myopia prevention and control among children and adolescents in China: a systematic review
10.1136/bjophthalmol-2021-319306 · 2023 · External reference
Digital screen time and myopia: a systematic review and dose-response meta-analysis
10.1001/jamanetworkopen.2024.60026 · 2025 · External reference
Myopia: histology, clinical features, and potential implications for the etiology of axial elongation
10.1016/j.preteyeres.2022.101156 · 2023 · External reference
Changes of the optic nerve head and macula in high myopia in a 10-Year follow-up: the beijing eye study
10.1167/iovs.66.15.39 · 2025 · External reference
Polarization-sensitive optical coherence tomography imaging of posterior staphyloma edges in eyes with high myopia
10.1167/iovs.66.11.6 · 2025 · External reference
Targeting choroidal vascular dysfunction via inhibition of circRNA-FoxO1 for prevention and management of myopic pathology
10.1016/j.ymthe.2021.02.025 · 2021 · External reference
Multiscale analysis of equatorial sclera anisotropy: revealing discrepancies in fiber orientation and mechanical properties
2025 · External reference
Candidate pathways for retina to scleral signaling in refractive eye growth
10.1016/j.exer.2022.109071 · 2022 · External reference
The role of retinal dysfunction in myopia development
10.1007/s10571-022-01309-1 · 2022 · External reference
Retinal glia in myopia: current understanding and future directions
10.3389/fcell.2024.1512988 · 2024 · External reference
Mechanisms underlying myopia progression from visual signaling to metabolic remodeling in retina
2025 · External reference
Eye on the horizon: the metabolic landscape of the RPE in aging and disease
10.1016/j.preteyeres.2024.101306 · 2025 · External reference
Metabolism dysregulation in retinal diseases and related therapies
10.3390/antiox11050942 · 2022 · External reference
A metabolic landscape for maintaining retina integrity and function
10.3389/fnmol.2021.656000 · 2021 · External reference
The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1
10.1007/s10522-022-09983-w · 2022 · External reference
Mitochondrial dynamics and their role in the pathogenesis of age-related macular degeneration: a comprehensive review
10.1016/j.redox.2025.103976 · 2026 · External reference
Crosstalk between mechanotransduction and metabolism
10.1038/s41580-020-00306-w · 2021 · External reference
Circadian-independent light regulation of Mammalian metabolism
10.1038/s42255-024-01051-6 · 2024 · External reference
Fundamentals of cancer metabolism
10.1126/sciadv.1600200 · 2016 · External reference
Pathway analysis identifies altered mitochondrial metabolism, neurotransmission, structural pathways and complement Cascade in retina/RPE/choroid in chick model of form-deprivation myopia
10.7717/peerj.5048 · 2018 · External reference
Changes in retinal metabolic profiles associated with form deprivation myopia development in Guinea pigs
10.1038/s41598-017-03075-3 · 2017 · External reference
SWATH based quantitative proteomics reveals significant lipid metabolism in early myopic Guinea pig retina
10.3390/ijms22094721 · 2021 · External reference
The potential role of amino acids in myopia: inspiration from metabolomics
10.1007/s11306-024-02207-x · 2024 · External reference
Lipid metabolism alterations in peripheral neuropathies
10.1016/j.neuron.2025.04.006 · 2025 · External reference
Dietary ω-3 polyunsaturated fatty acids are protective for myopia
10.1073/pnas.2104689118 · 2021 · External reference
Lipidomic analysis revealed n‐3 polyunsaturated fatty acids suppressed choroidal thinning and myopia progression in mice
10.1096/fj.202101947r · 2022 · External reference
Omega-3 polyunsaturated fatty acids as a protective factor for myopia
10.1016/j.ajo.2024.08.041 · 2024 · External reference
Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia
10.1016/j.isci.2024.110606 · 2024 · External reference
Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice
10.1038/s41467-025-62217-8 · 2025 · External reference
WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15
10.3892/ijo.2022.5314 · 2022 · External reference
Proteomic dissection of the rice-Fusarium fujikuroi interaction and the correlation between the proteome and transcriptome under disease stress
10.1186/s12864-019-5435-5 · 2019 · External reference
Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina
10.1073/pnas.1412441111 · 2014 · External reference
10.1172/jci86905
10.1172/jci86905 · External reference
Alteration of EIF2 signaling, glycolysis, and dopamine secretion in form-deprived myopia in response to 1% atropine treatment: evidence from interactive iTRAQ-MS and SWATH-MS proteomics using a Guinea pig model
2022 · External reference
Alteration of retinal metabolism and oxidative stress May implicate myopic eye growth: evidence from discovery and targeted proteomics in an animal model
2020 · External reference
A modified Arrestin1 increases lactate production in the retina and slows retinal degeneration
10.1089/hum.2021.272 · 2022 · External reference
Lactate protects against oxidative stress-induced retinal degeneration by activating autophagy
10.1016/j.freeradbiomed.2022.12.004 · 2023 · External reference
Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: insight gained from cell‐specific bsg deletion
10.1096/fj.201902961r · 2020 · External reference
pH in the vertebrate retina and its naturally occurring and pathological changes
10.1016/j.preteyeres.2024.101321 · 2025 · External reference
Retinal metabolism displays evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-krebs-cycle
2024 · External reference
Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa
10.1172/jci.insight.150898 · 2021 · External reference
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation
10.1186/s13024-023-00602-x · 2023 · External reference
Early quantitative profiling of differential retinal protein expression in lens-induced myopia in Guinea pig using fluorescence difference two-dimensional gel electrophoresis
2018 · External reference
Quercetin improves retinal glycolysis to slow myopia progression through orchestrating the AKT/FOXO/HK2 axis
10.1016/j.redox.2026.104139 · 2026 · External reference
Nonlinear pathological trajectory of a high-myopia C57/BL6J mouse model induced by form deprivation
10.3389/fphys.2024.1442000 · 2024 · External reference
Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina
10.1074/jbc.m115.698985 · 2016 · External reference
Molecular basis for increased lactate formation in the müller glial cells of retina
10.1016/j.brainresbull.2018.11.023 · 2019 · External reference
Proteomic analysis of CD29+ müller cells reveals metabolic reprogramming in rabbit myopia model
10.1038/s41598-024-75637-1 · 2024 · External reference
Müller cell glutamine metabolism links photoreceptor and endothelial injury in diabetic retinopathy
10.26508/lsa.202503434 · 2026 · External reference
Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival
10.7554/elife.100747.3 · 2025 · External reference
Amino acid metabolism and photoreceptor degenerative diseases: mechanisms, early diagnosis, and therapeutic prospects
10.1016/j.exer.2025.110563 · 2025 · External reference
Nitrosative stress in retinal pathologies: review
10.3390/antiox8110543 · 2019 · External reference
RNA-Seq and GSEA identifies suppression of ligand-gated chloride efflux channels as the major gene pathway contributing to form deprivation myopia
10.1038/s41598-021-84338-y · 2021 · External reference
Serine signaling governs metabolic homeostasis and health
10.1016/j.tem.2023.03.001 · 2023 · External reference
Metabolic characterization of human intraocular fluid in patients with pathological myopia
10.1016/j.exer.2022.109184 · 2022 · External reference
Glycine and aging: evidence and mechanisms
10.1016/j.arr.2023.101922 · 2023 · External reference
Suppressive effect of nitric oxide synthase (NOS) inhibitor L-NMMA acetate on choroidal fibrosis in experimental myopic Guinea pigs through the nitric oxide signaling pathway
10.1016/j.ejphar.2023.176111 · 2023 · External reference
Alpha 7‐nicotinic cholinoceptor regulation of pericyte‐containing retinal capillaries
10.1111/bph.16067 · 2023 · External reference
Lipid metabolism and retinal diseases
10.1111/aos.15226 · 2022 · External reference
Preliminary insights into serum metabolomics in atrophic myopic maculopathy: potential link to fatty acid metabolism dysregulation
10.1186/s12886-025-04220-7 · 2025 · External reference
Critical role of lipid metabolism in axial myopia development
10.18240/ijo.2025.11.23 · 2025 · External reference
