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References from TFAM Lys76 2-hydroxyisobutyrylation modulates oxidative stress and energy metabolism via the TFAM-ROS-AMPK axis in postoperative atrial fibrillation. Local targets link to admitted publications; unresolved targets remain external evidence.
Long-Term continuous monitoring of new-onset atrial fibrillation after coronary artery bypass grafting
10.1001/jama.2025.14891 · 2025 · External reference
Postoperative atrial fibrillation and long-term risk of stroke after isolated coronary artery bypass graft surgery
10.1161/circulationaha.120.046940 · 2020 · External reference
Postoperative atrial fibrillation after coronary artery bypass grafting
10.1253/circj.cj-25-0581 · 2025 · External reference
Risk factors of postoperative atrial fibrillation after isolated coronary artery bypass grafting surgery in the recent 10 years: clinical analysis of 6229 patients
10.1002/clc.24335 · 2024 · External reference
A myocardial Nox2 containing NAD(P)H oxidase contributes to oxidative stress in human atrial fibrillation
10.1161/01.res.0000183735.09871.61 · 2005 · External reference
Association of atrial nicotinamide adenine dinucleotide phosphate oxidase activity with the development of atrial fibrillation after cardiac surgery
10.1016/j.jacc.2007.07.085 · 2008 · External reference
A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement
10.1016/j.jacc.2013.07.014 · 2013 · External reference
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation
10.1161/circulationaha.113.003313 · 2013 · External reference
Mitochondrial dysfunction as an arrhythmogenic substrate: a translational proof-of-concept study in patients with metabolic syndrome in whom post-operative atrial fibrillation develops
10.1016/j.jacc.2013.03.061 · 2013 · External reference
Mitochondrial dysfunction in atrial tissue of patients developing postoperative atrial fibrillation
10.1016/j.athoracsur.2017.04.060 · 2017 · External reference
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression
10.1038/5089 · 1999 · External reference
A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts
10.1073/pnas.0308710100 · 2004 · External reference
Lysine 2-hydroxyisobutyrylation is a widely distributed active histone mark
10.1038/nchembio.1497 · 2014 · External reference
Lysine 2-hydroxyisobutyrylation of HXK1 alters energy metabolism and K(ATP) channel function in the atrium from patients with atrial fibrillation
10.1186/s12964-025-02108-z · 2025 · External reference
Modulation of abnormal vasoconstriction through 2-Hydroxyisobutyrylation of tropomyosin 3 Lys141: targeting histone deacetylase 3 as a key approach
10.1161/jaha.124.037400 · 2025 · External reference
Post-translational acylation of proteins in cardiac hypertrophy
10.1038/s41569-025-01150-1 · 2025 · External reference
Atlas of lysine propionylation of human right atrium and ALDH6A1-NADH pathway in new-onset atrial fibrillation after coronary surgery
10.1038/s42003-025-08264-9 · 2025 · External reference
IFN-alpha inhibits HBV transcription and replication by promoting HDAC3-mediated de-2-hydroxyisobutyrylation of histone H4K8 on HBV cccDNA minichromosome in liver
10.1038/s41401-021-00765-7 · 2022 · External reference
Lysine 2-Hydroxyisobutyrylation- and Succinylation-Based Pathways Act inside chloroplasts to modulate plant photosynthesis and immunity
2023 · External reference
Partial Cardiac denervation to prevent postoperative atrial fibrillation after coronary artery bypass grafting: the pCAD-POAF randomized clinical trial
10.1001/jamacardio.2024.4639 · 2025 · External reference
Transient inhibition of translation improves cardiac function after Ischemia/Reperfusion by attenuating the inflammatory response
10.1161/circulationaha.123.067479 · 2024 · External reference
Left atrial volume index and interleukin-6 as predictors for postoperative atrial fibrillation
10.1186/s13019-024-02813-9 · 2024 · External reference
Proteomics of the epicardial fat secretome and its role in post-operative atrial fibrillation
10.1093/europace/eux113 · 2018 · External reference
Postoperative atrial fibrillation and atrial epicardial fat: is there a link?
2022 · External reference
p300-Mediated lysine 2-Hydroxyisobutyrylation regulates glycolysis
10.1016/j.molcel.2018.04.011 · 2018 · External reference
Tissue-specific multi-omics analysis of atrial fibrillation
10.1038/s41467-022-27953-1 · 2022 · External reference
Functions of lysine 2-hydroxyisobutyrylation and future perspectives on plants
10.1002/pmic.202300045 · 2023 · External reference
Metabolic functions of lysine 2-Hydroxyisobutyrylation
2020 · External reference
Protein post-translational modification crotonylation of TXN and GLO1 in artery and vein grafts for coronary artery surgery
10.1016/j.redox.2025.103608 · 2025 · External reference
Acetylation and phosphorylation of human TFAM regulate TFAM-DNA interactions via contrasting mechanisms
10.1093/nar/gky204 · 2018 · External reference
Phosphorylation and acetylation of mitochondrial transcription factor A promote transcription processivity without compromising initiation or DNA compaction
10.1016/j.jbc.2022.101815 · 2022 · External reference
GCN5L1-mediated TFAM acetylation at K76 participates in mitochondrial biogenesis in acute kidney injury
10.1186/s12967-022-03782-0 · 2022 · External reference
Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart
2023 · External reference
Highly reactive isolevuglandins promote atrial fibrillation caused by hypertension
10.1016/j.jacbts.2020.04.004 · 2020 · External reference
Isolevuglandins promote mitochondrial dysfunction and electrophysiologic abnormalities in atrial cardiomyocytes
10.3390/cells13060483 · 2024 · External reference
Enhanced mitochondrial calcium uptake suppresses atrial fibrillation associated with Metabolic syndrome
10.1016/j.jacc.2022.09.041 · 2022 · External reference
Impaired atrial mitochondrial calcium handling in patients with atrial fibrillation
10.1161/circresaha.124.325658 · 2025 · External reference
PITX2 deficiency leads to atrial mitochondrial dysfunction
10.1093/cvr/cvae169 · 2024 · External reference
Oxidative stress causes mitochondrial and electrophysiologic dysfunction to promote atrial fibrillation in Pitx2(+/-) mice
10.1161/circep.124.013199 · 2025 · External reference
TFAM depletion overcomes hepatocellular carcinoma resistance to doxorubicin and sorafenib through AMPK activation and mitochondrial dysfunction
10.1016/j.gene.2020.144807 · 2020 · External reference
Lysine crotonylation of SERCA2a correlates to cardiac dysfunction and arrhythmia in Sirt1 cardiac-specific knockout mice
10.1016/j.ijbiomac.2023.125151 · 2023 · External reference
Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway
10.1038/cr.2017.149 · 2018 · External reference
LKB1-AMPK signaling pathway in cardiovascular and other diseases
10.1002/mco2.70601 · 2026 · External reference
Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease
10.1016/j.molcel.2012.10.023 · 2013 · External reference
Characterization of the cardiac succinylome and its role in ischemia-reperfusion injury
10.1016/j.yjmcc.2015.09.005 · 2015 · External reference
