References

Establishment, maintenance, and recall of inflammatory memory

10.1016/j.stem.2021.07.001 · 2021 · External reference

Epigenetic memory of coronavirus infection in innate immune cells and their progenitors

10.1016/j.cell.2023.07.019 · 2023 · External reference

Macrophage memory emerges from coordinated transcription factor and chromatin dynamics

2025 · External reference

Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts

10.1093/nar/gkaa858 · 2020 · External reference

10.1038/s41514-024-00172-2 · 2024 · Admitted local publication

Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence

10.1016/j.molcel.2024.08.006 · 2024 · External reference

Decoding the spatial chromatin organization and dynamic epigenetic landscapes of macrophage cells during differentiation and immune activation

10.1038/s41467-022-33558-5 · 2022 · External reference

Epigenetic regulation of macrophages: from homeostasis maintenance to host defense

10.1038/s41423-019-0315-0 · 2020 · External reference

Collaboration between distinct SWI/SNF chromatin remodeling complexes directs enhancer selection and activation of macrophage inflammatory genes

10.1016/j.immuni.2024.05.008 · 2024 · External reference

Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages

10.1016/j.immuni.2010.02.008 · 2010 · External reference

Effect of natural genetic variation on enhancer selection and function

10.1038/nature12615 · 2013 · External reference

A stringent systems approach uncovers gene-specific mechanisms regulating inflammation

10.1016/j.cell.2016.01.020 · 2016 · External reference

A landscape of gene expression regulation for synovium in arthritis

10.1038/s41467-024-45652-x · 2024 · External reference

The nuclear-mitochondrial crosstalk in aging: from mechanisms to therapeutics

10.1016/j.freeradbiomed.2025.03.012 · 2025 · External reference

Oxidative stress and central metabolism pathways impact epigenetic modulation in inflammation and immune response

10.1016/j.freeradbiomed.2025.04.004 · 2025 · External reference

From powerhouse to regulator: the role of mitoepigenetics in mitochondrion-related cellular functions and human diseases

10.1016/j.freeradbiomed.2024.03.025 · 2024 · External reference

An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn's disease

10.1016/j.jcmgh.2025.101665 · 2026 · External reference

Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells

10.1126/sciimmunol.adx4622 · 2026 · External reference

CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response

10.1038/s41588-020-0643-0 · 2020 · External reference

Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis

10.1038/s41514-021-00060-z · 2021 · External reference

Defining trained immunity and its role in health and disease

10.1038/s41577-020-0285-6 · 2020 · External reference

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

10.1016/j.cell.2017.11.025 · 2018 · External reference

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

10.1016/j.cmet.2016.10.008 · 2016 · External reference

NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential

10.1038/s41392-020-00311-7 · 2020 · External reference

Modulation of NAD metabolism by oxygen availability

10.1016/j.freeradbiomed.2025.07.014 · 2025 · External reference

Nicotinamide adenine dinucleotide homeostasis and signalling in heart disease: pathophysiological implications and therapeutic potential

10.1016/j.acvd.2015.10.004 · 2016 · External reference

CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism

10.1016/j.cmet.2016.05.006 · 2016 · External reference

The pharmacology of CD38/NADase: an emerging target in cancer and diseases of aging

10.1016/j.tips.2018.02.001 · 2018 · External reference

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

10.1038/s42255-020-00305-3 · 2020 · External reference

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline

10.1016/j.bbrc.2019.03.199 · 2019 · External reference

NAD(+) exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension

10.1038/s41392-023-01577-3 · 2023 · External reference

CD38 is a key mediator of NAD(+) depletion in the brain of ZIKV-infected mice

10.1016/j.isci.2025.114018 · 2025 · External reference

Hypothalamic astrocyte NAD(+) salvage pathway mediates the coupling of dietary fat overconsumption in a mouse model of obesity

10.1038/s41467-024-46009-0 · 2024 · External reference

SARM1 activation triggers axon degeneration locally via NAD+ destruction

10.1126/science.1258366 · 2015 · External reference

Extracellular NAD and ATP: partners in immune cell modulation

10.1007/s11302-006-9038-7 · 2007 · External reference

Structural basis of cellular dNTP regulation by SAMHD1

10.1073/pnas.1412289111 · 2014 · External reference

SAMHD1 acts at stalled replication forks to prevent interferon induction

10.1038/s41586-018-0050-1 · 2018 · External reference

SAMHD1 restricts the deoxyguanosine triphosphate pool contributing to telomere stability in telomerase-positive cells

10.1096/fj.202300122r · 2023 · External reference

Nucleotide salvage, genome instability, and potential therapeutic applications

10.1093/nar/gkag099 · 2026 · External reference

Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase

10.1158/0008-5472.can-13-1536-t · 2014 · External reference

Reciprocal regulation of autophagy and dNTP pools in human cancer cells

10.4161/auto.28954 · 2014 · External reference

The DNA replication checkpoint limits Okazaki fragment accumulation to protect and restart stalled forks

10.1016/j.molcel.2025.06.001 · 2025 · External reference

Ribonucleotide incorporation into mitochondrial DNA drives inflammation

10.1038/s41586-025-09541-7 · 2025 · External reference

Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria

10.1038/s41467-018-03552-x · 2018 · External reference

Mitochondrial DNA stress signalling protects the nuclear genome

10.1038/s42255-019-0150-8 · 2019 · External reference

Induction of MTHFD2 in macrophages inhibits reactive oxygen species-mediated NF-κB activation and protects against inflammatory responses

10.4049/jimmunol.2300209 · 2024 · External reference

MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

10.1016/j.immuni.2021.10.011 · 2022 · External reference

Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo

10.1038/s42255-022-00591-z · 2022 · External reference

Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications

10.1038/s41392-026-02583-x · 2026 · External reference

Oxidative DNA damage: mechanisms, mutation, and disease

10.1096/fj.02-0752rev · 2003 · External reference

Mitochondrial DNA Damage: Prevalence, Biological Consequence, and Emerging Pathways

10.1021/acs.chemrestox.0c00083 · 2020 · External reference

Prevention of artifactual oxidation in determination of cellular 8-oxo-7,8-dihydro-2′-deoxyguanosine by isotope-dilution LC-MS/MS with automated solid-phase extraction

10.1016/j.freeradbiomed.2007.10.003 · 2008 · External reference

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

10.1016/j.immuni.2022.06.007 · 2022 · External reference

The mitochondrial permeability transition: nexus of aging, disease and longevity

10.3390/cells10010079 · 2021 · External reference

Mitochondrial dysfunction acts as a modulator of the immunometabolic route for activating the cytosolic DNA sensor pathway in triggering innate immunosurveillance

10.1186/s12967-025-07392-4 · 2025 · External reference

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

10.1126/science.aav4011 · 2019 · External reference

Mitochondrial DNA release and cGAS-STING activation: emerging insights into anti-tumor immunity

10.1016/j.prp.2025.156158 · 2025 · External reference

Mitochondrial DNA signals driving immune responses: Why, How, Where?

10.1186/s12964-025-02042-0 · 2025 · External reference

Chlamydia psittaci infection induces IFN-I and IL-1β through the cGAS-STING-IRF3/NLRP3 pathway via mitochondrial oxidative stress in human macrophages

10.1016/j.vetmic.2024.110292 · 2024 · External reference

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

10.1016/j.immuni.2012.01.009 · 2012 · External reference

The NLRP3 inflammasome: an overview of mechanisms of activation and regulation

10.3390/ijms20133328 · 2019 · External reference

Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce T(FH) differentiation

10.1038/s41590-025-02179-7 · 2025 · External reference

Roles of mitochondrial DNA damage in kidney diseases: a new biomarker

10.3390/ijms232315166 · 2022 · External reference

Nanoimmunomodulation of the Aβ-STING feedback machinery in microglia for Alzheimer's disease treatment

10.1073/pnas.2427257122 · 2025 · External reference

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

10.1038/nrm.2017.53 · 2017 · External reference

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

10.1038/nrm3376 · 2012 · External reference

NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains

10.1038/s41467-018-03234-8 · 2018 · External reference

Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks

10.1038/s41467-025-67071-2 · 2025 · External reference

NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival

10.1091/mbc.e18-10-0650 · 2019 · External reference

Readers of poly(ADP-ribose): designed to be fit for purpose

10.1093/nar/gkv1383 · 2016 · External reference

Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1

10.1038/s41467-024-45237-8 · 2024 · External reference

Poly(ADP-ribose)-dependent chromatin unfolding facilitates the association of DNA-binding proteins with DNA at sites of damage

10.1093/nar/gkz820 · 2019 · External reference

Direct measurement of protein-protein interactions by FLIM-FRET at UV laser-induced DNA damage sites in living cells

10.1093/nar/gkaa859 · 2020 · External reference

PARP and PARG inhibitors in cancer treatment

10.1101/gad.334516.119 · 2020 · External reference

Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation

10.1074/jbc.ra118.004284 · 2018 · External reference

Histone PARylation factor 1: a review of its role in the DNA damage response

10.1093/nar/gkaf1170 · 2025 · External reference

Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation

10.1126/science.aaf7865 · 2016 · External reference

Trapping of PARP1 and PARP2 by clinical PARP inhibitors

10.1158/0008-5472.can-12-2753 · 2012 · External reference

Poly (ADP-ribose) polymerase inhibitors: recent advances and future development

10.1200/jco.2014.58.8848 · 2015 · External reference

PARPs and PARP inhibitors: molecular mechanisms and clinical applications

10.1186/s43556-025-00385-1 · 2025 · External reference

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

10.1016/j.jhep.2016.10.023 · 2017 · External reference

Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes

10.1172/jci139828 · 2022 · External reference

NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury

10.1038/s42255-023-00761-7 · 2023 · External reference

PARP inhibitors elicit a cellular senescence mediated inflammatory response in homologous recombination proficient cancer cells

10.1038/s41598-025-00336-4 · 2025 · External reference

Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1

10.1126/science.add8673 · 2023 · External reference

Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1

10.1038/nsmb.2446 · 2013 · External reference

RPA binds histone H3-H4 and functions in DNA replication-coupled nucleosome assembly

10.1126/science.aah4712 · 2017 · External reference

SIRT1 regulates UV-induced DNA repair through deacetylating XPA

10.1016/j.molcel.2010.07.006 · 2010 · External reference

Sirtuin signaling in cellular senescence and aging

10.5483/bmbrep.2019.52.1.290 · 2019 · External reference

Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer

10.5483/bmbrep.2013.46.9.180 · 2013 · External reference

The dual role of sirtuins in cancer: biological functions and implications

2024 · External reference

SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1

10.1128/mcb.00121-09 · 2009 · External reference

SIRT6 in health and diseases: from molecular mechanisms to therapeutic prospects

10.1016/j.phrs.2025.107984 · 2025 · External reference

Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus

10.1073/pnas.1002130107 · 2010 · External reference

Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity

10.1126/science.adq9006 · 2026 · External reference

Identification of BAF60b as a chromatin-remodeling checkpoint of diet-induced fatty liver disease

10.2337/db24-0002 · 2024 · External reference

Glomerular endothelial cells eliminate nicotinamide adenine dinucleotide to instruct CD103+ T cells in human lupus nephritis

10.1073/pnas.2507422122 · 2025 · External reference

SAMHD1: recurring roles in cell cycle, viral restriction, cancer, and innate immunity

10.1080/08916934.2018.1454912 · 2018 · External reference

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study

10.1016/s1474-4422(13)70258-8 · 2013 · External reference

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

10.1038/ng.373 · 2009 · External reference