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References from Doxycycline-induced mitohormesis attenuates intestinal ischemia–reperfusion injury through ATF5-associated mitochondria–peroxisome remodeling. Local targets link to admitted publications; unresolved targets remain external evidence.
Intestinal ischemia/reperfusion injury: mechanisms, diagnosis, and therapeutic advances
10.7150/ijbs.130025 · 2026 · External reference
Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
10.1038/s41392-023-01688-x · 2024 · External reference
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion
10.1038/s41419-020-03239-6 · 2020 · External reference
Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-dependent mitophagy
10.7150/ijbs.95853 · 2024 · External reference
Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model
10.1016/j.jgr.2025.04.006 · 2025 · External reference
TRIM25 triggers pyroptosis through mitochondrial DNA release in intestinal ischemia-reperfusion injury
10.1016/j.freeradbiomed.2026.02.019 · 2026 · External reference
MCU inhibition protects against intestinal ischemia-reperfusion by inhibiting Drp1-dependent mitochondrial fission
10.1016/j.freeradbiomed.2024.05.024 · 2024 · External reference
Mitohormesis
10.1016/j.cmet.2023.10.011 · 2023 · External reference
Adhesion-mediated mechanosignaling forces mitohormesis
10.1016/j.cmet.2021.04.017 · 2021 · External reference
The extracellular matrix integrates mitochondrial homeostasis
10.1016/j.cell.2024.05.057 · 2024 · External reference
Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice
10.1016/j.cmet.2026.01.012 · 2026 · External reference
Pharmaceutical manipulation of mitochondrial F0F1-ATP synthase enables imaging and protection of myocardial ischemia/reperfusion injury through stress-induced selective enrichment
2024 · External reference
ATF5-dependent GDF15 expression mediates anesthesia-induced neuroprotection against stroke
2026 · External reference
Mammalian mitohormesis: from mitochondrial stressors to organismal benefits
10.1038/s44318-025-00549-3 · 2025 · External reference
Mitochondrial dysfunction: mechanisms and advances in therapy
10.1038/s41392-024-01839-8 · 2024 · External reference
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
10.1007/s10456-024-09938-4 · 2024 · External reference
Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality
10.3389/fphar.2024.1422686 · 2024 · External reference
Tetracyclines activate mitoribosome quality control and reduce ER stress to promote cell survival
10.15252/embr.202357228 · 2023 · External reference
Tetracyclines promote survival and fitness in mitochondrial disease models
10.1038/s42255-020-00334-y · 2021 · External reference
Tetracycline-induced mitohormesis mediates disease tolerance against influenza
10.1172/jci151540 · 2022 · External reference
Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells
10.1038/s41419-021-03945-9 · 2021 · External reference
Effects of doxycycline on intestinal ischemia reperfusion injury induced by abdominal compartment syndrome in a rat model
10.1016/j.curtheres.2010.06.004 · 2010 · External reference
ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
10.1126/science.adn2804 · 2025 · External reference
Mitochondrial fission factor senses and governs ferroptosis
2026 · External reference
A cytosolic surveillance mechanism activates the mitochondrial UPR
10.1038/s41586-023-06142-0 · 2023 · External reference
The transcription factor ATF5 mediates a mammalian mitochondrial UPR
10.1016/j.cub.2016.06.002 · 2016 · External reference
UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication
10.1038/cr.2018.16 · 2018 · External reference
Atypical tetracyclines promote longevity and ferroptotic neuroprotection via translation attenuation
10.1111/acel.70587 · 2026 · External reference
Cardioprotection by the mitochondrial unfolded protein response requires ATF5
10.1152/ajpheart.00244.2019 · 2019 · External reference
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation
10.1126/science.1223560 · 2012 · External reference
Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance
10.1186/s12951-025-03420-z · 2025 · External reference
A novel ligustrazine-based nanodelivery system protects against doxorubicin-induced cardiotoxicity by targeting the SIRT5-DUSP1 axis for mitochondrial repair
10.1186/s12951-025-03667-6 · 2025 · External reference
Astragaloside VI attenuates mechanical stress-induced cardiac remodeling through piezo1-VDAC1 dependent endoplasmic reticulum unfolded protein response
10.1016/j.phymed.2025.157288 · 2025 · External reference
Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury
10.1016/j.jpha.2024.101034 · 2024 · External reference
Potential candidates of natural antioxidants from herbs for treating lung disorders: focus on redox balance and natural products
10.1002/ptr.70008 · 2025 · External reference
