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References from Construction of red-spotted grouper nervous necrosis virus (RGNNV) nonstructural protein B1/B2 mutant strains and dynamics during infection. Local targets link to admitted publications; unresolved targets remain external evidence.
Betanodavirus infections of teleost fish: a review
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Betanodavirus and VER disease: a 30-year research review
10.3390/pathogens9020106 · 2020 · External reference
Characterization of striped jack nervous necrosis virus subgenomic RNA3 and biological activities of its encoded protein B2
10.1099/vir.0.80902-0 · 2005 · External reference
B2 protein from betanodavirus is expressed in recently infected but not in chronically infected fish
10.3354/dao02015 · 2009 · External reference
Genomic classification of fish nodaviruses by molecular phylogenetic analysis of the coat protein gene
10.1128/aem.63.4.1633-1636.1997 · 1997 · External reference
Characterization of nodavirus and viral encephalopathy and retinopathy in farmed turbot, Scophthalmus maximus (L.)
10.1111/j.1365-2761.2004.00581.x · 2004 · External reference
Nuclear targeting of the betanodavirus B1 protein via two arginine-rich domains induces G1/S cell cycle arrest mediated by upregulation of p53/p21
10.1038/s41598-018-21340-x · 2018 · External reference
Red-grouper nervous necrosis virus B1 protein inhibits fish IFN response by targeting Ser5-phosphorylated RNA polymerase II to promote viral replication
10.1016/j.fsi.2023.108578 · 2023 · External reference
Betanodavirus non-structural protein B1: a novel anti-necrotic death factor that modulates cell death in early replication cycle in fish cells
10.1016/j.virol.2008.11.048 · 2009 · External reference
Sequestration and protection of double-stranded RNA by the betanodavirus b2 protein
10.1128/jvi.00079-06 · 2006 · External reference
Betanodavirus B2 is an RNA interference antagonist that facilitates intracellular viral RNA accumulation
10.1128/jvi.80.1.85-94.2006 · 2006 · External reference
Dissection of double-stranded RNA binding protein B2 from betanodavirus
10.1128/jvi.00009-07 · 2007 · External reference
Betanodavirus B2 causes ATP depletion-induced cell death via mitochondrial targeting and complex II inhibition in vitro and in vivo
10.1074/jbc.m110.164988 · 2010 · External reference
Beta-nodavirus B2 protein induces hydrogen peroxide production, leading to Drp1-recruited mitochondrial fragmentation and cell death via mitochondrial targeting
10.1007/s10495-014-1016-x · 2014 · External reference
Red-grouper nervous necrosis virus B2 protein negatively regulates fish interferon response by suppressing host transcription directed by RNA polymerase II
10.1016/j.aquaculture.2021.736488 · 2021 · External reference
Reverse genetics in virology: a double edged sword
10.1016/j.bsheal.2022.08.001 · 2022 · External reference
Replication of nodamura virus after transfection of viral RNA into mammalian cells in culture
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Recovery of infectious pariacoto virus from cDNA clones and identification of susceptible cell lines
10.1128/jvi.75.24.12220-12227.2001 · 2001 · External reference
Recovery of infectivity from cDNA clones of nodamura virus and identification of small nonstructural proteins
10.1006/viro.2002.1769 · 2003 · External reference
Establishment of an infectious RNA transcription system for striped jack nervous necrosis virus, the type species of the betanodaviruses
10.1099/0022-1317-82-11-2653 · 2001 · External reference
Establishment of reverse genetics system of betanodavirus for the efficient recovery of infectious particles
10.1016/j.jviromet.2008.04.002 · 2008 · External reference
A single amino acid change in the non-structural NV protein impacts the virulence phenotype of Viral hemorrhagic septicemia virus in trout
10.1099/jgv.0.000830 · 2017 · External reference
Deletion of accessory genes 3a, 3b, 5a or 5b from avian coronavirus infectious bronchitis virus induces an attenuated phenotype both in vitro and in vivo
10.1099/jgv.0.001130 · 2018 · External reference
Identification and characterization of a new strain of nervous necrosis virus isolated from pearl gentian grouper (Epinephelus lanceolatus × Epinephelus fuscoguttatus) in China
10.1016/j.aquaculture.2020.735663 · 2020 · External reference
CD4-1 and CD8α T lymphocytes subsets in spotted sea bass (Lateolabrax maculatus) and comparison on antigenicity of T lymphocytes subsets in other three marine fish species
10.1016/j.fsi.2022.10.004 · 2022 · External reference
Nectin1 is a pivotal host factor involved in attachment and entry of red-spotted grouper nervous necrosis virus in the early stages of the viral life cycle
10.1128/jvi.00901-24 · 2024 · External reference
Characterization of Nervous Necrosis Virus (NNV) nonstructural protein B2 and its enhancement on virus proliferation
10.3390/v14122818 · 2022 · External reference
In vitro and in vivo characterization of molecular determinants of virulence in reassortant betanodavirus
10.1099/vir.0.000064 · 2015 · External reference
Amino acid changes in the capsid protein of a reassortant betanodavirus strain: effect on viral replication in vitro and in vivo
10.1111/jfd.12916 · 2019 · External reference
Identification of B-Cell epitopes on capsid protein reveals two potential neutralization mechanisms in red-spotted grouper nervous necrosis virus
10.1128/jvi.01748-22 · 2023 · External reference
Tissue distribution of Red Spotted Grouper Nervous Necrosis Virus (RGNNV) genome in experimentally infected juvenile European seabass (Dicentrarchus labrax)
10.1016/j.vetmic.2011.06.029 · 2011 · External reference
Distribution of nervous necrosis virus (NNV) in infected sevenband grouper, Hyporthodus septemfasciatus by intramuscular injection or immersion challenge
10.1016/j.aquaculture.2018.01.042 · 2018 · External reference
Construction of attenuated strains for Red-Spotted Grouper Nervous Necrosis Virus (RGNNV) via reverse genetic System
10.3390/v14081737 · 2022 · External reference
Development of a reverse genetics system for Getah virus and characterization of rescued strains
10.1186/s13567-025-01515-x · 2025 · External reference
Two mutations in NS2B are responsible for attenuation of the yellow fever virus (YFV) vaccine strain 17D
2025 · External reference
Rotavirus reverse genetics systems and oral vaccine delivery vectors for mucosal vaccination
10.3390/microorganisms13071579 · 2025 · External reference
Generation of an artificially attenuated fowl adenovirus 4 viral vector using the reverse genetics system based on full-length infectious clone
10.1186/s13567-025-01496-x · 2025 · External reference
The S gene is necessary but not sufficient for the virulence of porcine epidemic Diarrhea virus novel variant strain BJ2011C
10.1128/jvi.00603-18 · 2018 · External reference
A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs
10.1007/s11427-020-1657-9 · 2020 · External reference
Recombinant live attenuated avian coronavirus vaccines with deletions in the accessory genes 3ab and/or 5ab protect against infectious bronchitis in chickens
10.1016/j.vaccine.2018.01.017 · 2018 · External reference
An attenuated zika virus encoding non-glycosylated envelope (E) and non-structural protein 1 (NS1) confers complete protection against lethal challenge in a mouse model
2019 · External reference
SARS-CoV-2 nonstructural protein 3 remodels the phosphorylation of target proteins via protein-protein interactions
2025 · External reference
Identification of three site mutations in nonstructural protein 1beta, glycoprotein 3 and glycoprotein 5 that correlate with increased interferon alpha resistance of porcine reproductive and respiratory syndrome virus
10.1016/j.vetmic.2019.108395 · 2019 · External reference
The Nsp12-coding region of type 2 PRRSV is required for viral subgenomic mRNA synthesis
10.1080/22221751.2019.1679010 · 2019 · External reference
In Vitro and In Vivo stability of P884T, a mutation that relocalizes Dengue virus 2 non-structural protein 5
10.1021/acsinfecdis.1c00441 · 2021 · External reference
How RNA viruses maintain their genome integrity
10.1099/vir.0.020818-0 · 2010 · External reference
Editing of the Sendai virus P/C mRNA by G insertion occurs during mRNA synthesis via a virus-encoded activity
10.1128/jvi.64.1.239-246.1990 · 1990 · External reference
Genesis of Sindbis virus by in vivo recombination of nonreplicative RNA precursors
10.1128/jvi.69.12.7391-7401.1995 · 1995 · External reference
Calicivirus RNA-Dependent RNA polymerases: Evolution, structure, protein dynamics, and function
10.3389/fmicb.2019.01280 · 2019 · External reference
Positive-strand RNA virus genome replication organelles: structure, assembly, control
10.1016/j.tig.2024.04.003 · 2024 · External reference
Nodavirus-induced membrane rearrangement in replication complex assembly requires replicase protein a, RNA templates, and polymerase activity
10.1128/jvi.01495-10 · 2010 · External reference
Multifunctional protein A is the only viral protein required for nodavirus RNA replication crown Formation
10.3390/v14122711 · 2022 · External reference