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References from Functional divergence of TLR5 paralogs reveals distinct roles for TLR5M and TLR5S in salmonid immunity. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathogen recognition and innate immunity
10.1016/j.cell.2006.02.015 · 2006 · External reference
Toll-like receptor signalling
10.1038/nri1391 · 2004 · External reference
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
10.1126/science.282.5396.2085 · 1998 · External reference
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
10.1038/35074106 · 2001 · External reference
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
10.1038/35099560 · 2001 · External reference
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
10.1126/science.1093616 · 2004 · External reference
A Toll-like receptor recognizes bacterial DNA
10.1038/35047123 · 2000 · External reference
Toll-like receptors in bony fish: from genomics to function
10.1016/j.dci.2011.03.006 · 2011 · External reference
Toll-like receptor signaling in teleosts
10.1007/s11427-024-2822-5 · 2025 · External reference
Frog skin innate immune defences: sensing and surviving pathogens
10.3389/fimmu.2018.03128 · 2019 · External reference
TLR5M and TLR5S synergistically sense flagellin in early endosome in lamprey Petromyzon marinus, switched by the N-Glycosylation site N239
10.4049/jimmunol.2300490 · 2024 · External reference
Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish, Fugu rubripes, genome
10.1007/s00251-002-0519-8 · 2003 · External reference
Genome-wide identification and characterization of toll-like receptor 5 (TLR5) in fishes
10.3389/fgene.2022.1083578 · 2023 · External reference
The Atlantic salmon genome provides insights into rediploidization
10.1038/nature17164 · 2016 · External reference
Sensing bacterial flagellin by membrane and soluble orthologs of Toll-like receptor 5 in rainbow trout (Oncorhynchus mykiss)
10.1074/jbc.m407634200 · 2004 · External reference
Studies on the use of flagellin as an immunostimulant and vaccine adjuvant in fish aquaculture
10.3389/fimmu.2018.03054 · 2019 · External reference
Differential transcriptomic profile of Piscirickettsia salmonis LF-89 and EM-90 during an in vivo spatial separation co-culture in Atlantic salmon
10.3390/microorganisms12122480 · 2024 · External reference
Dynamic immune response in the spleens of rainbow trout (Oncorhynchus mykiss) to infectious hematopoietic necrosis virus revealed by transcriptome and immune-related genes expression analysis
2023 · External reference
Molecular identification and expression analysis of TLR5M and TLR5S from orange-spotted grouper (Epinephelus coioides)
10.1016/j.fsi.2017.01.037 · 2017 · External reference
Immune response of Atlantic salmon to recombinant flagellin
10.1016/j.vaccine.2011.07.138 · 2011 · External reference
Molecular cloning, phylogenetic analysis and functional characterization of soluble Toll-like receptor 5 in gilthead seabream, Sparus aurata
10.1016/j.fsi.2013.03.374 · 2013 · External reference
A soluble TLR5 is involved in the flagellin-MyD88-mediated immune response via regulation rather than activation in large yellow croaker (Larimichthys crocea)
10.1016/j.cbpb.2024.111061 · 2025 · External reference
Fish soluble Toll-like receptor (TLR)5 amplifies human TLR5 response via physical binding to flagellin
10.1016/j.vaccine.2005.11.003 · 2006 · External reference
Cyprinid‐specific duplicated membrane TLR5 senses dsRNA as functional homodimeric receptors
10.15252/embr.202154281 · 2022 · External reference
TLR5M cooperates with TLR5S to activate NF-kappaB in Nile tilapia (Oreochromis niloticus)
10.1016/j.aquaculture.2022.738775 · 2023 · External reference
TLR5M and TLR5S play opposite roles in NF-kappaB pathway in Vibrio parahaemolyticus flagellin stimulation in orange-spotted grouper, Epinephelus coioides
10.1016/j.fsi.2019.04.194 · 2019 · External reference
CRISPR genome editing made easy through the CHOPCHOP website
10.1002/cpz1.46 · 2021 · External reference
Efficient genome editing in multiple salmonid cell lines using ribonucleoprotein complexes
10.1007/s10126-020-09995-y · 2020 · External reference
Efficient genome editing in multiple salmonid cell lines using ribonucleoprotein complexes
10.1007/s10126-020-09995-y · 2020 · External reference
Characterisation of eicosanoid-regulating genes in Atlantic salmon: insights into the control of pro-inflammatory and anti-inflammatory lipid mediators
10.1016/j.fsi.2026.111296 · 2026 · External reference
Cutadapt removes adapter sequences from high-throughput sequencing reads
10.14806/ej.17.1.200 · 2011 · External reference
Unresolved reference
2021 · External reference
SeqKit: a cross-platform and ultrafast toolkit for FASTA/Q file manipulation
10.1371/journal.pone.0163962 · 2016 · External reference
Minimap2: pairwise alignment for nucleotide sequences
10.1093/bioinformatics/bty191 · 2018 · External reference
1000 genome Project data processing subgroup, The sequence alignment/map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
Early innate immune response to highly pathogenic avian influenza and functional characterisation of the chicken IRF1 promoter
10.1016/j.dci.2026.105561 · 2026 · External reference
Unresolved reference
External reference
Unresolved reference
2026 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R
10.1186/1471-2105-12-35 · 2011 · External reference
Unresolved reference
2016 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method
10.1006/meth.2001.1262 · 2001 · External reference
Re-examination of the rainbow trout (Oncorhynchus mykiss) immune response to flagellin: Yersinia ruckeri flagellin is a potent activator of acute phase proteins, anti-microbial peptides and pro-inflammatory cytokines in vitro
10.1016/j.dci.2015.12.017 · 2016 · External reference
Transcriptome responses of Atlantic salmon (Salmo salar L.) to viral and bacterial pathogens, inflammation, and stress
10.3389/fimmu.2021.705601 · 2021 · External reference
Duplicated TLR5 of zebrafish functions as a heterodimeric receptor
10.1073/pnas.1719245115 · 2018 · External reference
Characterization and expression analysis of Nod-like receptor 3 (NLRC3) against infection with Piscirickettsia salmonis in Atlantic salmon
10.1016/j.dci.2020.103865 · 2021 · External reference
The NLRP3 inflammasome: an overview of mechanisms of activation and regulation
10.3390/ijms20133328 · 2019 · External reference
NLRP3 inflammasome activation and cell death
10.1038/s41423-021-00740-6 · 2021 · External reference
Negative regulator NLRC3: its potential role and regulatory mechanism in immune response and immune-related diseases
10.3389/fimmu.2022.1012459 · 2022 · External reference
Cytosolic flagellin-induced lysosomal pathway regulates inflammasome-dependent and -independent macrophage responses
10.1073/pnas.1305316110 · 2013 · External reference
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1 beta in salmonella-infected macrophages
10.1038/ni1346 · 2006 · External reference
Effects of recombinant flagellin B and its ND1 domain from Vibrio anguillarum on macrophages from gilthead seabream (Sparus aurata L.) and rainbow trout (Oncorhynchus mykiss, W.)
10.1016/j.fsi.2014.10.034 · 2015 · External reference
Immune responses of channel catfish following the stimulation of three recombinant flagellins of Yersinia ruckeri in vitro and in vivo
10.1016/j.dci.2017.02.015 · 2017 · External reference
LPS-induced inflammation and preconditioning in rainbow trout: markers of innate immunity and oxidative stress
10.3390/ani15243589 · 2025 · External reference
Evolution of LPS recognition and signaling: the bony fish perspective
10.1016/j.dci.2023.104710 · 2023 · External reference
Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation
10.4049/jimmunol.0801755 · 2009 · External reference
TLR4al senses heme as a key damage/danger-associated molecular pattern to activate immune responses in lower vertebrates
10.1093/jimmun/vkaf192 · 2025 · External reference
Proinflammatory effects of bacterial lipopolysaccharide (LPS) in Rainbow trout (Oncorhynchus mykiss) macrophage cells, fish
2003 · External reference
Generation of IgM+ B cell-deficient Atlantic salmon (Salmo salar) by CRISPR/Cas9-mediated IgM knockout
10.1038/s41598-025-87658-5 · 2025 · External reference
