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References from Sequence-resolved discovery and cellular validation of immunomodulatory peptides from cricket protein hydrolysate. Local targets link to admitted publications; unresolved targets remain external evidence.
Reactive astrocytes promote proteostasis in huntington’s disease through the JAK2-STAT3 pathway
10.1093/brain/awac068 · 2023 · External reference
Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases
10.3390/ijms23126827 · 2022 · External reference
The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in alzheimer’s and huntington’s diseases
10.1523/jneurosci.3516-14.2015 · 2015 · External reference
The role of inflammatory cascade and reactive astrogliosis in glial scar formation post-spinal cord injury
10.1007/s10571-024-01519-9 · 2024 · External reference
Design of protein-binding proteins from the target structure alone
10.1038/s41586-022-04654-9 · 2022 · External reference
Food-derived bioactive peptides: health benefits, structure–activity relationships, and translational prospects
10.1631/jzus.b2400106 · 2025 · External reference
Lipopolysaccharide-induced animal models for neuroinflammation – an overview
10.1016/j.jneuroim.2023.578273 · 2024 · External reference
Isolation and identification of antioxidant peptides derived from cricket (gryllus bimaculatus) protein fractions
10.3390/insects14080674 · 2023 · External reference
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
10.1038/s41392-023-01588-0 · 2023 · External reference
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression
10.1016/j.it.2008.05.002 · 2008 · External reference
Mechanisms underlying inflammation in neurodegeneration
10.1016/j.cell.2010.02.016 · 2010 · External reference
Neuroprotective effect of mealworm protein hydrolysate-derived bioactive peptides in human microglial cells
10.1163/23524588-00001313 · 2024 · External reference
Neuroinflammation as a common feature of neurodegenerative disorders
10.3389/fphar.2019.01008 · 2019 · External reference
Recent insights on astrocyte mechanisms in CNS homeostasis, pathology, and repair
10.1002/jnr.24922 · 2021 · External reference
Activation of microglia and astrocytes: a roadway to neuroinflammation and alzheimer’s disease
10.1007/s10787-019-00580-x · 2019 · External reference
Road to the red carpet of edible crickets through integration into the human food chain with biofunctions and sustainability: a review
10.3390/ijms23031801 · 2022 · External reference
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
10.1186/s40035-020-00221-2 · 2020 · External reference
Physicochemical properties of selenized quinoa protein hydrolysate and its regulatory effects on neuroinflammation and gut microbiota in hypoxic mice
10.1016/j.jfutfo.2025.09.044 · 2025 · External reference
GPETAFLR, a peptide from lupinus angustifolius L. prevents inflammation in microglial cells and confers neuroprotection in brain
10.1080/1028415x.2020.1763058 · 2022 · External reference
STAT3 inhibition protects against neuroinflammation and BACE1 upregulation induced by systemic inflammation
10.1016/j.imlet.2020.10.004 · 2020 · External reference
The JAK/STAT pathway: key mechanism in gene activation, disease regulation, and emerging therapeutic targets
10.1007/s11033-026-11847-2 · 2026 · External reference
Nutritional value, protein and peptide composition of edible cricket powders
10.1016/j.foodchem.2019.03.062 · 2019 · External reference
Hydrolyzed chicken meat extract attenuates neuroinflammation and cognitive impairment in middle-aged mouse by regulating M1/M2 microglial polarization
10.1021/acs.jafc.1c03541 · 2021 · External reference
Microglia in neurodegenerative disease
10.1038/nrneurol.2010.17 · 2010 · External reference
Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an alzheimer’s disease model
10.15252/emmm.201809665 · 2019 · External reference
STAT3 signaling pathway in health and disease
10.1002/mco2.70152 · 2025 · External reference
JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
10.1186/s43556-023-00151-1 · 2023 · External reference
Neuroinflammation across neurological diseases
10.1126/science.adx0043 · 2025 · External reference
Immunomodulatory properties of hempseed oligopeptides in an LRRK2-associated parkinson’s disease animal model
10.1039/d4fo03167a · 2024 · External reference
Bioaccessibility of bioactive peptides: recent advances and perspectives
10.1016/j.cofs.2021.03.005 · 2021 · External reference
Inhibitory effects of walnut (juglans regia) peptides on neuroinflammation and oxidative stress in lipopolysaccharide-induced cognitive impairment mice
10.1021/acs.jafc.9b07670 · 2020 · External reference
STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor
10.1073/pnas.1315862110 · 2013 · External reference
A comprehensive overview of edible crickets: nutritional composition, health benefits, and safety considerations
2026 · External reference
Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis
10.1186/s10020-025-01089-6 · 2025 · External reference
Cytokine–microglia interactions in neuroinflammation: mechanisms, disease dynamics, and therapeutic strategies
10.1177/15230864251401591 · 2026 · External reference
Role of neuroinflammation in neurodegeneration development
10.1038/s41392-023-01486-5 · 2023 · External reference
A comprehensive review of specific activity and intrinsic connections of food-derived bioactive peptides for human health
10.1002/fft2.373 · 2024 · External reference
Food protein-derived antioxidant peptides: molecular mechanism, stability and bioavailability
10.3390/biom12111622 · 2022 · External reference
A comprehensive review of specific activity and intrinsic connections of food-derived bioactive peptides for human health
10.1002/fft2.373 · ExternalCitation · doi-reference
Recent insights on astrocyte mechanisms in CNS homeostasis, pathology, and repair
10.1002/jnr.24922 · ExternalCitation · doi-reference
STAT3 signaling pathway in health and disease
10.1002/mco2.70152 · ExternalCitation · doi-reference
The role of inflammatory cascade and reactive astrogliosis in glial scar formation post-spinal cord injury
10.1007/s10571-024-01519-9 · ExternalCitation · doi-reference
Activation of microglia and astrocytes: a roadway to neuroinflammation and alzheimer’s disease
10.1007/s10787-019-00580-x · ExternalCitation · doi-reference
The JAK/STAT pathway: key mechanism in gene activation, disease regulation, and emerging therapeutic targets
10.1007/s11033-026-11847-2 · ExternalCitation · doi-reference
Mechanisms underlying inflammation in neurodegeneration
10.1016/j.cell.2010.02.016 · ExternalCitation · doi-reference
Bioaccessibility of bioactive peptides: recent advances and perspectives
10.1016/j.cofs.2021.03.005 · ExternalCitation · doi-reference
Nutritional value, protein and peptide composition of edible cricket powders
10.1016/j.foodchem.2019.03.062 · ExternalCitation · doi-reference
STAT3 inhibition protects against neuroinflammation and BACE1 upregulation induced by systemic inflammation
10.1016/j.imlet.2020.10.004 · ExternalCitation · doi-reference
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression
10.1016/j.it.2008.05.002 · ExternalCitation · doi-reference
Physicochemical properties of selenized quinoa protein hydrolysate and its regulatory effects on neuroinflammation and gut microbiota in hypoxic mice
10.1016/j.jfutfo.2025.09.044 · ExternalCitation · doi-reference
Lipopolysaccharide-induced animal models for neuroinflammation – an overview
10.1016/j.jneuroim.2023.578273 · ExternalCitation · doi-reference
Hydrolyzed chicken meat extract attenuates neuroinflammation and cognitive impairment in middle-aged mouse by regulating M1/M2 microglial polarization
10.1021/acs.jafc.1c03541 · ExternalCitation · doi-reference
Inhibitory effects of walnut (juglans regia) peptides on neuroinflammation and oxidative stress in lipopolysaccharide-induced cognitive impairment mice
10.1021/acs.jafc.9b07670 · ExternalCitation · doi-reference
Microglia in neurodegenerative disease
10.1038/nrneurol.2010.17 · ExternalCitation · doi-reference
Role of neuroinflammation in neurodegeneration development
10.1038/s41392-023-01486-5 · ExternalCitation · doi-reference
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
10.1038/s41392-023-01588-0 · ExternalCitation · doi-reference
Design of protein-binding proteins from the target structure alone
10.1038/s41586-022-04654-9 · ExternalCitation · doi-reference
Immunomodulatory properties of hempseed oligopeptides in an LRRK2-associated parkinson’s disease animal model
10.1039/d4fo03167a · ExternalCitation · doi-reference
STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor
10.1073/pnas.1315862110 · ExternalCitation · doi-reference
GPETAFLR, a peptide from lupinus angustifolius L. prevents inflammation in microglial cells and confers neuroprotection in brain
10.1080/1028415x.2020.1763058 · ExternalCitation · doi-reference
Reactive astrocytes promote proteostasis in huntington’s disease through the JAK2-STAT3 pathway
10.1093/brain/awac068 · ExternalCitation · doi-reference
Neuroinflammation across neurological diseases
10.1126/science.adx0043 · ExternalCitation · doi-reference
Neuroprotective effect of mealworm protein hydrolysate-derived bioactive peptides in human microglial cells
10.1163/23524588-00001313 · ExternalCitation · doi-reference
Cytokine–microglia interactions in neuroinflammation: mechanisms, disease dynamics, and therapeutic strategies
10.1177/15230864251401591 · ExternalCitation · doi-reference
Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis
10.1186/s10020-025-01089-6 · ExternalCitation · doi-reference
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
10.1186/s40035-020-00221-2 · ExternalCitation · doi-reference
JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions
10.1186/s43556-023-00151-1 · ExternalCitation · doi-reference
The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in alzheimer’s and huntington’s diseases
10.1523/jneurosci.3516-14.2015 · ExternalCitation · doi-reference
Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an alzheimer’s disease model
10.15252/emmm.201809665 · ExternalCitation · doi-reference
Food-derived bioactive peptides: health benefits, structure–activity relationships, and translational prospects
10.1631/jzus.b2400106 · ExternalCitation · doi-reference
Neuroinflammation as a common feature of neurodegenerative disorders
10.3389/fphar.2019.01008 · ExternalCitation · doi-reference
Food protein-derived antioxidant peptides: molecular mechanism, stability and bioavailability
10.3390/biom12111622 · ExternalCitation · doi-reference
Road to the red carpet of edible crickets through integration into the human food chain with biofunctions and sustainability: a review
10.3390/ijms23031801 · ExternalCitation · doi-reference
Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases
10.3390/ijms23126827 · ExternalCitation · doi-reference
Isolation and identification of antioxidant peptides derived from cricket (gryllus bimaculatus) protein fractions
10.3390/insects14080674 · ExternalCitation · doi-reference
