Research graph
References from Ras-MAPK somatic variants in mesial temporal lobe epilepsy. Local targets link to admitted publications; unresolved targets remain external evidence.
A randomized, controlled trial of surgery for temporal-lobe epilepsy
10.1056/nejm200108023450501 · 2001 · External reference
International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods
10.1111/epi.12220 · 2013 · External reference
Early identification of refractory epilepsy
10.1056/nejm200002033420503 · 2000 · External reference
Hippocampal sclerosis--origins and imaging
10.1111/j.1528-1167.2012.03610.x · 2012 · External reference
Influence of the type of initial precipitating injury and at what age it occurs on course and outcome in patients with temporal lobe seizures
10.3171/jns.1995.82.2.0220 · 1995 · External reference
Neurophysiologic and neuroradiologic features of intractable epilepsy after traumatic brain injury in adults
10.1001/archneur.57.11.1611 · 2000 · External reference
Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination
10.1002/ana.410340604 · 1993 · External reference
Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study
10.1002/ana.24081 · 2014 · External reference
Rare genetic variation and outcome of surgery for mesial temporal lobe epilepsy
10.1002/ana.26581 · 2023 · External reference
Twins with temporal lobe epilepsy: genetic contributions to hippocampal sclerosis and other subtypes
10.1093/brain/awaf209 · 2025 · External reference
Contribution of somatic Ras/Raf/mitogen-activated protein kinase variants in the hippocampus in drug-resistant mesial temporal lobe epilepsy
10.1001/jamaneurol.2023.0473 · 2023 · External reference
10.64898/2026.01.26.701822
10.64898/2026.01.26.701822 · External reference
Somatic variants as a cause of drug-resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis
10.1111/epi.17943 · 2024 · External reference
Rare variants and de novo variants in mesial temporal lobe epilepsy with hippocampal sclerosis
10.1212/nxg.0000000000000245 · 2018 · External reference
A targeted resequencing gene panel for focal epilepsy
10.1212/wnl.0000000000002608 · 2016 · External reference
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes
10.1038/s41593-024-01747-8 · 2024 · External reference
Ultra-rare genetic variation in the epilepsies: a whole-exome sequencing study of 17,606 individuals
10.1016/j.ajhg.2019.05.020 · 2019 · External reference
De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly
10.1038/ng.2329 · 2012 · External reference
Somatic activation of AKT3 causes hemispheric developmental brain malformations
10.1016/j.neuron.2012.03.010 · 2012 · External reference
Somatic mutations activating the mTOR pathway in dorsal telencephalic progenitors cause a continuum of cortical dysplasias
10.1016/j.celrep.2017.11.106 · 2017 · External reference
Dissecting the genetic basis of focal cortical dysplasia: a large cohort study
10.1007/s00401-019-02061-5 · 2019 · External reference
Somatic variants in diverse genes leads to a spectrum of focal cortical malformations
10.1093/brain/awac117 · 2022 · External reference
Detection of brain somatic variation in epilepsy-associated developmental lesions
10.1111/epi.17323 · 2022 · External reference
The genomic landscape across 474 surgically accessible epileptogenic human brain lesions
10.1093/brain/awac376 · 2023 · External reference
10.64898/2026.04.06.716727
10.64898/2026.04.06.716727 · External reference
Ganglioglioma with adverse clinical outcome and atypical histopathological features were defined by alterations in PTPN11/KRAS/NF1 and other RAS-/MAP-Kinase pathway genes
10.1007/s00401-023-02561-5 · 2023 · External reference
The role of KRAS mutations in cortical malformation and epilepsy surgery: a novel report of nevus sebaceous syndrome and review of the literature
10.3390/brainsci11060793 · 2021 · External reference
Assessment of genetic variant burden in epilepsy-associated brain lesions
10.1038/s41431-019-0484-4 · 2019 · External reference
New clinicopathological associations and histoprognostic markers in ILAE types of hippocampal sclerosis
10.1111/bpa.12596 · 2018 · External reference
Molecular landscapes of human hippocampal immature neurons across lifespan
10.1038/s41586-022-04912-w · 2022 · External reference
Neurogenesis in the adult human hippocampus
10.1038/3305 · 1998 · External reference
Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease
10.1038/s41586-026-10169-4 · 2026 · External reference
Universal patterns of selection in cancer and somatic tissues
10.1016/j.cell.2017.09.042 · 2017 · External reference
Rates and patterns of clonal oncogenic mutations in the normal human brain
10.1158/2159-8290.cd-21-0245 · 2022 · External reference
Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
10.1523/jneurosci.17-10-03727.1997 · 1997 · External reference
Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat
10.1016/s0006-8993(98)00030-4 · 1998 · External reference
Enhanced neurogenesis in the rodent hippocampus following traumatic brain injury
10.1002/1097-4547(20010215)63:4<313::aid-jnr1025>3.0.co;2-4 · 2001 · External reference
Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies
10.1007/s00401-009-0512-5 · 2009 · External reference
COSMIC: the catalogue of somatic mutations in cancer
10.1093/nar/gky1015 · 2019 · External reference
Clonal analysis of newborn hippocampal dentate granule cell proliferation and development in temporal lobe epilepsy
2016 · External reference
Signaling mechanisms regulating adult neural stem cells and neurogenesis
10.1016/j.bbagen.2012.09.002 · 2013 · External reference
Dentate gyrus development requires ERK activity to maintain progenitor population and mapk pathway feedback regulation
10.1523/jneurosci.4196-14.2015 · 2015 · External reference
MAPK signal pathways in the regulation of cell proliferation in mammalian cells
10.1038/sj.cr.7290105 · 2002 · External reference
Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus
10.1111/jnc.12035 · 2012 · External reference
Activation of ERK by spontaneous seizures in neural progenitors of the dentate gyrus in a mouse model of epilepsy
10.1016/j.expneurol.2010.03.003 · 2010 · External reference
Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
10.1046/j.1471-4159.2002.01085.x · 2002 · External reference
Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development
10.1242/dev.008227 · 2007 · External reference
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment
10.1016/j.neuron.2008.06.023 · 2008 · External reference
CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons
10.1523/jneurosci.0367-19.2019 · 2020 · External reference
Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways
10.1523/jneurosci.23-12-05149.2003 · 2003 · External reference
Differential regulation of the BDNF gene in cortical and hippocampal neurons
10.1523/jneurosci.2535-21.2022 · 2022 · External reference
A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition
10.1016/j.neuron.2008.09.024 · 2008 · External reference
Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus
10.1002/hipo.20410 · 2008 · External reference
Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
10.1016/j.expneurol.2004.11.016 · 2005 · External reference
BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF
10.1016/0896-6273(91)90234-q · 1991 · External reference
Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells
10.1523/jneurosci.0431-07.2007 · 2007 · External reference
Granule-like neurons at the Hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis
10.1523/jneurosci.20-16-06144.2000 · 2000 · External reference
Temporal lobe epilepsy: analysis of patients with dual pathology
10.1034/j.1600-0404.2003.00183.x · 2004 · External reference
Intrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model
10.1152/jn.00835.2014 · 2015 · External reference
BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors
10.1038/s41591-018-0172-x · 2018 · External reference
BRAFV600E expression in neural progenitors results in a hyperexcitable phenotype in neocortical pyramidal neurons
10.1152/jn.00523.2019 · 2020 · External reference
Reversibility and developmental neuropathology of linear nevus sebaceous syndrome caused by dysregulation of the RAS pathway
2023 · External reference
ERK activation causes epilepsy by stimulating NMDA receptor activity
10.1038/sj.emboj.7601911 · 2007 · External reference
Ganglioglioma cells potentiate neuronal network synchronicity and elicit burst discharges via released factors
10.1016/j.nbd.2023.106364 · 2024 · External reference
Unresolved reference
External reference
The viral hypothesis of mesial temporal lobe epilepsy – is human herpes virus-6 the missing link? A systematic review and meta-analysis
10.1016/j.seizure.2017.11.015 · 2018 · External reference
Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study
10.1016/s1474-4422(20)30220-9 · 2020 · External reference
Long-term outcome after temporal lobe surgery—prediction of late worsening of seizure control
10.1016/j.seizure.2005.10.007 · 2006 · External reference
Prophylactic drug management for febrile seizures in children
2021 · External reference
Pharmacological treatments for preventing epilepsy following traumatic head injury
2015 · External reference
Single-nucleus RNA sequencing: immature excitatory neurons and transformed glia build human BRAFV600E-negative gangliogliomas
10.1093/braincomms/fcaf372 · 2025 · External reference
10.64898/2026.04.18.719347
10.64898/2026.04.18.719347 · External reference
Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression
10.1038/s41598-017-18237-6 · 2017 · External reference
Ablation of newly generated hippocampal granule cells has disease-modifying effects in epilepsy
10.1523/jneurosci.1371-16.2016 · 2016 · External reference
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy
10.1038/s41467-021-21649-8 · 2021 · External reference
Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline
10.1038/ncomms7606 · 2015 · External reference
Treatment of refractory epilepsy with MEK inhibitor in patients with RASopathy
10.1016/j.pediatrneurol.2023.08.019 · 2023 · External reference
Dose-dependent seizure control with MEK inhibitor therapy for progressive glioma in a child with neurofibromatosis type 1
10.1007/s00381-022-05571-y · 2022 · External reference
Antiseizure effect of MEK inhibitor in a child with neurofibromatosis type 1—developmental and epileptic encephalopathy and optic pathway glioma
10.1002/epd2.20180 · 2024 · External reference
Neurophysiologic and neuroradiologic features of intractable epilepsy after traumatic brain injury in adults
10.1001/archneur.57.11.1611 · ExternalCitation · doi-reference
Contribution of somatic Ras/Raf/mitogen-activated protein kinase variants in the hippocampus in drug-resistant mesial temporal lobe epilepsy
10.1001/jamaneurol.2023.0473 · ExternalCitation · doi-reference
Enhanced neurogenesis in the rodent hippocampus following traumatic brain injury
10.1002/1097-4547(20010215)63:4<313::aid-jnr1025>3.0.co;2-4 · ExternalCitation · doi-reference
Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study
10.1002/ana.24081 · ExternalCitation · doi-reference
Rare genetic variation and outcome of surgery for mesial temporal lobe epilepsy
10.1002/ana.26581 · ExternalCitation · doi-reference
Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination
10.1002/ana.410340604 · ExternalCitation · doi-reference
Antiseizure effect of MEK inhibitor in a child with neurofibromatosis type 1—developmental and epileptic encephalopathy and optic pathway glioma
10.1002/epd2.20180 · ExternalCitation · doi-reference
Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus
10.1002/hipo.20410 · ExternalCitation · doi-reference
Dose-dependent seizure control with MEK inhibitor therapy for progressive glioma in a child with neurofibromatosis type 1
10.1007/s00381-022-05571-y · ExternalCitation · doi-reference
Towards a clinico-pathological classification of granule cell dispersion in human mesial temporal lobe epilepsies
10.1007/s00401-009-0512-5 · ExternalCitation · doi-reference
Dissecting the genetic basis of focal cortical dysplasia: a large cohort study
10.1007/s00401-019-02061-5 · ExternalCitation · doi-reference
Ganglioglioma with adverse clinical outcome and atypical histopathological features were defined by alterations in PTPN11/KRAS/NF1 and other RAS-/MAP-Kinase pathway genes
10.1007/s00401-023-02561-5 · ExternalCitation · doi-reference
BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF
10.1016/0896-6273(91)90234-q · ExternalCitation · doi-reference
Ultra-rare genetic variation in the epilepsies: a whole-exome sequencing study of 17,606 individuals
10.1016/j.ajhg.2019.05.020 · ExternalCitation · doi-reference
Signaling mechanisms regulating adult neural stem cells and neurogenesis
10.1016/j.bbagen.2012.09.002 · ExternalCitation · doi-reference
Universal patterns of selection in cancer and somatic tissues
10.1016/j.cell.2017.09.042 · ExternalCitation · doi-reference
Somatic mutations activating the mTOR pathway in dorsal telencephalic progenitors cause a continuum of cortical dysplasias
10.1016/j.celrep.2017.11.106 · ExternalCitation · doi-reference
Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
10.1016/j.expneurol.2004.11.016 · ExternalCitation · doi-reference
Activation of ERK by spontaneous seizures in neural progenitors of the dentate gyrus in a mouse model of epilepsy
10.1016/j.expneurol.2010.03.003 · ExternalCitation · doi-reference
Ganglioglioma cells potentiate neuronal network synchronicity and elicit burst discharges via released factors
10.1016/j.nbd.2023.106364 · ExternalCitation · doi-reference
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment
10.1016/j.neuron.2008.06.023 · ExternalCitation · doi-reference
A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition
10.1016/j.neuron.2008.09.024 · ExternalCitation · doi-reference
Somatic activation of AKT3 causes hemispheric developmental brain malformations
10.1016/j.neuron.2012.03.010 · ExternalCitation · doi-reference
Treatment of refractory epilepsy with MEK inhibitor in patients with RASopathy
10.1016/j.pediatrneurol.2023.08.019 · ExternalCitation · doi-reference
Long-term outcome after temporal lobe surgery—prediction of late worsening of seizure control
10.1016/j.seizure.2005.10.007 · ExternalCitation · doi-reference
The viral hypothesis of mesial temporal lobe epilepsy – is human herpes virus-6 the missing link? A systematic review and meta-analysis
10.1016/j.seizure.2017.11.015 · ExternalCitation · doi-reference
Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat
10.1016/s0006-8993(98)00030-4 · ExternalCitation · doi-reference
Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study
10.1016/s1474-4422(20)30220-9 · ExternalCitation · doi-reference
Temporal lobe epilepsy: analysis of patients with dual pathology
10.1034/j.1600-0404.2003.00183.x · ExternalCitation · doi-reference
Neurogenesis in the adult human hippocampus
10.1038/3305 · ExternalCitation · doi-reference
Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline
10.1038/ncomms7606 · ExternalCitation · doi-reference
De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly
10.1038/ng.2329 · ExternalCitation · doi-reference
Assessment of genetic variant burden in epilepsy-associated brain lesions
10.1038/s41431-019-0484-4 · ExternalCitation · doi-reference
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy
10.1038/s41467-021-21649-8 · ExternalCitation · doi-reference
Molecular landscapes of human hippocampal immature neurons across lifespan
10.1038/s41586-022-04912-w · ExternalCitation · doi-reference
Human hippocampal neurogenesis in adulthood, ageing and Alzheimer’s disease
10.1038/s41586-026-10169-4 · ExternalCitation · doi-reference
BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors
10.1038/s41591-018-0172-x · ExternalCitation · doi-reference
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes
10.1038/s41593-024-01747-8 · ExternalCitation · doi-reference
Ablation of peri-insult generated granule cells after epilepsy onset halts disease progression
10.1038/s41598-017-18237-6 · ExternalCitation · doi-reference
MAPK signal pathways in the regulation of cell proliferation in mammalian cells
10.1038/sj.cr.7290105 · ExternalCitation · doi-reference
ERK activation causes epilepsy by stimulating NMDA receptor activity
10.1038/sj.emboj.7601911 · ExternalCitation · doi-reference
Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
10.1046/j.1471-4159.2002.01085.x · ExternalCitation · doi-reference
Early identification of refractory epilepsy
10.1056/nejm200002033420503 · ExternalCitation · doi-reference
A randomized, controlled trial of surgery for temporal-lobe epilepsy
10.1056/nejm200108023450501 · ExternalCitation · doi-reference
Somatic variants in diverse genes leads to a spectrum of focal cortical malformations
10.1093/brain/awac117 · ExternalCitation · doi-reference
The genomic landscape across 474 surgically accessible epileptogenic human brain lesions
10.1093/brain/awac376 · ExternalCitation · doi-reference
Twins with temporal lobe epilepsy: genetic contributions to hippocampal sclerosis and other subtypes
10.1093/brain/awaf209 · ExternalCitation · doi-reference
Single-nucleus RNA sequencing: immature excitatory neurons and transformed glia build human BRAFV600E-negative gangliogliomas
10.1093/braincomms/fcaf372 · ExternalCitation · doi-reference
COSMIC: the catalogue of somatic mutations in cancer
10.1093/nar/gky1015 · ExternalCitation · doi-reference
New clinicopathological associations and histoprognostic markers in ILAE types of hippocampal sclerosis
10.1111/bpa.12596 · ExternalCitation · doi-reference
International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods
10.1111/epi.12220 · ExternalCitation · doi-reference
Detection of brain somatic variation in epilepsy-associated developmental lesions
10.1111/epi.17323 · ExternalCitation · doi-reference
Somatic variants as a cause of drug-resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis
10.1111/epi.17943 · ExternalCitation · doi-reference
Hippocampal sclerosis--origins and imaging
10.1111/j.1528-1167.2012.03610.x · ExternalCitation · doi-reference
Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus
10.1111/jnc.12035 · ExternalCitation · doi-reference
BRAFV600E expression in neural progenitors results in a hyperexcitable phenotype in neocortical pyramidal neurons
10.1152/jn.00523.2019 · ExternalCitation · doi-reference
Intrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model
10.1152/jn.00835.2014 · ExternalCitation · doi-reference
Rates and patterns of clonal oncogenic mutations in the normal human brain
10.1158/2159-8290.cd-21-0245 · ExternalCitation · doi-reference
Rare variants and de novo variants in mesial temporal lobe epilepsy with hippocampal sclerosis
10.1212/nxg.0000000000000245 · ExternalCitation · doi-reference
A targeted resequencing gene panel for focal epilepsy
10.1212/wnl.0000000000002608 · ExternalCitation · doi-reference
Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development
10.1242/dev.008227 · ExternalCitation · doi-reference
CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons
10.1523/jneurosci.0367-19.2019 · ExternalCitation · doi-reference
Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells
10.1523/jneurosci.0431-07.2007 · ExternalCitation · doi-reference
Ablation of newly generated hippocampal granule cells has disease-modifying effects in epilepsy
10.1523/jneurosci.1371-16.2016 · ExternalCitation · doi-reference
Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus
10.1523/jneurosci.17-10-03727.1997 · ExternalCitation · doi-reference
Granule-like neurons at the Hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis
10.1523/jneurosci.20-16-06144.2000 · ExternalCitation · doi-reference
Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways
10.1523/jneurosci.23-12-05149.2003 · ExternalCitation · doi-reference
Differential regulation of the BDNF gene in cortical and hippocampal neurons
10.1523/jneurosci.2535-21.2022 · ExternalCitation · doi-reference
Dentate gyrus development requires ERK activity to maintain progenitor population and mapk pathway feedback regulation
10.1523/jneurosci.4196-14.2015 · ExternalCitation · doi-reference
Influence of the type of initial precipitating injury and at what age it occurs on course and outcome in patients with temporal lobe seizures
10.3171/jns.1995.82.2.0220 · ExternalCitation · doi-reference
The role of KRAS mutations in cortical malformation and epilepsy surgery: a novel report of nevus sebaceous syndrome and review of the literature
10.3390/brainsci11060793 · ExternalCitation · doi-reference
10.64898/2026.01.26.701822
10.64898/2026.01.26.701822 · ExternalCitation · doi-reference
10.64898/2026.04.06.716727
10.64898/2026.04.06.716727 · ExternalCitation · doi-reference
10.64898/2026.04.18.719347
10.64898/2026.04.18.719347 · ExternalCitation · doi-reference