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References from Differential effects of amyloid-β and tau on UCH gene expression in Drosophila models of Alzheimer’s disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Pathogenesis, diagnostics, and therapeutics for Alzheimer's disease: Breaking the memory barrier
10.1016/j.arr.2024.102481 · 2024 · External reference
The ubiquitin-proteasome system in Alzheimer's disease: Mechanism of action and current status of treatment
10.3389/fnagi.2025.1730206 · 2025 · External reference
Impaired proteasome function in Alzheimer's disease
10.1046/j.1471-4159.2000.0750436.x · 2000 · External reference
UCH-L1 in Alzheimer’s disease: A crucial player in dementia-associated mechanisms
10.3390/ijms26189012 · 2025 · External reference
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
10.1074/jbc.m314124200 · 2004 · External reference
β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1
10.1074/jbc.m113.463711 · 2013 · External reference
Increased cerebrospinal fluid levels of ubiquitin carboxyl-terminal hydrolase L1 in patients with Alzheimer's disease
10.1159/000447239 · 2016 · External reference
Drosophila melanogaster: Deciphering Alzheimer’s disease
10.21315/mjms2016.24.2.2 · 2017 · External reference
Proteostasis disturbances and inflammation in neurodegenerative diseases
10.3390/cells9102183 · 2020 · External reference
The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease
10.1111/jnc.13411 · 2016 · External reference
Tau and neuroinflammation in Alzheimer’s disease: Interplay mechanisms and clinical translation
10.1186/s12974-023-02853-3 · 2023 · External reference
Hydrogen peroxide mediates amyloid β protein toxicity
10.1016/0092-8674(94)90131-7 · 1994 · External reference
beta Amyloid stimulation of microglia and monocytes results in TNFalpha dependent expression of inducible nitric oxide synthase and neuronal apoptosis
2001 · External reference
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
10.1038/s41467-022-29552-6 · 2022 · External reference
Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease
10.1186/s12974-022-02567-y · 2022 · External reference
NF‐κB signaling inhibits ubiquitin carboxyl‐terminal hydrolase L1 gene expression
10.1111/j.1471-4159.2011.07172.x · 2011 · External reference
Sp1 downregulates proinflammatory cytokine–induced catabolic gene expression in nucleus pulposus cells
10.3892/mmr.2016.5730 · 2016 · External reference
UCHL1 regulated by Sp1 ameliorates cochlear hair cell senescence and oxidative damage
10.3892/etm.2023.11793 · 2023 · External reference
Tau and amyloid beta differentially affect the innate immune genes expression in Drosophila models of Alzheimer’s disease and β-D Mannuronic acid (M2000) modulates the dysregulation
10.1016/j.gene.2021.145972 · 2022 · External reference
The Toll→ NFκB signaling pathway mediates the neuropathological effects of the human Alzheimer's Aβ42 polypeptide in Drosophila
10.1371/journal.pone.0003966 · 2008 · External reference
Tau polarizes an aging transcriptional signature to excitatory neurons and glia
10.7554/elife.85251 · 2023 · External reference
Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration
10.1002/alz.70746 · 2025 · External reference
Differential dysregulation of CREB and synaptic genes in transgenic Drosophila melanogaster expressing shaggy (GSK3), TauWT, or Amyloid-beta
10.1007/s11033-022-08059-9 · 2023 · External reference
Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila
10.1016/j.bbrc.2006.05.112 · 2006 · External reference
Dissecting the pathological effects of human Aβ40 and Aβ42 in Drosophila: A potential model for Alzheimer's disease
10.1073/pnas.0400895101 · 2004 · External reference
Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Drosophila model
10.4103/1673-5374.336872 · 2022 · External reference
Systematic Aβ analysis in Drosophila reveals high toxicity for the 1-42, 3-42 and 11-42 peptides, and emphasizes N-and C-terminal residues
10.1371/journal.pone.0133272 · 2015 · External reference
Role of Tau and Amyloid-beta in autophagy gene dysregulation through oxidative stress
10.1016/j.tice.2025.102765 · 2025 · External reference
DNT1 downregulation and increased ethanol sensitivity in transgenic Drosophila models of Alzheimer's disease
10.1016/j.archger.2021.104355 · 2021 · External reference
The distinctive role of tau and amyloid beta in mitochondrial dysfunction through alteration in Mfn2 and Drp1 mRNA Levels: A comparative study in Drosophila melanogaster
10.1016/j.gene.2020.144854 · 2020 · External reference
