Research graph
References from PD-1 expression reprograms tumor-associated macrophages polarization and influences progression and clinical outcomes in lung adenocarcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2021 · External reference
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
FOX-A1 contributes to acquisition of chemoresistance in human lung adenocarcinoma via transactivation of SOX5
10.1016/j.ebiom.2019.05.046 · 2019 · External reference
Lymphocyte-activation gene 3 in non-small-cell lung carcinomas: correlations with clinicopathologic features and prognostic significance
10.1038/s41379-021-00974-9 · 2022 · External reference
Tumor-associated macrophages: polarization, immunoregulation, and immunotherapy
10.3390/cells14100741 · 2025 · External reference
Targeting tumor-associated macrophages to synergize tumor immunotherapy
10.1038/s41392-021-00484-9 · 2021 · External reference
Development of toll-like receptor agonist-loaded nanoparticles as precision immunotherapy for reprogramming tumor-associated macrophages
10.1021/acsami.1c01453 · 2021 · External reference
Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer
10.1186/s13045-020-00887-1 · 2020 · External reference
USP7 targeting modulates anti-tumor immune response by reprogramming tumor-associated macrophages in lung cancer
10.7150/thno.47137 · 2020 · External reference
TPX2 influences the regulation of macrophage polarization via the NF-kappaB pathway in lung adenocarcinoma
10.1016/j.lfs.2024.122437 · 2024 · External reference
Stromal PD-1(+) tumor-associated macrophages predict poor prognosis in lung adenocarcinoma
10.1016/j.humpath.2019.12.007 · 2020 · External reference
Prognostic effect of different PD-L1 expression patterns in squamous cell carcinoma and adenocarcinoma of the cervix
10.1038/modpathol.2016.64 · 2016 · External reference
miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy
10.1038/s41388-018-0178-3 · 2018 · External reference
Correlation between PD-1/PD-L1 expression and polarization in tumor-associated macrophages: a key player in tumor immunotherapy
10.1016/j.cytogfr.2022.07.004 · 2022 · External reference
PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations
10.1080/21645515.2019.1571892 · 2019 · External reference
Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity
10.1016/j.cell.2024.06.036 · 2024 · External reference
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
10.1038/nature22396 · 2017 · External reference
Tumor-associated macrophages regulate PD-1/PD-L1 immunosuppression
10.3389/fimmu.2022.874589 · 2022 · External reference
PD-1 regulates the anti-tumor immune function of macrophages through JAK2-STAT3 signaling pathway in colorectal cancer tumor microenvironment
10.1186/s12967-025-06469-4 · 2025 · External reference
Inhibition of PD-1 alters the SHP1/2-PI3K/Akt axis to decrease M1 polarization of alveolar macrophages in lung ischemia-reperfusion injury
10.1007/s10753-022-01762-6 · 2023 · External reference
Increased PD-1-positive macrophages in the tissue of gastric cancer are closely associated with poor prognosis in gastric cancer patients
10.1186/s12885-020-6629-6 · 2020 · External reference
Reprogramming the immune microenvironment in lung cancer
2025 · External reference
PD-1 expression in tumor infiltrating lymphocytes as a prognostic marker in early-stage non-small cell lung cancer
10.3389/fonc.2024.1414900 · 2024 · External reference
LTA4H improves the tumor microenvironment and prevents HCC progression via targeting the HNRNPA1/LTBP1/TGF-β axis
2025 · External reference
Cancer statistics, 2025
2025 · External reference
The PD-1/PD-L1-checkpoint restrains T cell immunity in tumor-draining lymph nodes
10.1016/j.ccell.2020.09.001 · 2020 · External reference
Regulatory mechanisms of PD-1/PD-L1 in cancers
10.1186/s12943-024-02023-w · 2024 · External reference
B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma
10.1186/s13046-023-02711-3 · 2023 · External reference
Prognostic value of PD-L1 expression in resected lung adenocarcinoma and potential molecular mechanisms
10.7150/jca.26155 · 2018 · External reference
Shaping polarization of tumor-associated macrophages in cancer immunotherapy
2022 · External reference
Tumor-associated macrophages in tumor immunity
10.3389/fimmu.2020.583084 · 2020 · External reference
PDIA3 driven STAT3/PD-1 signaling promotes M2 TAM polarization and aggravates colorectal cancer progression
10.18632/aging.205847 · 2024 · External reference
Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape
10.1186/s12943-018-0928-4 · 2019 · External reference
Protein kinase Cι mediates immunosuppression in lung adenocarcinoma
10.1126/scitranslmed.abq5931 · 2022 · External reference
QSOX1 facilitates dormant esophageal cancer stem cells to evade immune elimination via PD-L1 upregulation and CD8 T cell exclusion
10.1073/pnas.2407506121 · 2024 · External reference
Uncovering therapeutic targets for macrophage-mediated T cell suppression and PD-L1 therapy sensitization
2024 · External reference
The enhanced antitumor activity of bispecific antibody targeting PD-1/PD-L1 signaling
10.1186/s12964-024-01562-5 · 2024 · External reference
TIAM2 contributes to osimertinib resistance, cell motility, and tumor-associated macrophage M2-like polarization in lung adenocarcinoma
10.3390/ijms231810415 · 2022 · External reference
