Research graph
References from Quality by design-assisted development and validation of a sustainable LC–MS/MS method for simultaneous quantification of berahyaluronidase alfa and pembrolizumab in rat plasma: Pharmacokinetic application and comprehensive greenness assessment. Local targets link to admitted publications; unresolved targets remain external evidence.
Pharmacokinetics and bioavailability of pembrolizumab with berahyaluronidase alfa for subcutaneous administration in participants with advanced or metastatic solid tumors: the phase 1 study 3475A-C18
10.1016/j.ejca.2025.115709 · 2025 · External reference
Abstract CT036: bioavailability of MK-3475A (pembrolizumab with berahyaluronidase alfa; "subcutaneous pembrolizumab") in participants with advanced or metastatic solid tumors
10.1158/1538-7445.am2025-ct036 · 2025 · External reference
Subcutaneous administration of pembrolizumab: a paradigm shift toward patient-centered cancer care
10.21037/jtd-2025-1825 · 2025 · External reference
Pembrolizumab (Keytruda)
10.1080/21645515.2016.1199310 · 2016 · External reference
Nivolumab and pembrolizumab as immune-modulating monoclonal antibodies targeting the PD-1 receptor to treat melanoma
10.1586/14737140.2015.1074862 · 2015 · External reference
The safety, tolerability, and pharmacokinetics of ALT-BB4 (a novel recombinant hyaluronidase): a randomized, double-blinded, placebo-controlled, phase 1 study in healthy volunteers
10.1007/s13555-025-01507-x · 2025 · External reference
Abstract CT035: pharmacokinetics (PK), safety, and tolerability of pembrolizumab with berahyaluronidase alfa administered subcutaneously Q3W in participants with advanced melanoma
10.1158/1538-7445.am2025-ct035 · 2025 · External reference
Qualitative and quantitative characterization of protein biotherapeutics with liquid chromatography mass spectrometry
10.1002/mas.21500 · 2017 · External reference
Highly sensitive ligand-binding assays in pre-clinical and clinical applications: immuno-PCR and other emerging techniques
10.1039/c5an00822k · 2015 · External reference
Improvement of hit-to-lead optimization by integration of in vitro HTS experimental models for early determination of pharmacokinetic properties
10.2174/1386207023330101 · 2002 · External reference
Current developments in LC-MS for pharmaceutical analysis
10.1039/c9an02145k · 2020 · External reference
A review on liquid chromatography-tandem mass spectrometry methods for rapid quantification of oncology drugs
10.3390/pharmaceutics10040221 · 2018 · External reference
Development and optimization of liquid chromatography analytical methods by using AQbD principles: overview and recent advances
10.1021/acs.oprd.9b00238 · 2019 · External reference
Green analytical chemistry metrics: a review
10.1016/j.talanta.2021.123046 · 2022 · External reference
Green chemical analysis: main principles and current efforts towards greener analytical methodologies
10.1039/d3ay01644g · 2023 · External reference
MA tool—multi-color assessment platform for white analytical chemistry: unified evaluation of method greenness, practicality, performance, and innovation
10.1016/j.microc.2025.114781 · 2025 · External reference
How to evaluate the greenness and whiteness of analytical procedures?
2025 · External reference
Assessing the greenness and environmental friendliness of analytical methods: modern approaches and recent computational programs
10.1080/10408347.2024.2304552 · 2025 · External reference
Chemometrics sustainability and environmental assessment tools for spectrophotometric determination of β-carotene in foods via supramolecular solvent and the ultrasound-assisted solidified floating organic drop microextraction procedure
10.1016/j.jfca.2025.108657 · 2025 · External reference
Selection of analytical technology and development of analytical procedures using the analytical target profile
10.1021/acs.analchem.1c03854 · 2022 · External reference
Using the analytical target profile to drive the analytical method lifecycle
10.1021/acs.analchem.8b04596 · 2019 · External reference
Development and validation of an LC–MS/MS method for the simultaneous estimation of tadalafil and macitentan in rat plasma: greenness assessment and design of experiment approach
10.1016/j.greeac.2025.100211 · 2025 · External reference
QbD-based, greenness and whiteness-assessed LC–MS/MS method for simultaneous determination of sodium phenylbutyrate and taurursodiol with pharmacokinetic application
10.1016/j.vascn.2026.108417 · 2026 · External reference
Casting a spotlight on factorial design: exploring the power of DoE for experiment screening and optimization: a review
10.5530/ijper.20257373 · 2025 · External reference
Quality by design-driven development, greenness, and whiteness assessment of a robust RP-HPLC method for simultaneous quantification of ellagic, sinapic, and syringic acids
10.1002/sscp.70126 · 2025 · External reference
Stability-indicating RP-HPLC method for lopinavir estimation in pharmaceutical co-crystals: a design of expert approach
10.1002/sscp.202400139 · 2025 · External reference
Eco-friendly LC–MS/MS method for quantitative analysis of deutivacaftor, tezacaftor, and vanzacaftor in rat plasma: optimization via design of experiment and pharmacokinetic evaluation
10.1016/j.microc.2025.114495 · 2025 · External reference
LC–MS/MS-based simultaneous quantification of chlorthalidone and cilnidipine in rat plasma: pharmacokinetic evaluation, green analytical assessment, and DoE-driven optimization
10.1016/j.vascn.2025.108400 · 2025 · External reference
ICH M10 bioanalytical method validation guideline—1 year later
10.1208/s12248-024-00974-y · 2024 · External reference
Unresolved reference
2019 · External reference
Central composite design optimization of salting-out assisted liquid-liquid extraction coupled with LC–MS/MS for sustainable duloxetine bioanalysis in human plasma with application in pharmacokinetic studies
10.1016/j.microc.2026.116880 · 2026 · External reference
A highly sensitive LC–MS/MS method for quantification of AB-38b in rat plasma, liver and kidney tissues: application to a pharmacokinetic study
10.1039/d5ay01136a · 2026 · External reference
AGREE—analytical GREEnness metric approach and software
10.1021/acs.analchem.0c01887 · 2020 · External reference
AGREEprep—analytical greenness metric for sample preparation
10.1016/j.trac.2022.116553 · 2022 · External reference
Analytical eco-scale for assessing the greenness of analytical procedures
10.1016/j.trac.2012.03.013 · 2012 · External reference
Introducing the carbon footprint reduction index (CaFRI) as a software-supported tool for greener laboratories in chemical analysis
10.1186/s13065-025-01486-2 · 2025 · External reference
Click analytical chemistry index as a novel concept and framework, supported with open source software to assess analytical methods
2025 · External reference
Complementary green analytical procedure index (ComplexGAPI) and software
10.1039/d1gc02318g · 2021 · External reference
A total scoring system and software for complex modified GAPI (ComplexMoGAPI) application in the assessment of method greenness
10.1016/j.greeac.2024.100126 · 2024 · External reference
Blue applicability grade index (BAGI) and software: a new tool for the evaluation of method practicality
10.1039/d3gc02347h · 2023 · External reference
