Research graph
References from PM2.5 and the global allergy burden: integrated mechanisms via systemic inflammation and lung microbiome-immune dysregulation. Local targets link to admitted publications; unresolved targets remain external evidence.
Oropharyngeal microbiota clusters in children with asthma or wheeze associate with allergy, blood transcriptomic immune pathways, and exacerbation risk
10.1164/rccm.202211-2107oc · 2023 · External reference
Meta-analysis of fine particulate matter exposure during pregnancy and birth weight: exploring sources of heterogeneity
2024 · External reference
The impact of outdoor pollution and extreme temperatures on asthma-related outcomes: a systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma
10.1111/all.16041 · 2024 · External reference
The impact of outdoor pollution and extreme temperatures on asthma-related outcomes: a systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma
10.1111/all.16041 · 2024 · External reference
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
10.1038/s41577-021-00538-7 · 2021 · External reference
Pathogenesis of PM(2.5)-related disorders in different age groups: children, adults, and the elderly
10.3390/epigenomes8020013 · 2024 · External reference
GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength
10.1016/j.jclinepi.2013.02.003 · 2013 · External reference
Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review
10.1186/s12931-025-03179-9 · 2025 · External reference
Trends in worldwide asthma prevalence
10.1183/13993003.02094-2020 · 2020 · External reference
GRADE guidelines: 3. Rating the quality of evidence
10.1016/j.jclinepi.2010.07.015 · 2011 · External reference
Association between first trimester exposure to ambient PM2.5 and NO2 and congenital heart defects: a population-based cohort study of 1,342,198 live births in Canada
10.1289/ehp11120 · 2023 · External reference
Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline
10.1136/bmj.l6890 · 2020 · External reference
Air pollution and systemic immune biomarkers in early life: A systematic review
10.1016/j.envres.2025.120838 · 2025 · External reference
The role of PM2.5 exposure in lung cancer: mechanisms, genetic factors, and clinical implications
10.1038/s44321-024-00175-2 · 2025 · External reference
Activation of Nrf2 signalling pathway by tectoridin protects against ferroptosis in particulate matter-induced lung injury
10.1111/bph.16085 · 2023 · External reference
Supplementary strategies identified additional eligible studies in qualitative systematic reviews
10.1016/j.jclinepi.2023.04.017 · 2023 · External reference
Gut microbiota maturity mediates the protective effect of siblings on food allergy
10.1016/j.jaci.2023.02.034 · 2023 · External reference
Comprehensive analysis of resilience of human airway epithelial barrier against short-term PM2.5 inorganic dust exposure using in vitro microfluidic chip and ex vivo human airway models
10.1111/all.16179 · 2024 · External reference
Managing the allergy and asthma epidemic in 2020s-Lessons from the Finnish experience
10.1111/all.15266 · 2022 · External reference
Advances and novel developments in mechanisms of allergic inflammation
10.1111/all.14632 · 2020 · External reference
Personal exposure to PM2.5 oxidative potential in association with pulmonary pathophysiologic outcomes in children with asthma
10.1021/acs.est.0c06114 · 2021 · External reference
PM2.5 aggravates NQO1-induced mucus hyper-secretion through release of neutrophil extracellular traps in an asthma model
10.1016/j.ecoenv.2021.112272 · 2021 · External reference
Citation tracking for systematic literature searching: a scoping review
10.1002/jrsm.1635 · 2023 · External reference
SYRCLE's risk of bias tool for animal studies
10.1186/1471-2288-14-43 · 2014 · External reference
Oxidative stress is the pivot for PM2.5-induced lung injury
10.1016/j.fct.2023.114362 · 2024 · External reference
The relationship between outdoor air pollutants and atopic dermatitis of adults: a systematic review and meta-analysis. Asian Pac
2022 · External reference
Evaluation of evidence for interaction between PM2.5 and aeroallergens on childhood asthma exacerbation in Philadelphia, PA, 2011 to 2016
10.1016/j.envres.2023.116395 · 2023 · External reference
A novel herbal extract blend product prevents particulate matters-induced inflammation by improving gut microbiota and maintaining the integrity of the intestinal barrier
10.3390/nu14102010 · 2022 · External reference
Long-term exposure to elemental carbon and disease incidence: a systematic review and meta-analysis
10.1186/s12940-025-01209-z · 2025 · External reference
Does ambient PM2.5 reduce the protective association of leisure-time physical activity with mortality? A systematic review, meta-analysis, and individual-level pooled analysis of cohort studies involving 1.5 million adults
10.1186/s12916-025-04496-y · 2025 · External reference
Respiratory benefits of multisetting air purification in children: a cluster randomized crossover trial
10.1001/jamapediatrics.2024.5049 · 2025 · External reference
PM2.5 exposure perturbs lung microbiome and its metabolic profile in mice
10.1016/j.scitotenv.2020.137432 · 2020 · External reference
PM(2.5) exacerbates nasal epithelial barrier damage in allergic rhinitis mice: A crosstalk between gut microbiota and NLRP3 inflammsome
10.1016/j.ecoenv.2025.118140 · 2025 · External reference
Chemical constituents of PM2.5 and their association with childhood asthma and lung function: a systematic review and meta-analysis
10.1007/s00431-025-06214-5 · 2025 · External reference
PM2.5 contributed to pulmonary epithelial senescence and ferroptosis by regulating USP3-SIRT3-P53 axis. Free Radic
2023 · External reference
PM(2.5) exposure associated with microbiota gut-brain axis: Multi-omics mechanistic implications from the BAPE study
2022 · External reference
Comparing human exposure to fine particulate matter in low and high-income countries: a systematic review of studies measuring personal PM2.5 exposure
10.1016/j.scitotenv.2022.155207 · 2022 · External reference
Fudosteine attenuates lung inflammation in mice with PM2.5-induced asthma exacerbation by inhibiting pyroptosis via the NLRP3/caspase-1/GSDMD pathway
10.1016/j.taap.2025.117346 · 2025 · External reference
Particulate matter exposure is associated with increased inflammatory cytokines and eosinophils in chronic rhinosinusitis
10.1111/all.16006 · 2024 · External reference
The gut-lung axis: a new perspective on the impact of atmospheric particulate matter exposure on chronic obstructive pulmonary disease
10.3389/fimmu.2025.1657675 · 2025 · External reference
Butyrate as a bioactive human milk protective component against food allergy
10.1111/all.14625 · 2021 · External reference
PM2.5 exposure regulates Th1/Th2/Th17 cytokine production through NF-κB signaling in combined allergic rhinitis and asthma syndrome
10.1016/j.intimp.2023.110254 · 2023 · External reference
Subchronic exposure to concentrated ambient PM2.5 perturbs gut and lung microbiota as well as metabolic profiles in mice
10.1016/j.envpol.2020.115987 · 2021 · External reference
Early life microbial exposures and allergy risks: opportunities for prevention
10.1038/s41577-020-00420-y · 2021 · External reference
Development of the SciRAP approach for evaluating the reliability and relevance of in vitro toxicity data
10.3389/ftox.2021.746430 · 2021 · External reference
Reagent and laboratory contamination can critically impact sequence-based microbiome analyses
10.1186/s12915-014-0087-z · 2014 · External reference
Food allergy across the globe
10.1016/j.jaci.2021.10.018 · 2021 · External reference
Salidroside prevents PM2.5-induced BEAS-2B cell apoptosis via SIRT1-dependent regulation of ROS and mitochondrial function
10.1016/j.ecoenv.2022.113170 · 2022 · External reference
Stop searching and you will find it: Search-Resistant Concepts in systematic review searches
10.1136/bmjebm-2023-112798 · 2025 · External reference
Lactobacillus rhamnosus probiotic prevents airway function deterioration and promotes gut microbiome resilience in a murine asthma model
10.1080/19490976.2020.1766345 · 2020 · External reference
ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions
10.1136/bmj.i4919 · 2016 · External reference
RoB 2: a revised tool for assessing risk of bias in randomised trials
10.1136/bmj.l4898 · 2019 · External reference
Neutral polysaccharide from platycodonis radix-ameliorated PM(2.5)-induced lung injury by inhibiting the TLR4/NF-κB p65 pathway and regulating the lung and gut microbiome
10.1021/acs.jafc.4c07319 · 2024 · External reference
The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges
10.1016/j.jaci.2020.08.026 · 2021 · External reference
The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2
10.1016/j.ecoenv.2023.114702 · 2023 · External reference
The effects and pathogenesis of PM2.5 and its components on chronic obstructive pulmonary disease
10.2147/copd.s402122 · 2023 · External reference
The Lung Microbiota Affects Pulmonary Inflammation and Oxidative Stress Induced by PM(2.5) Exposure
10.1021/acs.est.1c08888 · 2022 · External reference
Selenomethionine mitigate PM2.5-induced cellular senescence in the lung via attenuating inflammatory response mediated by cGAS/STING/NF-κB pathway
10.1016/j.ecoenv.2022.114266 · 2022 · External reference
Pretreatment with rosavin attenuates PM2.5-induced lung injury in rats through antiferroptosis via PI3K/Akt/Nrf2 signaling pathway
10.1002/ptr.7606 · 2023 · External reference
PM2.5 Induced Nasal Mucosal Barrier Dysfunction and Epithelial-Mesenchymal Transition to Promote Chronic Rhinosinusitis Through IL4I1-AhR Signaling Pathway
10.3390/toxics13060488 · 2025 · External reference
Unresolved reference
2000 · External reference
Modification of food allergy on the associations between early life exposure to size-specific particulate matter and childhood allergic rhinitis
10.1021/acs.est.3c05532 · 2024 · External reference
Probiotics ameliorates pulmonary inflammation via modulating gut microbiota and rectifying Th17/Treg imbalance in a rat model of PM2.5 induced lung injury
10.1016/j.ecoenv.2022.114060 · 2022 · External reference
PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice
10.1016/j.ecoenv.2021.112433 · 2021 · External reference
PM2.5 promotes macrophage-mediated inflammatory response through airway epithelial cell-derived exosomal miR-155-5p
10.2147/jir.s482509 · 2024 · External reference
Association between ambient fine particulate matter constituents and mortality and morbidity of cardiovascular and respiratory diseases: a systematic review and meta-analysis
10.1016/j.envpol.2025.126476 · 2025 · External reference
The transcription factor XBP1 in dendritic cells promotes the T(H)2 cell response in airway allergy
10.1126/scisignal.abm9454 · 2023 · External reference
Association between air pollution and allergic upper respiratory diseases: a meta-analysis
10.1183/16000617.0266-2024 · 2025 · External reference
PM2.5 and serum metabolome and insulin resistance, potential mediation by the gut microbiome: a population-based panel study of older adults in China
10.1289/ehp9688 · 2022 · External reference
Fine particulate matter induces childhood asthma attacks via extracellular vesicle-packaged Let-7i-5p-mediated modulation of the MAPK signaling pathway
10.1002/advs.202102460 · 2022 · External reference
Respiratory benefits of multisetting air purification in children: a cluster randomized crossover trial
10.1001/jamapediatrics.2024.5049 · ExternalCitation · doi-reference
Fine particulate matter induces childhood asthma attacks via extracellular vesicle-packaged Let-7i-5p-mediated modulation of the MAPK signaling pathway
10.1002/advs.202102460 · ExternalCitation · doi-reference
Citation tracking for systematic literature searching: a scoping review
10.1002/jrsm.1635 · ExternalCitation · doi-reference
Pretreatment with rosavin attenuates PM2.5-induced lung injury in rats through antiferroptosis via PI3K/Akt/Nrf2 signaling pathway
10.1002/ptr.7606 · ExternalCitation · doi-reference
Chemical constituents of PM2.5 and their association with childhood asthma and lung function: a systematic review and meta-analysis
10.1007/s00431-025-06214-5 · ExternalCitation · doi-reference
PM2.5 aggravates NQO1-induced mucus hyper-secretion through release of neutrophil extracellular traps in an asthma model
10.1016/j.ecoenv.2021.112272 · ExternalCitation · doi-reference
PM2.5-induced lung injury is attenuated in macrophage-specific NLRP3 deficient mice
10.1016/j.ecoenv.2021.112433 · ExternalCitation · doi-reference
Salidroside prevents PM2.5-induced BEAS-2B cell apoptosis via SIRT1-dependent regulation of ROS and mitochondrial function
10.1016/j.ecoenv.2022.113170 · ExternalCitation · doi-reference
Probiotics ameliorates pulmonary inflammation via modulating gut microbiota and rectifying Th17/Treg imbalance in a rat model of PM2.5 induced lung injury
10.1016/j.ecoenv.2022.114060 · ExternalCitation · doi-reference
Selenomethionine mitigate PM2.5-induced cellular senescence in the lung via attenuating inflammatory response mediated by cGAS/STING/NF-κB pathway
10.1016/j.ecoenv.2022.114266 · ExternalCitation · doi-reference
The effect of real-ambient PM2.5 exposure on the lung and gut microbiomes and the regulation of Nrf2
10.1016/j.ecoenv.2023.114702 · ExternalCitation · doi-reference
PM(2.5) exacerbates nasal epithelial barrier damage in allergic rhinitis mice: A crosstalk between gut microbiota and NLRP3 inflammsome
10.1016/j.ecoenv.2025.118140 · ExternalCitation · doi-reference
Subchronic exposure to concentrated ambient PM2.5 perturbs gut and lung microbiota as well as metabolic profiles in mice
10.1016/j.envpol.2020.115987 · ExternalCitation · doi-reference
Association between ambient fine particulate matter constituents and mortality and morbidity of cardiovascular and respiratory diseases: a systematic review and meta-analysis
10.1016/j.envpol.2025.126476 · ExternalCitation · doi-reference
Evaluation of evidence for interaction between PM2.5 and aeroallergens on childhood asthma exacerbation in Philadelphia, PA, 2011 to 2016
10.1016/j.envres.2023.116395 · ExternalCitation · doi-reference
Air pollution and systemic immune biomarkers in early life: A systematic review
10.1016/j.envres.2025.120838 · ExternalCitation · doi-reference
Oxidative stress is the pivot for PM2.5-induced lung injury
10.1016/j.fct.2023.114362 · ExternalCitation · doi-reference
PM2.5 exposure regulates Th1/Th2/Th17 cytokine production through NF-κB signaling in combined allergic rhinitis and asthma syndrome
10.1016/j.intimp.2023.110254 · ExternalCitation · doi-reference
The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges
10.1016/j.jaci.2020.08.026 · ExternalCitation · doi-reference
Food allergy across the globe
10.1016/j.jaci.2021.10.018 · ExternalCitation · doi-reference
Gut microbiota maturity mediates the protective effect of siblings on food allergy
10.1016/j.jaci.2023.02.034 · ExternalCitation · doi-reference
GRADE guidelines: 3. Rating the quality of evidence
10.1016/j.jclinepi.2010.07.015 · ExternalCitation · doi-reference
GRADE guidelines: 15. Going from evidence to recommendation-determinants of a recommendation's direction and strength
10.1016/j.jclinepi.2013.02.003 · ExternalCitation · doi-reference
Supplementary strategies identified additional eligible studies in qualitative systematic reviews
10.1016/j.jclinepi.2023.04.017 · ExternalCitation · doi-reference
PM2.5 exposure perturbs lung microbiome and its metabolic profile in mice
10.1016/j.scitotenv.2020.137432 · ExternalCitation · doi-reference
Comparing human exposure to fine particulate matter in low and high-income countries: a systematic review of studies measuring personal PM2.5 exposure
10.1016/j.scitotenv.2022.155207 · ExternalCitation · doi-reference
Fudosteine attenuates lung inflammation in mice with PM2.5-induced asthma exacerbation by inhibiting pyroptosis via the NLRP3/caspase-1/GSDMD pathway
10.1016/j.taap.2025.117346 · ExternalCitation · doi-reference
Personal exposure to PM2.5 oxidative potential in association with pulmonary pathophysiologic outcomes in children with asthma
10.1021/acs.est.0c06114 · ExternalCitation · doi-reference
The Lung Microbiota Affects Pulmonary Inflammation and Oxidative Stress Induced by PM(2.5) Exposure
10.1021/acs.est.1c08888 · ExternalCitation · doi-reference
Modification of food allergy on the associations between early life exposure to size-specific particulate matter and childhood allergic rhinitis
10.1021/acs.est.3c05532 · ExternalCitation · doi-reference
Neutral polysaccharide from platycodonis radix-ameliorated PM(2.5)-induced lung injury by inhibiting the TLR4/NF-κB p65 pathway and regulating the lung and gut microbiome
10.1021/acs.jafc.4c07319 · ExternalCitation · doi-reference
Early life microbial exposures and allergy risks: opportunities for prevention
10.1038/s41577-020-00420-y · ExternalCitation · doi-reference
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
10.1038/s41577-021-00538-7 · ExternalCitation · doi-reference
The role of PM2.5 exposure in lung cancer: mechanisms, genetic factors, and clinical implications
10.1038/s44321-024-00175-2 · ExternalCitation · doi-reference
Lactobacillus rhamnosus probiotic prevents airway function deterioration and promotes gut microbiome resilience in a murine asthma model
10.1080/19490976.2020.1766345 · ExternalCitation · doi-reference
Butyrate as a bioactive human milk protective component against food allergy
10.1111/all.14625 · ExternalCitation · doi-reference
Advances and novel developments in mechanisms of allergic inflammation
10.1111/all.14632 · ExternalCitation · doi-reference
Managing the allergy and asthma epidemic in 2020s-Lessons from the Finnish experience
10.1111/all.15266 · ExternalCitation · doi-reference
Particulate matter exposure is associated with increased inflammatory cytokines and eosinophils in chronic rhinosinusitis
10.1111/all.16006 · ExternalCitation · doi-reference
The impact of outdoor pollution and extreme temperatures on asthma-related outcomes: a systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma
10.1111/all.16041 · ExternalCitation · doi-reference
Comprehensive analysis of resilience of human airway epithelial barrier against short-term PM2.5 inorganic dust exposure using in vitro microfluidic chip and ex vivo human airway models
10.1111/all.16179 · ExternalCitation · doi-reference
Activation of Nrf2 signalling pathway by tectoridin protects against ferroptosis in particulate matter-induced lung injury
10.1111/bph.16085 · ExternalCitation · doi-reference
The transcription factor XBP1 in dendritic cells promotes the T(H)2 cell response in airway allergy
10.1126/scisignal.abm9454 · ExternalCitation · doi-reference
ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions
10.1136/bmj.i4919 · ExternalCitation · doi-reference
RoB 2: a revised tool for assessing risk of bias in randomised trials
10.1136/bmj.l4898 · ExternalCitation · doi-reference
Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline
10.1136/bmj.l6890 · ExternalCitation · doi-reference
Stop searching and you will find it: Search-Resistant Concepts in systematic review searches
10.1136/bmjebm-2023-112798 · ExternalCitation · doi-reference
Oropharyngeal microbiota clusters in children with asthma or wheeze associate with allergy, blood transcriptomic immune pathways, and exacerbation risk
10.1164/rccm.202211-2107oc · ExternalCitation · doi-reference
Trends in worldwide asthma prevalence
10.1183/13993003.02094-2020 · ExternalCitation · doi-reference
Association between air pollution and allergic upper respiratory diseases: a meta-analysis
10.1183/16000617.0266-2024 · ExternalCitation · doi-reference
SYRCLE's risk of bias tool for animal studies
10.1186/1471-2288-14-43 · ExternalCitation · doi-reference
Reagent and laboratory contamination can critically impact sequence-based microbiome analyses
10.1186/s12915-014-0087-z · ExternalCitation · doi-reference
Does ambient PM2.5 reduce the protective association of leisure-time physical activity with mortality? A systematic review, meta-analysis, and individual-level pooled analysis of cohort studies involving 1.5 million adults
10.1186/s12916-025-04496-y · ExternalCitation · doi-reference
Effects of urban airborne particulate matter exposure on the human upper respiratory tract microbiome: a systematic review
10.1186/s12931-025-03179-9 · ExternalCitation · doi-reference
Long-term exposure to elemental carbon and disease incidence: a systematic review and meta-analysis
10.1186/s12940-025-01209-z · ExternalCitation · doi-reference
Association between first trimester exposure to ambient PM2.5 and NO2 and congenital heart defects: a population-based cohort study of 1,342,198 live births in Canada
10.1289/ehp11120 · ExternalCitation · doi-reference
PM2.5 and serum metabolome and insulin resistance, potential mediation by the gut microbiome: a population-based panel study of older adults in China
10.1289/ehp9688 · ExternalCitation · doi-reference
The effects and pathogenesis of PM2.5 and its components on chronic obstructive pulmonary disease
10.2147/copd.s402122 · ExternalCitation · doi-reference
PM2.5 promotes macrophage-mediated inflammatory response through airway epithelial cell-derived exosomal miR-155-5p
10.2147/jir.s482509 · ExternalCitation · doi-reference
The gut-lung axis: a new perspective on the impact of atmospheric particulate matter exposure on chronic obstructive pulmonary disease
10.3389/fimmu.2025.1657675 · ExternalCitation · doi-reference
Development of the SciRAP approach for evaluating the reliability and relevance of in vitro toxicity data
10.3389/ftox.2021.746430 · ExternalCitation · doi-reference
Pathogenesis of PM(2.5)-related disorders in different age groups: children, adults, and the elderly
10.3390/epigenomes8020013 · ExternalCitation · doi-reference
A novel herbal extract blend product prevents particulate matters-induced inflammation by improving gut microbiota and maintaining the integrity of the intestinal barrier
10.3390/nu14102010 · ExternalCitation · doi-reference
PM2.5 Induced Nasal Mucosal Barrier Dysfunction and Epithelial-Mesenchymal Transition to Promote Chronic Rhinosinusitis Through IL4I1-AhR Signaling Pathway
10.3390/toxics13060488 · ExternalCitation · doi-reference
