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References from CLAD: translating basic science to clinical practice. Local targets link to admitted publications; unresolved targets remain external evidence.
Effect of once-per-day tacrolimus versus twice-per-day ciclosporin on 3-year incidence of chronic lung allograft dysfunction after lung transplantation in Scandinavia (ScanCLAD): a multicentre randomised controlled trial
10.1016/s2213-2600(23)00293-x · 2024 · External reference
Prophylactic azithromycin for chronic lung allograft dysfunction following lung transplantation: a systematic review and meta-analysis
10.21037/jtd-2025-365 · 2025 · External reference
Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT
10.1016/j.healun.2019.03.009 · 2019 · External reference
Fibroblasts as regulators of lung immunity, repair and fibrosis
10.1038/s41577-026-01268-4 · 2026 · External reference
The Contribution of Small Airway Obstruction to the Pathogenesis of Chronic Obstructive Pulmonary Disease
10.1152/physrev.00025.2015 · 2017 · External reference
A European multicentre, randomised controlled trial of pirfenidone in bronchiolitis obliterans syndrome after bilateral lung transplantation
10.1183/13993003.02154-2024 · 2026 · External reference
Human lung allografts experience persistent fibrogenic shift following acute cellular rejection
10.1016/j.healun.2026.02.1666 · 2026 · External reference
Exploring fibroblast activation protein as an early biomarker in chronic lung allograft dysfunction
10.1183/13993003.01738-2025 · 2026 · External reference
ISHLT Consensus Statement on Acute Lung Allograft Dysfunction (ALAD): Definition, Etiology, Diagnostic and Therapeutic Approaches, and Research Priorities
10.1016/j.healun.2026.02.1676 · 2026 · External reference
Considerations for Endpoints in Lung Transplant Clinical Trials: An ISHLT Consensus Statement
10.1016/j.healun.2025.09.017 · 2026 · External reference
Sustained Molecular Allograft Injury After Episodes of Acute Rejection and Organizing Pneumonia Increases the Risk of Lung Allograft Failure
10.1097/txd.0000000000001828 · 2025 · External reference
Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease
10.1007/s12016-018-8712-1 · 2019 · External reference
Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop
10.1172/jci.insight.93121 · 2017 · External reference
Murine orthotopic lung transplant models: A comprehensive overview of genetic mismatch degrees and histopathological insights into chronic lung allograft dysfunction
10.1016/j.ajt.2024.07.033 · 2024 · External reference
Precision cut lung slices: an innovative tool for lung transplant research
10.3389/fimmu.2024.1504421 · 2024 · External reference
Emergence of a senescent and inflammatory pulmonary CD4+ T cell population prior to lung allograft failure
10.1126/sciadv.adp9052 · 2025 · External reference
Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression
10.1016/j.healun.2024.02.007 · 2024 · External reference
Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation
10.1084/jem.20212059 · 2022 · External reference
NKG2D blockade impairs tissue-resident memory T cell accumulation and reduces chronic lung allograft dysfunction
10.1172/jci.insight.184048 · 2025 · External reference
Role of Th17 cells and IL-17 in lung transplant rejection
10.1007/s00281-011-0257-9 · 2011 · External reference
Donor IL-17 receptor A regulates LPS-potentiated acute and chronic murine lung allograft rejection
10.1172/jci.insight.158002 · 2023 · External reference
Intragraft regulatory T cells in the modern era: what can high-dimensional methods tell us about pathways to allograft acceptance?
10.3389/fimmu.2023.1291649 · 2023 · External reference
Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials
10.1016/s0140-6736(20)30167-7 · 2020 · External reference
Ex vivo delivery of regulatory T-cells for control of alloimmune priming in the donor lung
10.1183/13993003.00798-2021 · 2022 · External reference
Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism
10.1073/pnas.1414189111 · 2014 · External reference
Belumosudil for chronic graft-versus-host disease after 2 or more prior lines of therapy: the ROCKstar Study
10.1182/blood.2021012021 · 2021 · External reference
Extracorporeal photopheresis: a case of immunotherapy ahead of its time
10.1159/000508479 · 2020 · External reference
Extracorporeal photopheresis for the prevention of rejection after lung transplantation: a prospective randomised controlled trial
2025 · External reference
The value of extracorporeal photopheresis as an immunosuppression-modifying approach in solid organ transplantation: a potential solution to an unmet medical need
10.3389/fimmu.2024.1371554 · 2024 · External reference
De Novo DQ Donor-Specific Antibodies Are Associated with Chronic Lung Allograft Dysfunction after Lung Transplantation
10.1164/rccm.201509-1857oc · 2016 · External reference
Intragraft donor-specific anti-HLA antibodies in phenotypes of chronic lung allograft dysfunction
10.1183/13993003.00847-2019 · 2019 · External reference
Impaired complement regulation drives chronic lung allograft dysfunction after lung transplantation
10.1172/jci188891 · 2026 · External reference
Assessing the role of phosphorylated S6 ribosomal protein in the pathological diagnosis of pulmonary antibody-mediated rejection
10.1016/j.healun.2023.10.002 · 2024 · External reference
Donor-specific antibody characteristics, including persistence and complement-binding capacity, increase risk for chronic lung allograft dysfunction
10.1016/j.healun.2020.09.003 · 2020 · External reference
B Cell Immunity in Lung Transplant Rejection - Effector Mechanisms and Therapeutic Implications
10.3389/fimmu.2022.845867 · 2022 · External reference
Preemptive treatment of de novo donor-specific antibodies in lung transplant patients reduces subsequent risk of chronic lung allograft dysfunction or death
10.1016/j.ajt.2022.12.019 · 2023 · External reference
Chronic lung allograft dysfunction is associated with an increased number of non-HLA antibodies
10.1016/j.healun.2023.12.007 · 2024 · External reference
Antibodies to K-α 1 tubulin and collagen V are associated with chronic rejection after lung transplantation
10.1111/j.1600-6143.2012.04079.x · 2012 · External reference
Humoral immunity to lung antigens early post-transplant confers risk for chronic lung allograft dysfunction
10.1016/j.healun.2025.02.1577 · 2025 · External reference
Immunological diversity in phenotypes of chronic lung allograft dysfunction: a comprehensive immunohistochemical analysis
10.1111/tri.12882 · 2017 · External reference
High-dimensional tissue profiling of immune cell responses in chronic lung allograft dysfunction
10.1016/j.healun.2024.11.021 · 2025 · External reference
Local intragraft humoral immune responses in chronic lung allograft dysfunction
10.1016/j.healun.2024.07.019 · 2025 · External reference
The role of innate immunity in the long-term outcome of lung transplantation
10.21037/atm.2020.03.20 · 2020 · External reference
CD16(+) natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction
10.1016/j.ajt.2022.10.006 · 2023 · External reference
NKG2C Natural Killer Cells in Bronchoalveolar Lavage Are Associated With Cytomegalovirus Viremia and Poor Outcomes in Lung Allograft Recipients
10.1097/tp.0000000000002450 · 2019 · External reference
Elevated bronchoalveolar lavage eosinophilia correlates with poor outcome after lung transplantation
10.1097/tp.0b013e3182a6bae2 · 2014 · External reference
Deciphering the role of eosinophils in solid organ transplantation
10.1111/ajt.15660 · 2020 · External reference
Single-cell dissection of chronic lung allograft dysfunction reveals convergent and distinct fibrotic mechanisms
10.1172/jci.insight.197579 · 2025 · External reference
Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantation
10.1016/j.healun.2022.05.005 · 2022 · External reference
Axatilimab in Recurrent or Refractory Chronic Graft-versus-Host Disease
10.1056/nejmoa2401537 · 2024 · External reference
Lung microbiome quantification and bacterial density as prognostic markers in lung transplantation
10.1016/j.healun.2025.12.017 · 2026 · External reference
The Lung Microbiome Predicts Mortality and Response to Azithromycin in Lung Transplant Recipients with Chronic Rejection
10.1164/rccm.202308-1326oc · 2024 · External reference
Airway Microbiota Determines Innate Cell Inflammatory or Tissue Remodeling Profiles in Lung Transplantation
10.1164/rccm.201512-2424oc · 2016 · External reference
The lung microbiome in lung transplantation
10.1016/j.healun.2021.04.014 · 2021 · External reference
Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation
10.1067/mtc.2003.166 · 2003 · External reference
Identification of Lung Transplant Recipients with a Survival Benefit after Fundoplication
2021 · External reference
Utility of bile acids in large airway bronchial wash versus bronchoalveolar lavage as biomarkers of microaspiration in lung transplant recipients: a retrospective cohort study
10.1186/s12931-022-02131-5 · 2022 · External reference
Aspiration of conjugated bile acids predicts adverse lung transplant outcomes and correlates with airway lipid and cytokine dysregulation
10.1016/j.healun.2021.05.007 · 2021 · External reference
Airway pepsinogen A4 identifies lung transplant recipients with microaspiration and predicts chronic lung allograft dysfunction
10.1016/j.healun.2024.01.002 · 2024 · External reference
Pulmonary epithelial markers in phenotypes of chronic lung allograft dysfunction
10.1016/j.healun.2023.03.009 · 2023 · External reference
Club Cell Secretory Protein in Lung Disease: Emerging Concepts and Potential Therapeutics
10.1146/annurev-med-042921-123443 · 2023 · External reference
Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study
10.1016/j.healun.2023.02.1495 · 2023 · External reference
Reduced lung fluid club cell secretory protein informs chronic lung allograft dysfunction risk
10.1183/13993003.00182-2025 · 2026 · External reference
JAK-STAT activation contributes to cytotoxic T cell-mediated basal cell death in human chronic lung allograft dysfunction
10.1172/jci.insight.167082 · 2023 · External reference
Depletion of Airway Submucosal Glands and TP63(+)KRT5(+) Basal Cells in Obliterative Bronchiolitis
10.1164/rccm.201707-1368oc · 2018 · External reference
Short airway telomeres are associated with primary graft dysfunction and chronic lung allograft dysfunction
10.1016/j.healun.2023.08.018 · 2023 · External reference
The ASSIST CLAD study: A phase 2 randomized controlled trial of mesenchymal stromal cells for new-onset chronic lung allograft dysfunction
10.1016/j.healun.2026.03.032 · 2026 · External reference
Identification of a bone marrow-derived epithelial-like population capable of repopulating injured mouse airway epithelium
2009 · External reference
Small airway brush gene expression predicts chronic lung allograft dysfunction and mortality
10.1016/j.healun.2024.07.010 · 2024 · External reference
Persistent and progressive acute lung allograft dysfunction is linked to cell compositional and transcriptional changes in small airways
10.1016/j.healun.2025.03.010 · 2025 · External reference
Analysis of BAL extracellular vesicles unveils NF-kappaB activation at the onset of chronic lung allograft dysfunction
10.1042/cs20258651 · 2026 · External reference
Extracellular Vesicles in Lung Transplantation: Biomarkers, Pathophysiological Players, and Therapeutic Weapons?
10.1002/eji.70042 · 2025 · External reference
Circulating Vesicular-bound HLA-G as Noninvasive Predictive Biomarker of CLAD After Lung Transplantation
10.1097/tp.0000000000005175 · 2025 · External reference
The ASSIST CLAD study: A phase 2 randomized controlled trial of mesenchymal stromal cells for new-onset chronic lung allograft dysfunction
10.1016/j.healun.2026.03.032 · 2026 · External reference
Genome-wide association study reveals two novel genetic loci associated with chronic lung allograft dysfunction
10.1016/j.healun.2026.03.011 · 2026 · External reference
Description and first insights on a large genomic biobank of lung transplantation
10.1038/s41431-024-01683-y · 2025 · External reference
Inhaled immunosuppressants after lung transplantation -real potential to enhance patient outcomes
10.1080/17476348.2024.2434152 · 2024 · External reference
CD94(+) natural killer cells potentiate pulmonary ischaemia-reperfusion injury
10.1183/13993003.02171-2023 · 2024 · External reference
CD38-targeted therapy with Daratumumab in clinical lung transplantation: A single-center experience
10.1016/j.jhlto.2025.100386 · 2025 · External reference
A Randomized Phase 2 Trial of Felzartamab in Antibody-Mediated Rejection
10.1056/nejmoa2400763 · 2024 · External reference
Short-course rapamycin treatment preserves airway epithelium and protects against bronchiolitis obliterans
10.1016/j.athoracsur.2013.04.068 · 2013 · External reference