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References from Precision Oncology in Melanoma and Skin Cancer Surgery. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.hoc.2009.03.006
10.1016/j.hoc.2009.03.006 · External reference
High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
10.1200/jco.1999.17.7.2105 · 1999 · External reference
10.1186/1479-5876-10-85
10.1186/1479-5876-10-85 · External reference
10.1158/1535-7163.mct-10-0799
10.1158/1535-7163.mct-10-0799 · External reference
Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
10.1056/nejmoa1002011 · 2010 · External reference
BRIM-2: An open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAF V600E mutation-positive metastatic melanoma
10.1200/jco.2011.29.15_suppl.8509 · 2011 · External reference
Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
10.1056/nejmoa1103782 · 2011 · External reference
Phase I/II study of GSK2118436, a selective inhibitor of oncogenic mutant BRAF kinase, in patients with metastatic melanoma and other solid tumors
10.1200/jco.2010.28.15_suppl.8503 · 2010 · External reference
BREAK-2: a phase IIA trial of the selective BRAF kinase inhibitor GSK2118436 in patients with BRAF mutation-positive (V600E/K) metastatic melanoma
2011 · External reference
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
2012 · External reference
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
10.1038/nature09626 · 2010 · External reference
Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy
10.1158/2159-8290.cd-13-0642 · 2014 · External reference
Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
10.1200/jco.2010.33.2312 · 2011 · External reference
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
2011 · External reference
Vemurafenib in patients with BRAFV600 mutation-positive metastatic melanoma: Final overall survival results of the randomized BRIM-3 study
10.1093/annonc/mdx339 · 2017 · External reference
Long-term outcomes in patients with BRAF V600-mutant metastatic melanoma receiving dabrafenib monotherapy: Analysis from phase 2 and 3 clinical trials
10.1016/j.ejca.2019.10.033 · 2020 · External reference
Phase II study of the MEK1/MEK2 inhibitor trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor
10.1200/jco.2012.43.5966 · 2013 · External reference
Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma
10.1056/nejmoa1203421 · 2012 · External reference
Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations
10.1056/nejmoa1210093 · 2012 · External reference
Combined Vemurafenib and Cobimetinib in BRAF -Mutated Melanoma
2014 · External reference
Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial
10.1016/s1470-2045(16)30122-x · 2016 · External reference
5-year outcomes with cobimetinib plus vemurafenib in BRAFV600 mutation⇓positive advanced melanoma: Extended follow-up of the coBRIM study
10.1158/1078-0432.ccr-21-0809 · 2021 · External reference
Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: A multicentre, double-blind, phase 3 randomised controlled trial
2015 · External reference
Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib
10.1056/nejmoa1412690 · 2015 · External reference
Somatic activation of KIT in distinct subtypes of melanoma
10.1200/jco.2006.06.2984 · 2006 · External reference
STAT3 Mediates Nilotinib Response in KIT-Altered Melanoma: A Phase II Multicenter Trial of the French Skin Cancer Network
10.1016/j.jid.2017.07.839 · 2018 · External reference
A phase 2 trial of dasatinib in patients with locally advanced or stage IV mucosal, acral, or vulvovaginal melanoma: A trial of the ECOG-ACRIN Cancer Research Group (E2607)
10.1002/cncr.30663 · 2017 · External reference
Biomarker Analysis in a Phase II Study of Sunitinib in Patients with Advanced Melanoma
2015 · External reference
Treatment of NRAS-mutant melanoma
10.1007/s11864-015-0330-z · 2015 · External reference
Phase I Study of LY2940680, a Smo Antagonist, in Patients with Advanced Cancer Including Treatment-Naïve and Previously Treated Basal Cell Carcinoma
10.1158/1078-0432.ccr-17-0723 · 2018 · External reference
PD-1 Blockade with Cemiplimab in Advanced Cutaneous Squamous-Cell Carcinoma
10.1056/nejmoa1805131 · 2018 · External reference
Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 study): an open-label, nonrandomized, multicenter, phase II trial
10.1016/j.annonc.2021.07.008 · 2021 · External reference
Neoadjuvant Imatinib in Advanced Primary or Locally Recurrent Dermatofibrosarcoma Protuberans: A Multicenter Phase II DeCOG Trial with Long- term Follow-up
10.1158/1078-0432.ccr-13-1411 · 2014 · External reference
Efficacy and Biological Activity of Imatinib in Metastatic Dermatofibrosarcoma Protuberans(DFSP)
10.1158/1078-0432.ccr-15-1243 · 2016 · External reference
PD-1/PD-L1 pathway: current researches in cancer
2020 · External reference
The blockade of immune checkpoints in cancer immunotherapy
10.1038/nrc3239 · 2012 · External reference
Pooled analysis of long-term survival data from phase II and phase III trials of ipilimumab in unresectable or metastatic melanoma
10.1200/jco.2014.56.2736 · 2015 · External reference
Efficacy of PD-1/PD-L1 blockade monotherapy in clinical trials
10.1177/1758835920937612 · 2020 · External reference
Nivolumab in Previously Untreated Melanoma without BRAF Mutation
10.1056/nejmoa1412082 · 2015 · External reference
Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial
10.1016/s1470-2045(15)70076-8 · 2015 · External reference
Overall survival in patients with advanced melanoma who received nivolumab versus investigator’s choice chemotherapy in CheckMate 037: A Randomized, Controlled, Open-Label Phase III Trial
10.1200/jco.2016.71.8023 · 2018 · External reference
Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial
10.1016/s1470-2045(15)00083-2 · 2015 · External reference
Final overall survival for KEYNOTE-002: pembrolizumab (pembro) versus investigator-choice chemotherapy (chemo) for ipilimumab (ipi)-refractory melanoma
10.1093/annonc/mdw379.02 · 2016 · External reference
Pembrolizumab versus Ipilimumab in Advanced Melanoma
10.1056/nejmoa1503093 · 2015 · External reference
Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006)
10.1016/s0140-6736(17)31601-x · 2017 · External reference
Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma
10.1200/jco.21.02229 · 2022 · External reference
Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma
10.1056/nejmoa2109970 · 2022 · External reference
Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
10.1056/nejmoa1709684 · 2017 · External reference
Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): A randomised, double-blind, phase 3 trial
10.1016/s1470-2045(15)70122-1 · 2015 · External reference
Adjuvant ipilimumab versus placebo after complete resection of stage III melanoma: long-term follow-up results of the European Organisation for Research and Treatment of Cancer 18071 double-blind phase 3 randomised trial
10.1016/j.ejca.2019.07.001 · 2019 · External reference
Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma
10.1056/nejmoa1802357 · 2018 · External reference
Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): distant metastasis-free survival results from a double-blind, randomised, controlled, phase 3 trial
10.1016/s1470-2045(21)00065-6 · 2021 · External reference
Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma
10.1056/nejmoa1709030 · 2017 · External reference
Neoadjuvant therapy for melanoma: rationale for neoadjuvant therapy and pivotal clinical trials
10.1177/17588359221083052 · 2022 · External reference
Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma
10.1038/s41591-018-0198-0 · 2018 · External reference
Identification of the optimal combination dosing schedule of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma (OpACIN-neo): a multicentre, phase 2, randomised, controlled trial
10.1016/s1470-2045(19)30151-2 · 2019 · External reference
Neoadjuvant–Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma
10.1056/nejmoa2211437 · 2023 · External reference
Society for immunotherapy of cancer (sitc) clinical practice guideline on immune checkpoint inhibitor-related adverse events
10.1136/jitc-2021-002435 · 2021 · External reference
Management of Immunotherapy-Related Toxicities, Version 1.2022, NCCN Clinical Practice Guidelines in Oncology
2022 · External reference
Survival data of PRADO: A phase 2 study of personalized response-driven surgery and adjuvant therapy after neoadjuvant ipilimumab (IPI) and nivolumab (NIVO) in resectable stage III melanoma
10.1200/jco.2022.40.16_suppl.9501 · 2022 · External reference
Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
10.1056/nejmoa1406498 · 2014 · External reference
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
10.1126/science.aad0095 · 2015 · External reference
Tumor Mutational Burden, Toxicity, and Response of Immune Checkpoint Inhibitors Targeting PD(L)1, CTLA-4, and Combination: A Meta-regression Analysis
10.1158/1078-0432.ccr-20-0458 · 2020 · External reference
Comprehensive cancer-gene panels can be used to estimate mutational load and predict clinical benefit to PD-1 blockade in clinical practice
10.18632/oncotarget.5950 · 2015 · External reference
IFN-γ-related mRNA profile predicts clinical response to PD-1 blockade
10.1172/jci91190 · 2017 · External reference
Survival and biomarker analyses from the OpACIN-neo and OpACIN neoadjuvant immunotherapy trials in stage III melanoma
10.1038/s41591-020-01211-7 · 2021 · External reference
IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma
2023 · External reference
Early Use of High-Dose Glucocorticoid for the Management of irAE Is Associated with Poorer Survival in Patients with Advanced Melanoma Treated with Anti-PD-1 Monotherapy
10.1158/1078-0432.ccr-21-1283 · 2021 · External reference
Circulating cytokines predict immune-related toxicity in melanoma patients receiving anti-PD-1–based immunotherapy
10.1158/1078-0432.ccr-18-2795 · 2019 · External reference
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma
10.1038/s41591-021-01623-z · 2022 · External reference
Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors
10.1016/j.medj.2022.12.007 · 2023 · External reference
Predicting response and toxicity to immune checkpoint inhibitors in lung cancer using antibodies to frameshift neoantigens
10.1186/s12967-023-04172-w · 2023 · External reference
Predictive Biomarkers for Checkpoint Inhibitor Immune-Related Adverse Events
10.3390/cancers15051629 · 2023 · External reference
Atezolizumab, vemurafenib, and cobimetinib as first-line treatment for unresectable advanced BRAFV600 mutation-positive melanoma (IMspire150): primary analysis of the randomised, double-blind, placebo-controlled, phase 3 trial
10.1016/s0140-6736(20)30934-x · 2020 · External reference
Overall survival with first-line atezolizumab in combination with vemurafenib and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, randomised, phase 3 study
10.1016/s1470-2045(22)00687-8 · 2023 · External reference
KEYNOTE-022 part 3: A randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF-mutant melanoma
10.1136/jitc-2020-001806 · 2020 · External reference
Metastasectomy for Tumor-Infiltrating Lymphocytes: An Emerging Operative Indication in Surgical Oncology
10.1245/s10434-017-6266-8 · 2018 · External reference
Surgical Considerations for Tumor Tissue Procurement to Obtain Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
10.1097/ppo.0000000000000608 · 2022 · External reference
Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma
10.4049/jimmunol.138.3.989 · 1987 · External reference
Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report [see comments]
10.1056/nejm198812223192527 · 1988 · External reference
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
10.1084/jem.20050732 · 2005 · External reference
Tumour-infiltrating lymphocytes and interleukin-2 in treatment of advanced cancer
10.1016/s0140-6736(89)91609-7 · 1989 · External reference
Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2
10.1093/jnci/86.15.1159 · 1994 · External reference
A Phase I Study of Nonmyeloablative Chemotherapy and Adoptive Transfer of Autologous Tumor Antigen-Specific T Lymphocytes in Patients With Metastatic Melanoma
10.1097/00002371-200205000-00007 · 2002 · External reference
Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
10.1200/jco.2005.00.240 · 2005 · External reference
Adoptive cell therapy for patients with metastatic melanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens
10.1200/jco.2008.16.5449 · 2008 · External reference
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
10.1158/1078-0432.ccr-11-0116 · 2011 · External reference
Efficacy of adoptive cell transfer of tumor-infiltrating lymphocytes after lymphopenia induction for metastatic melanoma
10.1097/cji.0b013e31826e8f5f · 2012 · External reference
Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: Intent-to-treat analysis and efficacy after failure to prior immunotherapies
10.1158/1078-0432.ccr-13-0380 · 2013 · External reference
Randomized, prospective evaluation comparing intensity of lymphodepletion before adoptive transfer of tumor-infiltrating lymphocytes for patients with metastatic melanoma
10.1200/jco.2016.66.7220 · 2016 · External reference
Safety and efficacy of cryopreserved autologous tumor infiltrating lymphocyte therapy (LN-144, lifileucel) in advanced metastatic melanoma patients who progressed on multiple prior therapies including anti-PD-1
10.1200/jco.2019.37.15_suppl.2518 · 2019 · External reference
Impact of prior treatment on the efficacy of adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma
10.1158/1078-0432.ccr-21-1171 · 2021 · External reference
Neoantigen Identification and Response to Adoptive Cell Transfer in Anti–PD-1 Naïve and Experienced Patients with Metastatic Melanoma
10.1158/1078-0432.ccr-21-4499 · 2022 · External reference
Primary and acquired resistance to immune checkpoint inhibitors in metastatic melanoma
10.1158/1078-0432.ccr-17-2267 · 2018 · External reference
Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma
10.1200/jco.21.00612 · 2021 · External reference
10.1136/jitc-2022-005755
10.1136/jitc-2022-005755 · 2022 · External reference