Research graph
References from The Cardiac Calcium Handling Machinery is Remodeled in Friedreich’s Ataxia. Local targets link to admitted publications; unresolved targets remain external evidence.
Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity
10.1126/science.1098991 · 2004 · External reference
Molecular insights into frataxin-mediated iron supply for heme biosynthesis in Bacillus subtilis
10.1371/journal.pone.0122538 · 2015 · External reference
Clinical features of Friedreich ataxia
10.1177/0883073812448230 · 2012 · External reference
Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity
10.1371/journal.pone.0225147 · 2019 · External reference
Dilated Cardiomyopathy in Friedreich's Ataxia: 2D Echo and Tissue-Doppler Analysis of Left Ventricular and Atrial Function
10.1016/s1525-2167(03)00013-1 · 2003 · External reference
Friedreich's ataxia-associated childhood hypertrophic cardiomyopathy: a national cohort study
10.1136/archdischild-2021-322455 · 2022 · External reference
Friedreich ataxia: molecular mechanisms, redox considerations, and therapeutic opportunities
10.1089/ars.2009.3015 · 2010 · External reference
Frataxin activates mitochondrial energy conversion and oxidative phosphorylation
10.1073/pnas.220403797 · 2000 · External reference
Phospholamban: a crucial regulator of cardiac contractility
10.1038/nrm1151 · 2003 · External reference
Mechanisms of Altered Ca2+ Handling in Heart Failure
10.1161/circresaha.113.301651 · 2013 · External reference
Role of Ca(2+) in healthy and pathologic cardiac function: from normal excitation-contraction coupling to mutations that cause inherited arrhythmia
10.1007/s00204-022-03385-0 · 2023 · External reference
Inherited Dysfunction of Sarcoplasmic Reticulum Ca2+ Handling and Arrhythmogenesis
10.1161/circresaha.110.226845 · 2011 · External reference
Phospholamban inhibitory function is activated by depolymerization
10.1074/jbc.272.24.15061 · 1997 · External reference
Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits
10.1038/84818 · 2001 · External reference
Cardiomyopathy in Friedreich ataxia: clinical findings and research
10.1177/0883073812448535 · 2012 · External reference
Friedreich's ataxia. Revision of the phenotype according to molecular genetics
10.1093/brain/120.12.2131 · 1997 · External reference
The measurement of the QT interval
10.2174/1573403x10666140514103612 · 2014 · External reference
Normal Ventricular Repolarization and QT Interval: Ionic Background, Modifiers, and Measurements
10.1016/j.ccep.2017.05.007 · 2017 · External reference
Misinterpretation of the mouse ECG: 'musing the waves of Mus musculus'
10.1113/jphysiol.2014.279380 · 2014 · External reference
Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology
10.1152/ajpheart.00528.2017 · 2017 · External reference
Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice
10.1161/circresaha.110.239574 · 2011 · External reference
Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging
10.1093/gerona/gly139 · 2019 · External reference
A Protocol for Collecting Human Cardiac Tissue for Research
2016 · External reference
In-depth proteomic profiling of left ventricular tissues in human end-stage dilated cardiomyopathy
10.18632/oncotarget.15689 · 2017 · External reference
Use of the REVERT(®) total protein stain as a loading control demonstrates significant benefits over the use of housekeeping proteins when analyzing brain homogenates by Western blot: An analysis of samples representing different gonadal hormone states
10.1016/j.mce.2018.01.015 · 2018 · External reference
Purification of RNA using TRIzol (TRI reagent)
10.1101/pdb.prot5439 · 2010 · External reference
Frataxin gene editing rescues Friedreich’s ataxia pathology in dorsal root ganglia organoid-derived sensory neurons
10.1038/s41467-020-17954-3 · 2020 · External reference
Real time PCR quantification of frataxin mRNA in the peripheral blood leucocytes of Friedreich ataxia patients and carriers
10.1136/jnnp.2003.028605 · 2004 · External reference
A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates
10.1152/ajpheart.1985.249.5.h1056 · 1985 · External reference
Ca2+ current-gated focal and local Ca2+ release in rat atrial myocytes: evidence from rapid 2-D confocal imaging
10.1113/jphysiol.2002.024190 · 2002 · External reference
Enhancement of contraction and L-type Ca(2+) current by murrayafoline-A via protein kinase C in rat ventricular myocytes
10.1016/j.ejphar.2016.05.005 · 2016 · External reference
Mitochondrial Ca(2+) uptake in skeletal muscle health and disease
10.1007/s11427-016-5089-3 · 2016 · External reference
Regulation of myocardial function by histidine-rich, calcium-binding protein
10.1152/ajpheart.01211.2003 · 2004 · External reference
Cardiac Na+-Ca2+ exchanger: dynamics of Ca2+-dependent activation and deactivation in intact myocytes
10.1113/jphysiol.2013.252080 · 2013 · External reference
The reverse mode of the Na+/Ca2+ exchanger contributes to the pacemaker mechanism in rabbit sinus node cells
10.1038/s41598-022-25574-8 · 2022 · External reference
Caffeine-induced Ca2+ sparks in mouse ventricular myocytes
10.1152/ajpheart.2000.278.2.h666 · 2000 · External reference
The Effects of Exogenous Calcium Buffers on the Systolic Calcium Transient in Rat Ventricular Myocytes
10.1016/s0006-3495(01)76161-9 · 2001 · External reference
Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor
10.1042/bj20080489 · 2008 · External reference
Caffeine-induced contractions in developing rabbit heart
10.1203/00006450-199709000-00007 · 1997 · External reference
Mitochondrial membrane potential
10.1016/j.ab.2017.07.009 · 2018 · External reference
Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives
10.1016/s0006-3495(99)77214-0 · 1999 · External reference
Mitochondrial membrane potential probes and the proton gradient: a practical usage guide
10.2144/000113610 · 2011 · External reference
The mitochondrial membrane potential and Ca2+ oscillations in smooth muscle
10.1242/jcs.014522 · 2008 · External reference
Mitochondrial production of reactive oxygen species contributes to the β-adrenergic stimulation of mouse cardiomycytes
10.1113/jphysiol.2010.202838 · 2011 · External reference
Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload
10.1152/ajpheart.00638.2014 · 2015 · External reference
TNF-α-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes
10.1093/cvr/cvu112 · 2014 · External reference
Transthoracic echocardiography reference values in juvenile and adult 129/Sv mice
10.1186/1476-7120-11-12 · 2013 · External reference
Ryanodine Receptor S2808 Phosphorylation in Heart Failure
10.1161/circresaha.112.265579 · 2012 · External reference
Elevated Sarcoplasmic Reticulum Ca2+ Leak in Intact Ventricular Myocytes From Rabbits in Heart Failure
10.1161/01.res.0000093399.11734.b3 · 2003 · External reference
Frequency-encoding Thr17 Phospholamban Phosphorylation Is Independent of Ser16 Phosphorylation in Cardiac Myocytes
10.1074/jbc.c000253200 · 2000 · External reference
Role of phospholamban phosphorylation on Thr17 in cardiac physiological and pathological conditions
10.1016/j.cardiores.2005.08.010 · 2005 · External reference
Calcium Deregulation: Novel Insights to Understand Friedreich's Ataxia Pathophysiology
10.3389/fncel.2018.00264 · 2018 · External reference
Correlation between frataxin expression and contractility revealed by in vitro Friedreich’s ataxia cardiac tissue models engineered from human pluripotent stem cells
10.1186/s13287-019-1305-y · 2019 · External reference
Modeling of Friedreich ataxia-related iron overloading cardiomyopathy using patient-specific-induced pluripotent stem cells
10.1007/s00424-013-1414-x · 2014 · External reference
Efficient attenuation of Friedreich's ataxia (FRDA) cardiomyopathy by modulation of iron homeostasis-human induced pluripotent stem cell (hiPSC) as a drug screening platform for FRDA
10.1016/j.ijcard.2015.11.101 · 2016 · External reference
Poincaré plot analysis of electrocardiogram uncovers beneficial effects of omaveloxolone in a mouse model of Friedreich's ataxia
10.1016/j.hrthm.2024.12.041 · 2025 · External reference
Fixing ryanodine receptor Ca leak - a novel therapeutic strategy for contractile failure in heart and skeletal muscle
10.1016/j.ddmec.2010.09.009 · 2010 · External reference
Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases
10.3390/ijms23084435 · 2022 · External reference
Preventing the phosphorylation of RyR2 at canonical sites reduces Ca2+ leak and promotes arrhythmia by reactivating the INa current
10.1038/s44161-025-00693-3 · 2025 · External reference
