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References from Insulin resistance mediates the relationship between cardiovascular-kidney-metabolic syndrome and depression: A cross-sectional analysis. Local targets link to admitted publications; unresolved targets remain external evidence.
Global, regional, and national time trends in incidence for depressive disorders, from 1990 to 2019: an age-period-cohort analysis for the GBD 2019
10.1186/s12991-024-00513-1 · 2024 · External reference
Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010
10.1371/journal.pmed.1001547 · 2013 · External reference
Temporal and spatial trend analysis of all-cause depression burden based on global burden of disease (GBD) 2019 study
2024 · External reference
Cardiovascular-kidney-metabolic syndrome: a step toward multidisciplinary and inclusive care
10.1016/j.cmet.2023.10.015 · 2023 · External reference
The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies
10.1038/tp.2016.261 · 2017 · External reference
Depression and cardiovascular disease: a clinical review
10.1093/eurheartj/eht462 · 2014 · External reference
Bidirectional relations between depression symptoms and chronic kidney disease
10.1016/j.jad.2022.05.104 · 2022 · External reference
Metabolic syndrome and metabolic abnormalities in patients with major depressive disorder: a meta-analysis of prevalences and moderating variables
10.1017/s0033291713002778 · 2014 · External reference
Association of cardiovascular-kidney-metabolic health and social connection with the risk of depression and anxiety
10.1017/s0033291724002381 · 2024 · External reference
Peripheral versus central insulin and leptin resistance: role in metabolic disorders, cognition, and neuropsychiatric diseases
10.1016/j.neuropharm.2021.108877 · 2022 · External reference
Depression and insulin resistance: cross-sectional associations in young adults
10.2337/dc09-1940 · 2010 · External reference
Insulin resistance as a marker for the immune-metabolic subtype of depression
10.1016/j.jad.2021.08.151 · 2021 · External reference
Association between insulin resistance and the development of cardiovascular disease
10.1186/s12933-018-0762-4 · 2018 · External reference
Association between the triglyceride glucose-body mass index and future cardiovascular disease risk in a population with cardiovascular-kidney-metabolic syndrome stage 0-3: a nationwide prospective cohort study
10.1186/s12933-024-02352-6 · 2024 · External reference
Atherosclerotic cardiovascular disease risk estimates using the predicting risk of cardiovascular disease events equations
10.1001/jamainternmed.2024.1302 · 2024 · External reference
Cardiovascular-kidney-metabolic health: a presidential advisory from the american heart association
10.1161/cir.0000000000001184 · 2023 · External reference
Prevalence of cardiovascular-kidney-metabolic syndrome stages in US adults, 2011-2020
10.1001/jama.2024.6892 · 2024 · External reference
DEPRESsion screening Data (DEPRESSD) collaboration. Accuracy of patient health questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis
2019 · External reference
Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study
10.1186/s12933-025-02599-7 · 2025 · External reference
Cardiometabolic index is associated with increased depression: a population-based study
10.1016/j.jad.2023.12.073 · 2024 · External reference
Insulin resistance and heart failure: molecular mechanisms
10.1016/j.hfc.2012.06.005 · 2012 · External reference
Combination of cardiovascular, kidney, and metabolic diseases in a syndrome named cardiovascular-kidney-metabolic, with new risk prediction equations
10.1016/j.ekir.2024.05.033 · 2024 · External reference
Effect of renal ischemia reperfusion on brain neuroinflammation
10.3390/biomedicines10112993 · 2022 · External reference
Brain-kidney crosstalk
10.1186/cc13907 · 2014 · External reference
Sex differences in the hypothalamic-pituitary-adrenal axis’ response to stress: an important role for gonadal hormones
10.1038/s41386-018-0167-9 · 2019 · External reference
Hypothalamic-pituitary-end-organ axes: hormone function in female patients with major depressive disorder
10.1007/s12264-021-00689-6 · 2021 · External reference
Gender disparities in the association between educational attainment and cardiovascular-kidney-metabolic syndrome: cross-sectional study
10.2196/57920 · 2024 · External reference
Cardiovascular-kidney-metabolic (CKM) syndrome: a state-of-the-art review
10.1016/j.cpcardiol.2023.102344 · 2024 · External reference
Repurposing ketamine in the therapy of depression and depression-related disorders: recent advances and future potential
10.14336/ad.2024.0239 · 2025 · External reference
Incident major depressive disorder predicted by three measures of insulin resistance: a Dutch cohort study
10.1176/appi.ajp.2021.20101479 · 2021 · External reference
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
10.1073/pnas.1500877112 · 2015 · External reference
Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward
10.1038/ncomms9543 · 2015 · External reference
Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity
10.1210/endo.143.5.8809 · 2002 · External reference
Use of insulin sensitizers for the treatment of major depressive disorder: a pilot study of pioglitazone for major depression accompanied by abdominal obesity
10.1016/j.jad.2011.06.033 · 2012 · External reference
The PHQ-9: validity of a brief depression severity measure
10.1046/j.1525-1497.2001.016009606.x · 2001 · External reference
Prevalence of cardiovascular-kidney-metabolic syndrome stages in US adults, 2011-2020
10.1001/jama.2024.6892 · ExternalCitation · doi-reference
Atherosclerotic cardiovascular disease risk estimates using the predicting risk of cardiovascular disease events equations
10.1001/jamainternmed.2024.1302 · ExternalCitation · doi-reference
Hypothalamic-pituitary-end-organ axes: hormone function in female patients with major depressive disorder
10.1007/s12264-021-00689-6 · ExternalCitation · doi-reference
Cardiovascular-kidney-metabolic syndrome: a step toward multidisciplinary and inclusive care
10.1016/j.cmet.2023.10.015 · ExternalCitation · doi-reference
Cardiovascular-kidney-metabolic (CKM) syndrome: a state-of-the-art review
10.1016/j.cpcardiol.2023.102344 · ExternalCitation · doi-reference
Combination of cardiovascular, kidney, and metabolic diseases in a syndrome named cardiovascular-kidney-metabolic, with new risk prediction equations
10.1016/j.ekir.2024.05.033 · ExternalCitation · doi-reference
Insulin resistance and heart failure: molecular mechanisms
10.1016/j.hfc.2012.06.005 · ExternalCitation · doi-reference
Use of insulin sensitizers for the treatment of major depressive disorder: a pilot study of pioglitazone for major depression accompanied by abdominal obesity
10.1016/j.jad.2011.06.033 · ExternalCitation · doi-reference
Insulin resistance as a marker for the immune-metabolic subtype of depression
10.1016/j.jad.2021.08.151 · ExternalCitation · doi-reference
Bidirectional relations between depression symptoms and chronic kidney disease
10.1016/j.jad.2022.05.104 · ExternalCitation · doi-reference
Cardiometabolic index is associated with increased depression: a population-based study
10.1016/j.jad.2023.12.073 · ExternalCitation · doi-reference
Peripheral versus central insulin and leptin resistance: role in metabolic disorders, cognition, and neuropsychiatric diseases
10.1016/j.neuropharm.2021.108877 · ExternalCitation · doi-reference
Metabolic syndrome and metabolic abnormalities in patients with major depressive disorder: a meta-analysis of prevalences and moderating variables
10.1017/s0033291713002778 · ExternalCitation · doi-reference
Association of cardiovascular-kidney-metabolic health and social connection with the risk of depression and anxiety
10.1017/s0033291724002381 · ExternalCitation · doi-reference
Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward
10.1038/ncomms9543 · ExternalCitation · doi-reference
Sex differences in the hypothalamic-pituitary-adrenal axis’ response to stress: an important role for gonadal hormones
10.1038/s41386-018-0167-9 · ExternalCitation · doi-reference
The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies
10.1038/tp.2016.261 · ExternalCitation · doi-reference
The PHQ-9: validity of a brief depression severity measure
10.1046/j.1525-1497.2001.016009606.x · ExternalCitation · doi-reference
Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
10.1073/pnas.1500877112 · ExternalCitation · doi-reference
Depression and cardiovascular disease: a clinical review
10.1093/eurheartj/eht462 · ExternalCitation · doi-reference
Cardiovascular-kidney-metabolic health: a presidential advisory from the american heart association
10.1161/cir.0000000000001184 · ExternalCitation · doi-reference
Incident major depressive disorder predicted by three measures of insulin resistance: a Dutch cohort study
10.1176/appi.ajp.2021.20101479 · ExternalCitation · doi-reference
Brain-kidney crosstalk
10.1186/cc13907 · ExternalCitation · doi-reference
Association between insulin resistance and the development of cardiovascular disease
10.1186/s12933-018-0762-4 · ExternalCitation · doi-reference
Association between the triglyceride glucose-body mass index and future cardiovascular disease risk in a population with cardiovascular-kidney-metabolic syndrome stage 0-3: a nationwide prospective cohort study
10.1186/s12933-024-02352-6 · ExternalCitation · doi-reference
Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study
10.1186/s12933-025-02599-7 · ExternalCitation · doi-reference
Global, regional, and national time trends in incidence for depressive disorders, from 1990 to 2019: an age-period-cohort analysis for the GBD 2019
10.1186/s12991-024-00513-1 · ExternalCitation · doi-reference
Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity
10.1210/endo.143.5.8809 · ExternalCitation · doi-reference
Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010
10.1371/journal.pmed.1001547 · ExternalCitation · doi-reference
Repurposing ketamine in the therapy of depression and depression-related disorders: recent advances and future potential
10.14336/ad.2024.0239 · ExternalCitation · doi-reference
Gender disparities in the association between educational attainment and cardiovascular-kidney-metabolic syndrome: cross-sectional study
10.2196/57920 · ExternalCitation · doi-reference
Depression and insulin resistance: cross-sectional associations in young adults
10.2337/dc09-1940 · ExternalCitation · doi-reference
Effect of renal ischemia reperfusion on brain neuroinflammation
10.3390/biomedicines10112993 · ExternalCitation · doi-reference
