Research graph
References from Genome-wide transcriptomics and a machine learning-based random forest model identify novel biomarkers to predict phenotypic variability in Wilson disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Wilson disease
10.1038/s41572-018-0018-3 · 2018 · External reference
Modifying factors and phenotypic diversity in Wilson’s disease
10.1111/nyas.12420 · 2014 · External reference
Concordance rates of Wilson’s disease phenotype among siblings
10.1007/s10545-013-9625-z · 2014 · External reference
Effect of chelation therapy in pediatric Wilson’s disease: liver and endoscopic outcome
10.1002/jhbp.812 · 2021 · External reference
Integrative classification of human coding and noncoding genes through RNA metabolism profiles
10.1038/nsmb.3325 · 2017 · External reference
Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress
10.1074/jbc.m102925200 · 2001 · External reference
Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats
10.1186/ar1801 · 2005 · External reference
A single-cell transcriptomic atlas of immune cells in Wilson disease identifies copper-specific immune regulation
10.1016/j.isci.2025.112450 · 2025 · External reference
Integrated proteomics and single-cell transcriptomics reveal potential therapeutic targets in Wilson’s disease patients
10.3389/fimmu.2025.1635137 · 2025 · External reference
Is low serum tocopherol in Wilson’s disease a significant symptom?
10.1016/j.jns.2004.10.017 · 2005 · External reference
Do cytokines have any role in Wilson’s disease?
10.1111/j.1365-2249.2008.03755.x · 2008 · External reference
Genetics and epigenetic factors of Wilson disease
10.21037/atm.2019.01.67 · 2019 · External reference
Genetic defects in Indian Wilson disease patients and genotype-phenotype correlation
10.1016/j.parkreldis.2013.09.021 · 2014 · External reference
Update on Wilson disease
10.1016/b978-0-12-410502-7.00014-4 · 2013 · External reference
Nuances in ATP7B genetic testing and interpretation in India
10.1016/j.jceh.2025.103205 · 2026 · External reference
GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin
10.1073/pnas.1219004110 · 2013 · External reference
Long noncoding RNA OIP5-AS1 promotes the progression of liver hepatocellular carcinoma via regulating the hsa-miR-26a-3p/EPHA2 Axis
10.1016/j.omtn.2020.05.032 · 2020 · External reference
Tudor domain-containing protein 4 as a potential cancer/testis antigen in liver cancer
10.1620/tjem.224.41 · 2011 · External reference
Glucuronidation of trans-3′-hydroxycotinine by UGT2B17 and UGT2B10
10.1097/fpc.0b013e32834ff3a5 · 2012 · External reference
Probing and gauging of D-Penicillamine xenobiotics in hepatic Wilson disease patients
10.1016/j.bpc.2024.107306 · 2024 · External reference
Regulation and function of the RSK family of protein kinases
10.1042/bj20110289 · 2012 · External reference
The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation
10.3390/ijms20133328 · 2019 · External reference
Reactive oxygen species: drivers of physiological and pathological processes
10.2147/jir.s275595 · 2020 · External reference
Wilson’s disease-crossroads of genetics, inflammation and immunity/autoimmunity: clinical and molecular issues
10.3390/ijms25169034 · 2024 · External reference
Oxidative stress, apoptosis and inflammatory responses involved in copper-induced pulmonary toxicity in mice
10.18632/aging.103585 · 2020 · External reference
Regulation of MAP kinases by MAP kinase phosphatases
10.1016/j.bbamcr.2006.12.002 · 2007 · External reference
Pathological mitochondrial copper overload in livers of Wilson’s disease patients and related animal models
10.1111/nyas.12347 · 2014 · External reference
Characterization of the most frequent ATP7B mutation causing Wilson disease in hepatocytes from patient induced pluripotent stem cells
10.1038/s41598-018-24717-0 · 2018 · External reference
Identification of p38 MAPK and JNK as new targets for correction of Wilson disease-causing ATP7B mutants
10.1002/hep.28398 · 2016 · External reference
Role of p38 Mapk in development of acute hepatic injury in Long-Evans cinnamon (LEC) rats, an animal model of human Wilson’s disease
10.1292/jvms.13-0137 · 2013 · External reference
ATP6V0d2 alleviates acute liver injury via promoting hepatocyte autophagy
10.1016/j.bbadis.2026.168170 · 2026 · External reference
Progressive loss of hepatocyte nuclear factor 4 alpha activity in chronic liver diseases in humans
10.1002/hep.32326 · 2022 · External reference
Elevated copper impairs hepatic nuclear receptor function in Wilson’s disease
10.1172/jci78991 · 2015 · External reference
Keratin 79 is a PPARA target that is highly expressed by liver damage
10.1016/j.bbrc.2023.01.071 · 2023 · External reference
Evaluating the role of IER3+ macrophages in the prognosis of liver fibrosis by bulk and single-cell transcriptional analyses
10.1016/j.iliver.2024.100132 · 2024 · External reference
High expression of MRPL23 is associated with poor survival in clear-cell renal cell carcinoma
10.3390/cancers16233909 · 2024 · External reference
Alzheimer’s disease-associated P460L variant of EphA1 dysregulates receptor activity and blood-brain barrier function
10.1002/alz.13603 · 2024 · External reference
Liver Iron accumulation in Recompensated Wilson disease on chelation therapy: a prospective evaluation in children
10.1016/j.jceh.2026.103493 · 2026 · External reference
Liver mitochondrial membrane crosslinking and destruction in a rat model of Wilson disease
10.1172/jci45401 · 2011 · External reference
Alterations of lipid metabolism in Wilson disease
10.1186/1476-511x-10-83 · 2011 · External reference
Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption
10.1126/sciadv.abh3997 · 2021 · External reference
Neurotensin promotes hepatic steatosis by regulating lipid uptake and mitochondrial adaptation in hepatocytes
10.1038/s41419-025-07664-3 · 2025 · External reference
OLAH connects fatty acid metabolism to the severity of respiratory viral disease
10.1016/j.cell.2024.07.032 · 2024 · External reference
PCDH8 is frequently inactivated by promoter Hypermethylation in liver Cancer: diagnostic and clinical significance
10.7150/jca.13065 · 2016 · External reference
The Reprimo gene family: a novel gene lineage in gastric Cancer with tumor suppressive properties
10.3390/ijms19071862 · 2018 · External reference
Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones
10.1093/nar/gkab1044 · 2021 · External reference
Interaction of copper nd zinc cations with calcium-binding proteins
1988 · External reference
A novel missense mutation in the SLC6A19 gene in a Chinese family with Hartnup disorder
10.1111/j.1365-4632.2009.03989.x · 2009 · External reference
Expression in mouse kidney of membrane copper transporters Atp7a and Atp7b
10.1159/000064075 · 2002 · External reference
