Research graph
References from Region- and receptor-specific effects of chronic social stress on the central serotonergic system in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
The 5-HT1A receptor: signaling to behavior
10.1016/j.biochi.2018.10.015 · 2019 · External reference
Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus
10.1038/nn1399 · 2005 · External reference
Mouse social stress induces increased fear conditioning, helplessness and fatigue to physical challenge together with markers of altered immune and dopamine function
10.1016/j.neuropharm.2014.05.039 · 2014 · External reference
Serotonin modulates sensitivity to reward and negative feedback in a probabilistic reversal learning task in rats
10.1038/npp.2009.233 · 2010 · External reference
Serotonin in fear conditioning processes
10.1016/j.bbr.2014.07.028 · 2015 · External reference
Mouse psychosocial stress reduces motivation and cognitive function in operant reward tests: a model for reward pathology with effects of agomelatine
10.1016/j.euroneuro.2016.06.009 · 2016 · External reference
Chronic social stress in mice alters energy status including higher glucose need but lower brain utilization
10.1016/j.psyneuen.2020.104747 · 2020 · External reference
Oligodendrocyte gene expression is reduced by and influences effects of chronic social stress in mice
10.1111/gbb.12475 · 2019 · External reference
Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice
10.1016/j.ynstr.2018.01.004 · 2018 · External reference
Serotonin, amygdala and fear: assembling the puzzle
10.3389/fncir.2016.00024 · 2016 · External reference
Evidence that central 5-HT 2a and 5-HT 2B/C receptors regulate 5-HT cell firing in the dorsal raphe nucleus of the anaesthetised rat
10.1038/sj.bjp.0705328 · 2003 · External reference
In vivo evidence that 5-HT 2C receptors inhibit 5-HT neuronal activity via a GABAergic mechanism
10.1038/sj.bjp.0706935 · 2006 · External reference
Early-life stress induces persistent alterations in 5-HT1A receptor and serotonin transporter mRNA expression in the adult rat brain
10.3389/fnmol.2014.00024 · 2014 · External reference
Serotonin and brain function: a tale of two receptors
10.1177/0269881117725915 · 2017 · External reference
Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder
10.1016/j.biopsych.2007.03.016 · 2007 · External reference
Serotonin 5-HT1A receptors as targets for agents to treat psychiatric disorders: rationale and current status of research
10.1007/s40263-013-0071-0 · 2013 · External reference
Transbilayer (flip-flop) lipid motion and lipid scrambling in membranes
10.1016/j.febslet.2009.12.049 · 2010 · External reference
Serotonergic regulation of emotional and behavioural control processes
10.1016/j.tics.2007.10.011 · 2008 · External reference
The effects of benzofury (5-APB) on the dopamine transporter and 5-HT2-dependent vasoconstriction in the rat
10.1016/j.pnpbp.2013.08.013 · 2014 · External reference
A current view of serotonin transporters
10.12688/f1000research.8384.1 · 2016 · External reference
Ultrastructural localization of the serotonin 2A receptor in dopaminergic neurons in the ventral tegmental area
10.1016/s0006-8993(00)02062-x · 2000 · External reference
PET imaging of serotonin 1A receptor binding in depression
10.1016/s0006-3223(99)00189-4 · 1999 · External reference
Homeostatic regulation of serotonergic function by the serotonin transporter as revealed by nonviral gene transfer
10.1523/jneurosci.20-13-05065.2000 · 2018 · External reference
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3
10.1038/s41586-019-1024-7 · 2019 · External reference
The role of serotonin in reward, punishment and behavioural inhibition in humans: insights from studies with acute tryptophan depletion
10.1016/j.neubiorev.2014.07.024 · 2014 · External reference
Acute 5-HT1A autoreceptor knockdown increases antidepressant responses and serotonin release in stressful conditions
10.1007/s00213-012-2795-9 · 2013 · External reference
Repeated experience of social defeats increases serotonin transporter and monoamine oxidase A mRNA levels in raphe nuclei of male mice
10.1016/s0304-3940(01)02495-8 · 2002 · External reference
Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: both effects are reversed by inhibition of indoleamine 2,3-dioxygenase
10.1016/j.bbi.2015.12.020 · 2016 · External reference
A standardized protocol for repeated social defeat stress in mice
10.1038/nprot.2011.361 · 2011 · External reference
The landscape of transcription errors in eukaryotic cells
10.1126/sciadv.1701484 · 2017 · External reference
Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression
10.1016/j.neuroimage.2016.08.013 · 2016 · External reference
Imaging the serotonin 1A receptor using [11C]WAY100635 in healthy controls and major depression
10.1098/rstb.2012.0004 · 2013 · External reference
Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease
10.1016/j.neubiorev.2008.03.006 · 2008 · External reference
5-HT uptake sites and 5-HT2 receptors in brain of antidepressant-free suicide victims/depressives: increase in 5-HT2 sites in cortex and amygdala
10.1016/0006-8993(93)91015-k · 1993 · External reference
Establishing a probabilistic reversal learning test in mice: evidence for the processes mediating reward-stay and punishment-shift behaviour and for their modulation by serotonin
10.1016/j.neuropharm.2012.07.025 · 2012 · External reference
Stress impairs 5-HT2A receptor-mediated serotonergic facilitation of GABA release in juvenile rat basolateral amygdala
10.1038/npp.2008.71 · 2009 · External reference
Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice
10.1371/journal.pone.0191225 · 2018 · External reference
The 5-HT1A receptor in major depressive disorder
10.1016/j.euroneuro.2015.12.039 · 2016 · External reference
Association of different adverse life events with distinct patterns of depressive symptoms
10.1176/appi.ajp.2007.06091564 · 2007 · External reference
Chronic social stress leads to reduced gustatory reward salience and effort valuation in mice
10.3389/fnbeh.2018.00134 · 2018 · External reference
Early deprivation leads to long-term reductions in motivation for reward and 5-HT1A binding and both effects are reversed by fluoxetine
10.1016/j.neuropharm.2008.12.005 · 2009 · External reference
Brain region-specific alterations of 5-HT2A and 5-HT2C receptors in serotonin transporter knockout mice
10.1046/j.1471-4159.2003.01607.x · 2003 · External reference
Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography
10.1016/s0006-3223(98)00272-8 · 1998 · External reference
Serotonin receptor binding in a colony model of chronic social stress
10.1016/0006-3223(94)00152-s · 1995 · External reference
123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study
2015 · External reference
Low brain serotonin transporter binding in major depressive disorder
10.1016/j.pscychresns.2011.12.015 · 2012 · External reference
Different patterns of 5-HT receptor and transporter dysfunction in neuropsychiatric disorders-a comparative analysis of in vivo imaging findings
10.1515/revneuro-2015-0014 · 2016 · External reference
A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice
10.1016/j.bbrc.2006.01.021 · 2006 · External reference
Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice
10.1038/srep45907 · 2017 · External reference
Brain cell type specific gene expression and co-expression network architectures
10.1038/s41598-018-27293-5 · 2018 · External reference
Imaging the serotonin transporter during major depressive disorder and antidepressant treatment
2007 · External reference
Effect of stress on the behavior and 5-HT system in Sprague-Dawley and Wistar Kyoto rat strains
10.1007/bf02699783 · 1996 · External reference
Unresolved reference
2004 · External reference
5-HT1A receptor-regulated signal transduction pathways in brain
10.1016/j.cellsig.2010.03.019 · 2010 · External reference
Establishing a learned helplessness effect paradigm in C57BL/6 mice: behavioural evidence for emotional, motivational and cognitive effects of aversive uncontrollability per se
10.1016/j.neuropharm.2011.08.012 · 2012 · External reference
Chronic psychosocial stressors in adulthood: studies in mice, rats and tree shrews
10.1016/j.ynstr.2016.10.001 · 2017 · External reference
Translating the evidence for gene association with depression into mouse models of depression-relevant behaviour: current limitations and future potential
10.1016/j.neubiorev.2013.05.003 · 2013 · External reference
5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants
10.1016/j.neuron.2009.12.003 · 2010 · External reference
Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress
10.1073/pnas.1416866112 · 2015 · External reference
Brain serotonin(1A) receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment
10.1001/archpsyc.57.2.174 · 2000 · External reference
Discrete dorsal raphe to basal amygdala 5-HT circuit calibrates aversive memory
10.1016/j.neuron.2019.05.029 · 2019 · External reference
Application of brain microdialysis to study the pharmacology of the 5-HT1A autoreceptor
10.1016/0165-0270(90)90045-h · 1990 · External reference
The activity of the serotonin receptor 2C is regulated by alternative splicing
10.1007/s00439-017-1826-3 · 2017 · External reference
Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity
10.1523/jneurosci.18-18-07394.1998 · 1998 · External reference
Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter
10.1016/s0022-3956(03)00050-5 · 2003 · External reference
Dopamine neurons modulate neural encoding and expression of depression-related behaviour
10.1038/nature11740 · 2013 · External reference
Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity
10.1038/s41398-018-0309-1 · 2018 · External reference
Mouse repeated electroconvulsive seizure (ECS) does not reverse social stress effects but does induce behavioral and hippocampal changes relevant to electroconvulsive therapy (ECT) side-effects in the treatment of depression
10.1371/journal.pone.0184603 · 2017 · External reference
Serotonin in stress
2019 · External reference
The chronic mild stress (CMS) model of depression: history, evaluation and usage
10.1016/j.ynstr.2016.08.002 · 2017 · External reference
Serotonin and learned helplessness: a regional study of 5-HT(1A), 5-HT(2A) receptors and the serotonin transport site in rat brain
10.1016/s0022-3956(98)00041-7 · 1999 · External reference
The role of 5-HT receptors in depression Tim Bliss
10.1186/s13041-017-0306-y · 2017 · External reference
Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner
10.1111/jnc.12055 · 2012 · External reference