Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke. Local targets link to admitted publications; unresolved targets remain external evidence.
Controlled cortical impact severity results in graded cellular, tissue, and functional responses in a piglet traumatic brain injury model
10.1089/neu.2017.5551 · 2019 · External reference
Induced pluripotent stem cell-derived neural stem cell therapy enhances recovery in an ischemic stroke pig model
10.1038/s41598-017-10406-x · 2017 · External reference
Gait disturbances in patients with stroke
10.1016/j.pmrj.2013.12.017 · 2014 · External reference
White matter vulnerability to ischemic injury increases with age because of enhanced excitotoxicity
10.1523/jneurosci.5137-07.2008 · 2008 · External reference
Heart disease and stroke statistics-2019 update: a report from the American Heart Association
10.1161/cir.0000000000000659 · 2019 · External reference
Neural stem cell transplantation in ischemic stroke: a role for preconditioning and cellular engineering
10.1177/0271678x17700432 · 2017 · External reference
Mortality of space-occupying (’malignant’) middle cerebral artery infarction under conservative intensive care
10.1007/s001340050625 · 1998 · External reference
Hemorrhagic transformation of childhood arterial ischemic stroke
10.1161/strokeaha.110.604199 · 2011 · External reference
Oral pioglitazone reduces infarction volume and improves neurologic function following MCAO in rats
10.1007/978-1-4419-7756-4_22 · 2011 · External reference
Large animal stroke models vs. rodent stroke models, pros and cons, and combination?
10.1007/978-3-319-18497-5_13 · 2016 · External reference
Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats
10.1186/1423-0127-16-9 · 2009 · External reference
Tanshinone IIA exerts neuroprotective effects on hippocampus-dependent cognitive impairments in diabetic rats by attenuating ER stress-induced apoptosis
10.1016/j.biopha.2018.05.040 · 2018 · External reference
One-compound-multi-target: combination prospect of natural compounds with thrombolytic therapy in acute ischemic stroke
10.2174/1570159x14666160620102055 · 2017 · External reference
Neuroprotective capabilities of Tanshinone IIA against cerebral ischemia/reperfusion injury via anti-apoptotic pathway in rats
10.1248/bpb.35.164 · 2012 · External reference
Role of P-glycoprotein in restricting the brain penetration of tanshinone IIA, a major active constituent from the root of Salvia miltiorrhiza Bunge, across the blood-brain barrier
10.1080/00498250701411258 · 2007 · External reference
Treatment goals and selection of patients for rehabilitation with hemiplegia
1966 · External reference
PLGA-based nanoparticles: an overview of biomedical applications
10.1016/j.jconrel.2012.01.043 · 2012 · External reference
Pathobiology of ischaemic stroke: an integrated view
10.1016/s0166-2236(99)01401-0 · 1999 · External reference
Gait analysis in a pre- and post-ischemic stroke biomedical pig model
10.1016/j.physbeh.2013.11.004 · 2014 · External reference
Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia
10.1016/j.pbb.2007.04.015 · 2007 · External reference
The ischemic cascade and mediators of ischemic injury
10.1016/s0072-9752(08)01902-7 · 2009 · External reference
The resistance to ischemia of white and gray matter after stroke
10.1002/ana.20265 · 2004 · External reference
Modulation of anoxic injury in CNS white matter by adenosine and interaction between adenosine and GABA
10.1152/jn.1994.72.6.2609 · 1994 · External reference
PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug
10.1016/s0168-3659(98)00116-3 · 1999 · External reference
"Malignant’ middle cerebral artery territory infarction: clinical course and prognostic signs
10.1001/archneur.1996.00550040037012 · 1996 · External reference
Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion
10.1016/j.pharmthera.2007.09.008 · 2008 · External reference
Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice
10.1038/s41598-019-49028-w · 2019 · External reference
Analysis of impairments influencing gait velocity and asymmetry of hemiplegic patients after mild to moderate stroke
10.1016/s0003-9993(03)00030-3 · 2003 · External reference
The attenuation of traumatic brain injury via inhibition of oxidative stress and apoptosis by Tanshinone IIA
10.1155/2020/4170156 · 2020 · External reference
Unresolved reference
External reference
Drug therapy in stroke: from preclinical to clinical studies
10.1159/000356320 · 2013 · External reference
Traumatic brain injury results in dynamic brain structure changes leading to acute and chronic motor function deficits in a pediatric piglet model
10.1089/neu.2018.6303 · 2019 · External reference
Effect of edaravone on neurological symptoms in real-world patients with acute ischemic stroke
10.1161/strokeaha.118.024351 · 2019 · External reference
Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) regulates glycolysis and mediates resveratrol-induced ischemic tolerance
10.1161/strokeaha.117.018562 · 2017 · External reference
Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice
10.1078/094471103322004776 · 2003 · External reference
RIGOR guidelines: escalating STAIR and STEPS for effective translational research
10.1007/s12975-012-0209-2 · 2013 · External reference
Effects of edaravone, the free radical scavenger, on outcomes in acute cerebral infarction patients treated with ultra-early thrombolysis of recombinant tissue plasminogen activator
10.1016/j.clineuro.2018.02.026 · 2018 · External reference
The effects of Baicalin and Baicalein on cerebral ischemia: a review
10.14336/ad.2017.0829 · 2017 · External reference
The use of pigs in neuroscience: modeling brain disorders
10.1016/j.neubiorev.2007.02.003 · 2007 · External reference
The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke
10.1016/j.brainresbull.2010.04.005 · 2010 · External reference
Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis, properties, and nanomedical applications as drug delivery system
10.1007/s11051-012-1316-4 · 2012 · External reference
Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer’s disease
10.1016/j.phrs.2017.11.018 · 2018 · External reference
The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis
10.1016/j.pneurobio.2015.02.003 · 2015 · External reference
Tanshinone IIA attenuates cerebral aneurysm formation by inhibiting the NFkappaBmediated inflammatory response
2019 · External reference
Distinct types of microglial activation in white and grey matter of rat lumbosacral cord after mid-thoracic spinal transection
10.1097/nen.0b013e3181256b32 · 2007 · External reference
Experimental investigation of encephalomyosynangiosis using gyrencephalic brain of the miniature pig: histopathological evaluation of dynamic reconstruction of vessels for functional anastomosis. Laboratory investigation
10.3171/2008.6.peds0834 · 2009 · External reference
Development and characterization of a Yucatan miniature biomedical pig permanent middle cerebral artery occlusion stroke model
10.1186/2040-7378-6-5 · 2014 · External reference
Cytokines and the nervous system II: actions and mechanisms of action
10.1016/0166-2236(95)93890-a · 1995 · External reference
Drug solubility: importance and enhancement techniques
2012 · External reference
Progress on the protective effect of compounds from natural medicines on cerebral ischemia
10.3724/sp.j.1009.2013.00588 · 2013 · External reference
Recommendations for standards regarding preclinical neuroprotective and restorative drug development
10.1161/01.str.30.12.2752 · 1999 · External reference
Does Danshen improve disability after acute ischaemic stroke?
10.1111/j.1600-0404.2004.00369.x · 2005 · External reference
Protective effect of tanshinone IIA on the brain and its therapeutic time window in rat models of cerebral ischemia-reperfusion
10.3892/etm.2014.1936 · 2014 · External reference
The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats
10.1016/j.phymed.2010.03.017 · 2010 · External reference
Frequency and determinants for hemorrhagic transformation of cerebral infarction
10.1159/000229781 · 2009 · External reference
Stroke incidence on the east coast of Australia: the North East Melbourne Stroke Incidence Study (NEMESIS)
10.1161/01.str.31.9.2087 · 2000 · External reference
Effect of baicalin on matrix metalloproteinase-9 expression and blood-brain barrier permeability following focal cerebral ischemia in rats
10.1007/s11064-011-0526-y · 2011 · External reference
Neuroprotective effect of baicalin in a rat model of permanent focal cerebral ischemia
10.1007/s11064-009-9953-4 · 2009 · External reference
Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia
10.1016/j.brainres.2009.12.046 · 2010 · External reference
Dan Shen agents for acute ischaemic stroke
2007 · External reference
Pioglitazone prevents stroke in patients with a recent transient ischemic attack or ischemic stroke: a planned secondary analysis of the IRIS trial (Insulin Resistance Intervention After Stroke)
10.1161/circulationaha.117.030458 · 2018 · External reference
Epigallocatechin-3-Gallate (EGCG) attenuates traumatic brain injury by inhibition of Edema formation and oxidative stress
10.4196/kjpp.2015.19.6.491 · 2015 · External reference
Efficacy and safety of puerarin injection in curing acute ischemic stroke: a meta-analysis of randomized controlled trials
2017 · External reference
Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish
10.1016/j.taap.2018.04.037 · 2018 · External reference
Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
10.1177/0091270005282630 · 2005 · External reference
