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References from Reduction BACE1 expression via suppressing NF-κB mediated signaling by Tamibarotene in a mouse model of Alzheimer’s disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Differential regulation of BACE1 promoter activity by nuclear factor-kB in neurons and glia upon exposure to beta-amyloid peptides
10.1002/jnr.21252 · 2007 · External reference
Increased NF-kappaB signaling upregulates BACE1 expression and its therapeutic potential in Alzheimer’s disease
10.1017/s1461145711000149 · 2012 · External reference
Microglial genes regulating neuroinflammation in the progression of Alzheimer’s disease
10.1016/j.conb.2015.10.004 · 2016 · External reference
Retinoic acid attenuates β-Amyloid deposition and rescues memory deficits in Alzheimer’s disease transgenic mice
10.1523/jneurosci.3153-08.2008 · 2008 · External reference
Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia
10.1002/glia.20153 · 2005 · External reference
Curcumin-loaded namocapsules reverses the depressant-like behavior and oxidative stress induced by β–Amyloid in mice
10.1016/j.neuroscience.2019.09.032 · 2019 · External reference
Tamibarotene: a candidate retinoid drug for Alzheimer’s disease
10.1248/bpb.b12-00314 · 2012 · External reference
Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer’ disease pathology which can be attenuated by a retinoic acid receptor agonist
10.1111/ejn.12142 · 2013 · External reference
The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics
10.1126/science.1072994 · 2002 · External reference
Retinoic acid receptor-α signaling antagonizes both in tracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β
10.1111/j.1460-9568.2010.07426.x · 2010 · External reference
Design, synthesis, and biological characterization of tamibarotene analogs as anticancer agents
10.1111/cbdd.12778 · 2016 · External reference
Retinoic acid-elicited RARα/RXRα signaling attenuates Aβ production by directly γ-secretase-mediated cleavage of amyloid precursor protein
10.1021/cn400039s · 2013 · External reference
Oral administration of synthetic retinoid AM80 (Tamibarotene) decreases brain β-Amyloid peptides in APP23 Mice
10.1248/bpb.32.1307 · 2009 · External reference
A synthetic retinoid Am80 (Tamibarotene) rescues the memory deficit caused by scopolamine in a passive avoidance paradigm
10.1248/bpb.27.1887 · 2004 · External reference
Cooperative therapeutic action of retinoic acid receptor and retinoid X receptor agonists in a mouse model of Alzheimer’s disease
2014 · External reference
Neuroprotection of brain-targeted bioactive dietary Artoindonesianin O (AIO) from mulberry on rat neurons as a novel intervention for Alzheimer’s disease
10.1021/acs.jafc.5b00396 · 2015 · External reference
Amyloid precursor protein beta-secretase (BACE) mRNA expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines and growth factors
2000 · External reference
Microglial pathology
10.1186/s40478-014-0142-6 · 2014 · External reference
Retinoic acid receptor agonist Am80 inhibits CXCL2 production from microglial BV-2 cells via attenuation of NF-κB signaling
10.1016/j.intimp.2016.06.025 · 2016 · External reference
NF-kB-dependent control of BACE1 promoter transactivation by Aβ42.
10.1074/jbc.m706579200 · 2008 · External reference
All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of Nuclear Factor kB (NF-kB) signaling
10.1074/jbc.m115.662908 · 2015 · External reference
Trientine reduces BACE1 activity and mitigates amyloidosis via the AGE/RAGE/NF-kB pathway in a transgenic mouse model of Alzheimer’s disease
10.1089/ars.2012.5158 · 2013 · External reference
Tamibarotene for the treatment of bronchiolitis obliterans associated with chronic graft-vs-host disease
10.1016/j.chest.2018.08.1052 · 2019 · External reference
Luteolin reduces BACE1 expression through NF-kB and estrogen receptor mediated pathways in HEK293 and SH-SY5Y cells
10.3233/jad-142517 · 2015 · External reference