Research graph
References from Adolescent administration of Δ9-THC decreases the expression and function of muscarinic-1 receptors in prelimbic prefrontal cortical neurons of adult male mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Delta9-tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis study
10.1016/s0014-2999(01)00967-0 · 2001 · External reference
Hardwiring the brain: endocannabinoids shape neuronal connectivity
10.1126/science.1137406 · 2007 · External reference
The endoplasmic reticulum: a multifunctional signaling organelle
10.1016/s0143416002001823 · 2002 · External reference
“In vivo” intraneuronal trafficking of G protein coupled receptors in the striatum: regulation by dopaminergic and cholinergic environment
10.1016/s0248-4900(03)00080-7 · 2003 · External reference
Do thin spines learn to be mushroom spines that remember?
10.1016/j.conb.2007.04.009 · 2007 · External reference
Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice
10.1126/sciadv.aay1502 · 2020 · External reference
Regional enhancement of cannabinoid CB₁ receptor desensitization in female adolescent rats following repeated Delta-tetrahydrocannabinol exposure
10.1111/j.1476-5381.2010.00870.x · 2010 · External reference
CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex
10.1038/mp.2014.14 · 2014 · External reference
Optimization of differential immunogold-silver and peroxidase labeling with maintenance of ultrastructure in brain sections before plastic embedding
10.1016/0165-0270(90)90015-8 · 1990 · External reference
Cholinergic modulation of visual attention and working memory: dissociable effects of basal forebrain 192-IgG-saporin lesions and intraprefrontal infusions of scopolamine
10.1101/lm.70904 · 2004 · External reference
Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models
10.1038/s41593-018-0329-4 · 2019 · External reference
A unifying hypothesis for M1 muscarinic receptor signaling in pyramidal cells
10.1113/jp273627 · 2017 · External reference
Endocannabinoid-mediated short-term synaptic plasticity: depolarization-induced suppression of inhibition (DSI) and depolarization-induced suppression of excitation (DSE)
10.1038/sj.bjp.0705726 · 2004 · External reference
Acetylcholine facilitates a depolarization-induced enhancement of inhibition in Rat CA1 pyramidal neurons
2017 · External reference
Endocannabinoids in brain plasticity: cortical maturation, HPA axis function and behavior
10.1016/j.brainres.2016.08.037 · 2017 · External reference
Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment
10.1523/jneurosci.6410-09.2010 · 2010 · External reference
The impact of adolescent social isolation on dopamine D2 and cannabinoid CB1 receptors in the adult rat prefrontal cortex
10.1016/j.neuroscience.2013.01.021 · 2013 · External reference
Cannabinoid modulation of the dopaminergic circuitry: Implications for limbic and striatal output
10.1016/j.pnpbp.2011.12.004 · 2012 · External reference
Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR 141716A
10.1016/s0014-2999(98)00486-5 · 1998 · External reference
Unresolved reference
2000 · External reference
Insights into associative long-term potentiation from computational models of NMDA receptor-mediated calcium influx and intracellular calcium concentration changes
10.1152/jn.1990.63.5.1148 · 1990 · External reference
Cannabis and the developing brain: insights into its long-lasting effects
10.1523/jneurosci.1165-19.2019 · 2019 · External reference
Cannabis use and memory brain function in adolescent boys: a cross-sectional multicenter functional magnetic resonance imaging study
2010 · External reference
M1 muscarinic acetylcholine receptor in Alzheimer’s disease
10.1007/s12264-013-1406-z · 2014 · External reference
Molecular composition of the endocannabinoid system at glutamatergic synapses
10.1523/jneurosci.0309-06.2006 · 2006 · External reference
Receptor downregulation and multivesicular-body sorting
10.1038/nrm973 · 2002 · External reference
Neuroscience. Matters of size
10.1126/science.1137595 · 2006 · External reference
Muscarinic receptor control of pyramidal neuron membrane potential in the medial prefrontal cortex (mPFC) in rats
10.1016/j.neuroscience.2015.07.023 · 2015 · External reference
Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus
10.1016/j.neuropharm.2010.04.013 · 2010 · External reference
Ontogeny of cortical muscarinic receptor subtypes and muscarinic receptor-mediated responses in rat
10.1016/s0022-3565(25)19942-4 · 1990 · External reference
Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies
10.1523/jneurosci.11-10-03218.1991 · 1991 · External reference
Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence
10.1017/s1461145711001854 · 2013 · External reference
Sex-dependent long-term effects of adolescent exposure to THC and/or MDMA on neuroinflammation and serotoninergic and cannabinoid systems in rats
10.1111/bph.12519 · 2014 · External reference
Activation of genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells
10.1073/pnas.95.19.11465 · 1998 · External reference
Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in a xenopus oocyte expression system
10.1016/s0022-3565(24)35147-x · 1999 · External reference
The cholinergic innervation develops early and rapidly in the rat cerebral cortex: a quantitative immunocytochemical study
10.1016/s0306-4522(01)00389-x · 2001 · External reference
The role of the endocannabinoid system and genetic variation in adolescent brain development
10.1038/npp.2017.143 · 2018 · External reference
Degenerating processes identified by electron microscopic immunocytochemical methods
10.1007/978-1-61779-328-8_3 · 2011 · External reference
Estrogen receptor β contributes to both hypertension and hypothalamic plasticity in a mouse model of peri-menopause
10.1523/jneurosci.0164-21.2021 · 2021 · External reference
The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse
10.1101/lm.046672.117 · 2018 · External reference
Cannabinoids enhance NMDA-elicited Ca2+ signals in cerebellar granule neurons in culture
10.1523/jneurosci.19-20-08765.1999 · 1999 · External reference
Cholinergic-mediated response enhancement in barrel cortex layer V pyramidal neurons
10.1152/jn.00156.2012 · 2012 · External reference
Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex
10.1002/cne.24409 · 2018 · External reference
Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus
10.1046/j.1460-9568.2003.02732.x · 2003 · External reference
Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats
10.1177/0269881106065188 · 2006 · External reference
CB(1) antagonism increases excitatory synaptogenesis in a cortical spheroid model of fetal brain development
10.1038/s41598-021-88750-2 · 2021 · External reference
Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein
10.1073/pnas.0711568105 · 2008 · External reference
Unresolved reference
1991 · External reference
Chronic adolescent exposure to 9-tetrahydrocannabinol decreases NMDA current and extrasynaptic plasmalemmal density of NMDA GluN1 subunits in the prelimbic cortex of adult male mice
10.1038/s41386-019-0466-9 · 2020 · External reference
Cannabinoid-1 receptors in the mouse ventral pallidum are targeted to axonal profiles expressing functionally opposed opioid peptides and contacting N-acylphosphatidylethanolamine-hydrolyzing phospholipase D terminals
10.1016/j.neuroscience.2012.07.050 · 2012 · External reference
Spatial signal detection in rats is differentially disrupted by delta-9-tetrahydrocannabinol, scopolamine, and MK-801
10.1016/s0166-4328(98)00065-5 · 1999 · External reference
Chronic cannabinoid exposure during adolescence leads to long-term structural and functional changes in the prefrontal cortex
10.1016/j.euroneuro.2015.11.005 · 2016 · External reference
Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex
10.1016/j.nbd.2014.09.015 · 2015 · External reference
Chronic Delta-9-tetrahydrocannabinol treatment increases cAMP levels and cAMP-dependent protein kinase activity in some rat brain regions
10.1016/s0028-3908(99)00196-3 · 2000 · External reference
The influence of marijuana use on neurocognitive functioning in adolescents
10.2174/1874473710801010099 · 2008 · External reference
The adolescent brain and age-related behavioral manifestations
10.1016/s0149-7634(00)00014-2 · 2000 · External reference
Adolescent brain development and animal models
10.1196/annals.1308.002 · 2004 · External reference
Receptor-dependent formation of endogenous cannabinoids in cortical neurons
10.1016/s0014-2999(01)01182-7 · 2001 · External reference
Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance
10.1054/plef.2001.0356 · 2002 · External reference
Structural organization of signalling to and from IP3 receptors
10.1042/bst20130205 · 2014 · External reference
Cholinergic receptor agonists inhibit pirenzepine-induced dysfunction of spontaneous alternation performance in the mouse
10.1016/0306-3623(95)00038-0 · 1995 · External reference
Systemic, but not local, administration of cannabinoid CB1 receptor agonists modulate prefrontal cortical acetylcholine efflux in the rat
10.1002/syn.10202 · 2003 · External reference
Developmental changes in presynaptic muscarinic modulation of excitatory and inhibitory neurotransmission in rat piriform cortex in vitro: relevance to epileptiform bursting susceptibility
10.1016/j.neuroscience.2006.02.046 · 2006 · External reference
delta(9)-Tetrahydrocannabinol-dependent mice undergoing withdrawal display impaired spatial memory
10.1007/s00213-011-2305-5 · 2011 · External reference
Preferential localization of muscarinic M1 receptor on dendritic shaft and spine of cortical pyramidal cells and its anatomical evidence for volume transmission
10.1523/jneurosci.5719-09.2010 · 2010 · External reference
Diminished excitatory synaptic transmission correlates with impaired spatial working memory in neurodevelopmental rodent models of schizophrenia
10.1016/j.pbb.2021.173103 · 2021 · External reference