Research graph
References from β-Aminoisobutyric acid, L-BAIBA, protects PC12 cells from hydrogen peroxide-induced oxidative stress and apoptosis via activation of the AMPK and PI3K/Akt pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Does vigorous exercise have a neuroprotective effect in Parkinson disease?
10.1212/wnl.0b013e318225ab66 · 2011 · External reference
Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency
10.1038/oby.2008.337 · 2008 · External reference
The muscle-brain axis and neurodegenerative diseases: the key role of mitochondria in exercise-induced neuroprotection
10.3390/ijms22126479 · 2021 · External reference
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
10.1038/s41583-019-0132-6 · 2019 · External reference
TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice
10.1186/s12974-020-01853-x · 2020 · External reference
Mobilizing Parkinson’s disease: the future of exercise
10.3233/jpd-181489 · 2018 · External reference
Mitochondrial dysfunction leads to cortical under-connectivity and cognitive impairment.
10.1016/j.neuron.2019.04.013 · 2019 · External reference
Oxidants, oxidative stress and the biology of ageing
10.1038/35041687 · 2000 · External reference
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
10.1083/jcb.119.3.493 · 1992 · External reference
Octadecaneuropeptide ODN prevents hydrogen peroxide-induced oxidative damage of biomolecules in cultured rat astrocytes
10.1016/j.peptides.2015.06.010 · 2015 · External reference
Oxidative stress and Parkinson’s disease: conflict of oxidant-antioxidant systems
10.1016/j.neulet.2019.134296 · 2019 · External reference
BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARdelta-dependent pathway in mice
10.1007/s00125-015-3663-z · 2015 · External reference
Beta-aminoisobutyric acid, l-BAIBA, is a muscle-derived osteocyte survival factor
10.1016/j.celrep.2018.01.041 · 2018 · External reference
Sulfiredoxin-1 protects PC12 cells against oxidative stress induced by hydrogen peroxide
10.1002/jnr.23218 · 2013 · External reference
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
10.1038/nature05292 · 2006 · External reference
AKT/PKB signaling: navigating downstream
10.1016/j.cell.2007.06.009 · 2007 · External reference
Glutathione--a review on its role and significance in Parkinson’s disease
10.1096/fj.08-125443 · 2009 · External reference
Energy intake and exercise as determinants of brain health and vulnerability to injury and disease
10.1016/j.cmet.2012.08.012 · 2012 · External reference
Apoptosis and autophagy in rat cerebellar granule neuron death: role of reactive oxygen species
10.1002/jnr.22168 · 2010 · External reference
Human-specific transcriptome of ventral and dorsal midbrain dopamine neurons
10.1002/ana.25719 · 2020 · External reference
FGF-2 attenuates neuronal apoptosis via FGFR3/PI3k/Akt signaling pathway after subarachnoid hemorrhage
10.1007/s12035-019-01668-9 · 2019 · External reference
Muscles and their myokines
10.1242/jeb.048074 · 2011 · External reference
Apoptosis and oxidative stress in neurodegenerative diseases
10.3233/jad-132738 · 2014 · External reference
Beta-Aminoisobutyric acid induces browning of white fat and hepatic beta-oxidation and is inversely correlated with cardiometabolic risk factors
10.1016/j.cmet.2013.12.003 · 2014 · External reference
Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds
10.1016/s0026-895x(25)10550-6 · 1995 · External reference
beta-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetes
10.1038/srep21924 · 2016 · External reference
Acute aerobic exercise leads to increased plasma levels of R- and S-β-aminoisobutyric acid in humans
10.3389/fphys.2019.01240 · 2019 · External reference
Identification of physiologically active substances as novel ligands for MRGPRD
10.1155/2012/816159 · 2012 · External reference
Exercise benefits on Alzheimer’s disease: state-of-the-science
10.1016/j.arr.2020.101108 · 2020 · External reference
Gaussian and linear deconvolution of LC-MS/MS chromatograms of the eight aminobutyric acid isomers
10.1016/j.ab.2016.10.017 · 2017 · External reference
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V
10.1016/0022-1759(95)00072-i · 1995 · External reference
beta-Aminoisobutyric acid ameliorates the renal fibrosis in mouse obstructed kidneys via inhibition of renal fibroblast activation and fibrosis
10.1016/j.jphs.2016.12.005 · 2017 · External reference
AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes
10.1161/circresaha.109.212530 · 2010 · External reference
Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway
10.1007/s00726-019-02810-6 · 2020 · External reference
