Research graph
References from Protein network analysis to prioritize key genes in amyotrophic lateral sclerosis. Local targets link to admitted publications; unresolved targets remain external evidence.
ALSoD: a user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics
10.1002/humu.22157 · 2012 · External reference
Genotype-phenotype study in patients with valosin-containing protein mutations associated with multisystem proteinopathy
10.1111/cge.13095 · 2018 · External reference
Novel valosin-containing protein mutations associated with multisystem proteinopathy
10.1016/j.nmd.2018.04.007 · 2018 · External reference
Computing topological parameters of biological networks
10.1093/bioinformatics/btm554 · 2008 · External reference
An automated method for finding molecular complexes in large protein interaction networks
10.1186/1471-2105-4-2 · 2003 · External reference
C9orf72-mediated ALS and FTD: multiple pathways to disease
10.1038/s41582-018-0047-2 · 2018 · External reference
Network medicine: a network-based approach to human disease
10.1038/nrg2918 · 2011 · External reference
Network biology: understanding the cell’s functional organization
10.1038/nrg1272 · 2004 · External reference
Evolutionary and physiological importance of hub proteins
10.1371/journal.pcbi.0020088 · 2006 · External reference
Power and centrality: a family of measures
10.1086/228631 · 1987 · External reference
A graph-theoretic perspective on centrality
10.1016/j.socnet.2005.11.005 · 2006 · External reference
NEK1 mutations in familial amyotrophic lateral sclerosis
2016 · External reference
10.1080/14728222.2018.1439923
10.1080/14728222.2018.1439923 · External reference
RNA dysregulation in amyotrophic lateral sclerosis
10.3389/fgene.2018.00712 · 2018 · External reference
SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1
10.1038/s41598-019-53508-4 · 2019 · External reference
Gemin3: a novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems
10.1083/jcb.147.6.1181 · 1999 · External reference
MINT: the molecular INTeraction database
10.1093/nar/gkl950 · 2007 · External reference
Construction and analysis of protein-protein interaction network of heroin use disorder
10.1038/s41598-019-41552-z · 2019 · External reference
Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins
10.1038/s41598-018-27136-3 · 2018 · External reference
Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications
10.1016/s1474-4422(17)30401-5 · 2018 · External reference
Prognostic factors in ALS: a critical review
10.3109/17482960802566824 · 2009 · External reference
Power-law distributions in empirical data
10.1137/070710111 · 2009 · External reference
Mutations in the glycosyltransferase domain of GLT8D1 are associated with familial amyotrophic lateral sclerosis
10.1016/j.celrep.2019.02.006 · 2019 · External reference
Post-transcriptional inhibition of Hsc70-4/HSPA8 expression leads to synaptic vesicle cycling defects in multiple models of ALS
10.1016/j.celrep.2017.09.028 · 2017 · External reference
Dipeptide repeat (DPR) pathology in the skeletal muscle of ALS patients with C9ORF72 repeat expansion
10.1007/s00401-019-02050-8 · 2019 · External reference
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content
10.1093/hmg/ddm226 · 2007 · External reference
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
10.1016/j.neuron.2011.09.011 · 2011 · External reference
The role of FUS gene variants in neurodegenerative diseases
10.1038/nrneurol.2014.78 · 2014 · External reference
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
10.1038/nature10353 · 2011 · External reference
Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS
10.1038/s41598-018-32902-4 · 2018 · External reference
Specific physical exercise improves energetic metabolism in the skeletal muscle of amyotrophic-lateral- sclerosis mice
10.3389/fnmol.2017.00332 · 2017 · External reference
Understanding network concepts in modules
10.1186/1752-0509-1-24 · 2007 · External reference
A novel ALS-associated variant in UBQLN4 regulates motor axon morphogenesis
2017 · External reference
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
10.1038/nature09320 · 2010 · External reference
10.1101/307835
10.1101/307835 · External reference
Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein
10.1038/s41593-019-0530-0 · 2019 · External reference
Proteomic profile of sorafenib resistance in hepatocellular carcinoma; GRP78 expression is associated with inferior response to sorafenib
10.21873/cgp.20159 · 2019 · External reference
An imbalance between excitatory and inhibitory neurotransmitters in amyotrophic lateral sclerosis revealed by use of 3-T proton magnetic resonance spectroscopy
10.1001/jamaneurol.2013.234 · 2013 · External reference
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
10.1038/nn.4000 · 2015 · External reference
A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases
10.1038/ncomms2828 · 2013 · External reference
A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS
10.1101/gr.243592.118 · 2019 · External reference
Comparative genomics of centrality and essentiality in three eukaryotic protein-interaction networks
10.1093/molbev/msi072 · 2005 · External reference
IntAct: an open source molecular interaction database
10.1093/nar/gkh052 · 2004 · External reference
Senataxin mutations and amyotrophic lateral sclerosis
10.3109/17482968.2010.545952 · 2011 · External reference
Optineurin inclusions occur in a minority of TDP-43 positive ALS and FTLD-TDP cases and are rarely observed in other neurodegenerative disorders
10.1007/s00401-011-0813-3 · 2011 · External reference
ESC: an efficient synchronization-based clustering algorithm
10.1016/j.knosys.2012.11.015 · 2013 · External reference
Architecture of the human interactome defines protein communities and disease networks
10.1038/nature22366 · 2017 · External reference
A novel microtubule-tau association enhancer and neuroprotective drug candidate: Ac-SKIP
10.3389/fncel.2019.00435 · 2019 · External reference
From protein interaction networks to novel therapeutic strategies
10.1002/iub.1040 · 2012 · External reference
Lethality and centrality in protein networks
10.1038/35075138 · 2001 · External reference
Exome sequencing reveals VCP mutations as a cause of familial ALS
10.1016/j.neuron.2010.11.036 · 2010 · External reference
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis
10.1038/nn.3688 · 2014 · External reference
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
10.1038/ncomms12143 · 2016 · External reference
Lost in transportation: nucleocytoplasmic transport defects in ALS and other neurodegenerative diseases
10.1016/j.neuron.2017.07.029 · 2017 · External reference
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
10.1126/science.1166066 · 2009 · External reference
Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study
10.1016/s1474-4422(10)70184-8 · 2010 · External reference
Molecular and cellular mechanisms affected in ALS
10.3390/jpm10030101 · 2020 · External reference
S-nitrosylated GAPDH mediates neuronal apoptosis induced by amyotrophic lateral sclerosis-associated mutant SOD1G93A
10.1080/19768354.2016.1259182 · 2016 · External reference
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
10.1016/j.cell.2006.03.032 · 2006 · External reference
Whole exome sequencing reveals a broader variant spectrum of Charcot-Marie-Tooth disease type 2
10.1007/s10048-019-00591-4 · 2020 · External reference
Identifying disease-gene associations with graph-regularized manifold learning
10.3389/fgene.2019.00270 · 2019 · External reference
Unresolved reference
External reference
Kinless hubs are potential target genes in prostate cancer network
10.1016/j.ygeno.2020.09.033 · 2020 · External reference
What causes amyotrophic lateral sclerosis?
10.12688/f1000research.10476.1 · 2017 · External reference
Mutations of optineurin in amyotrophic lateral sclerosis
10.1038/nature08971 · 2010 · External reference
Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase
10.1074/jbc.m113.479345 · 2013 · External reference
ALS genetics, mechanisms, and therapeutics: where are we now?
10.3389/fnins.2019.01310 · 2019 · External reference
Oxidative stress biomarkers in sporadic ALS
10.1080/17482960801933942 · 2008 · External reference
10.1109/2.781637
10.1109/2.781637 · External reference
Intrinsically disordered domains, amyloids and protein liquid phases: evolving concepts and open questions
10.2174/0929866524666170206122106 · 2017 · External reference
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43
10.1093/hmg/ddu578 · 2015 · External reference
Apoptosis regulatory protein-protein interaction demonstrates hierarchical scale-free fractal network
10.1093/bib/bbu036 · 2015 · External reference
Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis
10.1038/ncomms12547 · 2016 · External reference
Genome-wide analyses identify KIF5A as a novel ALS gene
2018 · External reference
Dynamics of dynamin-related protein 1 in Alzheimer’s disease and other neurodegenerative diseases
10.3390/cells8090961 · 2019 · External reference
Differential variation patterns between hubs and bottlenecks in human protein-protein interaction networks
10.1186/s12862-016-0840-8 · 2016 · External reference
Dynamical and correlation properties of the internet
10.1103/physrevlett.87.258701 · 2001 · External reference
DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation
10.1074/jbc.m112.390120 · 2012 · External reference
Rechecking the centrality-lethality rule in the scope of protein subcellular localization interaction networks
10.1371/journal.pone.0130743 · 2015 · External reference
GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis
10.1016/j.jmb.2008.07.088 · 2008 · External reference
The DisGeNET knowledge platform for disease genomics: 2019 update
2020 · External reference
10.3389/fnmol.2019.00025
10.3389/fnmol.2019.00025 · External reference
Lipid phosphatases SKIP and SHIP2 regulate fibronectin-dependent cell migration in glioblastoma
10.1111/febs.14769 · 2019 · External reference
Hierarchical organization in complex networks
2003 · External reference
g:Profiler-a web server for functional interpretation of gene lists (2016 update)
10.1093/nar/gkw199 · 2016 · External reference
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
10.1016/j.neuron.2011.09.010 · 2011 · External reference
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
10.1038/362059a0 · 1993 · External reference
Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types
10.1126/sciadv.abd9036 · 2021 · External reference
Neuron-targeted caveolin-1 improves neuromuscular function and extends survival in SOD1(G93A) mice
10.1096/fj.201802652rr · 2019 · External reference
Optineurin in Huntington’s disease intranuclear inclusions
10.1016/j.neulet.2011.10.070 · 2012 · External reference
HINT1 gene pathogenic variants: the most common cause of recessive hereditary motor and sensory neuropathies in Russian patients
10.1007/s11033-019-05238-z · 2020 · External reference
Mutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism
10.4161/auto.36098 · 2015 · External reference
Regulation of molecular chaperone GRP78 by Hepatitis B virus: control of viral replication and cell survival
10.1128/mcb.00475-19 · 2020 · External reference
How RNA structure dictates the usage of a critical exon of spinal muscular atrophy gene
2019 · External reference
Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS
10.1016/j.neuron.2014.09.027 · 2014 · External reference
Towards Alzheimer’s root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction. Hypothetical role of the adapter protein ECSIT in familial and sporadic Alzheimer’s disease pathogenesis
10.1002/bies.201100193 · 2012 · External reference
A Systematic and comprehensive review on disease-causing genes in amyotrophic lateral sclerosis
10.1007/s12031-020-01569-w · 2020 · External reference
BioGRID: a general repository for interaction datasets
10.1093/nar/gkj109 · 2006 · External reference
A human protein-protein interaction network: a resource for annotating the proteome
10.1016/j.cell.2005.08.029 · 2005 · External reference
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP
10.1038/ncomms7171 · 2015 · External reference
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases
10.1074/jbc.m503341200 · 2005 · External reference
LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice
10.1038/s41418-019-0422-6 · 2020 · External reference
CytoNCA: a cytoscape plugin for centrality analysis and evaluation of protein interaction networks
10.1016/j.biosystems.2014.11.005 · 2015 · External reference
Mutations in the vesicular trafficking protein Annexin A11 are associated with amyotrophic lateral sclerosis Bradley N. Smith
2017 · External reference
Significant scales in community structure
10.1038/srep02930 · 2013 · External reference
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
2016 · External reference
The fine tuning of drp1-dependent mitochondrial remodeling and autophagy controls neuronal differentiation
10.3389/fncel.2019.00120 · 2019 · External reference
Interactome networks and human disease
10.1016/j.cell.2011.02.016 · 2011 · External reference
Power-law distributions in binned empirical data
10.1214/13-aoas710 · 2014 · External reference
Current knowledge and recent insights into the genetic basis of amyotrophic lateral sclerosis
2018 · External reference
STRING: a database of predicted functional associations between proteins
10.1093/nar/gkg034 · 2003 · External reference
The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function
10.1093/nar/gkq537 · 2010 · External reference
Jalview version 2--a multiple sequence alignment editor and analysis workbench
10.1093/bioinformatics/btp033 · 2009 · External reference
The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity
10.1074/jbc.m513452200 · 2006 · External reference
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia
10.1038/ncomms11253 · 2016 · External reference
Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity
10.1038/ncomms15558 · 2017 · External reference
ALSOD: the amyotrophic lateral sclerosis online database
10.1080/17482960802146106 · 2008 · External reference
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
10.1038/nature11280 · 2012 · External reference
Top 10 algorithms in data mining
10.1007/s10115-007-0114-2 · 2008 · External reference
The role of heat shock proteins during neurodegeneration in Alzheimer’s, Parkinson’s and Huntington’s Disease
10.1007/978-0-387-39954-6_7 · 2009 · External reference
DIP: the database of interacting proteins: 2001 update
10.1093/nar/29.1.239 · 2001 · External reference
GRP78 activates the Wnt/HOXB9 pathway to promote invasion and metastasis of hepatocellular carcinoma by chaperoning LRP6
10.1016/j.yexcr.2019.07.006 · 2019 · External reference
Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementia
10.1212/wnl.0b013e3181f07e0c · 2010 · External reference
U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish
10.1093/nar/gkv157 · 2015 · External reference
A network medicine approach to human disease
10.1016/j.febslet.2009.03.001 · 2009 · External reference
Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing
10.1074/jbc.m305191200 · 2003 · External reference
