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References from The type 1 cannabinoid receptor positive allosteric modulators GAT591 and GAT593 reduce spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg. Local targets link to admitted publications; unresolved targets remain external evidence.
Profiling two indole-2-carboxamides for allosteric modulation of the CB1 receptor
10.1111/jnc.12115 · 2013 · External reference
The future of type 1 cannabinoid receptor allosteric ligands
10.1080/03602532.2018.1428341 · 2018 · External reference
A brief history of typical absence seizures — Petit mal revisited
10.1016/j.yebeh.2018.01.007 · 2018 · External reference
Absence seizures: thalamic neurons and networks related to absence epilepsy
2009 · External reference
T-type calcium channels in burst-firing, network synchrony, and epilepsy
10.1016/j.bbamem.2012.07.028 · 2013 · External reference
Direct inhibition of T-type calcium channels by the endogenous cannabinoid anandamide
10.1093/emboj/20.24.7033 · 2001 · External reference
Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability
10.1016/s0896-6273(03)00235-6 · 2003 · External reference
Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy
10.1016/j.neuropharm.2012.11.017 · 2013 · External reference
Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures
10.1093/brain/awaa072 · 2020 · External reference
Identifying neural drivers with functional MRI: an electrophysiological validation
10.1371/journal.pbio.0060315 · 2008 · External reference
The genetic absence epilepsy rat from Strasbourg as a model to decipher the neuronal and network mechanisms of generalized idiopathic epilepsies
10.1016/j.jneumeth.2015.05.022 · 2016 · External reference
Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy
10.1111/epi.12118 · 2013 · External reference
The endocannabinoid system and its therapeutic exploitation
10.1038/nrd1495 · 2004 · External reference
Allosteric modulators of cannabinoid receptor 1: developing compounds for improved specificity
10.1080/03602532.2018.1428342 · 2018 · External reference
Fast oxygen dynamics as a potential biomarker for epilepsy
10.1038/s41598-018-36287-2 · 2018 · External reference
Application of fluorine- and nitrogen-walk approaches: defining the structural and functional diversity of 2-phenylindole class of cannabinoid 1 receptor positive allosteric modulators
10.1021/acs.jmedchem.9b01142 · 2020 · External reference
Discovery of a biased allosteric modulator for cannabinoid 1 receptor: preclinical anti-glaucoma efficacy
10.1021/acs.jmedchem.1c00040 · 2021 · External reference
Control of inhibition by the direct action of cannabinoids on GABAA receptors
10.1093/cercor/bhu045 · 2015 · External reference
Sociability impairments in Genetic Absence Epilepsy Rats from Strasbourg: reversal by the T-type calcium channel antagonist Z944
2017 · External reference
Dosage related efficacy and tolerability of cannabidiol in children with treatment-resistant epileptic encephalopathy: preliminary results of the CARE-E study
10.3389/fneur.2019.00716 · 2019 · External reference
Enantiospecific allosteric modulation of cannabinoid 1 receptor
10.1021/acschemneuro.6b00310 · 2017 · External reference
Positive allosteric modulation of the type 1 cannabinoid receptor reduces the signs and symptoms of Huntington's disease in the R6/2 mouse model
10.1016/j.neuropharm.2019.03.033 · 2019 · External reference
Probing the CB1 cannabinoid receptor binding pocket with AM6538, a high-affinity irreversible antagonist
10.1124/mol.119.116483 · 2019 · External reference
Advantages and limitations of brain imaging methods in the research of absence epilepsy in humans and animal models
10.1016/j.jneumeth.2012.10.018 · 2013 · External reference
From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology
10.1152/physrev.00002.2016 · 2016 · External reference
Pharmacological selection of cannabinoid receptor effectors: signalling, allosteric modulation and bias
10.1016/j.neuropharm.2021.108611 · 2021 · External reference
The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg
10.1016/j.nbd.2016.06.001 · 2016 · External reference
The Genetic Absence Epilepsy Rats from Strasbourg model of absence epilepsy exhibits alterations in fear conditioning and latent inhibition consistent with psychiatric comorbidities in humans
10.1111/ejn.13110 · 2016 · External reference
The T-type calcium channel blocker Z944 reduces conditioned fear in Genetic Absence Epilepsy Rats from Strasbourg and the non-epileptic control strain
10.1111/ejn.14406 · 2019 · External reference
Enantiomer-specific positive allosteric modulation of CB1 signaling in autaptic hippocampal neurons
10.1016/j.phrs.2017.11.019 · 2018 · External reference
The endocannabinoid system and the brain
10.1146/annurev-psych-113011-143739 · 2013 · External reference
Altered SWD stopping mechanism in WAG/Rij rats subchronically treated with the cannabinoid agonist R(+)WIN55,212-2
2020 · External reference
Cannabinoids in the treatment of epilepsy: hard evidence at last?
10.14581/jer.17012 · 2017 · External reference
Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures
10.1523/jneurosci.0753-07.2007 · 2007 · External reference
A Cav3.2 T-type calcium channel point mutation has splice-variant-specific effects on function and segregates with seizure expression in a polygenic rat model of absence epilepsy
10.1523/jneurosci.5295-08.2009 · 2009 · External reference
Seizure expression, behavior, and brain morphology differences in colonies of Genetic Absence Epilepsy Rats from Strasbourg
10.1111/epi.12840 · 2014 · External reference
Idiopathic generalised epilepsy of late onset: a separate nosological entity?
10.1136/jnnp.2009.176651 · 2010 · External reference
Cognitive impairments in touchscreen-based visual discrimination and reversal learning in Genetic Absence Epilepsy Rats from Strasbourg
10.1016/j.neuroscience.2020.01.028 · 2020 · External reference
Dissociable changes in spike and wave discharges following exposure to injected cannabinoids and smoked cannabis in Genetic Absence Epilepsy Rats from Strasbourg
2020 · External reference
Positive allosteric modulation of type 1 cannabinoid receptors reduces spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg
10.1016/j.neuropharm.2021.108553 · 2021 · External reference
Therapeutic effects of cannabinoids in animal models of seizures, epilepsy, epileptogenesis, and epilepsy-related neuroprotection
10.1016/j.yebeh.2016.11.006 · 2017 · External reference
Cannabinoid–glutamate interactions and neural oscillations: implications for psychosis
10.1111/ejn.13800 · 2018 · External reference
Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward
2020 · External reference
Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence
10.1016/j.biopsych.2017.06.032 · 2018 · External reference
Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts
10.1152/jn.00983.2004 · 2005 · External reference
T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures
10.1126/scitranslmed.3003120 · 2012 · External reference
Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels
10.1038/sj.emboj.7600784 · 2005 · External reference
WAGRij rats show a reduced expression of CB1 receptors in thalamic nuclei and respond to the CB1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges
10.1111/j.1528-1167.2009.02510.x · 2010 · External reference
Epilepsy: channelopathies
2009 · External reference
Compartmentation of glutamine, glutamate, and GABA metabolism in neurons and astrocytes: functional implications
10.1177/1073858403254006 · 2003 · External reference
Assessment of select synthetic cannabinoid receptor agonist bias and selectivity between the type 1 and type 2 cannabinoid receptor
10.1038/s41598-021-90167-w · 2021 · External reference
