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References from The efficacy of duloxetine depends on spinal cholinergic plasticity in neuropathic pain model rats. Local targets link to admitted publications; unresolved targets remain external evidence.
7,8–dihydroxyflavone, a TrkB receptor agonist, blocks long‐term spatial memory impairment caused by immobilization stress in rats
10.1002/hipo.20906 · 2012 · External reference
Donepezil provides positive effects to patients treated with gabapentin for neuropathic pain: an exploratory study
10.1111/aas.12218 · 2014 · External reference
Quantitative assessment of tactile allodynia in the rat paw.
10.1016/0165-0270(94)90144-9 · 1994 · External reference
Enhanced analgesic cholinergic tone in the spinal cord in a mouse model of neuropathic pain
10.1016/j.nbd.2021.105363 · 2021 · External reference
Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis
10.1016/s1474-4422(14)70251-0 · 2015 · External reference
Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery
10.1097/00000542-200703000-00021 · 2007 · External reference
Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function
10.1097/aln.0b013e3181de6d2c · 2010 · External reference
A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury
10.1016/j.jpain.2010.05.005 · 2011 · External reference
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain
10.1097/aln.0b013e31818dac9c · 2008 · External reference
Repeated administration of amitriptyline in neuropathic pain: modulation of the noradrenergic descending inhibitory system
10.1213/ane.0000000000002352 · 2017 · External reference
Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia
10.1016/j.brainres.2015.12.057 · 2016 · External reference
Antihyperalgesic effect of duloxetine and amitriptyline in rats after peripheral nerve injury: influence of descending noradrenergic plasticity
10.1016/j.neulet.2015.06.041 · 2015 · External reference
Repeated administration of duloxetine suppresses neuropathic pain by accumulating effects of noradrenaline in the spinal cord
10.1213/ane.0000000000002380 · 2018 · External reference
Spinal activation of tropomyosin receptor kinase-b recovers the impaired endogenous analgesia in neuropathic pain rats
10.1213/ane.0000000000003592 · 2019 · External reference
An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
10.1016/0304-3959(92)90041-9 · 1992 · External reference
Dexmedetomidine decreases hyperalgesia in neuropathic pain by increasing acetylcholine in the spinal cord
10.1016/j.neulet.2012.08.008 · 2012 · External reference
Impaired pain-evoked analgesia after nerve injury in rats reflects altered glutamate regulation in the locus coeruleus
10.1097/aln.0000000000000796 · 2015 · External reference
Involvement of spinal serotonin receptors in the regulation of intraspinal acetylcholine release
10.1016/j.ejphar.2004.12.017 · 2005 · External reference
Amitriptyline, but not pregabalin, reverses the attenuation of noxious stimulus-induced analgesia after nerve injury in rats
10.1213/ane.0000000000001301 · 2016 · External reference
Novel regulatory systems for acetylcholine release in rat striatum and anti‐Alzheimer’s disease drugs
10.1111/jnc.14701 · 2019 · External reference
An increase in spinal cord noradrenaline is a major contributor to the antihyperalgesic effect of antidepressants after peripheral nerve injury in the rat
10.1016/j.pain.2012.01.029 · 2012 · External reference
Monoamine-dependent, opioid-independent antihypersensitivity effects of intrathecally administered milnacipran, a serotonin noradrenaline reuptake inhibitor, in a postoperative pain model in rats
10.1124/jpet.110.168336 · 2010 · External reference
Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat
10.1097/aln.0000000000000593 · 2015 · External reference
The analgesia effect of duloxetine on post-operative pain via intrathecal or intraperitoneal administration
10.1016/j.neulet.2014.03.046 · 2014 · External reference
Tropomyosin receptor kinase B receptor activation in the locus coeruleus restores impairment of endogenous analgesia at a late stage following nerve injury in rats
10.1016/j.jpain.2018.11.008 · 2019 · External reference
Effects of duloxetine treatment on cognitive flexibility and BDNF expression in the mPFC of adult male mice exposed to social stress during adolescence
10.3389/fnmol.2016.00095 · 2016 · External reference
Superiority of duloxetine to placebo in improving diabetic neuropathic pain: results of a randomized controlled trial in Japan
10.1111/j.2040-1124.2010.00073.x · 2011 · External reference